This PDF is a selection from a published volume
... This paper describes three prototypical systems of therapeutic reference pricing (RI') for pharmaceuticalsGermany, the Netherlands, and New Zealandand examines their effects on the availability of new drugs, reimbursement levels, manufacturer prices, and out-of-pocket surcharges to patients. RP for ...
... This paper describes three prototypical systems of therapeutic reference pricing (RI') for pharmaceuticalsGermany, the Netherlands, and New Zealandand examines their effects on the availability of new drugs, reimbursement levels, manufacturer prices, and out-of-pocket surcharges to patients. RP for ...
Therapy Insight: drugs for gastrointestinal disorders in pregnant
... During pregnancy, the presence of gastrointestinal disease (that might be pre-existent to pregnancy or develop de novo) presents special challenges to the clinician. Drug therapy requires careful assessment and consideration before conception (for those with pre-existent disease), during pregnancy a ...
... During pregnancy, the presence of gastrointestinal disease (that might be pre-existent to pregnancy or develop de novo) presents special challenges to the clinician. Drug therapy requires careful assessment and consideration before conception (for those with pre-existent disease), during pregnancy a ...
Genetic screening of gamete donors: ethical issues
... For gamete donation, when performed in a clinical setting, only donors are used who have been screened for a range of medical risk factors including risks of transmitting genetic disease to the children conceived with their help. According to present recommendations genetic screening of gamete donor ...
... For gamete donation, when performed in a clinical setting, only donors are used who have been screened for a range of medical risk factors including risks of transmitting genetic disease to the children conceived with their help. According to present recommendations genetic screening of gamete donor ...
Triptans - Consumer Health Choices
... people get them more often. If you have migraines that last for more than four hours at least 15 days each month for at least six months, you would be classified as suffering from chronic migraines. Migraines can be difficult to diagnose because they can cause similar symptoms as other types of head ...
... people get them more often. If you have migraines that last for more than four hours at least 15 days each month for at least six months, you would be classified as suffering from chronic migraines. Migraines can be difficult to diagnose because they can cause similar symptoms as other types of head ...
INVESTIGATION OF THE IN VITRO METABOLISM PROFILE OF A
... potent and selective PDE-IV inhibitor (Hughes et al., 1997; Perry et al., 1998), and was in development for the treatment of asthma. The structure of CDP-840 is shown in Fig. 1. Drug metabolism studies during the early drug discovery stage are becoming increasingly important. They provide informatio ...
... potent and selective PDE-IV inhibitor (Hughes et al., 1997; Perry et al., 1998), and was in development for the treatment of asthma. The structure of CDP-840 is shown in Fig. 1. Drug metabolism studies during the early drug discovery stage are becoming increasingly important. They provide informatio ...
The History of Standardized Vaccine Development Current Vaccine
... In the aftermath of World War II, the U.S. Public Service Act of 1944 was signed into law. It mandated that the federal government issue licenses for all biological products, including vaccines (PBS). The legislation was designed to consolidate and organize the health system in the United States. In ...
... In the aftermath of World War II, the U.S. Public Service Act of 1944 was signed into law. It mandated that the federal government issue licenses for all biological products, including vaccines (PBS). The legislation was designed to consolidate and organize the health system in the United States. In ...
2015 AAHA/AAFP Pain Management Guidelines for Dogs and Cats*
... nonpharmacologic modalities to manage pain; they are evidence-based insofar as possible and otherwise represent a consensus of expert opinion. Behavioral changes are currently the principal indicator of pain and its course of improvement or progression, and the basis for recently validated pain scor ...
... nonpharmacologic modalities to manage pain; they are evidence-based insofar as possible and otherwise represent a consensus of expert opinion. Behavioral changes are currently the principal indicator of pain and its course of improvement or progression, and the basis for recently validated pain scor ...
Armodafinil-and-Modafinil-Safety-Series
... available since the late 1970’s. However, they have only become commonly known since the Food and Drug Administration (FDA) approved Modafinil under the brand name Provigil in 1998. Adrafinil (Pronounced ah DRAF i nil) The first commonly available Eugeroic was Adrafinil. It was invented by the Frenc ...
... available since the late 1970’s. However, they have only become commonly known since the Food and Drug Administration (FDA) approved Modafinil under the brand name Provigil in 1998. Adrafinil (Pronounced ah DRAF i nil) The first commonly available Eugeroic was Adrafinil. It was invented by the Frenc ...
The CFC to HFA Transition and Its Impact on
... new ways to more appropriately target those diseases, led to better MDIs. The ban on CFCs has also spurred new dry powder inhaler technology as well as many other classes of specialty inhalers. There are many HFA MDIs currently coexisting with CFC MDIs, but the CFC MDIs will eventually be eliminated ...
... new ways to more appropriately target those diseases, led to better MDIs. The ban on CFCs has also spurred new dry powder inhaler technology as well as many other classes of specialty inhalers. There are many HFA MDIs currently coexisting with CFC MDIs, but the CFC MDIs will eventually be eliminated ...
Drug effects on acetic acid-depressed locomotor
... present study was to evaluate an assay of noxious stimulus-depressed locomotor activity (LMA) in mice, to further evaluate the utility and sensitivity of preclinical methods that measure pain-depressed behavior. Assay development proceeded in three steps: 1) identification of conditions under which L ...
... present study was to evaluate an assay of noxious stimulus-depressed locomotor activity (LMA) in mice, to further evaluate the utility and sensitivity of preclinical methods that measure pain-depressed behavior. Assay development proceeded in three steps: 1) identification of conditions under which L ...
Clinical Research Protocol
... Describe the scenarios under which a subject may be withdrawn from the study prior the expected completion of that subject (e.g. safety reasons, failure of subject to adhere to protocol requirements, subject consent withdrawal, disease progression, etc.) Also, if abrupt termination of study treatmen ...
... Describe the scenarios under which a subject may be withdrawn from the study prior the expected completion of that subject (e.g. safety reasons, failure of subject to adhere to protocol requirements, subject consent withdrawal, disease progression, etc.) Also, if abrupt termination of study treatmen ...
Nucleotide Metabolism
... Nucleotide Metabolism Proceeds Through de novo and Salvage Pathways Purine Nucleotides are Built de novo Starting with Ribose-5-phosphate PRPP is Made From it and Then it is Aminated Simple Compounds, Such as Amino Acids and 1-Carbon Donors Make the Bases IMP is a Branch Point for Synthesis of GMP a ...
... Nucleotide Metabolism Proceeds Through de novo and Salvage Pathways Purine Nucleotides are Built de novo Starting with Ribose-5-phosphate PRPP is Made From it and Then it is Aminated Simple Compounds, Such as Amino Acids and 1-Carbon Donors Make the Bases IMP is a Branch Point for Synthesis of GMP a ...
DUSC - PBS
... Data for the number of prescriptions supplied and Government expenditure for pregabalin was extracted from the DUSC database from the date of listing on the PBS (1 March 2013) to the most current available data (March 2014). Data was also extracted for the RPBS pregabalin items prior to their deleti ...
... Data for the number of prescriptions supplied and Government expenditure for pregabalin was extracted from the DUSC database from the date of listing on the PBS (1 March 2013) to the most current available data (March 2014). Data was also extracted for the RPBS pregabalin items prior to their deleti ...
BCBSM Prior Authorization and Step Therapy Guidelines
... Off-Label / High-Cost Specialty program-Off-label means a drug is being used in a way that has not been approved by the U.S. Food and Drug Administration. Drugs with potential for off-label use and high-cost specialty drugs on this list require prior authorization for Blue Cross to cover them. ...
... Off-Label / High-Cost Specialty program-Off-label means a drug is being used in a way that has not been approved by the U.S. Food and Drug Administration. Drugs with potential for off-label use and high-cost specialty drugs on this list require prior authorization for Blue Cross to cover them. ...
Volume 4, Supplement 1
... Aims and Scope Global Antiviral Journal publishes peer-reviewed original works related to international efforts to advance antiviral discovery and development, including full-length articles and short papers, as well as solicited review articles, conference reports, letters and book reviews. Occasio ...
... Aims and Scope Global Antiviral Journal publishes peer-reviewed original works related to international efforts to advance antiviral discovery and development, including full-length articles and short papers, as well as solicited review articles, conference reports, letters and book reviews. Occasio ...
Biochemical Toxicity Induced By Tramadol
... Poison Control data (2002 AAPCC Annual Report) indicated that there were 2,400 exposures of tramadol reported to control centers, of those, 108 resulted in a major medical outcome and 8 resulted in death. Long- term administration of tramadol for management of pain, as well as its use as an acceptab ...
... Poison Control data (2002 AAPCC Annual Report) indicated that there were 2,400 exposures of tramadol reported to control centers, of those, 108 resulted in a major medical outcome and 8 resulted in death. Long- term administration of tramadol for management of pain, as well as its use as an acceptab ...
... Unless otherwise specified, all means presented are least-squares means from the particular model used. Within-group means are quoted with standard deviation (SD). Between-group differences are given with standard errors (SEM) of least-square means. All parametric analyses were based on F-tests deri ...
Dear Sir/Madam - University of Michigan College of Pharmacy
... the Mammalian Target of Rapamycin (mTOR) Inhibitor RAD001 in Combination with Imatinib (Gleevec) in Patients with Chronic Phase Chronic Myeloid Leukemia (CML) with Persistent Molecular Disease. PI: Moshe Talpaz, Co-I: Rose Feng, 15% effort for 2 years; (Clinical trial will start in 07/2010). A sta ...
... the Mammalian Target of Rapamycin (mTOR) Inhibitor RAD001 in Combination with Imatinib (Gleevec) in Patients with Chronic Phase Chronic Myeloid Leukemia (CML) with Persistent Molecular Disease. PI: Moshe Talpaz, Co-I: Rose Feng, 15% effort for 2 years; (Clinical trial will start in 07/2010). A sta ...
COMPARATIVE STUDY ON EFFECT OF DIFERENT TECHNIQUES USED IN THE FORMULATION OF FELODIPINE FAST DISSOLVING TABLETS
... properties. Felodipine fast dissolving tablets (FDT) have been prepared by direct compression method. Effect of method of preparation (i.e. solid dispersion and sublimation) on dissolution rate, disintegration time and wetting time was studied. Effect of superdisintegrants (such ...
... properties. Felodipine fast dissolving tablets (FDT) have been prepared by direct compression method. Effect of method of preparation (i.e. solid dispersion and sublimation) on dissolution rate, disintegration time and wetting time was studied. Effect of superdisintegrants (such ...
The Management of Persistent Pain in Older Persons
... patients and professionals for the many effective treatments that are available to help alleviate suffering.4 The clinical manifestations of persistent pain are commonly multifactorial. Because of the complex interplay among these factors across several domains (physiologic, psychologic, and social) ...
... patients and professionals for the many effective treatments that are available to help alleviate suffering.4 The clinical manifestations of persistent pain are commonly multifactorial. Because of the complex interplay among these factors across several domains (physiologic, psychologic, and social) ...
Methodology
... Metformin does not undergo hepatic metabolism and renal tubular secretion is the major mechanism responsible for the removal of metformin. The estimated average renal clearance is 507 ± 129 ml / min in patients with preserved renal function, approximately 3.5 times higher than the creatinine clearan ...
... Metformin does not undergo hepatic metabolism and renal tubular secretion is the major mechanism responsible for the removal of metformin. The estimated average renal clearance is 507 ± 129 ml / min in patients with preserved renal function, approximately 3.5 times higher than the creatinine clearan ...
Intestinal Permeability of Lamivudine Using Single Pass Intestinal
... function was maintained in all the experiments. For SPIP techniques drugs with Peff, rat>0.2×10−4 cm/s and Peff, man>0.7×10−4 cm/s can be considered as highly permeable[25,26]. For lamivudine, the Peff, rat was found out to be 0.33×10−4 cm/s and Peff, man was found out to be 1.36×10 −4 cm/s. These r ...
... function was maintained in all the experiments. For SPIP techniques drugs with Peff, rat>0.2×10−4 cm/s and Peff, man>0.7×10−4 cm/s can be considered as highly permeable[25,26]. For lamivudine, the Peff, rat was found out to be 0.33×10−4 cm/s and Peff, man was found out to be 1.36×10 −4 cm/s. These r ...