• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
First Amendment--Drug Paraphernalia Statutes and the Constitution
First Amendment--Drug Paraphernalia Statutes and the Constitution

... those items "designed or marketed for use" with illegal drugs was sufficiently precise to defeat challenges of unconstitutional overbreadth and vagueness. The ordinance's focus on the design and marketing of items should have been deemed unconstitutionally vague, however, because it fails to provide ...
A GENETIC LINKAGE MAP OF Phycomyces blakesleeanus
A GENETIC LINKAGE MAP OF Phycomyces blakesleeanus

... linkage groups. The map was then used as the starting point for the choice of markers for the map-based identification of madC, by crossing madC mutants to strain UBC21. madC was identified as a new gene required for fungal responses to their environment. The madC gene encodes a Ras GTPase activati ...
Bimatoprost (AGN 192024) in glaucoma treatment
Bimatoprost (AGN 192024) in glaucoma treatment

... Although other treatment strategies may eventually be used for glaucoma patients, such as neuroprotection, the current goal of glaucoma therapy is to lower and stabilize IOP. In clinical practice, many physicians set a target pressure for their patients to achieve on long-term therapy. Factors that ...
7 Antifungal therapy c h a P t e r
7 Antifungal therapy c h a P t e r

... antifungal agents that have been studied.37 Their exact mechanism of action has not been defined.37 It remains to be seen whether these and other targets that have or may be discovered in the fungal cell wall show promise for the development of future antifungal agents; nonetheless, some are undergo ...
FEASIBILITY BIOWAIVER EXTENSION OF IMMEDIATE RELEASE ORAL ACYCLOVIR 800 MG
FEASIBILITY BIOWAIVER EXTENSION OF IMMEDIATE RELEASE ORAL ACYCLOVIR 800 MG

... Food and Drug Administration Authority (FDA)[1] has developed a regular guidance for both immediate- and modified-release dosage forms to reduce the requirement of bioavailability studies as part of the formulation design and optimization. Increased development of immediate release dosage forms nece ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... significant with NAC P-<0.0001 (Wilcoxons matched pair test). In WHO physician mucositis score, NAC was found to have more significant improvement in mucositis as compared to MSM (P<0.0001) The mean change in the scoring as well as percentage decrease in the WHO physician grading, with MSM & NAC as ...
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of

... provide clinicians with evidence-based data on the efficacy, safety, and mode of use of these seven new AEDs, which can facilitate their choice of the appropriate drug in the management of children and adults with refractory partial seizure disorders, primary generalized epilepsy, and the Lennox-Gas ...
4 Alpha blockers
4 Alpha blockers

... The term alpha blockers covers a range of drugs, but for the purposes of this section it is primarily used to describe the selective alpha blockers that are mainly used for managing hypertension and benign prostatic hyperplasia. Other drugs that have alpha-blocking actions are covered elsewhere in t ...
pharmaceuticals: restrictions in use and availability
pharmaceuticals: restrictions in use and availability

... chemical names; the effective date on which the regulation came into force; a summary of regulatory measures taken by governments; brief explanatory comments where necessary; and legal and bibliographical references. While the information cannot be regarded as exhaustive, either in terms of products ...
Clinical Trials - Ritonavir
Clinical Trials - Ritonavir

... inhibitor, was approved by the FDA on March 1, 1996 (one day after approval was recommended by the FDA's Antiviral Drugs Advisory Committee). Ritonavir is also known as "Norvir." It belongs to a class of drugs called protease inhibitors. Protease inhibitors are used for the treatment of HIV infectio ...
Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient
Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient

... glucose control on cardiovascular complications remains uncertain; a more modest benefit is likely to be present, but probably emerges only after many years of improved control (5). Results from large trials have also suggested that overly aggressive control in older patients with more advanced disea ...


... The original Dutch hypothesis implied that BHR in smokers was likely to be similar to that associated with asthma and atopy and so to be 'endogenous' or 'constitutional' and presumably present al the onset of smoking. Such 'endogneous' allergic BHR is sufficiently common in the population of presmok ...
Economic Analysis of Panitumumab Compared With Cetuximab in
Economic Analysis of Panitumumab Compared With Cetuximab in

... treated with an anti-EGFR agent because these mutations are predictive of a lack of response to panitumumab and cetuximab.2,3 Approximately 50% of patients with mCRC have tumors exhibiting RAS mutations,13 including 40% with KRAS (exon 2) mutations.14 Therefore, 50% to 60% of patients with mCRC woul ...
History of Aerosol Therapy: Liquid Nebulization
History of Aerosol Therapy: Liquid Nebulization

... Dr Sales-Girons won the silver prize of the Paris Academy of Science in 1858 for his invention, which used a pump handle to draw liquid from the reservoir and force it through a nozzle against a plate.7 At that time, spa therapy was very popular in France, and the Sales-Girons “pulverisateur” was in ...
taste masking methods and agents in pharmaceutical formulations
taste masking methods and agents in pharmaceutical formulations

... Ion Exchange Resins Ion exchange resins are high molecular weight polymers with cationic and anionic functional groups. They can exchange their mobile ions of equal charge with surrounding medium. Synthetic ion exchange resins have been used in pharmacy for taste masking from so many years. Drugs ar ...
Guidelines on the management of latent
Guidelines on the management of latent

... Ibrahim Abubakar declared that his employer received grants from National Institute of Health (£2.7 million for PREDICT study: Prognostic Evaluation of IGRAs and Skin test in a cohort of 10,000 contacts and migrants) and UK Department of Health (£900 000 for a randomized controlled trial to assess i ...
pharmacy technician ce library - Minnesota Pharmacists Association
pharmacy technician ce library - Minnesota Pharmacists Association

... pharmacy law CE already required; and (b) twenty hours of pharmacy technician-specific CE beginning in 2015. • The number of acceptable CE hours will be modified as follows: (a) CE hours earned through college or university coursework will be lowered from 15 to 10 hours beginning in 2016; and (b) CE ...
Medications Development for Nicotine Dependence
Medications Development for Nicotine Dependence

... GABA activity ...
THE TITLE: Pharmacokinetic Drug Interaction with Gemfibrozil
THE TITLE: Pharmacokinetic Drug Interaction with Gemfibrozil

... Rosiglitazone is an anti-diabetic drug that improves the insulin sensitivity and glycemic control in type 2 diabetes mellitus as an adjunct to diet and exercise. This thiazolidinedione class agent is extensively metabolized by CYP isoenzyme 2C8, with CYP2C9 contributing as a minor pathway [3] with n ...
ADHD drugs compared - Consumer Health Choices
ADHD drugs compared - Consumer Health Choices

... These medicines don’t cure ADHD but they can reduce symptoms, such as hyperactivity and impulsivity, which might improve a person’s daily functioning. However, there is uncertainty about whether these benefits last for longer than two years, so you might want to periodically discuss with your physi ...
POST THORACOTOMY PAIN MANAGMENT
POST THORACOTOMY PAIN MANAGMENT

... Intravenous patient-controlled opioids is the main component of systemic analgesics . Systemic systemic opioids can be associated with significant side effects, which has prompted the search for alternative systemic medications. ...
16 Simple Patterns of Inheritance
16 Simple Patterns of Inheritance

... Germany, and Erich von Tschermak of Austria. Within a few years, the influence of Mendel’s landmark studies was felt around the world. In this section, we will examine Mendel’s experiments and how they led to the formulation of the basic genetic principles known as Mendel’s laws. We will see that th ...
Lovastatin and beyond
Lovastatin and beyond

... Anitschkow and Chalatow showed that feeding cholesterol to rabbits rapidly produces atheromatous disease similar to that found in man. However, physicians were sceptical of any causal link between cholesterol and CORONARY HEART DISEASE (CHD) because most patients with the disease have plasma cholest ...
Effects of a structured medical management intervention aimed at
Effects of a structured medical management intervention aimed at

... At T1 medication complexity was statistically significantly lower in the intervention than in the control group. This effect was partly reversed at T2 to statistically non-significant values. Propensity adjusted complete adherence rates at discharge and six weeks after discharge were slightly higher ...
Scintigraphic comparison of budesonide deposition from two dry powder inhalers
Scintigraphic comparison of budesonide deposition from two dry powder inhalers

... much budesonide in the lungs as a Turbuhaler, when used at similar peak inhaled flow rates. The Montreal protocol banning the use of CFC propellants has been a major stimulus to the development of novel inhaler technologies for asthma therapy, including many new DPIs [14]. Each of these new devices ...
< 1 ... 180 181 182 183 184 185 186 187 188 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report