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Forensic Toxicology PPT
Forensic Toxicology PPT

... slowing of psychomotor responses. • Sedation occurs 20-30 minutes after administration and lasts for hours. • The drug is not commonly used by physicians in the US. • The drug has been added to drinks at parties, where it is reportedly given to female party participants in hopes of lowered inhibitio ...
Meperidine - Home - KSU Faculty Member websites
Meperidine - Home - KSU Faculty Member websites

... Effects of meperidine: • The effects of meperidine are felt 10-15 minutes after ingestion and typically last anywhere from 2-4 hours. • mepiridine effects are very similar to morphine, with sedation, respiratory depression and euphoria less intense than that of morphine. • nausea and vomiting are c ...
Featured Article
Featured Article

abstracts
abstracts

... markets of the developing world are changing even more radically than those of the developed world. While there are significant opportunities in the developing world due to health care awareness both of governments and individuals, in case of developed countries, political compulsions to reduce heal ...
Basic Principles of Heredity
Basic Principles of Heredity

... where the shape of seeds is determined. This locus might be occupied by an allele for round seeds or one for wrinkled seeds. We will use the term allele when referring to a specific version of a gene; we will use the term gene to refer more generally to any allele at a locus. The genotype is the set ...
Molecules that changed our Lives Synthetic Organic
Molecules that changed our Lives Synthetic Organic

... cancer-is extracted from the bark of Taxus,the pacific yew tree.The supply of natural Taxol is limited because yew trees are uncommon and grow very slowly and stripping the bark kills the tree.Once chemistsdetermined the structure of Taxol, a successful synthesis has been accomplished. Prasanthi: No ...
Cholesterol and Triglycerides What You Should Know
Cholesterol and Triglycerides What You Should Know

... High levels of cholesterol or triglycerides are usually caused by genetic or inherited disorders of lipid metabolism. These lipids may also be increased by: ...
Coartem - Novartis Pharmaceuticals Corporation
Coartem - Novartis Pharmaceuticals Corporation

... The data described below reflect exposure to a 6-dose regimen of Coartem Tablets in 1,979 patients including 647 adults (older than 16 years) and 1,332 children (16 years and younger). For the 6-dose regimen, Coartem Tablets was studied in active-controlled (366 patients) and non-controlled, open-la ...
Assessment and Treatment of Alcohol Dependence
Assessment and Treatment of Alcohol Dependence

... sufficient alcohol for a sufficient period of time for the body to neuroadapt. As a clinically useful generalisation a person who is physically dependent on alcohol will try to maintain their blood alcohol above 0.1% and once they go below this level they will develop alcohol withdrawal symptoms. Gi ...
Liposomes in drug delivery
Liposomes in drug delivery

... Several methods have been developed for the preparation of large, unilamellar vesicles (LUV), including solvent (ether or ethanol) injection, detergent dialysis, calcium induced fusion, and reverse-phase evaporation (REV) techniques. SUV can be prepared from MLV or LUV by sonication (using probe son ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... shown to produce analgesia without causing significant respiratory depression after systemic, epidural or spinal administration. Although epidural clonidine may also cause hypotension, bradycardia and sedation in higher doses, serious adverse effects are uncommon in the dose range (1-2 µg/kg body we ...
SOTALOL HYDROCHLORIDE TABLETS, USP 80 mg, 120 mg, 160
SOTALOL HYDROCHLORIDE TABLETS, USP 80 mg, 120 mg, 160

... myocardial infarction, who did not necessarily have ventricular arrhythmias, sotalol did not produce increased mortality at doses up to 320 mg/day (see Clinical Studies). On the other hand, in the large postinfarction study using a non-titrated initial dose of 320 mg once daily and ...
The Drug of War
The Drug of War

... associated with psychomatic effects leading to concerns that it may increase the risk of posttraumatic stress disorder (PTSD). Recently, an American Military study (29) addressed this by investigating the prevalence of PTSD in American troops with burns injuries returning from conflict in the Middle ...
Formulary Review
Formulary Review

... multicenter, placebo-controlled, double-blind, randomized, parallel group trials in patients with primary hypercholesterolemia. Study A, which involved 243 patients, was a dose-response trial; study B, which involved 189 patients, was a dose-regimen trial. Both studies were comprised of three phases ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
SEIKO ABUBAKARI - Kwame Nkrumah University of Science

... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
Buprenorphine And The Anesthesia Considerations: A
Buprenorphine And The Anesthesia Considerations: A

... agonist opiates. By post injury day 3 (PID 3), the patient’s analgesic needs began to decline. Additional history revealed the patient was actively on a BMT and on PID 4, his regimen was restarted with the aim of obtaining better pain management. Tapering of narcotics did not happen, and on PID 6 th ...
Intramuscular aripiprazole for the treatment of agitation in
Intramuscular aripiprazole for the treatment of agitation in

... propensity for several adverse effects that sometime limit the clinical use of other drugs 19. The efficacy of oral aripiprazole on the positive and negative symptoms of schizophrenia and its tolerability have been extensively reviewed elsewhere 11 20. As reported for oral aripiprazole 11, the pharm ...
PHYSICOCHEMICAL PROPERTIES OF HESPERIDIN NANOCRYSTAL Research Article RACHMAT MAULUDIN
PHYSICOCHEMICAL PROPERTIES OF HESPERIDIN NANOCRYSTAL Research Article RACHMAT MAULUDIN

... Auweter using precipitation technique [14-17]. Drug is dissolved in solvent media and subsequently added non-solvent to obtain drug nanoparticles. Presence stabilizer such as surfactant into the media can avoid particles growth or microparticles formation. Similar method of this technique was report ...
Cost-effectiveness of anticoagulants for suspected
Cost-effectiveness of anticoagulants for suspected

... marked “advertisement” in accordance with 18 USC section 1734. ...
Psychotropic Medication and Interaction with Alcohol
Psychotropic Medication and Interaction with Alcohol

... Guidance on the administration of medicines to inpatients believed to have consumed alcohol Sussex Partnership NHS Trust clinical policy Alcohol, Harmful Substance and Illegal Drug Use by Service Users and Visitors in Inpatient Services and Trust Premises states that ‘any situation where a service u ...
(Dosing, switching, and other practical information).
(Dosing, switching, and other practical information).

... Aripiprazole should be used with caution in patients who have a history of seizure disorder or have conditions associated with seizures. ...
Facts about Marijuana - Institute for Student Achievement
Facts about Marijuana - Institute for Student Achievement

... For some people, smoking marijuana makes them feel good. Within minutes of inhaling, a user begins to feel “high,” or filled with pleasant sensations. THC triggers brain cells to release the chemical dopamine. Dopamine creates good feelings—for a short time. But that’s just one effect… Imagine this: ...
Pharmaceutical legislation and regulation
Pharmaceutical legislation and regulation

... In the Netherlands, the legal basis for licensing of pharmaceutical manufacturing and distribution was established in 1956. The Medicines Act of 1958 there­ after regulated the admission of medicines to the Dutch market through the Medicines Evaluation Board. But the board started to operate only af ...
Hemodynamic and clinical significance of the pulmonary
Hemodynamic and clinical significance of the pulmonary

... patient then received an initial dose of 25 mg of captopril orally followed by long-term therapy with the drug. Because the response to converting enzyme inhibition is not dose dependent (23,24), the doses of captopril prescribed for long-term treatment were based on each patient's renal function: p ...
opioid conversions - Palliativedrugs.com
opioid conversions - Palliativedrugs.com

... Newly recommended for use first line both orally and subcutaneously. At doses approaching 600mg/24hours it may be preferable to switch to diamorphine for reasons of volume. Morphine sulphate injection 10mg, 15mg, 20mg, 30mg per 1ml ampoule. Immediate release oral morphine: • Oramorph liquid 10mg/5ml ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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