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Performance Measures 2016 Clinical Measures for Adults
Performance Measures 2016 Clinical Measures for Adults

... QM-17: Inappropriate Prescription of a Direct Thrombin and Factor Xa Inhibitor (Rivaroxaban or Edoxaban) ...................................................................................................... 62 QM-18: Inappropriate Prescription of Aspirin and Oral Anticoagulation Therapy ........... ...
evaluation for flushing, safety and tolerability of niacin
evaluation for flushing, safety and tolerability of niacin

... EVALUATION FOR FLUSHING, SAFETY AND TOLERABILITY OF NIACIN (N) IN COMBINATION WITH 40 MG OF OXYCODONE (O) D. R. Jasinski; Johns Hopkins, Baltimore, MD ...
Lamictal - GSK Source
Lamictal - GSK Source

... See full prescribing information for complete boxed warning. • Cases of life-threatening serious rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and/or rash-related death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adu ...
Improving anti-drug antibody assay performance in
Improving anti-drug antibody assay performance in

... Today mAbs are used as targeting therapies for several diseases including autoimmune and infectious diseases, oncological disorders and transplant rejection (Hansel et al. 2010). In 2012 Sloan et al. reported that over 20 mAbs have been approved and that more than 200 are in development. One advanta ...
Prescribing information
Prescribing information

... LAMISIL Oral Granules are contraindicated for patients with chronic or active liver disease. Before prescribing LAMISIL Oral Granules, perform liver function tests because hepatotoxicity may occur in patients with and without preexisting liver disease. Cases of liver failure, some leading to liver t ...
Interpret a Prescription Order
Interpret a Prescription Order

... Oral Route (Insert Dari) Disadvantages: Sometimes inefficient certain drugs are not very well absorbed into the bloodstream. First-pass effect - drugs absorbed orally are transported to the general circulation via the liver. Drugs are then extensively metabolized in the liver reducing the amount of ...
Timolol Maleate Ophthalmic Solution, USP 0.25% and 0.5%
Timolol Maleate Ophthalmic Solution, USP 0.25% and 0.5%

... observed at this dose in rats, there were no adverse effects on postnatal development of offspring. Doses of 1000 mg/kg/day (142,000 times the systemic exposure following the maximum recommended human ophthalmic dose) were maternotoxic in mice and resulted in an increased number of fetal resorptions ...
4. post-exposure prophylaxis for hiv
4. post-exposure prophylaxis for hiv

... Evidence supporting the use of ARV drugs for post-exposure prophylaxis comes from animal studies (4) and a single casecontrol study in health care workers (5) that demonstrated that ARV drugs could prevent the establishment of chronic HIV infection if administered within a short time following expos ...
Sootheze Six Plus Paracetamol 250mg/5ml Oral Suspension
Sootheze Six Plus Paracetamol 250mg/5ml Oral Suspension

... Analgesics containing paracetamol have been available in the UK for much more than ten years. Their use is well established with recognised efficacy and acceptable safety. The application was submitted under the legal basis of a bibliographic application. In this regard, the applicant has submitted ...
Prescribing Information
Prescribing Information

... preterm birth (defined as delivery at less than 37 weeks of gestation following spontaneous preterm labor or premature rupture of membranes).1 At the time of randomization (between 16 weeks, 0 days and 20 weeks, 6 days of gestation), an ultrasound examination had confirmed gestational age and no kno ...
BOTOX COSMETIC
BOTOX COSMETIC

... Patients with a history of underlying neurologic disorders, dysphagia and/or aspiration should be treated with extreme caution. The botulinum toxin product should be used under specialist supervision in these patients and should only be used if the benefit of treatment is considered to outweigh the ...
Systematic Review of Treatment for Amphetamine
Systematic Review of Treatment for Amphetamine

... Japan have also presented data showing that amphetamine psychosis may persist for several years (Sato et al, ...
5% GLUCOSE INTRAVENOUS INFUSION In
5% GLUCOSE INTRAVENOUS INFUSION In

... To be used for intravenous administration as directed by the physician. The dosage of the glucose intravenous infusion is dependent upon the age, weight, concomitant therapy, clinical and metabolic conditions of the patient as well as laboratory determinations. Electrolyte supplementation may be ind ...
provincial guidelines for the management of epilepsy in adults and
provincial guidelines for the management of epilepsy in adults and

... The EITF is a subgroup of Provincial Neurosurgery Ontario (PNO), a committee working to develop a comprehensive provincial neurosurgical system. The EITF works in collaboration with PNO to support equitable and timely access to neurosurgical care, including epilepsy surgery, and to help maintain the ...
Provincial Guidelines for the Management of Epilepsy in Adults and
Provincial Guidelines for the Management of Epilepsy in Adults and

... The EITF is a subgroup of Provincial Neurosurgery Ontario (PNO), a committee working to develop a comprehensive provincial neurosurgical system. The EITF works in collaboration with PNO to support equitable and timely access to neurosurgical care, including epilepsy surgery, and to help maintain the ...
Mucuna pruriens in Parkinson`s disease: a double
Mucuna pruriens in Parkinson`s disease: a double

... The plasma concentration v time profiles of L-dopa after LD/ CD, 15 and 30 g mucuna ingestion are shown in fig 1A. Fig 1B shows the concurrent profiles for 3-OMD. The pharmacokinetic constants, as calculated from the logarithmic concentration v time plots of individual patients, are shown in table 3 ...
trainer manual
trainer manual

... Instruction regarding insulin injection is an integral part of the medication training course. Much of the content on this topic is covered in a separate publication, Managing Your Diabetes (an Eli Lilly and Company educational publication). Managing Your Diabetes, or a similar publication, will be ...
How close are you to your blood pressure and
How close are you to your blood pressure and

... previously had an allergic reaction to CADUET or to any of the inactive ingredients. It is not for those with liver problems. And it is not for women who are nursing, pregnant, or may become pregnant. If you take CADUET, tell your doctor if you feel any new muscle pain or weakness. This could be a s ...
Epidural Steroid Injections Safety Recommendations by the Multi
Epidural Steroid Injections Safety Recommendations by the Multi

... he regulations of the Food and Drug Administration (FDA) are crucial to the entire population of the United States. Since its establishment in 1906, however, a myriad of governmental agencies and nongovernmental organizations have openly criticized numerous controversial actions and regulations of t ...
Gamma Hydroxybutyric Acid (GHB) Intoxication Abstract 730
Gamma Hydroxybutyric Acid (GHB) Intoxication Abstract 730

... free radicals.2,5,6 Despite promising beneficial effects in basic science research, GHB has not found widespread clinical use. In the 1960–70’s, GHB was used as a general anesthetic agent but fell out of favor due to an association with abnormal electroencephalographic (EEG) patterns in animals.7,8 ...
Advanced Practice Nursing in Acute and Critical Care Environments
Advanced Practice Nursing in Acute and Critical Care Environments

... new ADA/EASD Guidelines issued on April 19, 2012, all of the following are true for managing older patients with T2D, EXCEPT: 1) The focus should be on achieving specific glycemic targets 2) The focus should be on drug safety 3) The patient should be invited to participate in the treatment decisions ...
Dopamine-Serotonin System Stabilizer
Dopamine-Serotonin System Stabilizer

... Aripiprazole, a novel antipsychotic agent, is assumed to be a “dopamine-serotonin system stabilizer”. According to preclinical studies, aripiprazole exerts partial agonistic action on D2 and 5-HT1A receptors. Thus, it may block a receptor if it is overstimulated and stimulate a receptor when activit ...
Prescribing Information - this is a very important time in your life
Prescribing Information - this is a very important time in your life

... 2.4 Discontinuation of Treatment Method of treatment discontinuation will vary depending on the patient’s last ANC: • See Tables 2 or 3 for appropriate ANC monitoring based on the level of neutropenia if abrupt treatment discontinuation is necessary because of moderate to severe neutropenia. ...
The use of antiviral drugs for influenza
The use of antiviral drugs for influenza

Tumescent Technique Chronicles Local Anesthesia, Liposuction
Tumescent Technique Chronicles Local Anesthesia, Liposuction

... convinced me that liposuction was destined to become an important dermatologic surgical procedure. In February 1985, I attended a liposuction course given by Gary Fenno, MD and sponsored by the American Society for Liposuction Surgery. None of the faculty had done liposuction by local anesthesia. L ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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