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The importance of genetic influences in asthma REVIEW H. Los* , G.H. Koppelman*
The importance of genetic influences in asthma REVIEW H. Los* , G.H. Koppelman*

... in 1650 [26]. At the beginning of this century, R. Cooke performed two large studies on the inheritance of atopy, one in 1916 and the other in 1924 [27, 28]. The first study examined asthma and its related phenotypes, e.g. allergy, urticaria and angioneurotic oedema, in 504 subjects. In the second s ...
Prescribing Framework for Phenelzine (MAOI) in the treatment of
Prescribing Framework for Phenelzine (MAOI) in the treatment of

... not be started until at least 1 week after stopping paroxetine CNS excitation or depression (hypertension or hypotension) when MAOIs given with pethidine—avoid concomitant use and for 2 weeks after stopping MAOIs avoidance of pholcodine for 2 weeks after stopping MAOIs advised by manufacturer of pho ...
D4/D5 The Miracle Drug It`s springtime. Imagine yourself walking
D4/D5 The Miracle Drug It`s springtime. Imagine yourself walking

... scratched by a rose thorn that caused Staphylococcus and Streptococcus infections. Upon given an injection of penicillin, Alexander showed remarkable recovery, but later died due to a supply shortage. 2 In addition, the use of penicillin to treat blood poisoning in children showed positive effects. ...
Transungual Drug Delivery: An Overview
Transungual Drug Delivery: An Overview

... The body normally hosts a variety of microorganisms, including bacteria and fungi. Some of these are useful to the body and others may cause infections. Fungi can live on the dead tissues of the hairs, nails. Continuous exposal of nail to warm, moist environments usually develops nail infection. Nai ...
product monograph - Sobi North America
product monograph - Sobi North America

... RA patients may be at higher risk (up to several fold) for the development of lymphoma. An increased rate of up to several fold has been reported in the RA population, and may be further increased in patients with more severe disease activity. In clinical trials, RA patients treated with KINERET® ha ...
TABLE OF CONTENTS - Epilepsy Foundation of Florida
TABLE OF CONTENTS - Epilepsy Foundation of Florida

... many practical steps you can take to minimize your risk for injury in case of seizure, for example: 1) set the thermostat of the water heater low enough to prevent scalding or purchase a scald protection product; 2) pad sharp corners; 3) try a microwave oven for cooking; 4) select chairs with arms t ...
Mining MIM: phenotype clustering as source of candidate
Mining MIM: phenotype clustering as source of candidate

... Dictionary-based systems for feature extraction are not limited to keyword sets. In fact, most systems that process full-text resources apply dictionaries. However, a dictionary-based system clearly cannot incorporate contextual information present in the text. Interpretation of context is the field ...
Coadministration of Oral Cyclosporin A Enables Oral Therapy with
Coadministration of Oral Cyclosporin A Enables Oral Therapy with

... patients and associated with significant and unpredictable side effects (4 – 6). The current commercially available i.v. formulation consists of a mixture of ethanol and Cremophor EL (polyoxyethyleneglycerol triricinoleate 35), and it is now well established that the latter plays a major role in the ...
PRODUCT MONOGRAPH CEFAZOLIN FOR INJECTION 500 mg, 1
PRODUCT MONOGRAPH CEFAZOLIN FOR INJECTION 500 mg, 1

... There are instances of patients who have had reactions to both penicillins and cephalosporins (including fatal anaphylaxis after parenteral use). Clinical and laboratory evidence of partial cross-allergenicity of the two drug classes exists. Cefazolin sodium should be administered cautiously and the ...
министерство здравоохранения республики беларусь
министерство здравоохранения республики беларусь

... — transfer ribonucleic acid W. bancrofti — wuchereria bancrofti ...
RP-HPLC METHOD DEVELOPMENT AND
RP-HPLC METHOD DEVELOPMENT AND

... blood pressure thus reducing the workload of the heart, which is particularly beneficial in heart failure patients. Norepinephrine also binds to the α1-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure. Carvedilol blocks this binding to the α1-adrenergic recep ...
About Methadone and Buprenorphine
About Methadone and Buprenorphine

... than it does heroin or morphine. When a person takes methadone regularly, it builds up and is stored in the body, so it lasts even longer when used for maintenance. Most people find that once they’re stabilized on a dose of methadone that’s right for them, a single oral dose will “hold” them for at ...
CEFOPERAZONE SODIUM + SULBACTAM
CEFOPERAZONE SODIUM + SULBACTAM

... sodium and sulbactam sodium in humans. Overdosage of the drug would be expected to produce manifestations that are principally extensions of the adverse reactions reported with the drug. The fact that high CSF concentrations of β-lactam antibiotics may cause neurologic effects, including seizures, s ...
DANISH BIOTECH COMPANIES YEAR OF ESTABLISHMENT TYPE
DANISH BIOTECH COMPANIES YEAR OF ESTABLISHMENT TYPE

... Researches and develops small molecule drug candidates within the fields of dermatology, cardiovascular diseases, antithrombotics, antibiotics, and bone metabolism. ...
Mrs - Vitrodiagnostic.com
Mrs - Vitrodiagnostic.com

... Salivary secretion is a reflex response controlled by both parasympathetic and sympathetic secretomotor nerves. Stimulation of sympathetic fibers to all glands causes vasoconstriction; in man, stimulation of the sympathetic trunk in the neck or injection of epinephrine causes secretion by the submax ...
Drug Class Review HMG-CoA Reductase Inhibitors (Statins) and
Drug Class Review HMG-CoA Reductase Inhibitors (Statins) and

... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
Statins - Amazon Web Services
Statins - Amazon Web Services

... In the United States, coronary heart disease and cardiovascular disease account for nearly 40% of all deaths each year. Coronary heart disease continues to be the leading cause of mortality and a significant cause of morbidity among North Americans. In 2006, coronary heart disease claimed 607 000 li ...
Dexmedetomidine - National Association of Veterinary Technicians
Dexmedetomidine - National Association of Veterinary Technicians

... sighthound and brachycephalic anesthesia as well as pain management. Tasha has been a featured speaker on various anesthesia and pain management topics at conferences such as Atlantic Coast Veterinary Conference, AVMA conference and the Wild West Veterinary Conference. In July of 2012 Tasha authored ...
maxzide
maxzide

... This fixed combination drug is not indicated for the initial therapy of edema or hypertens ion except in individuals in whom the development of hypokalemia cannot be ris ked. 1. MAXZIDE (triamterene and hydrochlorothiazide) is indicated for the treatment of hypertension or edema in patients who deve ...
Prescribing Information Only Fluticasone Propionate Nasal Spray
Prescribing Information Only Fluticasone Propionate Nasal Spray

... A total of 13 randomized, double-blind, parallel-group, multicenter, vehicle placebo-controlled clinical trials were conducted in the United States in adults and pediatric patients (4 years of age and older) to investigate regular use of fluticasone propionate nasal spray in patients with seasonal o ...
Insect repellents
Insect repellents

... The Lancet, « Insect Repellents and the efficacy of sunscreens » Vol. 349, June 7, 1997. New England Journal of Medicine, « Comparative Efficacy of Insect Repellents against Mosquito Bite » 347:13-18, July 4, 2002. HealthCanada, « Tips on using personal insect repellents » September, 2004. Proceedin ...
Pfizer Guitly of Violating California Unfair Competition Law
Pfizer Guitly of Violating California Unfair Competition Law

... Commissioner of the FDA from 1990 to 1997. (Trial Tr. vol. 1, 154-56, Feb. 22, 2010.) He is currently a professor of pediatrics, epidemiology and biostatistics and the University of California - San Francisco. (Id. at 156.) ...
protein 2 gene: study of a cohort of Israeli patients - MRC
protein 2 gene: study of a cohort of Israeli patients - MRC

... estimates of MECP2_e1 and MECP2_e2 expression levels in peripheral blood. A systematic analysis of an Israeli cohort of 82 patients with classic and atypical RTT is presented, including sequence analysis of the MECP2-coding region, MLPA, XCI and quantitative expression assays. Results and conclusion ...
Renal Drug Metabolism - Pharmacological Reviews
Renal Drug Metabolism - Pharmacological Reviews

SDZ HTF 919 Stimulates Canine Colonic Motility and Transit In Vivo
SDZ HTF 919 Stimulates Canine Colonic Motility and Transit In Vivo

... time, and the lag time (time for 10% of the isotope to be emptied from the stomach) and the slope (or fractional emptying rate) of the gastric emptying curve were calculated as in previous studies, using a linear model (Camilleri et al., 1989). The slope was estimated by linear regression analysis o ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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