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This PDF is a selection from an out-of-print volume from... of Economic Research
This PDF is a selection from an out-of-print volume from... of Economic Research

... conditions. Subjects were four healthy individuals who did not meet diagnostic criteria for cocaine or any other form of drug dependence (except nicotine) but were recent, occasional users of cocaine. Drug was administered intranasally in 10 mg unit doses of cocaine hydrochloride or a placebo consis ...
10/15/2014 Caffeine is the Most Widely Used Psychoactive Drug Worldwide
10/15/2014 Caffeine is the Most Widely Used Psychoactive Drug Worldwide

... Tea is the most widely consumed beverage in the world Tea is the most widely consumed beverage in the world. ...
FAQs FOR ONTARIO HEALTH CARE PROVIDERS What is HIV Post
FAQs FOR ONTARIO HEALTH CARE PROVIDERS What is HIV Post

... regarding study design and sample sizes, there are no efficacy studies of HIV PEP following nonoccupational HIV exposures (such as intravenous drug use, or sexual assault). Probable efficacy of HIV PEP following sexual assault and other non-occupational exposures is supported by data from occupation ...
Cocaine Addiction
Cocaine Addiction

... someone from their days of using, returning to the same must be acknowledged as the first gradient to overcoming environment and places, or even small things such as the problem. The next hurdle is being willing to seek & smells and objects trigger memories which can create accept help from an addic ...
Hydroxyzine Dihydrochloride
Hydroxyzine Dihydrochloride

... In subjects with hepatic dysfunction secondary to primary biliary cirrhosis, total body clearance was approximately 66% that of normal subjects. The half-life was increased to 37 hours and the serum concentrations of the carboxylic metabolite, cetirizine, were higher than in young patients with a no ...
PRODUCT INFORMATION - Medicines Information
PRODUCT INFORMATION - Medicines Information

... hypercholesterolaemic men and women with coronary heart disease. In this randomised, double-blind, controlled clinical trial, 404 patients with total-C values of 5.5 to 8.0 mmol/L and a mean baseline LDL-C value of 4.4 mmol/L were treated with conventional measures and with simvastatin 20 mg/d or pl ...
Impact of levalbuterol versus Albuterol in Kentucky Medicaid Patients
Impact of levalbuterol versus Albuterol in Kentucky Medicaid Patients

... treatment of asthma. Racemic albuterol has been used for more than 40 years but is associated with several side effects including tremor. When levalbuterol was approved in 2005 its manufacturer and several studies suggested that using levalbuterol results in better respiratory parameters, fewer hosp ...
based Micro and Nanoparticles for the Controlled Drug Delivery of
based Micro and Nanoparticles for the Controlled Drug Delivery of

... temperature of 35—40°C [50, 51]. Lactide is a cyclic dimer of lactic acid, which has two optically isomeric forms, d and l [48]. Llactide is the naturally occurring isomer, whereas dl-lactide is the synthetic blend of d-lactide and l-lactide. The homopolymer of llactide (PLLA) is a semicrystalline p ...
Clinical and genetic patterns ofneurofibromatosis 1 and 2
Clinical and genetic patterns ofneurofibromatosis 1 and 2

... intron (a 'non-coding region') of the NFl gene. These small genes 'within a gene' are interesting: the OMgp (oligodendrocyte myelin glycoprotein) gene because of its role in cellcell communication in the central nervous system,'1 and the EV12A and EV12B genes because of their mouse homologues playin ...
scheme of examination - Guru Gobind Singh Indraprastha University
scheme of examination - Guru Gobind Singh Indraprastha University

... analysis, Preliminaries and definitions, Significant figures, Rules for retaining significant digits, Types of errors, Mean deviation, Standard deviation, Statistical treatment of small data sets, Selection of sample, Precision and accuracy, Fundamentals of volumetric analysis, methods of expressing ...
Levonorgestrel - Therapeutic Goods Administration
Levonorgestrel - Therapeutic Goods Administration

... cytotoxicity, haemolysis and genotoxicity and in vivo in studies on acute toxicity, local tolerance and skin sensitisation that used extracts of the material. Additional studies involved assessment of local tolerance in rabbits following intramuscular implantation of silver rods used in the manufact ...
Wellbutrin - GSK Source
Wellbutrin - GSK Source

... Pooled analyses of short-term placebo-controlled trials of antidepressant drugs (selective serotonin reuptake inhibitors [SSRIs] and others) show that these drugs increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (ages 18 to 24) with MDD and ...
Acyclovir Tablets USP Acyclovir Tablets USP
Acyclovir Tablets USP Acyclovir Tablets USP

... acyclovir given daily for 4 months to 10 years prevented or reduced the frequency and/or severity of recurrences in greater than 95% of patients. In a study of patients who received acyclovir 400 mg twice daily for 3 years, 45%, 52%, and 63% of patients remained free of recurrences in the first, sec ...
intestinal metabolism: the role of enzyme localization in phenol
intestinal metabolism: the role of enzyme localization in phenol

... administered at vascular doses of 1400 and 2500 ␮g to the reservoir. Samples (300 ␮l) were taken from the reservoir and portal vein at 3, 8, 15, 30, 45, and 60 min. In addition, a reservoir sample taken before the start of the experiment was used to calculate the dose. Samples were centrifuged at 13 ...
Category 2000
Category 2000

... We have genotyped two large Angus mapping populations for 415 microsatellites and 9 SNP markers for all Bos taurus autosomes and the X chromosome and have tested for quantitative trait loci (QTL) influencing marbling, ribeye area, carcass weight, and fat thickness. The first population is comprised ...
Testimony of Dr. Thomas Perls
Testimony of Dr. Thomas Perls

... long-term treatment of short stature associated with Turner syndrome; ...
medicines code - Sussex Partnership NHS Foundation Trust
medicines code - Sussex Partnership NHS Foundation Trust

... procedures contained in the Code. Those in charge of wards and departments are responsible for ensuring that their staff, especially new starters and locum staff, follow procedures in the Medicines Code, which may differ from procedures elsewhere. Copies of the Code will be available in all wards an ...
Drug-Induced Acneform Eruptions: Definitions and
Drug-Induced Acneform Eruptions: Definitions and

... natural distribution shunts because of numerous sebaceous follicles, which allow more of the drug to penetrate to subepidermal structures.8 There is a defective epidermal barrier in atopic dermatitis, and the penetration of topical corticosteroids is 2 to 10 times greater than that through healthy ...
naratriptan, rizatriptan, sumatriptan, and zolmitriptan
naratriptan, rizatriptan, sumatriptan, and zolmitriptan

... Generic triptans may be covered at the doses at which they have been shown to be safe and effective. Up to 12 triptan tablets, 6 nasal sprays or 6 injections per month may be covered per month. Coverage of quantities exceeding these limits is allowed only when specific criteria are met. ...
Reference genome sequence of the model plant Setaria
Reference genome sequence of the model plant Setaria

... differences may be due to instances of retained heterozygosity in the Yugu1 accession or to differences between the Yugu1 seed stocks used as DNA sources for the BAC library and WGS sequencing. Setaria genome annotation and analysis Transposable element and gene (as represented by exons) distributio ...
Nucleotide Metabolism - Oregon State University
Nucleotide Metabolism - Oregon State University

... Nucleotide Metabolism Proceeds Through de novo and Salvage Pathways Purine Nucleotides are Built de novo Starting with Ribose-5-phosphate PRPP is Made From it and Then it is Aminated Simple Compounds, Such as Amino Acids and 1-Carbon Donors Make the Bases IMP is a Branch Point for Synthesis of GMP a ...
DEMONSTRATED EFFICACY. SIMPLE DOSING REGIMEN.
DEMONSTRATED EFFICACY. SIMPLE DOSING REGIMEN.

... been reported rarely. Although rare, fatalities have been reported. As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If super-infection occurs, discontinue use and institute alternative therapy. Patients should be advised not to wear ...
(PSD) November 2016 PBAC Meeting - (Word 109KB)
(PSD) November 2016 PBAC Meeting - (Word 109KB)

... addition to second-line use following failure with gemcitabine-based therapy). The ESC noted there is no evidence for efficacy for irinotecan (nanoliposomal) with 5-FU/folinic acid as second-line treatment following failure with the irinotecan containing FOLFIRINOX therapy. ...
Drug Testing Appropriateness Document
Drug Testing Appropriateness Document

... This document focuses on clinical drug testing for identification, treatment and recovery of patients with, or at risk for, addiction. ASAM recognizes that drug testing is used in other contexts (for example, criminal justice, workplace and pain management settings). ASAM’s intent with this document ...
Covariate Analysis of QTc and T
Covariate Analysis of QTc and T

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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