• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload


... Category I, acute bacterial prostatitis, has been quite effectively managed in the past using a Wide spectrum of antibiotics. Category II, chronic bacterial prostatitis, is most often treated With higher potency drugs for management ...
Inbreeding 1
Inbreeding 1

... Half of heterozygosity is lost each generation. ...
Bioidentical Hormone Therapy
Bioidentical Hormone Therapy

... treatment of menopausal symptoms. As a result of the WHI, many women ask their physicians for non–FDA-approved compounded bioidentical HT (CBHT), which is also known as OBUVSBM)5, believing that it is safer than FDA-approved therapy.3,4 It is estimated that CBHT is a multibillion-dollar industry, p ...
Pharmacology/Therapeutics I Block II Lectures – 2013‐14   
Pharmacology/Therapeutics I Block II Lectures – 2013‐14   

... leading to expulsion of norepinephrine into the synapse. Dietary sources of certain amino acids can produce adverse reactions when combined with MAO inhibitors. For example, tyramine can be taken up into noradrenergic cells. However, ingested tyramine is normally subject to significant first pass me ...
PDF - Romanian Journal of Anaesthesia and Intensive Care
PDF - Romanian Journal of Anaesthesia and Intensive Care

... variant of MOR receptors (μ-opioid receptor) is impaired, and this may have important consequences in a clinical setting for individuals carrying the N40D allele. The N40D variant is the most common MOR receptor variant present in 10-50% of the population [44] and could be responsible for genetical ...
Project Title: Genetic Improvement of Photosynthetic Efficiency and
Project Title: Genetic Improvement of Photosynthetic Efficiency and

... improved photosynthetic efficiency, we will investigate the lines developed by “CIMMYT and University of Lancaster” that display desirable architecture, flag leaf and spike photosynthesis traits. As it is not known how these lines perform under unique Canadian conditions, we will conduct critical fi ...
ALDORIL - methyldopa and hydrochlorothiazide
ALDORIL - methyldopa and hydrochlorothiazide

... It is important to recognize that a positive Coombs test, hemolytic anemia, and liver disorders may occur with methyldopa therapy. The rare occurrences of hemolytic anemia or liver disorders could lead to potentially fatal complications unless properly recognized and managed. Read this section caref ...
Tretinoin - BC Cancer Agency
Tretinoin - BC Cancer Agency

... 22. Christ E, Linka A, Jacky E, et al. Sweet's syndrome involoving the musculoskeletal system during treatment of promyelocytic leukemia with all-trans retinoic acid. Leukemia 1996;10(4):731-734. 23. Hatake K, Uwai M, Ohtsuki T, et al. Rare but important adverse effects of all-trans retinoic acid in ...
leukoclastic vasculitis
leukoclastic vasculitis

... Drug-induced vasculitis represents approximately 10% of acute cutaneous vasculitis cases and is difficult to diagnose. Diagnosis and assessment of an underlying cause of a drug includes an analysis of features such as timing of drug exposure, onset, course of reaction, and nature of a recurrent erup ...
Clinical Guideline for the Management of Extravasation of Cytotoxic
Clinical Guideline for the Management of Extravasation of Cytotoxic

... area may have serious consequences. It is recommended that the antecubital fossa should only be used as a last resort.  Smaller gauge flexible cannulas are preferable for the administration of vesicants; rigid steel cannulas should not be used. The correct clear dressing should be used to secure ...
Cyclophosphamide versus Placebo in
Cyclophosphamide versus Placebo in

... received at least one dose of study medication withdrew from the study, had conditions that met the protocol definition of treatment failure, or died (Fig. 1). A total of 20 patients in the cyclophosphamide group and 13 in the placebo group withdrew within 12 months after randomization, most of them ...
clinical trials patient-assisted research studies What you need to know about...
clinical trials patient-assisted research studies What you need to know about...

... diagnosis and are available for people with all stages of cancer. New lung cancer treatments and other medical approaches are being developed through clinical trials. Clinical trial participants receive the best available standard of care and may have access to the very newest treatment approaches. ...
Cannabis Dependence
Cannabis Dependence

... and a fear of ‘going crazy’. However, these effects are mostly found in the inexperienced user, and can usually be managed with reassurance and support. Psychotic symptoms such as delusions and hallucinations can occur in individuals using very high doses of THC, although this is a rare occurrence. ...
Dose-finding and 24-h monitoring for efficacy and safety of E.M. App
Dose-finding and 24-h monitoring for efficacy and safety of E.M. App

... taken at intervals before and after inhalation. Mucus rigidity decreased following NAL inhalation, with the maximum effect observed at 4 h; the 1-, 2- and 4-h NAL rheology results were significantly different from placebo. No adverse effects were observed. The drug was well tolerated in both studies ...
Guideline on Fixed Combinations - EMA
Guideline on Fixed Combinations - EMA

... of Population Exposure to Assess Clinical Safety), safety data on 300-600 patients for six months or longer will be required. The absence of such data should be justified by the applicant. ...
Genetic control of agronomically important traits of
Genetic control of agronomically important traits of

... lower values (2.81, 1.68, 1.49, and 1.32 g, respectively). On the other hand, P3 (BGH473354) had a higher average compared to the other pungent peppers but was similar to that of P6 (BGH1716-16) and P7 (BGH4201-32). These results are consistent with the majority of pungent peppers, which in general ...
Z66Ind gene detection and its relationship with the titer of antibodies
Z66Ind gene detection and its relationship with the titer of antibodies

... chemotaxis power causing bacteria make direct contact with host cells [7]. Serotype motility functions H1-j is reduced due to changes in the function of flagella, so invasiveness and clinical levels of disease can also be reduced. Reduced motility serotype H1-j be an important contributor to the dec ...
Women and Drugs - National Drug Strategy
Women and Drugs - National Drug Strategy

... o Registered in Australia (as ReVia®) for use as an adjunctive therapy to maintain abstinence following detoxification from opioids. Not currently registered for use in detoxification ...
The effect of Lisinopril on blood glucose level given
The effect of Lisinopril on blood glucose level given

... continued monitoring for optimal blood sugar level in patients because it can prevent many of the complications of diabetes like retinopathy, neuropathy, nephropathy and vascular abnormalities. Avoidance of hypoglycemia is very important because that is also dangerous and can lead to convulsion, com ...
GHB
GHB

... Long Term effects • More prolonged “burn out” or “crash periods” up to a week later • Dental Damage • Depression for weeks • Renal failure ...
IFU - Beckman Coulter
IFU - Beckman Coulter

... Methaqualone is a sedative-hypnotic drug. It is usually taken orally and is rapidly absorbed with peak plasma concentrations reached within 1.5 to 2 hours. Methaqualone is extensively metabolized by the liver and excreted in the urine in the form of multiple metabolites.4 Methaqualone and its metabo ...
ADPE02B0805 - Piracetam
ADPE02B0805 - Piracetam

... Monotherapy may have put our patients at a disadvantage if a synergistic effect with antiepileptic drugs explains greater piracetam efficacy in cortical myoclonus (14). Piracetam monotherapy had no effect on myoclonus in one study (13), but was effective in two others (10, 11). An argument could als ...
Electrical potential difference, sodium absorption and
Electrical potential difference, sodium absorption and

... Carbenoxolone sodium is of proven value in the treatment of gastric ulcer (Doll, Hill, Hutton, and Underwood, 1962) but its use is sometimes complicated by the development of side effects, particularly fluid retention, hypokalaemia, and hypertension. These mineralocorticoid-like effects might be ant ...
DOCX 133 KB
DOCX 133 KB

... benzodiazepine in the anesthetic plan, the doses of K and DMED can be decreased, which in turn reduces their potential for adverse effects. The author has found midazolam to be an excellent choice for tranquilization and sedation in chelonians and commonly uses it as part of the premedication or ind ...
Antihistamines in pediatric allergy
Antihistamines in pediatric allergy

... of the antihistamine can result, and its adverse effects may thus increase as well. This occurs when coadministering the drug with other P450 cytochrome substrates that competitively inhibit its metabolism, such as the macrolides, antifungals or calcium antagonists.28 In these cases the safety margi ...
< 1 ... 184 185 186 187 188 189 190 191 192 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report