• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Does Oral Trenbolone Really Have the Best Steroid
Does Oral Trenbolone Really Have the Best Steroid

... over a period of weeks. When the drug is in powder form, some users will make a suspension suitable for injection. This method presents a danger because the solution will not be sterile and therefore unsafe. ...
Dosage Adjustment for Cytotoxics in Renal Impairment
Dosage Adjustment for Cytotoxics in Renal Impairment

... SPC (Hospira 2006) – Dose reduce with renal impairment and monitor haematological nadirs and renal function. Myelosuppression is closely related to renal clearance. Carboplatin is contra-indicated with CrCl <20ml/min. Faulding – CrCl >40ml/min, max dose = 400mg/m2 CrCl 20-39ml/min, max dose = 250mg/ ...
DATA SHEET Tramal Capsules Solution for Injection
DATA SHEET Tramal Capsules Solution for Injection

... When tramadol treatment of pain is required long-term, careful and regular monitoring should be carried out to establish whether, and to what extent, ongoing treatment is necessary. Carcinogenesis, mutagenesis and impairment of fertility Tramadol was not mutagenic in the following assays: Ames Salmo ...
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB  Research Article PROF.M.V.NAGABHUSHANAM
HYDROPHILIC POLYMERS FOR DISSOLUTION ENHANCEMENT OF CELECOXIB Research Article PROF.M.V.NAGABHUSHANAM

... anti-pyretic activities is used in the treatment of rheumatoid arthritis and osteoarthritis (1,2). Celecoxib is also used in the management of acute pain and dysmenorrhoea, as an adjunct to standard therapy (3) to reduce the number of adenomatous colorectal polyps in patients with familial adenomato ...
Clinical Pharmacokinetics Of
Clinical Pharmacokinetics Of

... these ...
Comprehensive List of Insulins
Comprehensive List of Insulins

... contained in Afrezza is regular human insulin. Following pulmonary absorption into systemic circulation, the metabolism and elimination are comparable to regular human insulin. Clinical trials have shown reduction in HbA1c with a reduced risk of hypoglycemia when compared to other rapid-acting analo ...
Statins Transport, side effects and cytoxicity_Rev2
Statins Transport, side effects and cytoxicity_Rev2

... with the lactones having a higher metabolic rate. [17,18] While it has been found that rosuvastatin is not significantly metabolized by the CYP enzymes, and is largely excreted unchanged, this situation is complicated by the finding that glucuronidation products of simvastatin acid, cerivastatin aci ...
PRODUCT MONOGRAPH UNIPHYL Theophylline Sustained
PRODUCT MONOGRAPH UNIPHYL Theophylline Sustained

... considered. Overdoses of theophylline may cause serious side effects such as tachycardia, arrhythmias, seizures, vascular collapse and even death. These may occur without warning and may not be preceded by less severe side effects such as nausea or restlessness. ...
drug registration guidance document
drug registration guidance document

... of persons as he thinks necessary for the better carrying out of the provisions of these Regulations and which in particular relate to - (a) product quality, safety and efficacy; (b) labeling; (c) change of particulars of a product; (d) transfer of licences; (e) manufacturing; (f) storage includes r ...
These highlights do not include all the information needed to use
These highlights do not include all the information needed to use

... year. PERFOROMIST Inhalation Solution was studied in a 12-week, placebo- and active-controlled trial (123 subjects treated with PERFOROMIST Inhalation Solution) and a 52-week, active-controlled trial (463 subjects treated with PERFOROMIST Inhalation Solution). Patients were mostly Caucasians (88%) b ...
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH

... hypoprothrombinemia. Hepatic/Biliary/Pancreatic There is an enhanced effect of corticosteroids on patients with cirrhosis. Immune Corticosteroids may mask some signs of infections and new infections may appear. Persons who are on drugs which suppress the immune system are more susceptible to infecti ...
[Salvia divinorum - a potential drug for abuse]
[Salvia divinorum - a potential drug for abuse]

... Selective kappa receptoragonists have been shown to produce analgesic effects with potential for reduced tolerance and dependence. However, psychotomimesis (hallucinogenic and/or psychotic effects), dysphoria and diuresis have been observed with their therapeutic use (Tidgewell et aI., 2004). In add ...
An overview of management of drug
An overview of management of drug

... scalp hair, eyebrows and eyelashes [5] . Full regrowth is expected in majority of cases, but the patient should be educated that the recovery will take several months [1] . In some cases diffuse, permanent alopecia has been reported [2] . Anagen effluvium is almost exclusively observed after treatme ...
PEDIATRIC PHARMACOTHERAPY
PEDIATRIC PHARMACOTHERAPY

... component of the management of children who have received a solid organ transplant. The calcineurin inhibitors, cyclosporine and tacrolimus, have been the primary immunosuppressive agents used in children for the past two decades; however, each is associated with a significant number of adverse effe ...
NLA Task Force On Statin Safety - 2014 Update
NLA Task Force On Statin Safety - 2014 Update

... dementia, cancer, substance abuse, history of noncompliance, and active rheumatologic or musculoskeletal conditions. Thus, patients who are more susceptible to adverse events may be underrepresented in RCTs. In assessing safety or harm of any therapy, going beyond RCTs is thus very important. Eviden ...
bioequivalence guideline
bioequivalence guideline

... the applications made for generic medicines and increases assurance regarding the acceptance of their applications and reduces the amount of time the authorities need to debate borderline issues. Key improvements offer clarification on many study design issues, including the inclusion of a scaled ap ...
ACE Inhibitors and Angiotensin II
ACE Inhibitors and Angiotensin II

... from the Drug Tariff, January 2008. Category M drugs are reviewed on a quarterly basis and therefore the prices may change in the future. ...
Treatment of Bronchial Asthma
Treatment of Bronchial Asthma

...  They are 1000-fold more potent than histamine in stimulating airway smooth muscle constriction.  They also promote microvascular leakage, mucus secretion and eosinophil chemotaxis.  Pathway augmented by COX inhibitors (i.e. NSAIDs) ...
EC-NAPROSYN (naproxen delayed-release tablets) NAPROSYN (naproxen tablets)
EC-NAPROSYN (naproxen delayed-release tablets) NAPROSYN (naproxen tablets)

... pain and dysmenorrhea. Onset of pain relief can begin within 1 hour in patients taking naproxen and within 30 minutes in patients taking naproxen sodium. Analgesic effect was shown by such measures as reduction of pain intensity scores, increase in pain relief scores, decrease in numbers of patients ...
Pepcid - Transplant Companions
Pepcid - Transplant Companions

... MAXIMUM STRENGTH PEPCID® AC Famotidine Tablets 20mg WHAT IS MAXIMUM STRENGTH PEPCID® AC? MAXIMUM STRENGTH PEPCID® AC contains a medicine, different from antacids, which doctors have prescribed for years to treat acid-related problems in millions of people. Each MAXIMUM STRENGTH PEPCID® AC tablet con ...
CLINDOXYL GEL - Skin Therapy Letter
CLINDOXYL GEL - Skin Therapy Letter

... Topically applied clindamycin phosphate formulations can be absorbed in sufficient amounts to produce systemic effects (see WARNINGS). If medication is applied excessively, marked redness and peeling may occur. There are no reports of human ingestion overdosage with CLINDOXYL Gel (clindamycin phosph ...
auspar-rilpivirine-1.. - Therapeutic Goods Administration (TGA)
auspar-rilpivirine-1.. - Therapeutic Goods Administration (TGA)

... The Therapeutic Goods Administration (TGA) is a division of the Australian Government Department of Health and Ageing, and is responsible for regulating medicines and medical devices. ...
Sedation for diagnostic and therapeutic procedures in children and
Sedation for diagnostic and therapeutic procedures in children and

... The aims of sedation during diagnostic or therapeutic procedures include reducing fear and anxiety, augmenting pain control and minimising movement. The importance of each of these aims will vary depending on the nature of the procedure and the characteristics of the patient. There are many sedation ...
View - OhioLINK ETD
View - OhioLINK ETD

... violations in some statistical methods for genetic association studies and use simulations to test the robustness of these methods. In genetic studies, one of the major objectives is to apply statistical models to identify genes contributing to variations in specific quantitative traits. In order to ...
Antimicrobial Dosing for Adults in Renal Impairment
Antimicrobial Dosing for Adults in Renal Impairment

... The latest edition of the British National Formulary gives dosage adjustments for many drugs expressed in terms of eGFR rather than creatinine clearance. Although the two equations are not interchangeable, there is relatively good correlation between the two for calculating renal function in patient ...
< 1 ... 29 30 31 32 33 34 35 36 37 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report