• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
recurrent episodes of acute pancreatitis in a cystic fibrosis carrier
recurrent episodes of acute pancreatitis in a cystic fibrosis carrier

... cirrhosis develops with secondary pulmonary portal hypertension.(15) The pathophysiology of the condition is related to obstruction of small biliary calculi and it is likely that modifier genes in addition to CFTR dysfunction play an important part in this process. Screening for liver disease is tak ...
Fluorine in medicine (PDF Available)
Fluorine in medicine (PDF Available)

... common strategies in drug development (Alkorta et al. 2000). Fluorine substitution in a drug molecule can influence not only pharmacokinetic properties, such as absorption, tissue distribution, secretion, and the route and rate of biotransformation but also its pharmacodynamics and toxicology (Wakse ...
Two novel heterozygous mutations of EVC2 cause a mild phenotype
Two novel heterozygous mutations of EVC2 cause a mild phenotype

... these low scores may mean the two types do not exist in this instance. The last alternative splicing could lead to intron retention, producing a truncated protein containing 241 amino acids. Given these possibilities, exon 6 skipping appears to be the most likely form of alternative splicing. A cons ...
Can Isotretinoin Induce Sacroiliitis: Three Cases
Can Isotretinoin Induce Sacroiliitis: Three Cases

... However, the mechanism by which isotretinoin leads to arthritis/sacroiliitis is poorly understood. The etiology of rheumatic disorders associated with retinoids is still obscure however it is presumed that immunomodulation by several mechanisms (such as an alteration of the cytokine balance) is prob ...
Increasing Nitrogen Use Efficiency in Lettuce
Increasing Nitrogen Use Efficiency in Lettuce

... NH4NO3” treatment (Prob > F = 0.1069). These results indicate that when averaged across the entire DxM RIL population, root growth is sensitive to nitrate (NO3) concentration but not ammonium (NH4). However, significant genetic variation exists which suggests a possible role in contributing to root ...
ANTI-INFLAMMATORIES Alison Clode, DVM, DACVO Port City
ANTI-INFLAMMATORIES Alison Clode, DVM, DACVO Port City

... The efficacy of a topically applied ophthalmic corticosteroid depends upon multiple drug- and patientrelated factors, which influence transcorneal and intraocular penetration and anti-inflammatory activity. Of the drug-related factors, the base steroid and its relative potency, concentration, and fo ...
Systemic Antibiotics
Systemic Antibiotics

... antibiotics depends also on the density of the bacterial population and the timing of the infection. They are more effective against small bacterial inocula than against a dense culture because of the amount of β-lactamase produced and the phase of growth of the culture. Their effectiveness decrease ...
OXYCODONE AND ACETAMINOPHEN CAPSULES USP 5 mg/500
OXYCODONE AND ACETAMINOPHEN CAPSULES USP 5 mg/500

... Following an acute overdosage, toxicity may result from the oxycodone or the acetaminophen. Signs and Symptoms Toxicity from oxycodone poisoning includes the opioid triad of: pinpoint pupils, depression of respiration, and loss of consciousness. Serious overdosage with oxycodone is characterized by ...
LIDOCAINE VISCOUS 2%
LIDOCAINE VISCOUS 2%

... Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. The net effect is normally a modest h ...
Incomplete penetrance of MHC susceptibility genes
Incomplete penetrance of MHC susceptibility genes

... To explore methods of study of incompletely penetrant polygenic ...
Opioid Induced Hyperalgesia
Opioid Induced Hyperalgesia

... A 33 yo female presents with diffuse pain, impaired sleep, migraines, irritable bowel syndrome, and TMJ syndrome. She has been using oxycodone 30 mg Q4 hours for 6 months with no resolution of symptoms. The following statement regarding this case is false: – Differential diagnosis includes fibromyal ...
handout
handout

... The combination of selection and drift is difficult to model theoretically. The required mathematics will soon venture outside the depth of knowledge you are required to have for this course, so we will not be able to show much derivation. You will be responsible for knowing the main findings and im ...
AusPAR: Ocriplasmin  - Therapeutic Goods Administration
AusPAR: Ocriplasmin - Therapeutic Goods Administration

... The proposed dose is a single dose of 0.125 mg (0.1 mL) administered by intravitreal (IVT) injection to the affected eye. Administration to both eyes concurrently (education material prepared by the sponsor defines it as concurrent or within 7 days of initial injection) is not recommended. Repeat ad ...
Salmeterol/Fluticasone STADA 25 μg/50 μg/dose, 25 μg/125 μg
Salmeterol/Fluticasone STADA 25 μg/50 μg/dose, 25 μg/125 μg

... The potential serious risk to public health from a quality point of view is that equivalence of the test and reference product has not been demonstrated when the products are used with a spacer device using clinically relevant manoeuvres. With regard to clinical aspects, therapeutic equivalence is n ...
CASE  4-16180/-JCIP APPENDIX  F
CASE 4-16180/-JCIP APPENDIX F

... Submitted Annual Report covering period of July “2t 1996 through July I, 1997 and Stability Report. ...
Busulfex - Otsuka Canada Home
Busulfex - Otsuka Canada Home

... advised to use effective contraception during and up to 6 months after treatment. BUSULFEX may damage spermatozoa and testicular tissue, resulting in possible genetic fetal abnormalities. Men treated with BUSULFEX are advised not to father a child during and up to 6 months after treatment. ...
Rep. Waxman`s Statement: Merck Documents Show Aggressive
Rep. Waxman`s Statement: Merck Documents Show Aggressive

... another major study, over 100 million Vioxx prescriptions in the United States had been filled. We now laow that many of these prescriptions were dangerous and unnecessary. ...
Clinical Use of Dietary Supplements and Nutraceuticals
Clinical Use of Dietary Supplements and Nutraceuticals

... sheer expert opinion to an evidence-based approach (3). Notwithstanding the incompleteness of a purely evidencebased practice of medicine, the inherent flaws in nutrition research, and the paucity of valid data, this task force will rely solely on published scientific clinical evidence when making s ...
DCM in Dobermann is a disease with variable Prevalence and
DCM in Dobermann is a disease with variable Prevalence and

... grateful to the authors for their contribution, although their findings are an “inconvenient truth” for many people. When numbers appear fade fables. Data of prevalence reported in the Discussion by the same authors for dogs from the United States or ...
Ibuprofen lysine (NeoProfen) for the treatment of patent ductus
Ibuprofen lysine (NeoProfen) for the treatment of patent ductus

... 48 hours later. The closure rate was 69% in the indomethacin group vs 73% in the ibuprofen group. For adverse events, 15% of the patients in the indomethacin group experienced oliguria vs 1% in the ibuprofen group (P = 0.017). Posttreatment serum creatinine levels were significantly higher in the in ...
managing insomnia
managing insomnia

SCI 30 UA CH 2.2 Inheritance
SCI 30 UA CH 2.2 Inheritance

... of traits that he observed in his pea-plant studies. Since the purple flower colour trait is dominant to the white trait, Mendel stated that the purple flower colour is a dominant trait in pea plants. Dominant traits are caused by dominant alleles. If an offspring receives even one dominant allele, ...
AusPAR: Retigabine - Therapeutic Goods Administration
AusPAR: Retigabine - Therapeutic Goods Administration

... reviewed. Model control streams and data were only provided in printable form which would prevent any evaluation or testing of the model by a reviewer. The PSC agreed that covariate analysis would have been helpful in establishing dosing protocol. ...
The use of botulinum toxin in the treatment of chronic spinal pain
The use of botulinum toxin in the treatment of chronic spinal pain

... The word Botulism is associated with food poisoning and death from muscle paralysis. The infective agent, Clostridia Botulinum, produces a toxin which causes the paralysis and is known as Botulinum toxini. It is this toxin, rather than the bacteria, which causes the muscle paralysis, although the to ...


... vitamins, acupuncture, cranio-sacral therapy, magnets, hyperbaric oxygen and hypnosis. A few of these therapies have been researched in an attempt to verify the anecdotal claims. But the results have not conclusively identified these treatments as helpful for tinnitus. Amplification (Hearing Aids) S ...
< 1 ... 171 172 173 174 175 176 177 178 179 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report