The use of antiviral drugs for influenza
... not currently approved for use; therefore, influenza chemoprophylaxis and therapy with this drug will not be discussed further. Cross-resistance occurs between amantadine and rimantadine. These agents have no effect on influenza B due to differing conformation of the proton channel protein BM2. Simi ...
... not currently approved for use; therefore, influenza chemoprophylaxis and therapy with this drug will not be discussed further. Cross-resistance occurs between amantadine and rimantadine. These agents have no effect on influenza B due to differing conformation of the proton channel protein BM2. Simi ...
MetroCream
... Because of the minimal absorption of metronidazole, and consequently its insignificant plasma concentration after topical administration, the systemic adverse reactions reported with the oral form of the drug should not be expected with METROGEL, METROCREAM, or METROLOTION (metronidazole topical gel ...
... Because of the minimal absorption of metronidazole, and consequently its insignificant plasma concentration after topical administration, the systemic adverse reactions reported with the oral form of the drug should not be expected with METROGEL, METROCREAM, or METROLOTION (metronidazole topical gel ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... titration may be appropriate. Efficacy has been demonstrated in a range of 4-16 mg/day [see Clinical Studies (14.1)]. However, doses above 6 mg/day for twice daily dosing were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other advers ...
... titration may be appropriate. Efficacy has been demonstrated in a range of 4-16 mg/day [see Clinical Studies (14.1)]. However, doses above 6 mg/day for twice daily dosing were not demonstrated to be more efficacious than lower doses, were associated with more extrapyramidal symptoms and other advers ...
Interleukin?1 gene cluster variants with innate cytokine production
... interplay between secreted IL-1 and IL-1Ra levels must be taken into account, since together they influence IL-1 bioavailability (18). The genes encoding IL-1␣, IL-1, and IL-1Ra (IL1A, IL1B, and IL1RN, respectively) reside within a 430-kb region on chromosome 2q13. Although observed only in relat ...
... interplay between secreted IL-1 and IL-1Ra levels must be taken into account, since together they influence IL-1 bioavailability (18). The genes encoding IL-1␣, IL-1, and IL-1Ra (IL1A, IL1B, and IL1RN, respectively) reside within a 430-kb region on chromosome 2q13. Although observed only in relat ...
ramelteon
... minutes prior to the start of the dark period to characterize their effects on sleep and wakefulness (light NREM [Non-rapid eye movement] sleep [Stage 1 and Stage 2, Light Sleep: LS], slow wave sleep [Stage 3 and Stage 4, Slow Wave Sleep: SWS], REM [Rapid eye movement] sleep). Ramelteon (0.3 mg/kg) ...
... minutes prior to the start of the dark period to characterize their effects on sleep and wakefulness (light NREM [Non-rapid eye movement] sleep [Stage 1 and Stage 2, Light Sleep: LS], slow wave sleep [Stage 3 and Stage 4, Slow Wave Sleep: SWS], REM [Rapid eye movement] sleep). Ramelteon (0.3 mg/kg) ...
Marine Origin Polysaccharides in Drug Delivery Systems
... not soluble in water. Sodium alginate may be used for the purpose of extending the drug release [31]. Studies using tablets containing ibuprofen demonstrated that it is possible to control the absorption ratio of the tablets. By using sodium alginate with different chemical structure and degree of v ...
... not soluble in water. Sodium alginate may be used for the purpose of extending the drug release [31]. Studies using tablets containing ibuprofen demonstrated that it is possible to control the absorption ratio of the tablets. By using sodium alginate with different chemical structure and degree of v ...
Valerian - E
... Are there safety concerns? Valerian is LIKELY SAFE for most people when used in medicinal amounts short-term. Clinical studies have reported safe use of valerian for medicinal purposes in over 12,000 people in trials lasting up to 28 days. The safety of long-term use is unknown. Some information sug ...
... Are there safety concerns? Valerian is LIKELY SAFE for most people when used in medicinal amounts short-term. Clinical studies have reported safe use of valerian for medicinal purposes in over 12,000 people in trials lasting up to 28 days. The safety of long-term use is unknown. Some information sug ...
Stability considerations in liquid dosage forms extemporaneously
... who are unable to swallow solid dosage forms such as tablets or capsules; (iii) patients who must receive medications via nasogastric or gastrostomy tubes; and (iv) patients who require non-standard doses that are more easily and accurately measured by using a liquid formulation (1-10). It is common ...
... who are unable to swallow solid dosage forms such as tablets or capsules; (iii) patients who must receive medications via nasogastric or gastrostomy tubes; and (iv) patients who require non-standard doses that are more easily and accurately measured by using a liquid formulation (1-10). It is common ...
Regulatory requirements for the development of medicinal products
... [2] Substantial: i.e. in general 50,000 patients, but nature and severity of the condition should be taken into account (5). ...
... [2] Substantial: i.e. in general 50,000 patients, but nature and severity of the condition should be taken into account (5). ...
Ezetimibe (Zetia): a new type of lipid-lowering
... disease. Treatment should address both diet and pharmacological therapy regimens. It may be concluded that 7% of American adults are candidates for lipid-lowering agents, since dietary intervention alone reduces LDL cholesterol by only 10%. Modification of risk factors such as hyperlipidemia may be ...
... disease. Treatment should address both diet and pharmacological therapy regimens. It may be concluded that 7% of American adults are candidates for lipid-lowering agents, since dietary intervention alone reduces LDL cholesterol by only 10%. Modification of risk factors such as hyperlipidemia may be ...
Australian public assessment for vortioxetine hydrobromide
... Department of Health and is responsible for regulating medicines and medical devices. ...
... Department of Health and is responsible for regulating medicines and medical devices. ...
Intravenous Anesthesia 1991
... hypotension. Patients in hypovolemic shock should not be induced with propofol. Premedication with opioids decreases the propofol dose necessary for induction of anesthesia, decreases the hemodynamic response to noxious stimuli such as laryngoscopy and intubation, and increases the likelihood of hyp ...
... hypotension. Patients in hypovolemic shock should not be induced with propofol. Premedication with opioids decreases the propofol dose necessary for induction of anesthesia, decreases the hemodynamic response to noxious stimuli such as laryngoscopy and intubation, and increases the likelihood of hyp ...
Modelling of tolerance and rebound in normal and
... Pharmacokinetics describes the absorption, distribution, metabolism and excretion of a drug whereas pharmacodynamics represents the relationship between drug concentration and the onset, intensity and duration of a pharmacological response [1, 2]. Pharmacodynamics includes the exploration and assess ...
... Pharmacokinetics describes the absorption, distribution, metabolism and excretion of a drug whereas pharmacodynamics represents the relationship between drug concentration and the onset, intensity and duration of a pharmacological response [1, 2]. Pharmacodynamics includes the exploration and assess ...
Product Monograph ZANTAC Histamine H
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
PRODUCT MONOGRAPH Pr CILOXAN® 0.3% Ciprofloxacin
... Ophthalmic Solution has been used in 123 children between the ages of one and twelve years and CILOXAN (Ciprofloxacin Hydrochloride) Ophthalmic Ointment has been used in 182 children between the ages of one and twelve years. No serious adverse event was reported in these patients. ...
... Ophthalmic Solution has been used in 123 children between the ages of one and twelve years and CILOXAN (Ciprofloxacin Hydrochloride) Ophthalmic Ointment has been used in 182 children between the ages of one and twelve years. No serious adverse event was reported in these patients. ...
nitropress
... oxidative metabolism. In this situation, cells may be able to provide for their energy needs by utilizing anaerobic pathways, but they thereby generate an increasing body burden of lactic acid. Other cells may be unable to utilize these alternative pathways, and they may die hypoxic deaths. CN¯ leve ...
... oxidative metabolism. In this situation, cells may be able to provide for their energy needs by utilizing anaerobic pathways, but they thereby generate an increasing body burden of lactic acid. Other cells may be unable to utilize these alternative pathways, and they may die hypoxic deaths. CN¯ leve ...
(500 mg metronidazole and 100,000 IU nystatin) Vaginal Ovules Vaginal Cream
... Patients should be warned about the potential for confusion, dizziness, hallucinations, convulsions or eye disorders when treated with metronidazole, and advised not to drive or operate machinery if these symptoms occur. DRUG INTERACTIONS Precautions must be borne in mind, as it is possible that dru ...
... Patients should be warned about the potential for confusion, dizziness, hallucinations, convulsions or eye disorders when treated with metronidazole, and advised not to drive or operate machinery if these symptoms occur. DRUG INTERACTIONS Precautions must be borne in mind, as it is possible that dru ...
THE ROLE OF PREGNANE X RECEPTOR IN 2-ACETYLAMINOFLUORENE-MEDIATED
... induction of MRP2 in PXR⫹/⫹ but not PXR⫺/⫺ animals after the administration of various other PXR ligands (Kast et al., 2002; Teng and Piquette-Miller, 2004), demonstrating involvement of PXR in MRP2 induction. Our results demonstrate a 2-AAF-mediated induction of OATP2 mRNA in PXR⫹/⫹ mice, but not i ...
... induction of MRP2 in PXR⫹/⫹ but not PXR⫺/⫺ animals after the administration of various other PXR ligands (Kast et al., 2002; Teng and Piquette-Miller, 2004), demonstrating involvement of PXR in MRP2 induction. Our results demonstrate a 2-AAF-mediated induction of OATP2 mRNA in PXR⫹/⫹ mice, but not i ...
LIPIDIL MICRO PM
... Statins and cyclosporine Severe myositis and rhabdomyolisis have occurred when a statin or cyclosporine was administered in combination therapy with a fibrate. Therefore, the benefits and risks of using LIPIDIL MICRO® concomitantly with these drugs should be carefully considered. Some severe cases o ...
... Statins and cyclosporine Severe myositis and rhabdomyolisis have occurred when a statin or cyclosporine was administered in combination therapy with a fibrate. Therefore, the benefits and risks of using LIPIDIL MICRO® concomitantly with these drugs should be carefully considered. Some severe cases o ...
Here - Semantic Scholar
... For those elements of the gametic and zygotic algebras which represent populations, multiplication of two such elements represents random mating between the two populations. It seems logical that the order in which populations mate is significant. I.e., if population P mates with population Q and th ...
... For those elements of the gametic and zygotic algebras which represent populations, multiplication of two such elements represents random mating between the two populations. It seems logical that the order in which populations mate is significant. I.e., if population P mates with population Q and th ...
Epzicom (abacavir sulfate and lamivudine) tablets label
... unknown HLA-B*5701 status, screening for the allele is recommended prior to reinitiation of EPZICOM. If hypersensitivity cannot be ruled out, DO NOT reintroduce EPZICOM or any other abacavir-containing product. Even in the absence of the HLA-B*5701 allele, it is important to permanently discontinue ...
... unknown HLA-B*5701 status, screening for the allele is recommended prior to reinitiation of EPZICOM. If hypersensitivity cannot be ruled out, DO NOT reintroduce EPZICOM or any other abacavir-containing product. Even in the absence of the HLA-B*5701 allele, it is important to permanently discontinue ...
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF
... Human Leukocyte Antigen (HLA) allele B*1502 increases the risk for developing SJS/TEN in patients treated with carbamazepine. The chemical structure of oxcarbazepine is similar to that of carbamazepine. Available clinical evidence, and data from nonclinical studies showing a direct interaction betwe ...
... Human Leukocyte Antigen (HLA) allele B*1502 increases the risk for developing SJS/TEN in patients treated with carbamazepine. The chemical structure of oxcarbazepine is similar to that of carbamazepine. Available clinical evidence, and data from nonclinical studies showing a direct interaction betwe ...
Listing proposed for C1-INH - Medical Services Advisory Committee
... enzyme (ACE) inhibitors, oral contraceptive pill). Attacks may be preceded by symptoms such as tingling or a non-itchy rash anywhere on the body, and typically take 24 hours to peak and 48 to 72 hours to resolve. The mean age of symptom onset is 8 to 12 years, but HAE diagnosis does not usually occ ...
... enzyme (ACE) inhibitors, oral contraceptive pill). Attacks may be preceded by symptoms such as tingling or a non-itchy rash anywhere on the body, and typically take 24 hours to peak and 48 to 72 hours to resolve. The mean age of symptom onset is 8 to 12 years, but HAE diagnosis does not usually occ ...