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Factors leading to PPI overuse Despite FDA alerts/concerns of PPI
Factors leading to PPI overuse Despite FDA alerts/concerns of PPI

... the long-term side effects to patients is lacking so education is imperative— something a pharmacist is trained to do. ...
Your Daily Treatment Journal
Your Daily Treatment Journal

... Prolonged use of Xtampza ER during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant ...
What is a low dose of oxycodone
What is a low dose of oxycodone

... how much can i make on social security disability 2017 bestbuy official agario.biz.tr unblocked what is stronger norco or nucynta 75 mg esrx pa forms earth taken 4 unblocked kreditkarma.com sign in printable medical assistant study guide SITEMAP Bingo halls mail Find patient medical information for ...
HLA matching, compatibility testing and donor selection
HLA matching, compatibility testing and donor selection

... Medium resolution typing implies that a DNA based test has been used, but it not discriminatory enough to tell us the exact allele i.e. it can define specific allele groups (often as a ‘string’ of possible alleles). For example an HLA-A*0201 allele may be typed as an A*0201/0205/0209/0240 with the t ...
Protocol S1.
Protocol S1.

... treatments (18). Although not actively assessed, no adverse events were reported after mebendazole treatment in the week following the administration of anthelminthics in Pemba (48). No severe adverse reactions were reported from a trial conducted in Zanzibar in 2006 to assess the safety of triple d ...
Colchicine for Prevention of Postpericardiotomy Syndrome and
Colchicine for Prevention of Postpericardiotomy Syndrome and

... CI, 1.1%-18.7%; number needed to treat = 10). There were no significant differences between the colchicine and placebo groups for the secondary end points of postoperative AF (colchicine, 61 patients [33.9%]; placebo, 75 patients [41.7%]; absolute difference, 7.8%; 95% CI, −2.2% to 17.6%) or postope ...
Review on clinical studies with cannabis and cannabinoids 2010-2014
Review on clinical studies with cannabis and cannabinoids 2010-2014

... No treatment-related serious adverse events (SAEs) were observed. In sum, it was concluded that the synergy between THC and CBD results in higher analgesic efficacy than THC alone. Based on the promising results, an open-label follow-up study was conducted (Johnson et al. 2013) in order to evaluate ...
Safety of formoterol in asthma clinical trials: an update Malcolm R. Sears
Safety of formoterol in asthma clinical trials: an update Malcolm R. Sears

... outcomes when following this latter recommendation [18–20]. The FDA has mandated, and pharmaceutical companies have initiated, large clinical trials to determine the safety of LABA by assessing outcomes in patients using LABA with ICS compared with the identical dose of ICS without LABA [21]. These ...
Relenza inhalation powder pre
Relenza inhalation powder pre

... Zanamivir has no or negligible influence on ability to drive and use machines. ...
What’s special about methadone?
What’s special about methadone?

... • SSRIs boost methadone levels in rapid metabolizers – have produced respiratory arrest when added to methadone • Venlafaxine has least potential for drug interaction ...
Deutsches Herzzentrum (Direktor: Univ.
Deutsches Herzzentrum (Direktor: Univ.

... Endovascular therapy offers several distinct advantages over open surgical revascularization for selected lesions. It is performed with local anesthesia, which enables the treatment of patients who are at high risk for general anesthesia. The morbidity and mortality from catheter-based therapy is ex ...
Duloxetine and pregabalin: High-dose
Duloxetine and pregabalin: High-dose

... [2,9,11,12], are the only 2 drugs approved by both the US Food and Drug Administration and the European Medicines Agency for the treatment of neuropathic pain in diabetes [28]. However, when given as monotherapy at standard doses (60 and 300 mg/day, respectively), it has been shown that both drugs p ...
Genetics and heritability of coronary artery disease and myocardial
Genetics and heritability of coronary artery disease and myocardial

... as CAD or myocardial infarction may be grouped into two major categories: susceptibility genes and disease-causing genes. Susceptibility genes are genes that increase or decrease the risk of disease manifestation. These genes may or may not contribute to the variability of the disease in the context ...
Afrezza®: Inhaled insulin approved by the FDA
Afrezza®: Inhaled insulin approved by the FDA

...  Co-developped by Pfizer and Sanofi-Aventis  January 2006 : US/EU approval (Diabetes type 1 and 2: rapid-acting insulin)  Pfizer bought from Sanofi-Aventis $1.3 billion the worldwide marketing rights  Manufactured by Pfizer in collaboration with Nektar Therapeutics ...
Preview the material
Preview the material

... popularity after they were first introduced and in the years following their initial marketing. People who had difficulties with falling asleep used barbiturates successfully, but they also experienced feelings of euphoria, which is the main effect associated with these drugs. Hence, the reason thes ...
Standards of Practice for Oncology Pharmacy in Canada
Standards of Practice for Oncology Pharmacy in Canada

... Oncology pharmacy, a patient focused practice, addresses the pharmaceutical care of both adults and children living with cancer. The provision of direct patient care by oncology pharmacists includes patient interviews, observation and contribution to the selection, modification and monitoring of pat ...
COMMITTEE OPINION Committee on Gynecologic Practice Number 484 • April 2011
COMMITTEE OPINION Committee on Gynecologic Practice Number 484 • April 2011

... that could be converted to testosterone, such as androstenedione (2). Current clinical uses of these substances in women include libido disorders, cachexia related to chronic disease such as human immunodeficiency virus (HIV), and anemia. Clinical use requires a prescription from a licensed physicia ...
Selective Suppression of Cocaine- versus Food
Selective Suppression of Cocaine- versus Food

... cocaine-appropriate responding and response rates were compared with the effects of each test drug by two-factor analysis of variance, with test drug dose and time after treatment as the two factors. A significant analysis of variance was followed by individual means comparison using the Bonferroni ...
Bromday_CDER_letter_Nov_30
Bromday_CDER_letter_Nov_30

... Bromday should not be used to treat more than one eye in a postoperative setting. ISTA had at least four options for responding to the complete response letter: (1) resubmit the supplement, addressing the deficiencies identified by the agency; (2) withdraw the supplement; (3) seek formal dispute res ...
Hardy Weinberg Equilibrium
Hardy Weinberg Equilibrium

... –  Rare  deleterious  recessives  o>en  remain  in  a   popula
Chapter 9 lesson 1 - ROP Pharmacology for Health Care
Chapter 9 lesson 1 - ROP Pharmacology for Health Care

... Figure 9–3 Celecoxib (Celebrex). This is a COX-2 inhibitor drug used to treat the pain and inflammation of osteoarthritis. Celebrex is protected by a patent until 2015. When a drug company's patent expires, other drug companies begin to make their own generic versions of the drug. The generic drugs ...
ANTIBIOTICS A brief overview for DMAT PA-1
ANTIBIOTICS A brief overview for DMAT PA-1

... very useful in nongonococcal urethritis caused by chlamydia, lower respiratory tract infections, mycobacterium avium complex infection, pharyngitis, pelvic inflammatory disease, nongonococcal urethritis caused by chlamydia, Legionnaire’s disease pregnancy category B Clarithromycin(Biaxin) XL oral ta ...
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER
HIGH-MOLECULAR WEIGHT OF BIOPOLYMER

... the free-radical-catalyzed degradation of HA may be useful in maintaining the integrity of dermal HA in addition to its moisturizing properties. It should be noted that the concentrations of ascorbate and Cu (II) were comparable to those that may occur during an early stage of the acute phase of joi ...
Development of a 100 mg theophylline sustained
Development of a 100 mg theophylline sustained

... levels of the drug in time, in order to minimize the adverse effects of the drugs containing them. This makes possible their use in a preventive way. These general considerations are more valid when the treatment of infants is considered. The international market shows many sustained released formul ...
SOLID LIPID NANOPARTICLES: A REVIEW
SOLID LIPID NANOPARTICLES: A REVIEW

... Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to tradition colloidal carriers such as - emulsions, liposomes and polymeric micro – and nanoparticles1. Nanoparticles made from solid lipids are attracting major attention as novel colloidal drug carrier for ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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