• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia

... What happens after the baby is born? If the diagnosis of CAH has definitely been excluded no further action is necessary. If a baby is known to be at a 1 in 2 (or 1 in 4) risk of CAH, further testing will depend on the available information on genetic changes. Gene tracking studies (known as linkage ...
AN EVOLUTIONARY APPROACHS IN DEVELOPMENT OF NEEDLE FREE INJECTION TECHNOLOGIES Review Article
AN EVOLUTIONARY APPROACHS IN DEVELOPMENT OF NEEDLE FREE INJECTION TECHNOLOGIES Review Article

... injections are psychological resistances to self-injection or needlephobia, awareness of serious problems has caused physicians and their patients to either delay therapy initiation or seek out lessinvasive alternatives and even at some cost to clinical effectiveness. To overcome the problems relate ...
Antiviral drugs for cytomegalovirus diseases
Antiviral drugs for cytomegalovirus diseases

... vary by socioeconomic class and geographic location, but the overall seroprevalence in developed countries is estimated to be in the range of 30–70% (Pass, 1985). Primary infection in immunocompetent individuals is usually benign, with minimal or no clinical manifestations (although approximately 10 ...
Formulary 2016 - South West London and St George`s Mental
Formulary 2016 - South West London and St George`s Mental

...  additional information pertinent to the safe & effective use of the medicine  Medicines in the same order as the British National Formulary (BNF), with headings  Only psychotropic medicines (see local Hospital Formularies for medicines for physical complaints).  Nicotine replacement treatments ...
Moderate Sedation Provider Packet
Moderate Sedation Provider Packet

... Sedation is a continuum. It is not always possible to predict how an individual patient receiving sedation will respond. Qualified individuals must be trained to monitor patients carefully to maintain them at the desired level of sedation, to recognize problems and to promptly institute appropriate ...
ELOCON Lotion
ELOCON Lotion

... for suppression were: basal cortisol level of ≤5 mcg/dL, 30-minute post-stimulation level of ≤18 mcg/dL, or an increase of <7 mcg/dL. Follow-up testing 2 to 4 weeks after stopping treatment, available for 8 of the subjects, demonstrated suppressed HPA axis function in 1 subject, using these same cri ...
AusPAR Dexamethasone - Therapeutic Goods Administration
AusPAR Dexamethasone - Therapeutic Goods Administration

... corrected visual acuity (BCVA) [area under the curve (AUC)] change from baseline) and this difference was small (1 to 2 letters over the 3 year study) and of questionable clinical significance (the minimal clinically important difference used in the sample size calculation was a 4 letter difference ...
Update on Kidney Transplantation in HIV-Infected
Update on Kidney Transplantation in HIV-Infected

... high as 90% among intravenous drug users13. Hepatitis B-associated membranous nephropathy has been documented in HIV-positive patients along with traditional causes such as DM and hypertension14,15. In addition to the HIV-associated causes of CKD, some antiretroviral (ARV) agents may result in kidne ...
10117sgp02ppt
10117sgp02ppt

... Residual daytime sedation  daytime ability to function ...
Inhaled  nedocromil  sodium  as  additional ... to  high  dose  inhaled  corticosteroids
Inhaled nedocromil sodium as additional ... to high dose inhaled corticosteroids

... PEF were statistically significant. These improvements were concurrent with a reduction in inhaled bronchodilator use. No effect of treatment was seen on responsiveness to histamine. Eight weeks is, however, a relatively short time to detect changes in bronchial responsiveness and longer observation ...
Pharmacokinetics Pallasch, TJ Anes. Progress 35:133
Pharmacokinetics Pallasch, TJ Anes. Progress 35:133

... patients cannot be easily aroused but respond purposefully following repeated or painful stimulation. The ability to independently maintain ventilatory function may be impaired. Patients may require assistance in maintaining a patent airway, and spontaneous ventilation may be inadequate. Cardiovascu ...
to Print Topic Help File ,
to Print Topic Help File ,

... Geriatric patients often require special consideration when designing dosage regimen. Pediatric patients are not just little adults. They also need pediatric doses. In both geriatric and pediatric doses, the technician should use references such as USP/DI, Drug Facts and Comparison, and product pack ...
AusPAR: Perampanel (as hemisesquihydrate)
AusPAR: Perampanel (as hemisesquihydrate)

RESEARCH NOTE–PRESCRIBING DIAMORPHINE FOR MEDICAL
RESEARCH NOTE–PRESCRIBING DIAMORPHINE FOR MEDICAL

... from the mistaken notion that legal strictures can be devised which apply equally well to the legal and the extralegal use of narcotics” (Lasagna, 1965, p. 58). In the United States, in particular, it has also been suggested that the present American prohibition of medical diamorphine is immovable a ...
Vincristine, Vincent Ting - UC Davis Department of Chemistry
Vincristine, Vincent Ting - UC Davis Department of Chemistry

... sensations of pain and temperature. Another side affect would be a disturbance of nerve fibers that help muscles around the colon that move stool, which means that the patient will experience constipation. Toxic effects may include numbness, pain, tingling, headaches, rashes, a change in blood press ...
Suggestive Association With Ocular Phoria at Chromosome 6p22
Suggestive Association With Ocular Phoria at Chromosome 6p22

... one for being a population outlier. The genetic data from 988 participants were used in the GWAS. Genotyped SNPs were excluded from the analysis if genotypes were missing for more than 2% of individuals (12,706 SNPs), or if the minor allele frequency was below 1% (77,738 SNPs). After excluding these ...
Correcting the Bias of WRIGHT`S Estimates of the Number of Genes
Correcting the Bias of WRIGHT`S Estimates of the Number of Genes

... distributionsof effects of P element insertson bristle numbers indicate that the value of the composite parameter is likely to be about three or larger for many quantitative characters.There are,however, some serious problems with the current method, such as the irregular behavior of the statistic a ...
Drug misuse and dependence: UK guidelines on clinical
Drug misuse and dependence: UK guidelines on clinical

... The working group considered NICE clinical guidelines and technology appraisals in drafting the 2007 Clinical Guidelines. The working group interpreted and incorporated the NICE suite of guidance as appropriate, but the 2007 Clinical Guidelines cover the management and treatment of drug misusers in ...
atorvastatin - Clinical Trial Results
atorvastatin - Clinical Trial Results

... LIPITOR® 10 mg (n=73), 20 mg (n=51), 40 mg (n=61), 80 mg (n=10); simvastatin 10 mg (n=70), 20 mg (n=49), 40 mg (n=61); pravastatin 10 mg (n=14), 20 mg (n=41), 40 mg (n=25); lovastatin 20 mg (n=16), 40 mg (n=16), 80 mg (n=11); fluvastatin 20 mg (n=12), 40 mg (n=12). Baseline LDL-C values were similar ...
lecture 03 - Hardy-Weinberg - Cal State LA
lecture 03 - Hardy-Weinberg - Cal State LA

... does the frequency of alleles change over time? Assume a population where there are two alleles of a gene, A and a - frequency of allele A in the gene pool is 60%, or 0.6 - in other words, 60% of sperm and 60% of eggs made by adults in this population carry the A allele - frequency of allele a in th ...
Exome sequencing as a tool for Mendelian disease gene discovery
Exome sequencing as a tool for Mendelian disease gene discovery

... of complex diseases has been much smaller than its contribution to our understanding of Mendelian traits. Exome sequencing is often used in conjunction with two sampling strategies: family-based phenotypes (to exploit parent–child transmission patterns) and extreme phenotypes (to increase efficiency ...
Detection of mutation status of IgVH genes and minimal residual
Detection of mutation status of IgVH genes and minimal residual

... developed by Rai at al. and Binet et al[11, 12]. These systems define early (Rai 0, Binet A), intermediate (Rai I/II, Binet B) and advanced (Rai III/IV, Binet C) stage disease with median estimated survival times of more than 10, 5-7, and 1-3 years, respectively. However, there is a ...
AusPAR Lenvatinib mesilate - Therapeutic Goods Administration
AusPAR Lenvatinib mesilate - Therapeutic Goods Administration

... Management of persistent or recurrent disease (minimal versus extensive) is also discussed. A subset of patients has radioiodine negative, serum thyroglobulin positive disease; of these, some with progressive macrometastatic disease unresponsive to radioiodine are considered (by Tuttle) for systemic ...
supporting material
supporting material

... Rational Use of High Dose Inhaled Corticosteroids in Asthma and Chronic Obstructive Pulmonary Disease ...
A dynamic deterministic model to optimize a multiple
A dynamic deterministic model to optimize a multiple

... taking into account the whole population (male and female) or a part of the population (female or male) for a given age. The decrease in genetic progress for the polygenic trait may be considered as a penalty term, which may be defined as a strict or as a progressive penalty. Under a strict penalty, ...
< 1 ... 176 177 178 179 180 181 182 183 184 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report