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DXM
DXM

... •  Users saw their DXM use as having been more beneficial than harmful. across a variety of life areas, finding DXM especially beneficial for their mental health. Responses across the areas were highly consistent (Cronbach’s α = 0.83).! ...
Evaluation of Quality Control Parameters of Two Brands of
Evaluation of Quality Control Parameters of Two Brands of

... therapeutically active and standard drug. It can be achieved by following some parameters that are specified in the respective monograph of the drug. This research work was aimed to investigate the quality control parameters of two brands of diazepam (Seduxen®, Sedil®) which are available in market. ...
Treatment with leptin
Treatment with leptin

... This drug is a major cause of drug induced hypoglycemia. The risk is increased against other sulfonylureas. Cholestatic jaundice is noted. Glibenclamide may be contraindicated in those with G6PD deficiency, as it may cause acute haemolysis. • Recently published data suggest glibenclamide is associat ...
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF
FULL PRESCRIBING INFORMATION HIGHLIGHTS OF

... Human Leukocyte Antigen (HLA) allele B*1502 increases the risk for developing SJS/TEN in patients treated with carbamazepine. The chemical structure of oxcarbazepine is similar to that of carbamazepine. Available clinical evidence, and data from nonclinical studies showing a direct interaction betwe ...
TAXUS® Express2 - Boston Scientific
TAXUS® Express2 - Boston Scientific

... release of the drug from the stent surface into the artery walls, to minimize release into the blood stream. Both the amount of drug and release rate have been determined so that healing can occur while allowing the processes leading to restenosis to be minimized, thus reducing the need for addition ...
Tramadol - Medsafe
Tramadol - Medsafe

... tachycardia" and "nausea/urge to vomit/vomiting" was significantly increased with rapid intravenous administration and also tended to be dose dependent. Drug abuse and dependence Although tramadol can produce drug dependence of the µ-opioid type (like codeine or dextropropoxyphene) and potentially m ...
14 A N A L G E S I C S
14 A N A L G E S I C S

... Pain is a common human problem. Approximately $120 billion dollars is spent each year on treatment, lost revenues, and wages for chronic pain clients in the United States alone. Approximately 28% to 30% of the U.S. population suffers from some chronic pain condition. According to a June 2000 Gallup ...
zChap07_140901 - Online Open Genetics
zChap07_140901 - Online Open Genetics

... a recombinant genotype. On the other hand, if no recombination occurs during meiosis, the products have their original combinations and are said to have a nonrecombinant, or parental genotype. Recombination is important because it contributes to the genetic variation that may be observed between ind ...
data sheet
data sheet

... have received high doses of methadone. Patients developing QT prolongation while on Pallidone treatment should be evaluated for the presence of modifiable risk factors, such as concomitant medications with cardiac effects, medicines which might cause electrolyte abnormalities, and medicines which mi ...
Pediatric allergic rhinitis: Factors affecting treatment
Pediatric allergic rhinitis: Factors affecting treatment

... authors express some concern about the use of intranasal glucocorticosteroids in children, and they stress the need for monitoring these children. Very few intranasal glucocorticosteroid therapies have been approved for children, and none is available for children younger than 3 years of age. In con ...
Report of the National Lipid Association`s Statin Safety Task Force
Report of the National Lipid Association`s Statin Safety Task Force

... of coronary artery disease (CAD) events, the nation’s number 1 killer. In particular, the availability of the 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, with their superior ability to modify lipid levels as well as mechanisms of disease, has given us the power t ...
50-State Survey of Laws Regulating the
50-State Survey of Laws Regulating the

... found in a variety of sources, including medical records laws, privacy and health privacy laws, genetic testing/genetic information laws, and laws on human subject protection. State laws may require researchers to obtain prior written informed consent from individuals for specific research uses of t ...
Position Paper: Gastric Lavage
Position Paper: Gastric Lavage

... Seventeen fasting volunteers ingested 30 gelatin capsules prepared with Tc99m bound to sulfur colloid, a nonabsorbable radioactive marker (6). At a mean time of 19 minutes (range 9 –42 minutes) later, gastric lavage was performed and the mean recovery of tracer was 30.3% ( ± SD 17.4). Wide subject-t ...
as a PDF
as a PDF

... are used frequently and intensively in clinical practice for many different indications. Their anti-inflammatory effect is used in inflammatory diseases (e.g. asthma and rheumatoid arthritis) and their immunosuppressive effect is used in autoimmune diseases (e.g. systemic lupus erythematosus [SLE]) ...
GPAT 2010 Question Paper
GPAT 2010 Question Paper

... Q.88 Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above Ans. Q.89 The following protein / polypeptide has a quaternary str ...
MSc Seminar: Donald Dunbar
MSc Seminar: Donald Dunbar

... MSc Seminar 8th February 2012 ...
Your Treatment Supporting
Your Treatment Supporting

... Why do prescription pain medications result in dependence in some people? Even when used properly, opioid medications prescribed for acute, chronic, or postoperative pain can cause symptoms of tolerance and withdrawal. This can cause the brain to want more opioids, setting up the cycle of craving. ...
- International Journal of Pharmaceutical Sciences and
- International Journal of Pharmaceutical Sciences and

... the oral route achieved such popularity may be in part attributed to its ease of administration. Over the years, patient convenience and patient compliance-oriented research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which, medicated ...
1999 Dekkers: BREEDING IN THE 21st CENTURY
1999 Dekkers: BREEDING IN THE 21st CENTURY

... markers, relying on within-family linkage disequilibrium between markers and QTL, by including QTL as random effects along with residual polygenic effects. With increasing marker densities and evidence of extensive linkage disequilibrium across the population (Coppieters et al. 1999), it seems clear ...
Administration of the Combination Clonazepam
Administration of the Combination Clonazepam

... To prevent the clonazepam intake from jeopardizing the comparison between treatment outcomes after Deanxit or placebo, the group assignment (A or B) was added as factor in the general model of repeated measures. This taken into consideration, both outcomes of Treatments 1 and 2 could be compared wit ...
The Science of Gua sha
The Science of Gua sha

... Gua sha’s immune and anti-inflammatory effect: heme oxygenase-1 (HO-1) Practitioners who are familiar with Gua sha know that it can reduce a fever and alter the course of an acute infectious illness as well as reduce inflammatory symptoms in chronic illness. A group at Harvard used bioluminescent im ...
RM-Ii3201  B DIS SPECIFICATION
RM-Ii3201 B DIS SPECIFICATION

... reversal of heparinization, protamine sulfate (1% Injection) by slow infusion will neutralize heparln sodium. No more than 50 mg should be administered, very Slowly, lo any 10 minute period. Each mg of protamine sulfate neutralizes approximately 100 USP heparin units. The amount of protamine require ...
000927 - JHBS Revista Cientifica 3ª edicao
000927 - JHBS Revista Cientifica 3ª edicao

... is not always included in automated systems, and its detection depends on the high skill level of microbiology laboratory professionals. This paper describes the characteristics of L. monocytogenes isolates fortuitously obtained from an endocarditis case in Recife, PE, Brazil. Methods: Six bacterial ...
Acetylcholine-Activated Potassium Channel as a Novel Target for AF
Acetylcholine-Activated Potassium Channel as a Novel Target for AF

... practice with prevalence of over 2,200,000 and 1,300,000 in the United States and Japan, respectively. The prevalence of AF is strongly age dependent; less than 1% of individuals aged <60 years, but approximately 5% of those older than 65 years and about 8% of those older than 80 years are affected ...


... substances used to treat insomnia in 1995 at $1.97 billion, with prescription drugs accounting for less than half of this cost. Other costs of insomnia are due to decreased productivity, absenteeism, and occupational and motor vehicle accidents.3,4 These indirect costs are difficult to estimate, but ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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