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Drysdale_pheno_CSH
Drysdale_pheno_CSH

... Using Observable + attribute + value + qualif ier + pm ontology term: Phenotype: (with asl2 ) adult | viability | viable | recessive Phenotype: (with asl3 ) adult | viabilit y | viable | recessive Phenotype: adult | femal e_fertilit y | female_sterile | recessive ...
summary of product characteristics
summary of product characteristics

... VIPomas: The biochemical characteristics of these tumours is overproduction of vasoactive intestinal peptide (VIP). In most cases, administration of octreotide results in alleviation of the severe secretory diarrhoea typical of the condition, with consequent improvement in quality of life. This is a ...
Treatment Options for Glioblastoma and other Gliomas
Treatment Options for Glioblastoma and other Gliomas

... prescribe them. Thus, patients themselves need to become familiar with these new agents and the evidence available regarding their clinical effectiveness. It is possible, although by no means proven, that some combination of these newly repurposed agents offers the best possibility for survival. Pat ...
NEW YORK STATE MEDICAID PROGRAM PHYSICIAN
NEW YORK STATE MEDICAID PROGRAM PHYSICIAN

... TIME: The inclusion of time in the definitions of levels of E/M services has been implicit in prior editions. The inclusion of time as an explicit factor beginning in 1992 is done to assist practitioners in selecting the most appropriate level of E/M services. It should be recognized that the specif ...
PRODUCT MONOGRAPH KADIAN CAPSULES (Morphine
PRODUCT MONOGRAPH KADIAN CAPSULES (Morphine

... vomiting, intestinal spasm, diarrhea, coryza and repetitive sneezing, increase in body temperature, blood pressure, respiratory rate and heart rate. Because of excessive loss of fluids through sweating, vomiting and diarrhea, there is usually marked weight loss, dehydration, ketosis and disturbances ...


... about effects on nasal disease by topical bronchial treatment with these drugs. The present study examined effects on nasal allergic disease of inhaled budesonide (avoiding nasal deposition of the drug). Patients with seasonal allergic rhinitis, but without asthma, were thus given inhalations of bud ...
Chapter 32 Airway Pharmacology
Chapter 32 Airway Pharmacology

... Use of intranasal steroids is for control of allergic & non-allergic rhinitis. ...
The neural basis of drug craving: an incentive
The neural basis of drug craving: an incentive

... causes excessive incentive salience to be attributed to the act of drug taking and to stimuli associated with drug taking. It is specifically the sensitization of incentive salience, therefore, that transforms ordinary ‘wanting’ into excessive drug craving. (4) It is further proposed that sensitizat ...
to obtain your Full Skin Care Routine with Refissa
to obtain your Full Skin Care Routine with Refissa

... Local reactions such as peeling, dry skin, burning, stinging, erythema, and pruritus were reported by almost all subjects during therapy with Tretinoin Cream, USP (Emollient) 0.05%. These signs and symptoms were usually of mild to moderate severity and generally occurred early in therapy. In most pa ...
the preparation and administration of blincyto ® brochure
the preparation and administration of blincyto ® brochure

... Premedicate with dexamethasone 20 mg intravenously 1 hour prior to the first dose of BLINCYTO® of each cycle, prior to a step dose (such as cycle 1 day 8), or when restarting an infusion after an interruption of 4 or more hours. Do not flush the BLINCYTO® infusion line, especially when changing infu ...
Protocol Template Guidelines
Protocol Template Guidelines

... Describe the scenarios under which a subject may be withdrawn from the study prior the expected completion of that subject (e.g. safety reasons, failure of subject to adhere to protocol requirements, subject consent withdrawal, disease progression, etc.) Also, if abrupt termination of study treatmen ...
Morphine Sulfate Extended-Release Tablets
Morphine Sulfate Extended-Release Tablets

... Morphine may be expected to have additive effects when used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression because respiratory depression, hypotension, and profound sedation or coma may result. (See WARNINGS: Interactions with other CNS Depr ...
Insomnia - ISpatula
Insomnia - ISpatula

... • When hypnotic drug therapy is considered appropriate, it is recommended for short periods of time only. • lack of evidence to distinguish between zaleplon, zolpidem, zopiclone or shorter acting BDZ hypnotics → drug with the lowest purchase cost should be prescribed. • switching from one of these h ...
Genetics of Primary ciliary dyskinesia - HAL
Genetics of Primary ciliary dyskinesia - HAL

... about 62 kb of genomic DNA. It encodes a 699-amino-acid protein orthologous to the Chlamydomonas ODA protein IC78. Mutations in DNAI1 have been found in several PCD patients including patients with Kartagener syndrome 3, 30-32. Although allelic heterogeneity was noted in the very first studies, it w ...
Use of Sedation in Non-Hospital Dental Practice
Use of Sedation in Non-Hospital Dental Practice

... physical stimuli and verbal command. In dentistry, sedation may be indicated to treat patient anxiety associated with dental treatment, to enable treatment for patients who have cognitive impairment or motor dysfunction which prevents adequate dental treatment, to treat patients below the age of rea ...
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... mutations in the genome of the bacteria associated with resistance against individual drugs can be used. Table 1 provides the definitions of MDR-TB and XDR-TB, based on the results of bacteriological methods [18]. Recently, WHO has revised the case definitions of TB and drug-resistant TB so that als ...
plavix* data sheet
plavix* data sheet

... with caution in patients who may be at risk of increased bleeding from trauma, surgery or other pathological conditions, as follows: If a patient is to undergo elective surgery and an anti-platelet effect is not desired, clopidogrel should be discontinued at least 5 days prior to surgery. If the pat ...
Preview Sample 2
Preview Sample 2

... consistent manner. In most cases you will be given information about phenotypes, so the diagram would be: Phenotype of one parent × phenotype of the other parent → phenotype(s) of progeny The goal is to assign genotypes to the parents and then use these predicted genotypes to generate the genotypes, ...
Actemra CC
Actemra CC

Charcot-Marie
Charcot-Marie

... investigate family members, as advice given in genetic counselling will vary depending on the type of CMT and its mode of inheritance. This may require detailed family investigations, as some mildly affected family members may not have any symptoms. What is the cause of CMT? There have been major ad ...
- Thieme Connect
- Thieme Connect

... ite preparation using trivial analytical equipment available in almost all analytical laboratories [13–18]. Also, the biological effects of different Aconitum sp. in vitro and in vivo have been studied in depth, revealing the molecular targets of each major component [19–21]. Recently, studies repor ...
Fluconazole to Prevent Yeast Infections in Bone Marrow
Fluconazole to Prevent Yeast Infections in Bone Marrow

... The incidence of systemic candidiasis was similar in the two groups (Table 3). By day 50, there were 12 systemic fungal infections (5 with Candida species; 6 with Aspergillus species; 1 with both). Fungal infections occurred in 9 (8%) high-dose recipients (95% CI: 3% to 13%) and 3 (2%) low-dose reci ...
Clinical Actions of Specific Agents
Clinical Actions of Specific Agents

... United States Pharmacopeial Convention (USP) reviewed the MRDs for local anesthetics and no longer adjusts them for inclusion of a ...
File - Ms. Walajtys` Pharmacy Tech Class Sidekick
File - Ms. Walajtys` Pharmacy Tech Class Sidekick

... tone and consciousness • Patient may collapse, head drop, arm or leg may go limp • Lasts few seconds to a minute, then patient can stand and walk again ...
Adrenal suppression: A practical guide to the screening and
Adrenal suppression: A practical guide to the screening and

... random cortisol measurement is not an adequate measure of AS in children. Other measures of adrenal insufficiency are available, such as the assessment of urinary or salivary cortisol levels; however, these tests have not been well-studied in children with AS [50-52]. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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