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PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT
PrZOFRAN® Tablets, Oral Solution and Injection PrZOFRAN® ODT

... QTc Interval Prolongation: Ondansetron prolongs the QT interval (see ACTION AND CLINICAL PHARMACOLOGY, Electrocardiography). The magnitude of QTc prolongation will depend on the dose and the infusion rate. In addition, post-marketing cases of torsade de pointes have been reported in patients using o ...
Vol 1   Pg 22 ACETAMINOPHEN PRODUCTS
Vol 1 Pg 22 ACETAMINOPHEN PRODUCTS

... and combination-ingredient products for adults and children, as well as acetaminophencontaining products under the Sudafed® and Benadryl® brand names for adults. As the manufacturer of these products, McNeil is committed to encouraging scientifically appropriate and adequate labeling, which includes ...
View Full Prescribing Information
View Full Prescribing Information

... Preparation and Dilution in Bag for Infusion 1. Calculate the milligrams of ANTHIM injection needed by multiplying the recommended mg/kg dose in Table 2 by the patient weight in kilograms. 2. Calculate the required volume in milliliters of ANTHIM injection and number of vials needed for the dose by ...
Modification of Microbial Polyacids for Drug Delivery Systems  U
Modification of Microbial Polyacids for Drug Delivery Systems U

... copolymers are the preferred materials for the manufacture of a variety of devices for temporal applications in medicine and pharmacology; these biodegradable polymers can be chemically synthesized or biologically produced. Biotechnological polymers have attracted much attention because two main adv ...
Lamictal XR (lamotrigine) Extended-Release Tablets
Lamictal XR (lamotrigine) Extended-Release Tablets

... LAMICTAL® XR™ can cause serious rashes requiring hospitalization and discontinuation of treatment. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.8% (8 per 1,000) in pediatric patients (aged 2 to 16 years) receiving immediate-release lamotrigine as ad ...
1. Exposure Data - IARC Monographs
1. Exposure Data - IARC Monographs

... 1.2–8.6; five cases). The excess risk for death from brain cancer persisted after exclusion of cases prevalent at the time of entry into the study. No deaths from thyroid carcinoma were recorded. The SMR for all cancers was approximately 1.0 in patients treated with 131I or surgery (with or without ...
Central Nervous System Permeation of Non
Central Nervous System Permeation of Non

... acting in both the peripheral tissues and the central nervous system (CNS). However, knowledge on CNS permeation of these drugs in children in sparse. Therefore cerebrospinal fluid (CSF) penetration of diclofenac, ibuprofen, indomethacin, ketorolac, and paracetamol was studied in 160 healthy childre ...
world preview 2014, outlook to 2020
world preview 2014, outlook to 2020

... sales for 2014 are forecast to be an equally impressive $7.6bn in the US alone. Priced at $1,000 per pill, or $84,000 per treatment, some in the industry are questioning the basis of Gilead’s pricing. Proponents, on the other hand, argue that the price per pill is irrelevant and economic benefit is ...
Drug utilisation sub-committee (DUSC)
Drug utilisation sub-committee (DUSC)

... therapies co administered with ezetimibe products. The analyses imputed drug regimens for the prevalent treated population since ezetimibe was first available (August 2004). The methodology is fully described in Appendix C. All ezetimibe products are priced above the general patient copayment, howev ...
THE AMERICAN UNIVERSITY IN CAIRO School of Sciences and Engineering
THE AMERICAN UNIVERSITY IN CAIRO School of Sciences and Engineering

... Abstract Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility ...
(Acetaminophen) in products with and without opioid: an analysis
(Acetaminophen) in products with and without opioid: an analysis

... nomogram (the nomogram will be discussed later) should be lowered from 200 mcg/mL to 100 mcg/mL.12 The benefits of this approach are at this time uncertain,12,13 and, in the United States the dose that is considered to be toxic and the treatment line on the Rumack-Matthews nomogram have not been cha ...
The Science of Megestrol Acetate Delivery | SpringerLink
The Science of Megestrol Acetate Delivery | SpringerLink

... doses ranging from 160 to 1600 mg/day, megestrol acetate has been shown to stimulate appetite, increase caloric intake, induce a sense of wellbeing, and produce weight gain (for details see review in Drugs[18]). Weight gain occurs predominantly in the form of fat, which is potentially beneficial bec ...
MTM essentials for cough management
MTM essentials for cough management

... number of guidelines from various countries exist, including the comprehensive, evidence-based “Diagnosis and Management of Cough” from the American College of Chest Physicians (ACCP) in the United States, hereafter referred to as the ACCP guideline.4 This guideline was published in 2006 and include ...
Ceftin (cefuroxime axetil) tablets USP - GlaxoSmithKline
Ceftin (cefuroxime axetil) tablets USP - GlaxoSmithKline

... compared with that of the fasting state and tend to cancel the effect of enhanced postprandial absorption. In common with other antibiotics, cefuroxime axetil may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral contraceptives. Drug-Laboratory Test I ...
Ribavirin - Hepatitis C Online
Ribavirin - Hepatitis C Online

... Ribavirin (Copegus) is available in 200 mg tablets (Figure 2) and should be taken with food. The daily dose when given as fixed dosing is 800 mg per day in two divided doses. When given as weight-based, the dose is 1000 mg/day for persons less than 75 kg and 1200 mg/day for those 75 kg or greater. R ...
Deca Durabolin Results, Side Effects and Dosage Cycles
Deca Durabolin Results, Side Effects and Dosage Cycles

... Deca Durabolin is made up of the hormone Nandrolone. Deca Nandrolone is a naturally occurring substance produced in small amounts in the body. Deca Durabolin is the brand name for an injectable form of Nandrolone Decanoate. There are other similar anabolics on the market, including Nandrolone Phenyl ...
HUMAN PHARMACOLOGY AYAHUASCA Director de la Tesi:
HUMAN PHARMACOLOGY AYAHUASCA Director de la Tesi:

... Colombia, Daime or Hoasca in Brazil, natema in Ecuador and pinde along the Pacific coast of Colombia. More than 70 indigenous groups are known to employ ayahuasca, for which 42 different vernacular names have been reported (Luna, 1986). The use of this pan-Amazonian psychotropic beverage appears to ...
Product Monograph Template - Standard - GlaxoSmithKline
Product Monograph Template - Standard - GlaxoSmithKline

... Cardiovascular Effects Pharmacological side-effects of beta-2 agonist treatment, such as palpitations have been reported, but tend to be transient and to reduce with regular therapy (see ADVERSE REACTIONS). A small increase in QTc interval has been reported with therapeutic doses of salmeterol. Card ...
EFFECT OF VALERIAN ROOT EXTRACTS (VALERIANA
EFFECT OF VALERIAN ROOT EXTRACTS (VALERIANA

Avastin : EPAR - Scientific Discussion
Avastin : EPAR - Scientific Discussion

... rate, determined in 348 patients with measurable disease (448 patients in total were randomised to receive treatment), was 32.6% vs 14.4% and the time to progression was 27.6 vs 22 weeks for the de Gramont and the Mayo regimens, respectively. However, the trial did not meet its primary objective of ...
Pharmacokinetic and pharmacodynamic drug interactions
Pharmacokinetic and pharmacodynamic drug interactions

... a traditional beverage in the Pacific Islands. During the past few decades, kava has also gained popularity in Western countries as well, due to its anxiolytic and sedative properties. However, in recent years, kava has been implicated in several liver failure cases which led to its ban in many coun ...
The prokinetic cinitapride has no clinically relevant pharmacokinetic
The prokinetic cinitapride has no clinically relevant pharmacokinetic

... considered prudent to investigate the electrocardiographic effects of cinitapride under conditions known to favor arrhythmogenesis with cisapride. Such conditions are those where the metabolism of cisapride is inhibited, especially by co-administration with drugs blocking the cytochrome P450 CYP3A4 ...
Adenosine Injection, USP
Adenosine Injection, USP

... Adenosine exerts its effect by decreasing conduction through the A-V node and may produce a short lasting first-, second or third-degree heart block. Appropriate therapy should be instituted as needed. Patients who develop high-level block on one dose of adenosine should not be given additional dose ...
Document
Document

... dry mouth (the antisecretory effect) but this can be much reduced by transdermal administration. • In motion sickness treatment, hyoscine can be supplied via an impregnated patch worn behind the ear. ...
overview of comments received on community - EMA
overview of comments received on community - EMA

... For several of the extracts mentioned above, published data do not support a lower limit of hyperforin of 2 %. This applies to the extracts C) and G), as documented in the publications of Melzer et al. 1998, Wurglics et al. 2001a, Wurglics et al. 2001b, Volz and Zeller 2000) which mention hyperforin ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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