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(PSD) July 2016 PBAC Meeting
(PSD) July 2016 PBAC Meeting

ASPIRIN
ASPIRIN

... Diazepam should only be used if the patient has been fitting for >5 minutes (and is still fitting), or if fits recur in rapid succession without time for full recovery in between. There is no value in giving this drug “preventatively” if the fit has ceased. In any clearly sick or ill child, there must b ...
Herbs and HIV: caveat emptor
Herbs and HIV: caveat emptor

... Liquorice (Glycyrriza glabra) is the most widely used herb in Chinese medicine. In the pre-HAART era, several studies suggested that its active ingredient, glycyrrhizin, had anti-HIV effects. Its use was revived in a trial in Zambia22 in 1999, where it appeared to delay progression to AIDS. Lutein a ...
Manitoba Medications Return Program
Manitoba Medications Return Program

... funded by leading suppliers in the health products industry to administer Medications Return Programs and Sharps Collection Programs throughout the country. As a Producer Responsibility Organization (PRO), the HPSA administers the regulated Extended Producer Responsibility (EPR) programs for health ...
Synergistic interaction between metformin and
Synergistic interaction between metformin and

... regression, and the effective doses for 50% of subjects (ED50) ± SE were calculated according to Tallarida (22). The interactions between metformin and sulfonylureas were characterized by isobolographic analysis assuming that the combinations are constituted by equi-effective doses of the individual ...
Reductil description
Reductil description

... The long-term effects of sibutramine on the morbidity and mortality associated with obesity have not been established. Weight loss was examined in 11 double-blind, placebo-controlled obesity trials with study durations of 12 to 52 weeks and doses ranging from 1 to 30 mg once daily. Weight was signif ...


... employed to assess aerosol deposition, the type of radioactive label used may influence the findings [18]. Direct assay of the active drug in the MDI formulation is a simple, inexpensive and reliable method of measuring aerosol deposition [19–21]. Types of in vitro models. Various models of the vent ...
Psychopharmacotherapy of anorexia nervosa, bulimia nervosa and
Psychopharmacotherapy of anorexia nervosa, bulimia nervosa and

... observed in patients with anorexia nervosa,39,40 are also reported to thwart central serotonergic activity.40 These findings suggest reduced serotonergic activity that could be a state-related phenomenon because dieting is known to reduce the availability of tryptophan, the precursor of serotonin.41 ...
Neurobiological substrates for the dark side of compulsivity in
Neurobiological substrates for the dark side of compulsivity in

... whole animal to produce organized activity’’ (Hebb, 1972), and such motivational states are not constant but rather vary over time. Early work by Wikler stressed the role of changes in drive states associated with dependence. Subjects described withdrawal changes as a ‘‘hunger’’ or primary need and ...
Genetic Alteration of p53 in Brain Astrocytic Tumors
Genetic Alteration of p53 in Brain Astrocytic Tumors

... multiple factors including continuous exposure to a chemical, radiation or due to genetic factors. On the molecular level there are certain genetic mutations can occur. One of the most commonly mutated genes is the TP53 which was investigated in this study. ...
Cyclodextrins in peptide and protein delivery
Cyclodextrins in peptide and protein delivery

... the properties necessary for optimal transfer between the site of administration and the pharmacological target site in the body [1]. There are considerable hurdles to be overcome before practical use can be made of therapeutic peptides and proteins due to chemical and enzymatic instability, poor ab ...
Relatedness in the post-genomic era: is it still
Relatedness in the post-genomic era: is it still

... A simulation — about its expected value θ. Indeed, differences in θʹ can be exploited to estimate narrow-sense heritability (h2) using pairs of individuals with the same θ, such as siblings10,11 or even unrelated individuals (θ = 0) (REF. 12). This contrasts with traditional h2 estimates that requir ...
Provisional PDF - Thrombosis Journal
Provisional PDF - Thrombosis Journal

... are at increased risk of bleeding and possibly pulmonary embolism. We examined the efficacy and safety of oral rivaroxaban in patients with VTE with and without renal impairment. Methods: Prespecified subgroup analysis of the EINSTEIN DVT and EINSTEIN PE studies comparing fixed-dose rivaroxaban with ...
View the 2016 Prior Authorization Criteria
View the 2016 Prior Authorization Criteria

... CYP2D6 extensive metabolizers and intermediate metabolizers taking a strong or moderate CYP2D6 inhibitor (e.g., paroxetine, terbinafine) concomitantly with a strong or moderate CYP3A inhibitor (e.g., ketoconazole, fluconazole). CYP2D6 intermediate metabolizers and poor metabolizers taking a strong C ...
Hot Flashes in a Young Girl: A Wake-up Call Concerning
Hot Flashes in a Young Girl: A Wake-up Call Concerning

... used in male adults for the treatment of benign prostatic hyperplasia (BPH). Although the effect of this plant is thought to be limited, S repens is unquestionably most widely used for the care of BPH.2 S repens has also shown antiestrogenic action and is believed to decrease available sex hormone–b ...
procainamide hcl
procainamide hcl

... NAPA’s activity is similar to that of procainamide when equal plasma concentration are compared , however , other have found that approximately 10 to 20 mg/L are required for partial suppression of ventricular concentration . Plasma concentration of NAPA of approximately equal to procainamide in man ...
Kwartaalbericht
Kwartaalbericht

... PPIs can probably induce tongue discolouration due to their ability to decrease saliva production and increase the pH of the oral mucosa and therefore cause an altered microbial flora. Six cases of tongue discoloration were reported in association with PPIs, including one patient with a positive rec ...
terbutaline sulfate injection usp
terbutaline sulfate injection usp

... because of insufficient clinical data to establish safety and effectiveness. Geriatric Use Clinical studies of terbutaline sulfate injection did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical ex ...
PART III
PART III

... your doctor, nurse, or pharmacist that this has happened to you. Are already taking a blood pressure-lowering medicine that contains aliskiren (such as Rasilez®) and you have diabetes or kidney disease. Have been diagnosed with hereditary angioedema: an increased risk of getting an allergic reaction ...
Kempegowda Institute of Medical Sciences
Kempegowda Institute of Medical Sciences

... sympathetic activity3. Intrathecal morphine provides prolonged postoperative analgesia but is associated with increased risk of nausea, vomiting, itching and respiratory depression4. Short acting opiods like fentanyl and sufentanil have been used intrathecally in elderly population to provide pain r ...
Genetic linkage studies in the pseudoautosomal
Genetic linkage studies in the pseudoautosomal

... the role of specific genes, specific environmental factors, and interactions between genes and environment in determining a particular trait of interest. This trait can be either a binary trait such as a particular disease (schizophrenia, breast cancer) or a quantitative trait (serum cholesterol lev ...
Ranzith®
Ranzith®

... taken in patients with severe renal impairment. Overdosage There is no data on over dosage with Azithromycin. Typical symptoms of over dosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhea. Gastric lavage and general supportive measures are indicated. Drug Inte ...
Long-term in vitro study of paclitaxel
Long-term in vitro study of paclitaxel

... body's own cells in the body [18]. In cancer therapy, surgical treatment is usually carried out for patients with a resectable carcinoma. However, treatment failure due to local recurrence of primary tumors or metastatic spread often occurs. Surgical adjuvant chemotherapy employing an anticancer age ...
Melatonin - Wolverhampton Formulary
Melatonin - Wolverhampton Formulary

... alternative to either of these options. However, to the extent that Circadin® is a licensed product, its use outside of licence (in so far as the tablet is broken or crushed) is considered preferable to an unlicensed presentation of melatonin. If an unlicensed product is clinically indicated, rather ...
This copy is for personal use only
This copy is for personal use only

... temperature 21 ± 1°C, relative humidity 55 ± 5%). After 7 days of adaptation to laboratory conditions, the animals were randomly assigned to experimental groups consisting of 8 mice per group. Each mouse was used only once. All tests were performed between 09.00-15.00. Procedures involving animals a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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