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About - Blu By The Sea
About - Blu By The Sea

... When pregnant women use heroin, the drug also affects the fetus. Heroin use while pregnant may result in a greater chance of miscarriage or premature delivery. Babies who are born to heroin users have a higher risk of low birth rate, cardiovascular and respiratory function issues, as well as an incr ...
Tamoxifen or Raloxifene in Postmenopausal Women for Prevention
Tamoxifen or Raloxifene in Postmenopausal Women for Prevention

... particularly after treatment has been stopped (carryover effect). In fact, a beneficial carryover effect is beginning to emerge in the initial primary prevention trials of tamoxifen versus placebo such that reduction in risk for breast cancer seems to continue after treatment with tamoxifen is compl ...
Migraine — Current Understanding and Treatment
Migraine — Current Understanding and Treatment

... therapies. Nonpharmacologic therapies include education of the patient about the disorder, its mechanisms, approaches to treatment, and changes in lifestyle involved in the avoidance of triggers of migraine. In patients with migraine, the brain does not seem to tolerate the peaks and troughs of life ...
Dermatology Workshop
Dermatology Workshop

... – Bedrest and isolation of stressors with large doses of antihistamine at bedtime – Daily tub soaks followed by topical steroid ointment under wet pajamas and a sauna suit ...
Haploidy, Diploidy and Evolution of Antifungal Drug Resistance Saccharomyces cerevisiae
Haploidy, Diploidy and Evolution of Antifungal Drug Resistance Saccharomyces cerevisiae

... the MATa/ diploid were established in 1 ml of 0.5 YPD. These cultures were batch transferred daily at a dilution rate of 1:10 for the first 50 generations. This dilution rate has been shown to be optimal for the fixation of mutations conferring adaptive advantage in a given environment (Wahl and K ...
Macugen®, pegaptanib - Medication Policy Manual | Index
Macugen®, pegaptanib - Medication Policy Manual | Index

... bevacizumab (Avastin) and ranibizumab (Lucentis) in improving visual acuity in patients with wAMD based on a high quality systematic review which demonstrated that pegaptanib (Macugen) was associated with smaller improvements in visual acuity compared to the other two VEGF inhibitors. This same stud ...
Methadone Conversion Guideline
Methadone Conversion Guideline

... Converting from methadone back to morphine or other opioids is especially complex, because methadone affects more opioid receptors than other opioid analgesics; assistance from palliative care or pain management experts is generally advisable for this transition if patients have been on more than 30 ...
(4)CCF DRUGS
(4)CCF DRUGS

...  In failing hearts digoxin produces bradycardia by decreasing sympathetic tone • By increasing contractility, digoxin will increase cardiac output and thereby remove the stimulus for the elevated sympathetic tone in CHF  Toxic doses can cause arrhythmias by increasing sympathetic activity and auto ...
TASTE MASKED CHEWABLE DISPERSIBLE TABLET OF ATOMOXETINE HYDROCHLORIDE  Research Article HUDA.I.G*
TASTE MASKED CHEWABLE DISPERSIBLE TABLET OF ATOMOXETINE HYDROCHLORIDE Research Article HUDA.I.G*

... employed commercial products. The CDT has remarkable disintegration properties; it can disintegrate without water in the mouth. CDTs are useful in patients such as pediatric, geriatric, bedridden, or developmentally disabled who may face difficulty in swallowing conventional tablets or capsules lead ...
STATISTICAL GENETICS `98 Transmission Disequilibrium, Family
STATISTICAL GENETICS `98 Transmission Disequilibrium, Family

... The TDT method has been widely applied to test for linkage between candidate-gene regions and a variety of complex disorders. Some issues regarding the interpretation of positive findings by the TDT method warrant discussion. If only affected subjects are sampled and a candidate gene is evaluated, t ...
MtM essentials for asthma management: part 2
MtM essentials for asthma management: part 2

... chronic and troublesome symptoms, maintaining (near) normal pulmonary function, maintaining normal activity levels, using rescue medication no more than two days per week, and meeting the patient’s and family’s expectations and satisfaction with asthma care.1 Similarly, risk can be reduced by provid ...
Guidelines for the Biological Treatment of Substance Use and
Guidelines for the Biological Treatment of Substance Use and

... these practice guidelines after a systematic review of the available evidence pertaining to the treatment of opioid dependence. On the basis of the evidence, the Task Force reached a consensus on practice recommendations, which are intended to be clinically and scientifically meaningful for physicia ...
words - Investor Relations Solutions
words - Investor Relations Solutions

... period includes a non-cash in-process research and development charge of $24.3 million related to Curis's license agreement with Aurigene. Revenues were $1.7 million for each of the first quarters of 2016 and 2015. Revenues for both periods are comprised primarily of royalty revenues recorded on Gen ...
PROPOSED PACKAGE INSERT Cefepime for Injection
PROPOSED PACKAGE INSERT Cefepime for Injection

... - 12 To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefepime for Injection and other antibacterial drugs, Cefepime for Injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Whe ...
Selected Operating and Administrative Practices of the Bureau of
Selected Operating and Administrative Practices of the Bureau of

... during our audit period, indicating a lack of strategic direction from prior Bureau management in establishing investigative priorities. This disparity can undermine the effectiveness of the Bureau in detecting and ceasing large scale criminal conduct, and the resulting deterrent effect that should ...
Xolair® (Omalizumab) - UnitedHealthcareOnline.com
Xolair® (Omalizumab) - UnitedHealthcareOnline.com

... 18% and 82% at entry to 53%, 30% and 17% at week 20, and to 67%, 25% and 8% at week 52, respectively (p<0.0001). Reported exacerbation and hospitalization rates decreased by 72% and 88.5%, respectively. At 12 months, forced expiratory volume in 1 s (FEV1) improved by 4.9% (p=0.023), and inhaled cort ...
Quantification of Pharmacodynamic Interactions between
Quantification of Pharmacodynamic Interactions between

... Cardiovascular and EEG Signals. Cardiovascular and EEG signals were recorded continuously and processed as previously described (Bol et al., 1997a). Briefly, a transducer was connected via a tee to the arterial catheter and connected to a Cardiomax-II interface (Grass, Quincy, MA) that derived arter ...
Nimodipine - 25% ME Group
Nimodipine - 25% ME Group

... from day 1 to day 5 of a trial when the amount of the drug found in the blood serum remained constant. The amount of the drug found in the blood serum varies widely between individuals with younger persons absorbing much less than the elderly, on average. Tests show that the blood flow increases as ...
9 - TGA
9 - TGA

... conventional medicine. They are defined by the World Health Organisation as: “A broad set of health care practices that are not part of the country’s own tradition and are not integrated into the dominant healthcare system.” The use of complementary medicine is more common than ever amongst patients ...
intravenous paracetamol
intravenous paracetamol

... administered regularly over a number of days, and patients may have low glutathione levels due to starvation or preexisting nutritional deficiency.7,8 The treatment for paracetamol toxicity is IV infusion of acetylcysteine, which restores the ability of the liver to produce glutathione. Nomograms fo ...
zoloft - Medsafe
zoloft - Medsafe

... commence at 25 mg/day (half a 50 mg tablet), increasing to 50 mg/day after one week. Subsequent doses may be increased in case of lack of response in 50 mg/day increments, up to 200 mg/day, as needed. In a clinical trial in patients aged 6 to 17 years with depression or OCD, sertraline appeared to h ...
IBOGAINE IN THE TREATMENT OF HEROIN WITHDRAWAL ——Chapter 8——
IBOGAINE IN THE TREATMENT OF HEROIN WITHDRAWAL ——Chapter 8——

... Pharmacokinetic measurements have been obtained from human drugdependent patient volunteers who had received single oral doses of ibogaine (Table 1; Figure 2). Figure 2 illustrates the pharmacokinetic profile of ibogaine and the metabolite following oral doses of the drug in a representative male su ...
Antihypertensive Efficacy of Candesartan
Antihypertensive Efficacy of Candesartan

... DBP and SBP from baseline to Week 8 were analyzed by analysis of covariance (ANCOVA) with the baseline BP as the covariate, and the changes were compared using least squares means from the ANCOVA model. Ninety-five percent confidence intervals (CIs) for the least squares mean changes from baseline a ...
Noses in dysmorphology - Romanian Journal of Rhinology
Noses in dysmorphology - Romanian Journal of Rhinology

... nose between the orbits)3. There is a wide range of normal variation of this nose structure in the normal population, related to some familial traits or specific age variations (e.g. a depressed nasal bridge is very common in infancy)4. 3.1. Wide nasal bridge The nasal bridge is defined as wide if ...
Intravenous Lidocaine Versus Intravenous Amiodarone (in a New
Intravenous Lidocaine Versus Intravenous Amiodarone (in a New

... Patients who were crossed over to the alternative received lidocaine and 18 received amiodarone as treatment group were considered a drug failure and first-line therapy following electroshock. Patient decounted as a failure in the initial randomization group. mographics are listed in Table 1. Both g ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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