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A bitter pill. Overview of ecstasy (MDMA, MDA) related
A bitter pill. Overview of ecstasy (MDMA, MDA) related

... and 2002. Gill et al. (2002) commented on the causes of death of 22 MDMA positive fatalities occurring in New York between January 1997 and June 2000; although the size of their sample was small, results showed a 3-fold increase in the number of deaths in 1999 and 2000 with respect to previous years ...


... observed, few of these have demonstrated to have major clinical relevance.28 Despite such statements, it has also been contended that both pharmacokinetic and pharmacodynamic factors play a role in determining the optimal dosage regimen of an antihypertensive agent for the individual patient.29 The ...
Sinemet® CR Product Monograph
Sinemet® CR Product Monograph

... that these events are NOT limited to initiation of therapy. Patients should also be advised that sudden onset of sleep has occurred without warning signs and should be specifically asked about factors that may increase the risk with SINEMET® CR such as concomitant medications or the presence of slee ...
Instructions For Use
Instructions For Use

... scoring done through 6 months (Sinonasal Outcomes Test 22 (SNOT22), Rhinosinusitis Disability Index (RSDI), and a total nasal symptom scoring instrument (TNSS)). Ocular examinations consisted of IOP measurement and dilated slit-lamp examination for lens opacities at baseline and Day 30. The implant ...
Drug-coated balloon treatment for lower extremity vascular disease
Drug-coated balloon treatment for lower extremity vascular disease

... publication demonstrated that following DCB dilatation, a proportion of the paclitaxel is retained on the vessel surface and is not acutely dissolved into the tissue. It seemed apparent that arterial wall levels of paclitaxel were driven by the sustained retention of drug on the surface of the vesse ...
CURRICULUM VITAE Stacey C. Sigmon, Ph.D. February 2014
CURRICULUM VITAE Stacey C. Sigmon, Ph.D. February 2014

... Higgins, S.T., Heil, S.H., & Sigmon, S.C. (2012). Voucher-based contingency management in the treatment of substance use disorders. In G.J. Madden (Ed.), APA Handbook of Behavior Analysis. Washington, DC: American Psychological Association, pp. 481-500. (R) Higgins, S.T., Silverman, K., Sigmon, S.C. ...
IN-SITU INJECTABLE THERMOSENSITIVE GEL BASED ON POLOXAMER AS A NEW... FOR TAMOXIFEN CITRATE
IN-SITU INJECTABLE THERMOSENSITIVE GEL BASED ON POLOXAMER AS A NEW... FOR TAMOXIFEN CITRATE

... drug hydrophobic moiety in the cyclodextrin (CD) cavity that has similar hydrophobic nature as the drug. The outer surface of CD is characterized by being hydrophilic; thus enhancing aqueous solubility of the drug [9]. Although solubility enhancement of TMC may improve its bioavailability from oral ...
Maricopa County Superior Court Family Court
Maricopa County Superior Court Family Court

...  EtG has also been isolated in hair follicles *G.Heiseth, B. Yttredal, et.al. ; JATox: July 2010 ...
TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY
TASTE MASKED ORODISPERSIBLE TABLETS: A HIGHLY

... Methods: Pediatric and geriatric populations are the most sensitive to the bad taste of medicaments, thus in these cases patient compliance reduces. This reason is an initiative for the development of various taste masking technologies by which the characteristics of ODT is improved and good patient ...
Adverse Health Effects of Marijuana Use
Adverse Health Effects of Marijuana Use

... may also explain the association between regular marijuana use and poor grades.29 The relationship between cannabis use by young people and psychosocial harm is likely to be multifaceted, which may explain the inconsistencies among studies. For example, some studies suggest that long-term deficits m ...
Chapter 4 ciccarelli
Chapter 4 ciccarelli

... works only in a person’s immediate consciousness, while a hidden “observer” remained aware of all that was going on. • Social-cognitive theory of hypnosis theory that assumes that people who are hypnotized are not in an altered state but are merely playing the role expected of them in the situation. ...
THE PROMISE OF IMAGING BIOMARKERS
THE PROMISE OF IMAGING BIOMARKERS

... penetration, you’re getting a ratio between [drug levels in the] brain and blood. I think we are reasonably confident these measures correspond to reality,” says Rabiner. He gives the example of antipsychotic medication that targets the D2 dopamine receptor. “It’s been generally accepted that for ac ...
Testosterone Replacement Therapy
Testosterone Replacement Therapy

... is increasingly being used as a lifestyle therapy for men who are older, frail, or want to look better or feel younger and stronger. There is continued debate on whether older men, with or without androgen deficiency and symptoms of hypogonadism, will benefit from long-term testosterone replacement ...
Monitoring cancer prognosis, diagnosis and treatment efficacy using
Monitoring cancer prognosis, diagnosis and treatment efficacy using

... Several metabolic markers have been associated with cancer status (Table 1), however this information is yet to be used for routine cancer screening in the clinic. To ensure future success of metabolic biomarkers in cancer patients certain aspects must be considered. Biomarkers should be more inform ...
Antipsychotic Drugs - Pharmacological Reviews
Antipsychotic Drugs - Pharmacological Reviews

... however, no antipsychotic activity was seen (Bristow et al., 1997). Although not much is known about the pharmacodynamics and pharmacokinetics of the drug in question, this observation is consistent with the view that the D4 receptor does not play a major role in the antipsychotic actions of the oth ...
Full Prescribing Information
Full Prescribing Information

... delayed-release pellets must not be crushed or damaged when breaking up the tablet. Any loss of pellets in the transfer would prevent using the dose. The applesauce/DORYX mixture should be swallowed immediately without chewing and may be followed by a glass of water if desired. The applesauce should ...
Amlodipin Accord 10 mg tablets
Amlodipin Accord 10 mg tablets

... patients have shown that amlodipine does not lead to clinical deterioration as measured by exercise tolerance, left ventricular ejection fraction and clinical symptomatology. A placebo-controlled study (PRAISE) designed to evaluate patients in NYHA Class III-IV heart failure receiving digoxin, diure ...
Adverse Health Effects of Marijuana Use
Adverse Health Effects of Marijuana Use

... may also explain the association between regular marijuana use and poor grades.29 The relationship between cannabis use by young people and psychosocial harm is likely to be multifaceted, which may explain the inconsistencies among studies. For example, some studies suggest that long-term deficits m ...
clinical dilemmas and surgical treatment of penoscrotal, scrotal and
clinical dilemmas and surgical treatment of penoscrotal, scrotal and

... however, recent studies have revealed possible involvement of sonic hedgehog (SHH), fibroblast growth factors  and  (FGF and FGF), and homeobox A and D (HOXA and HOXD) genes in early genital tubercle outgrowth and patterning (). As discussed earlier, antiandrogen might plays a role in ...
Progress in the Understanding of the Genetic Etiology of Vertebral
Progress in the Understanding of the Genetic Etiology of Vertebral

... with a symmetric thoracic cage and nonprogressive scoliosis. Mutations in Notch signaling pathway genes [delta-like 1 (DLL3); mesoderm posterior 2 (MESP2); and lunatic fringe (LFNG)] have been found to cause SCD, a heterogeneous group of vertebral malformation syndromes. ...
diclofenac - Endo Pharmaceuticals
diclofenac - Endo Pharmaceuticals

... necrosis, jaundice, fulminant hepatitis with and without jaundice, and liver failure. Some of these reported cases resulted in fatalities or liver transplantation. Physicians should measure transaminases periodically in patients receiving long-term therapy with diclofenac, because severe hepatotoxic ...
AusPAR: Vernakalant - Therapeutic Goods Administration
AusPAR: Vernakalant - Therapeutic Goods Administration

HYDROCODONE BITARTRATE AND ACETAMINOPHEN ORAL
HYDROCODONE BITARTRATE AND ACETAMINOPHEN ORAL

... hydrocodone and acetaminophen combination products in adults with additional data which support the development of metabolic pathways in children two years of age and over (see DOSAGE AND ADMINISTRATION for pediatric dosage information). Geriatric Use Clinical studies of hydrocodone bitartrate and ...
PDF - Problems of Forensic Sciences
PDF - Problems of Forensic Sciences

... Clonazepam is a benzodiazepine exhibiting anticonvulsive activity. It is used in epilepsy treatment. In the practice of the Institute of Forensic Research in Krakow, 57 cases involving clonazepam in biological material were recorded from 2003 to 2006. The highest number of cases (29) associated with ...
Chronic Pain Management - Colorado Pain Consultants
Chronic Pain Management - Colorado Pain Consultants

... it to its normal length.  Cold is better for acute/inflammatory injuries, but can be used long-term based on px’s preference for muscle tightness.  Heat/Ultrasound is best tolerated in subacute/chronic conditions, but is better for loosening collagen and stiff joints than ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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