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DRUGS - PBworks
DRUGS - PBworks

... What doest his matter? It’s easier to use by IV Provides high that lasts 3 – 4 hours – deep sense of well being, drowsiness ...
RUZICH, Richard T.
RUZICH, Richard T.

... • Protocols, CRFs, and results of all completed and ongoing clinical trials available? • Adequately designed to achieve intended goal? • Audited? GCP, again! • IRB approval for the studies? • Enough detail and care taken to review IND/IMPD documentation and related updates? ...
Topic 9. Clinical-pharmacological characteristics of anti
Topic 9. Clinical-pharmacological characteristics of anti

... 5th inhabitants for the planet is allergy sufferer. Today >40% of the world population has allergies history. Every 10 years the number of patients with allergic diseases doubled. According to forecasts, in the coming decade, everyone on Earth suffers from allergic disease. According to official dat ...
Eating Disorders - psychlotron.org.uk
Eating Disorders - psychlotron.org.uk

... EDs should run in families Degree of relatedness to ED patient should influence risk of developing EDs in others ...
Bile Acid Sequestrants - The Center for Cholesterol Management
Bile Acid Sequestrants - The Center for Cholesterol Management

... adults contemplating a potential lifetime of exposure to a medication and are the only class of drugs recommended by NCEP for use in children. The three most common adverse events that have been reported are constipation, rarely leading to obstruction, increase in plasma triglyceride levels, and dec ...
New Drugs Update from APC
New Drugs Update from APC

... Administered Medication Record Card are available under Prescribing Guidelines on the CCG intranet. Drug induced QT Prolongation Recently there have been warnings relating to drug-induced QT prolongation for three commonly used drugs – citalopram, domperidone and ondansetron. This Medicines Q+A disc ...
Abstract - Anil Jegga - Cincinnati Children`s Hospital
Abstract - Anil Jegga - Cincinnati Children`s Hospital

... and homologs with clinical information. This integration of the massive amounts of accumulating heterogeneous genetic information in the clinical environment is expected to support tailor-made medicine, where clinical diagnosis and treatments will be supported by information at molecular level. The ...
Dose-response relationship - National Tsing Hua University
Dose-response relationship - National Tsing Hua University

... occurred after administration was discontinued. 5/5 died suddenly, liver failure. ...
Write down on your post it note - PE-Teaching
Write down on your post it note - PE-Teaching

...  Can cause cancer, emphysema or heart disease.  It's estimated smoking contributes to 120,000 premature deaths in the UK every year. ...
Trulance™ - plecanatide
Trulance™ - plecanatide

... Treatment of chronic idiopathic constipation (CIC) in adults  Patients less than 6 years of age due to the risk of serious dehydration  Patients with known or suspected mechanical gastrointestinal obstruction Risk of serious dehydration in pediatric patients Diarrhea: Patients may experience sever ...
1097-Ahmadi-_b
1097-Ahmadi-_b

... • This combined with the age-related decline in physiological functions (decreased cardiac reserve, decreased immunological response, decreased renal function) that in younger patients may be protective from severity of an adverse drug reaction make the older patient particularly at risk for polypha ...
The  Pharmaceutical Industry and The Process of Drug Discovery
The Pharmaceutical Industry and The Process of Drug Discovery

... What criteria MUST new drugs meet?  Drugs must address a new need or provide a significant “added benefit” over an existing medicine  Drugs must also meet five criteria:  Must be safe, effective, of high quality  …cost effective (1980s)  ……….affordable (1990s)  ……………REALLY affordable (2000+) ...
Gene Hunting
Gene Hunting

... Medical Records: Provides information on phenotypes, but this can be complex, difficult to define, not available to the patient in full detail. Genetic Records: Also known as genetic maps. Developed from tissue samples, blood etc. using a range of different techniques including search for genetic ma ...
project description - Standard drugs and drug standards
project description - Standard drugs and drug standards

... personality tests, drug action tests, as well as with diagnostic categories. On the other hand, consuming psychoactive drugs can be described as a technology of the self, with different drugs in different times promoting certain values and norms. The cooperation between the pharmaceutical industry a ...
NEWS YOU CAN USE 2015 08 UPD
NEWS YOU CAN USE 2015 08 UPD

... familial hypercholesterolemia or patients with clinical atheroschlerotic cardiovascular disease • It is to be used in addition to diet and ...
9BYO3IvgcQkevbgH5m4MVg5J_nF9t8U45TqcqcBmrETKoHMWh
9BYO3IvgcQkevbgH5m4MVg5J_nF9t8U45TqcqcBmrETKoHMWh

... 14. Serum enzyme tests that may aid in the diagnosis of Myocardial Infarction include:a. Alkaline Phosphatase b. CPK(creatinine phosphokinase) c. LDH (Lactic acid dehydrogenase) d. a+b e. b+c 15. Tinea Pedis is commonly known as:a. Athlete's foot b. corns c. calluses d. warts e. blackheads 16. Sign ...
BETAHISTINE HYDROCHL ORIDE
BETAHISTINE HYDROCHL ORIDE

... are very low, pharmacokinetic analyses are therefore based on 2-PAA measurements in plasma and urine. Peak plasma concentrations of 2-PAA achieved one hour after oral administration in fasting subjects and declines with a half-life of about 3.5 hours. Tissue distribution of betahistine in humans is ...
Navigating the World of Adverse Drug Reactions
Navigating the World of Adverse Drug Reactions

... Which organ systems were involved? Respiratory When during the course did the reaction occur? One month after starting • Why was the medication prescribed? High BP • What other meds were being taken? Aspirin, ...
Sample Senior Thesis Poster (Powerpoint #2)
Sample Senior Thesis Poster (Powerpoint #2)

... and tribal leaders wanted to understand if the disease had a genetic basis so that predisposed individuals could take preventative measures. They asked two professors at Arizona State University to help them, consenting specifically to experiments about diabetes. Unfortunately, one of the professors ...
Drugs as Evidence
Drugs as Evidence

... Recreational users will use intravenous injection for more intense experience. ...
Iquix Drug Monograph
Iquix Drug Monograph

... activity against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Iquix® binds stronger to DNA gyrase, while Vigamox® and Zymar® bind with a high affinity to both topoisomerase IV and DNA gyrase. In two randomized, double masked, multicenter controlled clinical trials comparing ...
Significant Drug Interactions with Tuberculosis Medications
Significant Drug Interactions with Tuberculosis Medications

Therapeutic Objective
Therapeutic Objective

... 1. Administration- dosage size and route - Because of errors in administration routes and dosage and at wrong time there are many discrepancies in what patient gets and could cause more harm than good - Errors could be made by pharmacists, physicians, or nurses - Should give patients complete instru ...
Memo - Magellan Rx Management
Memo - Magellan Rx Management

... and clinical issues that result in an approval or denial. When applicable, the pharmacist will receive a text message listing alternate drugs that do not require prior authorization. Prescribers whose patients do not meet required criteria will receive notification of a claim denial including the re ...
factors affecting therapeutic drug monitoring
factors affecting therapeutic drug monitoring

... • For example if a drug has a half life of four hours, four hours after the initial dose, 50% of the drug will be removed. • Eight hours after the initial dose, half of the remaining drug (25% of total) will be removed, for a total of 75% having been removed at that time, and so on. • Half-life info ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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