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Makena® (hydroxyprogesterone caproate injection) is supported via
Makena® (hydroxyprogesterone caproate injection) is supported via

... As a patient who has been prescribed Makena, I have access to My Adherence Program (“Program”), a program designed to help me stay on track with treatment and provide me with educational information throughout my pregnancy. I understand that my participation in the Program will mean that I may be co ...
Available as a free here - European Cystic Fibrosis Society
Available as a free here - European Cystic Fibrosis Society

... are difficult to diagnose and manage because there is poor agreement between sweat test results and respective clinical signs and symptoms. Currently, over 1700 mutations and polymorphisms have been identified in the CFTR gene (see The Cystic Fibrosis Mutation Database; http://www.genet. sickkids.on.c ...
Extract from the Clinical Evaluation Report for Propranolol
Extract from the Clinical Evaluation Report for Propranolol

... approved in any country for the treatment of IHs. Prior to 2008, corticosteroids (systemic, topical, or intralesional) were used for first-line therapy of IHs (Dickson et al., 2011; Chen et al., 2013), while other systemic therapies included interferon and vincristine (Chen et al., 2013). Treatment ...
Ibuprofen is a non-steriodal anti-inflammatory drug with established
Ibuprofen is a non-steriodal anti-inflammatory drug with established

... The efficacy of ibuprofen in the treatment of pyrexia has been studied in comparator and placebo-controlled studies. The comparator most frequently used is paracetamol. Licensed doses of ibuprofen vary between countries, as they do for paracetamol. For all licensed doses, ibuprofen has been shown t ...
NEW ZEALAND DATA SHEET 1. PRODUCT NAME 2
NEW ZEALAND DATA SHEET 1. PRODUCT NAME 2

... should continue on this diet during treatment with simvastatin. The usual starting dose is 20 mg/day given as a single dose in the evening. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg/day given as a single dose in the evening. Patients who require only a m ...
- Wiley Online Library
- Wiley Online Library

... OXA-type enzymes are not as well inhibited by sulbactam as TEM-1 and other clinically used inhibitors. In general, b-lactamase inhibitors have negligible antimicrobial activity themselves, but restore antimicrobial activity to other b-lactams when used in combination. However, sulbactam is exception ...
The Origins of Genetics
The Origins of Genetics

... Before Mendel’s experiments, many people thought offspring were a blend of the characteristics of their parents. For example, if a tall plant were crossed with a short plant, the offspring would be medium in height. Mendel’s results did not support the blending hypothesis. Mendel correctly concluded ...
PDF - NOCITA - Aratana Therapeutics
PDF - NOCITA - Aratana Therapeutics

... will vary with the type of surgical procedure performed. The perception of pain occurs during the inflammatory phase of wound healing, which lasts approximately 72 hours; consequently, 72 hours is the recommended minimum amount of time analgesics should be provided following surgery.5 In humans, acu ...
Drug treatments for Parkinson`s booklet Word version
Drug treatments for Parkinson`s booklet Word version

... While there is no cure yet for Parkinson’s, there are many different drugs that can help manage the symptoms.1 This booklet is for people with Parkinson’s and their families. It provides information about the drugs most commonly used to help manage the condition. This booklet starts with some pract ...
Product Monograph
Product Monograph

... PHARMACOLOGY, Special Populations and Conditions - Pediatrics). Therefore, until further data are available, use of linezolid in this age group is not recommended Geriatrics: Of the 2046 patients treated with ZYVOXAM in phase III comparator-controlled clinical trials, 589 (29%) were 65 years or olde ...
Sovaldi - Gilead
Sovaldi - Gilead

... intervention have been reported when amiodarone is coadministered with SOVALDI in combination with an investigational agent (NS5A inhibitor) or simeprevir. A fatal cardiac arrest was reported in a patient receiving a sofosbuvir-containing regimen (HARVONI (ledipasvir/sofosbuvir)). Bradycardia has ge ...
Ibuprofen and paracetamol for patent ductus arteriosus
Ibuprofen and paracetamol for patent ductus arteriosus

... al. successfully treated with paracetamol two patients with ibuprofen-resistant PDA at 3-18 days of life [13], while Oncel et al. successfully treated with paracetamol 5 preterm infants with ibuprofen-resistant PDA at 5-27 days of life [16]. The mechanism by which paracetamol can close ibuprofen ref ...
Technical Guide for countries to set targets for universal
Technical Guide for countries to set targets for universal

... WHO publications – whether for sale or for non-commercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; e-mail: [email protected]). The designations employed and the presentation of the material in this publication do not imply the expression of any o ...
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50
NEW ZEALAND DATA SHEET TOPIRAMATE ACTAVIS 15, 25, 50

... In humans, the major route of elimination of unchanged topiramate and its metabolites is via the kidney (at least 81% of the dose). Approximately 66% of a dose of 14C-topiramate was excreted unchanged in the urine within four days. Following twice a day dosing with 50 mg and 100 mg of topiramate the ...
CONTROLLED SUBSTANCES
CONTROLLED SUBSTANCES

... (c) "Department" means the department of community health. (d) "Electronic signature" means an electronic sound, symbol, or process attached to or logically associated with a record and executed or adopted by a person with the intent to sign the record. An electronic signature also is a unique ident ...
Australian public assessment for everolimus
Australian public assessment for everolimus

... The mTOR pathway is central to many signal transduction pathways and metabolic processes in the cell and is known to be upregulated in some tumours. Everolimus can potentially be combined with a variety of anti cancer agents. This was tested by the sponsor in vitro and in vivo (with trastuzumab only ...
11.1-11.3 Notes
11.1-11.3 Notes

... Mendel realized that the principles of probability could be used to explain the results of his genetic crosses. Probability is the likelihood that a particular event will occur. For example, there are two possible outcomes of a coin flip: The coin may land either heads up or tails up. The chance, or ...
Linköping University Post Print rivaroxaban on commonly used coagulation
Linköping University Post Print rivaroxaban on commonly used coagulation

... overdosing is another possible indication for testing. Furthermore, in bleeding patients on rivaroxaban treatment, it would be helpful to know if the drug is present or not in cases where it may be considered to try to use reversal agents, although there are not yet any established antidotes. There ...
Lecture 8 (One compartment IV model for renal clearance
Lecture 8 (One compartment IV model for renal clearance

... But now, moxi has other routes of elimination…? ...
Advances in phage display technology for drug discovery
Advances in phage display technology for drug discovery

... confers host cell recognition by the attachment of phage pIII to the F pilus of a male E. coli. The phage genome is then transferred to the cytoplasm of the bacterial cell where it is converted from single strand DNA to double-stranded plasmid replicative form by host DNA replication machinery. By r ...
Antidote–Opioids
Antidote–Opioids

... withdrawal is present, the administration of metoclopramide, clonidine, or a benzodiazepine is usually adequate.43 What constitutes an appropriate observation period after antagonist administration depends on many factors. After IV bolus naloxone, observation for two hours should be adequate to dete ...
SYNAGIS® (palivizumab) CODING RESOURCE
SYNAGIS® (palivizumab) CODING RESOURCE

... initial exposure or re-exposure to Synagis. Other acute hypersensitivity reactions, which may be severe, have also been reported on initial exposure or re-exposure to Synagis. The relationship between these reactions and the development of antibodies to Synagis is unknown. If a significant hypersens ...
Shaping the future of retail pharmacy
Shaping the future of retail pharmacy

... requirements, available cash flow and any other factors that the Board of Directors may consider relevant, it is the intention of the Board of Directors to declare a comparable quarterly dividend on an ongoing basis. It is expected that future dividend payments will be made to shareholders of record ...
PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION
PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION

... contraceptive precautions should commence as early as possible after Mifegymiso administration (see WARNINGS AND PRECAUTIONS, Special Populations, Pregnant Women). Cardiovascular Rare serious cardiovascular accidents have been reported following administration of prostaglandins including misoprostol ...
The Health Consequences of Smoking - Rx for Change
The Health Consequences of Smoking - Rx for Change

... *Currently regulated by the FDA Center for Drug Evaluation and Research. It is anticipated that the FDA Center for Tobacco Control Products will regulate other nicotine-containing products , including electronic cigarette products that do not make a therapeutic claim, in the future. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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