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Acetylsalicylic acid - Wiley Online Library
Acetylsalicylic acid - Wiley Online Library

... A literature search was performed via Google and PubMed using keywords, including BCS, ASA, polymorphs, hydrate, absolute bioavailability, fraction absorbed (FA), pharmacokinetics, BE, mucosa, and hydrolysis. Solubility Determination of ASA In order to determine the solubility of ASA, buffers were p ...
Thalidomide and its Analogs: A Potential Immunomodulatory
Thalidomide and its Analogs: A Potential Immunomodulatory

... few are expensive, unstable and palliative or may cause side effects. Novel thalidomide analogs have been synthesized with improved stability and potency as TNF-α inhibitory and immunomodulatory agents, besides low or none teratogenicity. Experimental assessment of thalidomide and its analogs in ani ...
Prescribing Information - PI
Prescribing Information - PI

... 20 kg and greater: 20 mg 1 month to less 3 to less than 5 kg: 2.5 mg than 1 year 5 to less than 10 kg: 5 mg 10 kg and greater: 10 mg 1 to 16 years 5 to less than 10 kg: 5 mg 10 to less than 20 kg: 10 mg 20 kg and greater: 20 mg ...
What factors need to be considered when prescribing for lactose
What factors need to be considered when prescribing for lactose

ZOFRAN  Tablets, Oral Solution and Injection PRODUCT MONOGRAPH
ZOFRAN Tablets, Oral Solution and Injection PRODUCT MONOGRAPH

... therefore recommended and a total daily dose of 8 mg should not be exceeded. This may be given as a single intravenous or oral dose. As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration. Onda ...
Tenofovir disoproxil fumarate / Emtricitabine
Tenofovir disoproxil fumarate / Emtricitabine

“All flesh is coupled by the wave of circular rotational similarity” 1
“All flesh is coupled by the wave of circular rotational similarity” 1

... treatment with the medical product in normal dose and ultralow dose received the name “bipathy” (O. I. Epstein). Bipathy holds much promise for pharmaco logy. The researches could focus their attention on study of bipathy. However, the direction of investigations sharply changed. In stage III, thes ...
Clopidogrel Markedly Increases the Plasma Concentrations of the
Clopidogrel Markedly Increases the Plasma Concentrations of the

... DMD Fast Forward. Published on June 3, 2016 as DOI: 10.1124/dmd.116.070375 This article has not been copyedited and formatted. The final version may differ from this version. ...
ABO genotyping in leukemia patients reveals new ABO variant alleles
ABO genotyping in leukemia patients reveals new ABO variant alleles

... common variants were determined in the early 1990s (Yamamoto and Hakomori, 1990; Yamamoto et al., 1990a). This gene, mapped on chromosome 9q34.1-34.2, consists of 7 exons ranging from 28 to 688 bp. More than 90% of the coding sequence is located in exons 6 and 7, and contains the catalytic domain (Y ...
Edi Schwager
Edi Schwager

... induce transient mydriasis. In patients with narrow angles, pupillary dilation can provoke an acute attack of angle-closure glaucoma. These agents should also be avoided in patients with other forms of glaucoma, as mydriasis may occasionally increase intraocular pressure.[28] Amphetamine has been sh ...
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR  PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY 
COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR  PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY 

... dissolution testing apparatus II (paddle method).   The  dissolution  test  was  performed  using  900  ml  of  phosphate  buffer (pH 7.4) at 370C and 50 rpm. A sample (10 ml) of the solution  was withdrawn from the dissolution apparatus at 2, 5, 10, 15, 20, 25  and  30  min.  The  samples  were  re ...
Cathinone derivatives: A review of their chemistry, pharmacology
Cathinone derivatives: A review of their chemistry, pharmacology

... number of cathinone-related substances. However, by the middle of the next decade, matters began to change with a number of cathinone derivatives appearing as ‘legal highs’, initially only in certain countries. For example, methylone emerged for sale under the trade name ‘Explosion’ around 2004 in J ...
PREZISTA® (darunavir) oral suspension PREZISTA® (darunavir
PREZISTA® (darunavir) oral suspension PREZISTA® (darunavir

... For antiretroviral treatment-experienced patients genotypic testing is recommended. However, when genotypic testing is not feasible, PREZISTA/ ritonavir 600/100 mg twice daily dosing is recommended. 2.2 Pediatric Patients (age 3 to less than 18 years) Healthcare professionals should pay special att ...
Drug Formulary
Drug Formulary

... myriad of drugs that can be used to anesthetize animals--however most of them were not developed for use in animals and are therefore being used in an extra-label manner. Animal species differ in their responses to various drugs, and much of the information that we have about dosage, and especially ...
Genetic characterizations of three male-steriles in wheat, Triticum aestivum L.
Genetic characterizations of three male-steriles in wheat, Triticum aestivum L.

Effects of different doses of venlafaxine on serotonin and
Effects of different doses of venlafaxine on serotonin and

... complete blood count, electrolytes, liver enzymes, urea and creatinine, hepatitis B and HIV testing, and urine drug screening. Participants met the following inclusion criteria : (1) male, between the ages of 18 and 40 years old ; females were not included to avoid having to control for menstrual cy ...
Influence of Vesicle Size, Lipid Composition, and
Influence of Vesicle Size, Lipid Composition, and

... Tissue Distribution Studies. Doxorubicin, as free drug or in liposomeLiposomal Preparation. Vesicles were prepared by hydrating a lipid encapsulated form, was injected via a tail vein at a dose of 20 mg/kg film (dried down from (ÕKÕ,for 12 h under high vacuum) in the body weight to groups of five ...
Malaria Prevention (NDOH 2009)
Malaria Prevention (NDOH 2009)

... Parasite resistance to antimalarials used for chemoprophylaxis and treatment has increased significantly over time. Resistance to chloroquine and sulfadoxine-pyrimethamine (in certain areas for treatment2) has become so widespread that these drugs can no longer be used as monotherapy3,4. This has nec ...
Effects of Caffeine in Operant Learning and Locomotor Activity
Effects of Caffeine in Operant Learning and Locomotor Activity

... solidified our understanding of caffeine as a stimulant. It has been cited to increase general physiological arousal as measured by increased cortisol production, heart rate and respiration (Fisone, Borgvist & Usiello, 2004). In addition to its stimulant properties, caffeine is often used as a reinf ...
Development and preliminary evidence for the validity of an
Development and preliminary evidence for the validity of an

... Defined as the logic used to classify alert priority levels. A catalog of all alert level categories should be made available to users, clearly indicating how priority levels are set (eg, based on the severity of patient harm). The goal of this philosophy should be to minimize the overall number of ...
United States Anti-Doping Agency - United States Apnea Association
United States Anti-Doping Agency - United States Apnea Association

... 1. Beta-2 agonists are prohibited both in- and out-of-competition. There are four beta-2 agonists that may be used by inhalation following the submission of an Abbreviated TUE- salbutamol, salmeterol, formoterol, and terbutaline. Albuterol (salbutamol) concentrations greater than 1000 ng/mL in the u ...
2013 ESH/ESC Guidelines for the management of arterial
2013 ESH/ESC Guidelines for the management of arterial

... providing the recommendation class and the level of evidence is now regarded as important for providing interested readers with a standard approach, by which to compare the state of knowledge across different fields of medicine. It was also thought that this could more effectively alert physicians o ...


... 1. Beta-2 agonists are prohibited both in- and out-of-competition. There are four beta-2 agonists that may be used by inhalation following the submission of an Abbreviated TUE- salbutamol, salmeterol, formoterol, and terbutaline. Albuterol (salbutamol) concentrations greater than 1000 ng/mL in the u ...
Ann N Y Acad Sci
Ann N Y Acad Sci

... RE: Ketamine abstracts effects including dysphoria, hallucinations, and paranoid feelings were attenuated with benzodiazepines. 68 yo w post stroke central pain ...
details - Global Pharmaceuticals Pakistan
details - Global Pharmaceuticals Pakistan

... Effect on ability to Drive and Use Machines: Clinical experience with sulbactam/ cefoperazone indicates that it is unlikely to impair a patients ability to drive or use machinery Undesirable Effects: Sulbactam/ cefoperazone is generally well tolerated. The majority of adverse events of mild or moder ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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