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Synthesis of polyphosphazenes with different side
Synthesis of polyphosphazenes with different side

... important thing in the selection of side groups is biocompatibility, as they may produce toxic products upon degradation. ...
Renerve G
Renerve G

... physician according to individual tolerance and efficacy. Adults and adolescents: In clinical trials, the effective dosing range was 900 to 3600 mg/day. Therapy may be initiated by titrating the dose as described in Table or by administering 300 mg three times a day (TID) on Day 1. Thereafter, based ...
Supplementary Figure Legends (doc 34K)
Supplementary Figure Legends (doc 34K)

... complete homozygosity situation in only 10% of the cases (step ). Around half of them harbour a complete or partial deletion of the NF1 locus as confirmed by real-time PCR-based gene dosage. Custom high resolution array-CGH enables the accurate characterization of the deletion type. NF1 complete an ...
APRI 7149$
APRI 7149$

... “kicks” and as an “upper” or “energizer” . Many of these cases resulted in adverse reactions or overdoses treated in emergency room visits. DEA has found that ephedrine is used as precursor material for the clandestine manufacture of controlled substances. Ephedrine is one of the primary precursors ...
Salmeterol_Fluticasone Cipla pressurised inhalation, suspension
Salmeterol_Fluticasone Cipla pressurised inhalation, suspension

... The management of asthma should normally follow a stepwise programme and patient response should be monitored clinically and by lung function tests. Salmeterol/Fluticasone Cipla should not be used to treat acute asthma symptoms for which a fast and short acting bronchodilator is required. Patients s ...
Product Monograph - Ask Novartis Pharma
Product Monograph - Ask Novartis Pharma

... As a consequence of inhibiting the renin-angiotensin-aldosterone system, changes in renal function have been seen in susceptible individuals. In patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, such as patients with bilateral renal artery stenosis ...
Roux`s Arch Dev Biol 193, 283
Roux`s Arch Dev Biol 193, 283

... enough progeny so that eggs could be collected from them. Cuticle preparations of embryos were made from the 7100 lines in which at least a quarter of the eggs remained unhatched. The cuticle preparations were screened for morphological abnormalities. The test lines were distributed among four broad ...
Alleles of a reelin CGG repeat do not convey
Alleles of a reelin CGG repeat do not convey

... A shortcut method is association analysis of candidate genes, which are candidates on the basis of biological reasoning. Ideally there would also be evidence for linkage in the vicinity of the biological candidate. The biological and linkage evidence need not coincide, however, if the variants in th ...
Impact of Urinary Incontinence
Impact of Urinary Incontinence

... Up to 50% of UI in hospitalized patients and 33% of UI in community-dwelling patients may be due to reversible etiologies ...
Warcillin LPD Version 2.0
Warcillin LPD Version 2.0

... amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin. Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. This has been demonstrated in vitro; however, the clinical significance of this intera ...
Product Monograph Template - Standard
Product Monograph Template - Standard

... Special Patient Populations-Treatment of Pregnant Women During the Third Trimester). Potential for reduced efficacy of Tamoxifen with concomitant SSRI use, including PAXIL® The antitumor agent tamoxifen is a pro-drug requiring metabolic activation by CYP2D6. Inhibition of CYP2D6 can lead to reduced ...
Can my homozygous polled bull give me scurred calves?
Can my homozygous polled bull give me scurred calves?

... smooth polled bull and breed him to a group of cows; if any of his heifer calves have scurs then he is a  scur allele carrier.  However, if no heifer calves have scurs, even if the bull calves have scurs, then he  may not be a carrier, but unless the bull is bred to a very large number of cows it is ...
Using METHOCEL Cellulose Ethers for Controlled
Using METHOCEL Cellulose Ethers for Controlled

... registered and periodically inspected by the FDA. METHOCEL Premium products are produced from dedicated processes and equipment to further ensure their consistency and purity. METHOCEL Premium products are available which meet and exceed the requirements of U.S., Japanese, and European Pharmacopeias ...
Switching from lisinopril to valsartan
Switching from lisinopril to valsartan

... GENERIC NAME: VALSARTAN - ORAL (val-SAR-tan) BRAND NAME(S): Diovan. Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose. Sacubitril; valsartan can cause fetal harm when administered to a pregnant woman. Once pregnancy is detected, every effort should be ...
Paresthesia (including formication) (postmarketing AE), reformating
Paresthesia (including formication) (postmarketing AE), reformating

... Pre-existing Structural Cardiac Abnormalities or Other Serious Heart Problems and Sudden Death Children/Adolescents: Sudden death has been reported with sympathomimetic drugs used for ADHD treatment at therapeutic doses in children/adolescents with structural cardiac abnormalities or other serious ...
C 5  P450
C 5 P450

... inhibitors of p38α kinase (p38α MAPK or p38α kinase) and simultaneous structure elucidation by high resolution mass spectrometry (HR-MS) (20). p38α kinase is an important drug target in contemporary drug discovery because it plays a central role in inflammatory cellular signaling processes (21). Sev ...
nw-qa143-5-glucosamine-adverse
nw-qa143-5-glucosamine-adverse

... unknown) for between six to twelve months. Increases in total cholesterol ranged from 0.9 to 2.4mmol/l while taking the supplement. In one case, total cholesterol returned to pre-treatment levels when glucosamine was discontinued; outcomes in the other patients are unknown (23). Changes in lipid lev ...
Virus-Infected Patients )-Methadone in Human Immunodeficiency R
Virus-Infected Patients )-Methadone in Human Immunodeficiency R

... significantly decreased the mean dose-adjusted AUC of methadone by 41%. AUC reductions were similar for patients taking racemic methadone (37%; n ⴝ 11) and (R)-methadone (44%; n ⴝ 9). AUC changes ranged from mild increases in three patients to decreases of up to 70%. Fourteen of 20 patients required ...
Traumeel Zeel Injection Booklet
Traumeel Zeel Injection Booklet

... 2 Orlandini, A., Rossi, M., Setti, M., The Effectiveness of Zeel® Injection Solution and new Research Methods in Rheumatology. Biologische Medizin. Vol. 26 (4) 1997, 164-165. ...
Vol. 20, No. 3 Evra Transdermal System
Vol. 20, No. 3 Evra Transdermal System

... Evra®, soon to be marketed by Janssen-Ortho TM , is the first transdermal contraceptive delivery system approved for use in Canada. Health Canada approved the use of Evra® for the prevention of pregnancy in August 2002. The company anticipates this product will be available in Canadian pharmacies du ...
Dose: Contra-indications: Warnings : Interactions : Pregnancy : Side
Dose: Contra-indications: Warnings : Interactions : Pregnancy : Side

... injuries, where administration may affect both the respiratory function and the pupillary responses required for neurological assessment. Pethidine should be avoided in patients with low respiratory reserve due to the respiratory effects of the drug. Pethidine should only be given with caution and i ...
Epidemiology and clinical management of XDR-TB: a systematic review by TBNET REVIEW
Epidemiology and clinical management of XDR-TB: a systematic review by TBNET REVIEW

... Clinical and epidemiological features of cases enrolled All selected studies were reviewed to extract the following data regarding the clinical and epidemiological features of cases enrolled: 1) the drugs tested to define XDR-TB cases; 2) the features of the cohort, including the number of MDR and X ...
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients
Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients

... The mean serumw concentration–time curves are shown in figure 2. The baseline median (IQR) AUC0–12 of linezolid of 36.3 mg?h?L-1 (33.2–46.3 mg?h?L-1) in patients with a body weight of median 71.5 kg (IQR 56.8–72.0 kg), is lower than the median (IQR) AUC0–12 of linezolid of 57.6 mg?h?L-1 (38.5–64.2 m ...
TITLE: 1000 mg versus 600/650 mg Acetaminophen for Pain or
TITLE: 1000 mg versus 600/650 mg Acetaminophen for Pain or

... in efficacy between the two doses was not reported in some studies. The NNT was lower for patients receiving acetaminophen 1000 mg in order to get one patient with beneficial effect, compared to acetaminophen 600/650 mg, but this difference was not statistically significant. The risk of adverse even ...
Grapefruit Interactions
Grapefruit Interactions

... A number of other medications also appear to interact with grapefruit, or might be expected to interact with grapefruit based on the fact that they are metabolized by the cytochrome P450 3A4 enzyme. The antidepressants nefazodone (Serzone) and trazodone (Desyrel) are among them. Antipsychotic medica ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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