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domperidone (dom-per-i-done) - DavisPlus
domperidone (dom-per-i-done) - DavisPlus

... use in Canada by the Therapeutic Products Directorate, a division of Health Canada’s Health Products and Food Branch. The medication is not approved by the United States Food and Drug Administration; however, a similar formulation carrying a different generic or brand name might be available in the ...
Pharmacokinetics and Pharmacodynamics
Pharmacokinetics and Pharmacodynamics

... The term adverse reaction is defined as unwanted, seriously unpleasant, or even harmful effects. Side effects is to be the undesired effects unrelated to therapeutic aim and occurring at doses intended for therapeutic effect. ①It is often slight, recoverable functional alteration of the body. ②Some ...
DRUGS TO TRY AND AVOID IN WARFARIN PATIENTS
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... warfarin. Patients already on any of these drugs may be started on warfarin and the dose adjusted as required. Drug interactions with warfarin tend to be variable and unpredictable and on the whole affect a fairly small proportion of patients. If any of the drugs below are to be started in these pat ...
DRUG INTERACTIONS
DRUG INTERACTIONS

... They may also result from inhibition of metabolism of a drug with epileptogenic properties. For instance, when erythromycin is prescribed for someone receiving clozapine, the antibiotic inhibits CYP3A4, thereby decreasing the metabolism and increasing the plasma concentration of the antipsychotic. T ...
[XENAZINE® (tetrabenazine) Tablets] Indications and Usage
[XENAZINE® (tetrabenazine) Tablets] Indications and Usage

... • XENAZINE is also contraindicated in patients who have impaired hepatic function or are taking monoamine oxidase inhibitors (MAOIs) or reserpine. XENAZINE should not be used in combination with an MAOI, or within a minimum of 14 days of discontinuing therapy with an MAOI. At least 20 days should el ...
Marijuana, LSD and Club Drugs
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Febuxostat - ACI Limited
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... Pharmacogenetics • “The study of how genes affect people’s response to medicines” (NIH) • A subset of complex genetics for which the traits relate to drugs • First observed in 1957 • Part of “personalized medicine” • 20-95% of variability in drug disposition and effects is thought to be genetic • N ...
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... e) Lowered resistance to infections 52) A package insert lists a drug dose for a neonate as being 10 mcg/kg/ day. The age range for a neonate is considered to be : a) birth to 1 month b) 1 month to 6 months c) 1 month to 1 year d) birth to 1 week e) 1 year through 5 years ...
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... result of competing for absorption mechanism, metabolic route, chemical reaction between the drugs or pharmacodynamic; similar or opposing mechanisms at site of action lead to increased or decreased effects. Adverse reactions increase with numbers of drugs taken; 7% incidence in patients taking 6-10 ...
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Carolinas HealthCare System: Medication Management for Older
Carolinas HealthCare System: Medication Management for Older

... (increased half-life) • Lower serum proteins (like albumin) increases the concentration of unbound (free or active) form of drugs ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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