• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
PDF - Pharmacological Reviews
PDF - Pharmacological Reviews

... A. An approach of merging the mass-action law with mathematical induction and deduction . . 1. The power of mathematical induction and deduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. Nature’s law . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
minutes cpic October 2013
minutes cpic October 2013

... Details on how to group CPIC evaluations and mechanisms for publishing are not yet decided. Members provided feedback and there was support for the need for these evaluations, particularly for drugs whose genes are already the subject of other CPIC guidelines or genes that are commonly included in c ...
The dilemma of dominance
The dilemma of dominance

... in forming organisms, then one is less likely to imagine cases of collaboration, cooperation or reconciliation in society – or to see them as viable.5 In decisionmaking contexts, equal voice or shared authority become ‘unnatural.’ A feminist perspective here may highlight how the concept is gendered ...
Sumatriptan Succinate Injection - Pack Insert
Sumatriptan Succinate Injection - Pack Insert

... The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the subjects. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Cluster Headache: In the controlled clinical trials assessing the efficacy of sumatript ...
Dapagliflozin (as propanediol monohydrate) / Metformin hydrochloride
Dapagliflozin (as propanediol monohydrate) / Metformin hydrochloride

... action to improve both fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) in patients with type 2 diabetes: dapagliflozin, a SGLT2 inhibitor, and metformin hydrochloride, a member of the biguanide class. Dapagliflozin Dapagliflozin is a reversible competitive inhibitor of sodium gluc ...
product monograph
product monograph

... ASA or dual antiplatelet therapy with either ELIQUIS or warfarin increases the risk of major bleeding in patients with atrial fibrillation. Other platelet aggregation inhibitors such as prasugrel and ticagrelor, have not been studied with ELIQUIS in any patient population, and are not recommended as ...
Lesson Overview
Lesson Overview

... How To Make a Punnett Square for a OneFactor Cross Write the genotypes of the two organisms that will serve as parents in a cross. In this example we will cross a male and female osprey that are heterozygous for large beaks. They each have genotypes of Bb. ...
Claforan - Sanofi Canada
Claforan - Sanofi Canada

... Prolonged use of CLAFORAN may result in the overgrowth of nonsusceptible organisms. Constant evaluation of the patient's condition is essential. If superinfection occurs, therapy should be discontinued and appropriate measures taken. CLAFORAN, like other parenteral anti-infective drugs, may be local ...
Using Genetic Algorithms with Sexual or Asexual Transposition: a
Using Genetic Algorithms with Sexual or Asexual Transposition: a

... 50's (when the DNA structure was not yet completely understood). She proved that certain phenomena present in living beings exposed to UV radiation could not be the result of the normal recombination and mutation processes. She found that certain genetic elements in corn occasionally move producing ...
Review Advances in nucleoside monophosphate prodrugs as anti
Review Advances in nucleoside monophosphate prodrugs as anti

... attempts have shown encouraging results [9]. Chimpanzees are currently the most useful animal model to study antiviral agents for HCV infections; however, ©2010 International Medical Press 1359-6535 (print) 2040-2058 (online) ...
Nicotine increases sucrose selfadministration and seeking in rats
Nicotine increases sucrose selfadministration and seeking in rats

... INTRODUCTION Quitting smoking predicts weight gain and an increase in waist circumference in both men and women (Perkins 1993; Pisinger & Jorgensen 2007). There are likely several biological factors that contribute to this increase in body fat, including insulin resistance (Chiolero et al. 2008); ho ...
[Product Monograph Template - Standard]
[Product Monograph Template - Standard]

... USP should be restricted to hospitalized patents so as to provide constant clinical supervision. Maximum dosage should not exceed 2.5 mg/kg/day or a total of 200 mg/day in patients with normal renal function. Intramuscular dosage is not recommended routinely because of severe pain at injection sites ...
Docetaxel in non-small cell lung cancer
Docetaxel in non-small cell lung cancer

... cyclosporin A) have been shown to increase intestinal absorption of oral docetaxel. Although there is a wide variability in paclitaxel infusion duration, clinical trials of docetaxel uniformly utilized a 1-h infusion. Moreover, no formal dose-intensification studies of docetaxel were conducted in NS ...
Liposomes as drug delivery system
Liposomes as drug delivery system

... suggested the structures be called liposomes, which he then defined as “microscopic vesicles composed of one or more lipid bilayers”. This discovery led the way to a large field of research. The uses found for liposomes have been wide-spread and even include drug delivery systems for cosmetics (Deam ...
Review Nucleotide prodrugs for HCV therapy
Review Nucleotide prodrugs for HCV therapy

... The HCV polymerase has been shown to be a uniquely selective polymerase as it relates to the development of nucleoside/nucleotide inhibitors. Over the last 10 years only two broad classes of nucleosides have emerged as inhibitors of this polymerase [23–25]. These include the 2′-methyl and the 4′-azi ...
AusPAR Attachment 2: Extract from the Clinical Evaluation Report
AusPAR Attachment 2: Extract from the Clinical Evaluation Report

... Department of Health, and is responsible for regulating medicines and medical devices. ...
PreviDent 5000 - Colgate Professional
PreviDent 5000 - Colgate Professional

... damage in rodents, while other studies using similar protocols report negative results. Potential adverse reproductive effects of fluoride exposure in humans has not been adequately evaluated. Adverse effects on reproduction were reported for rats, mice, fox, and cattle exposed to 100 ppm or greater ...
Naloxone: Frequently Asked Questions
Naloxone: Frequently Asked Questions

... Does naloxone only work for overdose cases caused by opioids? Yes. Naloxone only reverses the effects of opioids such as heroin, methadone, morphine, opium, codeine, or hydrocodone. It does not counter the effect of other types of drugs, such as benzodiazepines (drugs including diazepam, midazolam, ...
Ischaemic Heart Disease
Ischaemic Heart Disease

... The assumption that direct and indirect bilirubins represent conjugated and unconjugated bilirubins, respectively although in several assays this may be incorrect. The lack of adequate standards for calibration of the direct bilirubin assay. Direct bilirubin assays have used unconjugated bilirubin f ...
Quantitative analysis of SMN1 and SMN2 genes based on DHPLC
Quantitative analysis of SMN1 and SMN2 genes based on DHPLC

... centromeric SMN (SMN2; MIM# 601627), have been identified. These two SMN genes are highly homologous and differ in only two nucleotides in the coding region. These nucleotide differences, located in exons 7 and 8, allow the SMN1 gene to be distinguished from the SMN2 gene [Lefebvre et al., 1995]. It ...
Medicines Information Bulletin - Oxford Health NHS Foundation
Medicines Information Bulletin - Oxford Health NHS Foundation

... contains sodium valproate) for manic episodes as well as for prevention of further episodes. None of the valproate preparations are licensed for long term prophylaxis in bipolar disorder, although they are often used in this way. ...
Sulfato de Atropina. Monografia.
Sulfato de Atropina. Monografia.

... nursing woman. Pediatric Use A review of published literature supports the safety and effectiveness of atropine in the setting of organophosphate insecticide poisoning in all pediatric age groups. The starting dose is 0.05 mg/kg IM every 5-20 minutes as needed to provide complete atropinization. (se ...
Piracetam - Rebound Health
Piracetam - Rebound Health

... whatever causes dyslexia. Piracetam also seems to inhibit brain damage caused by a variety of factors including hypoxia and excessive alcohol consumption.[7][8] Piracetam has been studied in an extensive number of clinical experiments, and has shown positive results in the treatment of post-stroke a ...
Tartrazine: a potentially hazardous dye in Canadian drugs.
Tartrazine: a potentially hazardous dye in Canadian drugs.

... none of the "nonallergic" patients reacted. Although the dose of tartrazine used in this study was several times greater than the amount of tartrazine usually found in medications, a lower dose (10 mg) produced the same response in the four patients who were rechallenged. From these reports it appea ...
Efficacy and Safety of Sitagliptin in the Treatment of Type 2 Diabetes
Efficacy and Safety of Sitagliptin in the Treatment of Type 2 Diabetes

< 1 ... 19 20 21 22 23 24 25 26 27 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report