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Migranal - Valeant Pharmaceuticals
Migranal - Valeant Pharmaceuticals

... treatment of migraine headaches was evaluated in four randomized, double blind, placebo controlled studies in the U.S. The patient population for the trials was predominantly female (87%) and Caucasian (95%) with a mean age of 39 years (range 18 to 65 years). Patients treated a single moderate to se ...
Does The Addition Of Dexamethasone To Local Anesthetic Used
Does The Addition Of Dexamethasone To Local Anesthetic Used

... It can be concluded from this study that intravenous dexamethasone is equivalent to perineural dexamethasone in prolonging analgesia. Intravenous dexamethasone at a dose of 0.10.2 milligrams/kilogram could have a comparable analgesic effect and eliminate the need for perineural dexamethasone injecti ...
CITALOPRAM 10 MG, 20 MG AND 40 MG TABLETS PL 36390/0024-6 UKPAR
CITALOPRAM 10 MG, 20 MG AND 40 MG TABLETS PL 36390/0024-6 UKPAR

... generally recognised to occur early in the treatment of this disorder. Although there may be an increased potential for undesirable effects at higher doses, if after some weeks on the recommended dose insufficient response is seen, some patients may benefit from having their dose increased gradually ...
DOXOrubicin vials - Sagent Pharmaceuticals
DOXOrubicin vials - Sagent Pharmaceuticals

... lead to heart failure, which is a condition in which the heart does not pump well. Heart failure is irreversible in some cases and can lead to death. Heart failure can happen during your treatment with Doxorubicin or months to years after stopping treatment. Your risk of heart muscle damage increase ...
Chloramphenicol
Chloramphenicol

... Chloramphenicol palmitate ester is inactive, and is hydrolysed to active chloramphenicol in the small intestine. There is no difference in bioavailability between chloramphenicol and chloramphenicol palmitate. The intravenous (IV) preparation of chloramphenicol is the succinate ester, because pure c ...
Apnea in the Newborn
Apnea in the Newborn

... 2-2.5 mg/kg/hr. Doxapram may be tried for a period of 48 hours before weaning the drug. Methylxanthine therapy should be continued during doxapram infusion. Adverse effects include seizures, hypertension, hyperactivity, hyperglycemia and abdominal distension. It should be avoided in the initial few ...
Assessment of zopiclone - World Health Organization
Assessment of zopiclone - World Health Organization

... (Dündar et al., 2004). Twenty-four studies were identified for review, including 13 with data on zopiclone, but were found provide a confusing diversity of possible comparisons, outcome measures, and interpretations of the rarely standardized outcomes, making the authors to state explicitly the need ...
Product Monograph
Product Monograph

... number of patients (29) ranging in age from 1 day to 6 months have been treated safely with DIFLUCAN. Use in Elderly DIFLUCAN was well tolerated by patients aged 65 years and over. Fluconazole is primarily cleared by renal excretion as unchanged drug. Because elderly patients are more likely to have ...
AusPAR: Rifaximin  - Therapeutic Goods Administration
AusPAR: Rifaximin - Therapeutic Goods Administration

... increased the area under the plasma concentration time curve (AUC) approximately 2 fold but this is still considered negligible. The drug was developed more than 20 years ago and was formulated as 200 mg tablets for the treatment of traveller’s diarrhoea. At that time, polymorphism in rifaximin was ...


... blood flow [27], and the route of furosemide administration. Furosemide infusion is, in general, more effective than boluses in inducing diuresis [28, 29], even in patients with hypoalbuminaemia [30]. The amount of furosemide secreted into the urine appears to be similar after either an intravenous ...
Benefits and risks of furosemide in acute kidney injury
Benefits and risks of furosemide in acute kidney injury

... blood flow [27], and the route of furosemide administration. Furosemide infusion is, in general, more effective than boluses in inducing diuresis [28, 29], even in patients with hypoalbuminaemia [30]. The amount of furosemide secreted into the urine appears to be similar after either an intravenous ...
Applying Mendel`s Principles
Applying Mendel`s Principles

... principles and learned that they applied not just to pea plants but to other organisms as well. The basic principles of Mendelian genetics can be used to study the inheritance of human traits and to calculate the probability of certain traits appearing in the next generation. ...
Dyslipidemia Dx. Rx. by Dr Sarma
Dyslipidemia Dx. Rx. by Dr Sarma

...  Headache, Myalgia, Fatigue, GI intol. Flu-like symptoms  Increase in liver enzymes – serious problems are very rare  Occurs in 0.5 to 2.5% of cases in dose-dependent manner  Myopathy occurs in 0.2 to 0.4% of patients ...
SCIENTIFIC DISCUSSION 1. Introduction
SCIENTIFIC DISCUSSION 1. Introduction

... doses, the cyclic antidepressants tend to have dose-related side effects such as anticholinergic and orthostatic effects, as well as sedation, weight gain, and sexual dysfunction. Overdose of cyclic antidepressants can cause potentially lethal arrhythmias, anticholinergic toxicity and seizures. Neve ...
Martindale: The Complete Drug Reference
Martindale: The Complete Drug Reference

... Cefuroxime may be given to neonates and children for the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria and for surgical prophylaxis. It is given orally (as cefuroxime axetil), or (as the sodium salt) by injection, either intramuscularly or intravenously (by s ...
STAXYN PRODUCT MONOGRAPH
STAXYN PRODUCT MONOGRAPH

... ADVERSE REACTIONS, Post-Market Adverse Drug Reactions). Otologic Sudden decrease or loss of hearing has been reported in a few postmarketing and clinical trial cases with the use of PDE5 inhibitors, including vardenafil. These events, which may be accompanied by tinnitus and dizziness, have been rep ...
PRODUCT MONOGRAPH OFLOXACIN TABLETS 200, 300 and 400 mg
PRODUCT MONOGRAPH OFLOXACIN TABLETS 200, 300 and 400 mg

... laryngeal, throat or facial edema/swelling, etc.), airway obstruction (including bronchospasm, shortness of breath, and acute respiratory distress), dyspnea, urticaria/hives, itching and other serious skin reactions. A few patients had a history of hypersensitivity reactions. The drug should be disc ...
Teschke2009_kava
Teschke2009_kava

... meeting of experts who defined various parameters such as time to onset, course of improvement of laboratory data, risk factors, concomitant drugs, search for nondrug causes, previous information on hepatotoxicity of the drug, and response to readministration. It provides with each of these parameter ...
The effect of anticholinergic drugs on the
The effect of anticholinergic drugs on the

... The results are given in Table 1, the volume after the anticholinergic drugs being listed in order of decreasing volumes of secretion for each patient. These results show that with increasing anticholinergic suppression of gastric secretion there is METHODS AND MATERIALS a drop in acid concentration ...
Naproxen Naproxen Sodium
Naproxen Naproxen Sodium

... Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis. For the symptomatic treatment of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis, but excluding acute gouty arthritis), the usual adult dosage of naproxen is 250–500 mg (275–550 mg of naproxen sodium) twice daily in th ...
Effects of Smoking on the Pharmacokinetics of Erlotinib
Effects of Smoking on the Pharmacokinetics of Erlotinib

... were done at baseline and before each erlotinib dose to confirm each subject’s smoking status. Following each single dose erlotinib administration, the subjects stayed in the clinic for at least 48 hours. Pharmacokinetic methods. Eleven plasma sampling times were used to determine the pharmacokineti ...
What are the perioperative risk benefits of garlic supplementation
What are the perioperative risk benefits of garlic supplementation

... research suggests that garlic may possess risks and benefits during the perioperative period. During the preanesthesia assessment for the patients scheduled to receive anesthesia, most anesthesia providers inquire about patients’ prescription drug use. Due to limited clinical trials providing eviden ...
pharmaceutical informations on the web
pharmaceutical informations on the web

... What can we use ATC for? • The more equal level two product has, the more „similar” they are • Marketing: level 4 ATC groups used for getting information on competitor products • Competitor product: a product from the same therapeutic group with the same or a similar active ingredient. A product wh ...
Blue Care Network Custom Drug List Prior Approval and Step
Blue Care Network Custom Drug List Prior Approval and Step

... Blue Care Network Custom Drug List Prior Approval and Step Therapy Guidelines January 2017 Blue Care Network’s Prior Approval and Step Therapy Guidelines help ensure that safe, high-quality cost-effective drugs are prescribed prior to the use of more expensive agents that may not have proven value o ...
Randa Elfadil Ibrahim abdalla
Randa Elfadil Ibrahim abdalla

... Our results indicate that total level of serum IgE and IL4 in patients were considerably higher than controls. Serum electrophoresis showed that the distribution of Hp phenotypes of Hp1-1, Hp2-1 and Hp2-2 among asthmatic patients were17.5%, 50.8 % and 31.7%, respectively. Distributions of different ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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