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Consensus guidelines for the management of postoperative nausea
Consensus guidelines for the management of postoperative nausea

... The present guidelines are the most recent data on postoperative nausea and vomiting (PONV) and an update on the 2 previous sets of guidelines published in 2003 and 2007. These guidelines were compiled by a multidisciplinary international panel of individuals with interest and expertise in PONV unde ...
cocaine 68, 111, 145, 150, 164, 192, 201, 208, 209, 226, 270, 274
cocaine 68, 111, 145, 150, 164, 192, 201, 208, 209, 226, 270, 274

... Drug addiction is characterized by compulsive drug-seeking and drug-taking behavior and by a high rate of relapse even after long periods of abstinence. Although the mesocorticolimbic dopamine (DA) pathway is thought to play a critical role in drug craving and relapse, recent evidence also implicate ...
Marijuana
Marijuana

... If marijuana is consumed in foods or beverages, these can have profound effects. effects are somewhat delayed — usually appearing after 30 For example, THC is able to alter the functioning minutes to 1 hour — because the drug must first pass through of the hippocampus (see “Marijuana, Memory, and th ...
Aloe vera: Plant of Immortality - International Journal of Pharma
Aloe vera: Plant of Immortality - International Journal of Pharma

... main activity against cytomegalovirus was shown 12-36 hours after infection. An in vitro study using zinc acetate and lyophilized Aloe barbadensis (7.5 and 10 percent) demonstrated an antiviral and spermicidal effect. The authors concluded that it might be useful as a contraceptive, especially signi ...
Extract from Clinical Evaluation Report: Ivacaftor
Extract from Clinical Evaluation Report: Ivacaftor

... blister packs. The G551D mutation of the CFTR gene is classified as a gating mutation. KALYDECO (Ivacaftor) was granted Orphan Drug Designation on 14th March 2012 in relation to the following indication: “Treatment of Cystic fibrosis (CF) in patients who have a gating or an R117H mutation in the CFT ...
All about osteoporosis - South Eastern Health and Social Care Trust
All about osteoporosis - South Eastern Health and Social Care Trust

... increase slowly until a person’s late 20s. At this point the balance between bone demolition and bone construction becomes stable. After the age of around 35, bone loss increases very gradually as part of the natural ageing process. This can lead to osteoporosis and an increased risk of broken bones ...
children
children

... Montelukast with or without food daily in the evening. • Onset of effect - 2-3 weeks. ...
Over-the-Counter Sleep Aid Medications and Insomnia
Over-the-Counter Sleep Aid Medications and Insomnia

... In 1982, the Food and Drug Administration authorized the initial marketing of diphenhydramine HCl and diphenhydramine citrate as active ingredients in non-prescription sleep aids. Other general medical uses include relief of allergies, motion sickness, and coughing. Table 1 lists the various OTC pro ...
6. Kelly CP. A 76-year-old man with recurrent
6. Kelly CP. A 76-year-old man with recurrent

... There are many antibiotics available in the United States to treat various forms of infection. Understanding the benefits and risks of antibiotic therapy, such as adverse effects associated with specific antibiotics, and the safe administration and monitoring of patients receiving antibiotics can ap ...
to the Akten FAQs PDF
to the Akten FAQs PDF

... lidocaine is protein bound. Binding is also dependent on the plasma concentration of the alpha-1-acid glycoprotein. Lidocaine is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, ...
Restless Legs Syndrome
Restless Legs Syndrome

... The diagnosis of RLS usually requires the following four conditions be present: 1. An urge to move the legs due to an unpleasant feeling in the legs. 2. The urge to move the legs, or the unpleasant feelings in the legs, begins or gets worse when you are at rest or not moving around frequently. 3. Th ...
SUMMARY OF PRODUCT CHARACTERISTIC
SUMMARY OF PRODUCT CHARACTERISTIC

Antiparasitic Chemotherapy for Human and Veterinary Use 3rd
Antiparasitic Chemotherapy for Human and Veterinary Use 3rd

... Leishmania targets the host cell membrane fusion machinery to modulate immune responses Albert Descoteaux INRS- Institut Armand-Frappier, Laval, QC, Canada ...
serotonin syndrome
serotonin syndrome

Review articles Treatment of Myoclonus
Review articles Treatment of Myoclonus

... who had to stop treatment because of sedation. Three patients felt dramatic improvement within the first week of treatment, but the improvement then completely disappeared at the same dose. Two patients had good and two others mild improvement. Two of these seven patients had evidence for cortical i ...
Evaluation of Pharmacokinetic Interaction between PA
Evaluation of Pharmacokinetic Interaction between PA

... CYP3A4 and/or p-glycoprotein and have interactions with drugs for the treatment of TB, such as rifampin, that are inducers of hepatic enzymes (9). In vitro data indicate that PA-824 is not an inducer but is a weak substrate and potential weak inhibitor of CYP3A4 (data not shown). An assessment of PA ...
UNDERSTANDING OUR NATURAL NAIL – ANTIFUNGAL AGENTS Review  Article
UNDERSTANDING OUR NATURAL NAIL – ANTIFUNGAL AGENTS Review Article

... Topical delivery can be defined as the application of a drug containing formulation to the skin to directly treat cutaneous disorders (e.g. acne) or the cutaneous manifestations of a general disease (e.g. psoriasis) with the intent of the pharmacological or other effect of the drug to the surface of ...
Neonatal Seizures
Neonatal Seizures

... – May not have a dramatic effect with IV pyridoxine thus maintain on oral pyridoxine 10 ...
Neuroscience of psychoactive substance use and dependence Neur
Neuroscience of psychoactive substance use and dependence Neur

... strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses are needed to address these problems in different societies. Many gaps remain ...
ppt - Home
ppt - Home

... • Used alone, aprepitant (40 mg po) prevents PONV • Used in combination with a 5-HT3 RA and dexamethasone, aprepitant prevents CINV better than a 5-HT3 RA plus dexamethasone alone ...
RE:Docket No.98N-0148 ;International Drug
RE:Docket No.98N-0148 ;International Drug

... calming ...
Levitra - GSK Source
Levitra - GSK Source

... LEVITRA should be used with caution by patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis, or Peyronie’s disease) or by patients who have conditions that may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia). 5.4 Effects o ...
Peer-reviewed Article PDF
Peer-reviewed Article PDF

... complexity [22]. Volunteers were required to be non-smokers or exsmokers (less than 5 pack-years and stopped smoking for more than 1 year), have normal blood pressure and heart rate (supine), normal laboratory tests, have a 12-lead ECG with computerized protocol interpretation considered as normal o ...
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT

... QTc Interval Prolongation: Ondansetron prolongs the QT interval (see ACTION AND CLINICAL PHARMACOLOGY, Electrocardiography). The magnitude of QTc prolongation will depend on the dose and the infusion rate. In addition, post-marketing cases of torsade de pointes have been reported in patients using o ...
View Full Prescribing Information
View Full Prescribing Information

... Preparation and Dilution in Bag for Infusion 1. Calculate the milligrams of ANTHIM injection needed by multiplying the recommended mg/kg dose in Table 2 by the patient weight in kilograms. 2. Calculate the required volume in milliliters of ANTHIM injection and number of vials needed for the dose by ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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