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Patient Access User Manual
Patient Access User Manual

... The Director of ICT is accountable for the maintenance of Carecast and other reporting systems on which all waiting lists are held. The Director of Performance and Partnerships is accountable for the management of data once it has been entered onto Carecast and on other reporting systems on which al ...
SHPA Medicines Information Procedure Manual
SHPA Medicines Information Procedure Manual

... This manual provides information about the resources and skills required to establish, operate and maintain a medicines information (MI) service. In this manual, medicines information (MI) refers to information or advice provided in response to a request from a health professional, organisation, or ...
The Breast Cancer Polygene and Longevity Genes: The Implications
The Breast Cancer Polygene and Longevity Genes: The Implications

... The Punnet square for parental genotypes AaBbCc × AaBbCc. The 23 possible gamete formations for the parents are shown along the top and down the left. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The matrix for parental polygenotypes AaBbCc×AaBbCc showing the genotypes’ influence on can ...
opioid conversions - Palliativedrugs.com
opioid conversions - Palliativedrugs.com

... Newly recommended for use first line both orally and subcutaneously. At doses approaching 600mg/24hours it may be preferable to switch to diamorphine for reasons of volume. Morphine sulphate injection 10mg, 15mg, 20mg, 30mg per 1ml ampoule. Immediate release oral morphine: • Oramorph liquid 10mg/5ml ...
The diffusion of Performance and Image
The diffusion of Performance and Image

... SWIM has found it to inhibit the action of Ketamine, though SWIM wished it had done so more the last time he sat on the edge of a bed trying to persuade his hands to cram Piracetam pills in his mouth after a 250 mg K nightmare. SWIM has really tried to like that substance but it seems like K and SWI ...
21 hydroxylase deficiency
21 hydroxylase deficiency

... 17OHP assessments should not be made in the first 24h of life. Premature infants and term infants under severe stress may have elevated 17-OHP. 3ß HSD – P450cII deficiences ...
full prescribing information in pdf format
full prescribing information in pdf format

... The effectiveness of PROVIGIL in reducing the excessive sleepiness (ES) associated with narcolepsy was established in two US 9-week, multicenter, placebo-controlled, two-dose (200 mg per day and 400 mg per day) parallel-group, double-blind studies of outpatients who met the ICD-9 and American Sleep ...
Understanding Stimulant Drugs
Understanding Stimulant Drugs

... circulation- an effect that historically has made cocaine the preferred local anesthetic agent for eye surgery and other delicate procedures. The local anesthetic effects of cocaine are most pronounced when it is applied to the skin or mucous membranes. Thus, when cocaine is “snorted” it temporarily ...
Pregnancy and Cardiovascular Disease
Pregnancy and Cardiovascular Disease

...  Drug treatment of severe HPN in pregnancy is required and beneficial, yet treatment of less severe hypertension is controversial.  Although it might be beneficial for the mother with hypertension to reduce her BP, a lower BP may impair uteroplacental perfusion and ...
How to Protect Yourself Against Malaria
How to Protect Yourself Against Malaria

... should be permitted since mosquitoes will spend hours searching for an opening. Soaking your bed net in a permethrin solution like Sawyer Permethrin Soak Treatment Kit will impregnate it and provide additional protection since it kills the mosquitoes on contact. Similarly, spraying your clothes with ...
CORE MODULES & FORMS OF TOBACCO
CORE MODULES & FORMS OF TOBACCO

... This brief intervention can be achieved in less than 1 minute. ...
Chemmart® ALPRAZOLAM TABLETS
Chemmart® ALPRAZOLAM TABLETS

... In general, benzodiazepines should be prescribed for short periods only (e.g. 2–4 weeks). With the exception of the use of alprazolam for the treatment of panic disorder (see INDICATIONS), continuous long-term use of alprazolam is not recommended. There is evidence that tolerance develops to the sed ...
Glycolysis as a target for the design of new anti
Glycolysis as a target for the design of new anti

... Central and South America, where it is endemic in 21 countries.The disease affects 16–18 million people, and about 5–6 million of these have developed chronic incurable complications (such as cardiac lesions, digestive disorders, peripheral neurological lesions) appearing 10–20 years after the initi ...
Ribavirin Dose Modification Based on Renal Function Is Necessary
Ribavirin Dose Modification Based on Renal Function Is Necessary

... daily). Patients were grouped according to the decrease in the percentage of hematocrit after the introduction of ribavirin, with their baseline serum creatinine and creatinine clearance calculated using the Cockcroft-Gault formula. The decrease in the percentage of hematocrit after ribavirin treatm ...
Allergic Rhinitis Marshall Plaut, M.D., and Martin D. Valentine, M.D.
Allergic Rhinitis Marshall Plaut, M.D., and Martin D. Valentine, M.D.

... (Table 1).19 Maintenance doses are often given at intervals ranging from two to six weeks; data are lacking to compare various dosing frequencies. The magnitude of symptom reduction during immunotherapy is variable, although in some trials patients had a reduction of more than two thirds in symptoms ...
ROPINIROLE-GA PRODUCT INFORMATION (ropinirole) NAME OF
ROPINIROLE-GA PRODUCT INFORMATION (ropinirole) NAME OF

... necessitate dosage adjustment of either drug. Drugs metabolised by Cytochrome P450 1A2 It has been established from in vitro experiments that ropinirole is principally metabolised by the cytochrome P450 enzyme CYP1A2. There is therefore the potential for an interaction between ropinirole hydrochlori ...
Treatment of Giardiasis
Treatment of Giardiasis

... response with release of cytokines and mucosal inflammation (41, 48, 61, 78, 83, 106, 110, 157, 259). Additionally, it is likely that there are genetic differences between Giardia isolates which may confer virulence (115, 173, 182, 190). The surface of Giardia may also undergo antigenic variation in ...
Pennsaid - Medication Policy Manual | Index
Pennsaid - Medication Policy Manual | Index

... Diclofenac topical solution is a topical non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis of the knee. Topical NSAIDs [diclofenac (Voltaren, Pennsaid, Flector®)] are likely as effective as oral NSAIDs in relieving localized, acute pain. There is no evidence showin ...
AusPAR: Trastuzumab
AusPAR: Trastuzumab

... evaluator’s question the sponsor stated the following: ‘For the submission in Switzerland, the sponsor decided that the requests from Swissmedic, which included introduction of an applicator and provision of additional data relating to adjuvant breast cancer administration, could not be provided wit ...
THE EFFECT OF KETOTIFEN ON EOSINOPHILIC CHEMOTACTIC FACTORS IN EXPERIENTIALLY
THE EFFECT OF KETOTIFEN ON EOSINOPHILIC CHEMOTACTIC FACTORS IN EXPERIENTIALLY

... So many Environmental and genetical factors are effective in this disease. Allergy is one of the immunological responses which is categorized under the hyper sensitivity reactions (Shaikh, 2001). There is a high genetic potential for evolution the allergy immediate hypersensitivity reaction. There a ...
butorphanol tartrate injection usp
butorphanol tartrate injection usp

... caution (see below and the appropriate sections in PRECAUTIONS). For pain relief the recommended initial dosage regimen of butorphanol tartrate injection is 1 mg IV or 2 mg IM with repeated doses every 3 to 4 hours, as necessary. This dosage regimen is likely to be effective for the majority of pati ...
Chapter 15 - Dr. Gerry Cronin
Chapter 15 - Dr. Gerry Cronin

... • Antipyretics: reduce fever • Some of these types of drugs also have anti-inflammatory properties ...
Biodegradable Janus Nanoparticles for Local Pulmonary Delivery of
Biodegradable Janus Nanoparticles for Local Pulmonary Delivery of

... Fairlawn, NJ) and 1.2 mL/100 mL penicillin−streptomycin (Sigma, St. Louis, MO). Cells were grown at 37 °C in a humidified atmosphere of 5% CO2 (v/v) in air. All experiments were performed on cells in the exponential growth phase. Synthesis of Janus Particles and Loading with Drugs. For the in vitro a ...
continuing professional Development PRACTICAL PoINTERS
continuing professional Development PRACTICAL PoINTERS

... between individuals, with a five- to eightfold variation in CYP3A4 activity between individuals, and greater than 50% variation between individuals for CYP2D6 activity. This variation is in the normal population. Five to 10% of Europeans and less than 1% of Asian people are poor metabolisers of medi ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... appreciate by Humphrey Davy from the time that nitrous oxide was first used for analgesia by Horace wells in 1844 until 1956, nitrous oxide was considered to be completely benign. The first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al in the Lancet in ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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