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SCP Modafinil April 2014
SCP Modafinil April 2014

... Contra-indications (click for details in SPC)  Hypersensitivity to the active substance or to any of the excipients.  Uncontrolled moderate to severe hypertension and in patients with cardiac arrhythmias. Special warnings and precautions for use (click for details in SPC)  An ECG is recommended ...
Prescription Drug Abuse - Henry Ford Health System
Prescription Drug Abuse - Henry Ford Health System

... acetaminophen to warn of the risk of liver damage. effective April 2010. • “Liver warning: Severe liver damage may occur if you take • more than 4,000 mg of acetaminophen in 24 hours • with other drugs containing acetaminophen • 3 or more alcoholic drinks every day while using this product.” ...
LEARNING ACTIVITY 2.3 Matching: Patterns of Genetic Inheritance
LEARNING ACTIVITY 2.3 Matching: Patterns of Genetic Inheritance

... B. Alleles are imprinted, or chemically marked, in such a way that one member of the pair is activated, regardless of its makeup. C. Refers to each form of a gene. D. When heterozygous individuals with just one recessive allele can pass that trait to their children. E. A pattern of inheritance in wh ...
Idaho Medicaid Drug Utilization Review Program
Idaho Medicaid Drug Utilization Review Program

... with certain conditions because of the risk of QT prolongation, ECG monitoring and/or electrolyte monitoring is recommended if citalopram must be used in such patients.  Patients with congenital long QT syndrome are at particular risk of Torsade de Pointes, ventricular tachycardia, and sudden death ...
Adverse Event and Patient Safety Use Cases for HL7 FHIR Adverse
Adverse Event and Patient Safety Use Cases for HL7 FHIR Adverse

... Overview: Parents administer an expired drug to their child. Story: A 10-year old boy develops a sore throat with a high fever, a rash on his trunk, but no cough or nasal congestion. His parents recognize the symptoms from the boy’s previous bouts of strep throat. The mother remembers that they have ...
What is Xerostomia?
What is Xerostomia?

...  Hypo and Hyper thyroidism ...
Symax DuoTab - Capellon Pharmaceuticals
Symax DuoTab - Capellon Pharmaceuticals

... effects of anticholinergics. Close supervision is recommended for infants and children with spastic paralysis or brain damage since an increased response to anticholinergics has been reported in these patients and dosage adjustments are often required. When anticholinergics are given to children whe ...
Prescription Medications for the Treatment of Obesity WIN
Prescription Medications for the Treatment of Obesity WIN

... weeks”) is also considered off-label use. ...
Dugs
Dugs

... • A cancer is an abnormal growth of cells caused by a change in the genes which control growth. • The tumour damages healthy cells and tissues as it grows and can spread to other areas of the body. • Smoking increases the risk of lung cancer, mouth cancer and throat cancer. ...
File
File

... followed by effect • Antagonist: a drug that interact with a receptor but with no effect • Partial Agonist: a drug that bind to a receptor followed by weak effect ...
Potential drug interactions with smoking and quitting
Potential drug interactions with smoking and quitting

... metabolizing enzymes (primarily CYP1A2) in the liver. As a result, smokers have higher clearance of  certain drugs and require higher doses to achieve clinical response. Conversely, when smokers quit  smoking, their induced enzyme levels revert to normal. This may result in toxic drug levels in thes ...
Beyond Dominant and Recessive Alleles
Beyond Dominant and Recessive Alleles

... 1. The inheritance of traits is determined by individual units known as genes. In organisms that reproduce sexually, genes are passed from parents to their offspring (children). 2. In cases in which two or more forms of the gene for a single trait exist, some forms of the gene may be dominant and ot ...
Analgesia in Patients with Impaired Renal Function – Formulary
Analgesia in Patients with Impaired Renal Function – Formulary

... Nefopam is an atypical analgesic which can be used as an adjuvant in mildmoderate pain. It is not renally excreted or nephrotoxic so can be used safely in patients with renal impairment. Side effects include gastrointestinal upset and confusion, and it should be avoided in patients with epilepsy. Ef ...
Amitiza - DavisPlus
Amitiza - DavisPlus

... ● Inform patient that dyspnea may occur within 1 hr of first dose; usually resolves ...
Autonomy Autonomy Autonomy? The Elements of Autonomy
Autonomy Autonomy Autonomy? The Elements of Autonomy

... y Lack of comprehension of treatment benefits y The occurrence of undiscussed side effects y The cost of prescription medicine y Poor communication or lack of trust between the  ...
Lecture 8
Lecture 8

... Reduced liver and kidney function can increase half-life and by this the risk of toxicity ...
Pharmacological Therapy Part 1
Pharmacological Therapy Part 1

... samples are drawn to maintain blood levels within a therapeutic margin Peak: draw a peak level 30 min after IV administration and 1 hour after IM administration Trough: draw a trough level just before the next dose (sometimes before the 3rd dose) ...
Chapter 2: The Human Heritage: Genes and the Environment
Chapter 2: The Human Heritage: Genes and the Environment

... Cause: Defective recessive gene that reduces the body’s ability to convert one amino acid (phenylalanine) into another (tyrosine), resulting in retarded development of prefrontal cortex ...
Roach: Introductory Clinical Pharmacology
Roach: Introductory Clinical Pharmacology

... allow less frequent dosing and help patient to have longer undisturbed periods during night • ALERT-signs of drug overdosage include muscle rigidity and spasms, salivation and clenching of the jaw, difficulty breathing (signs of the disease itself) – Managing urinary retention: • Place the call ligh ...
Test Info Sheet
Test Info Sheet

... in the SMN1 gene causative for spinal muscular atrophy (SMA) will not be detected by this test. However, upon request, GeneDx can utilize other types of diagnostic tests in conjunction with the XomeDxPrenatal test to increase the likelihood of identifying a molecular cause for the fetal abnormalitie ...
Example of Irish GP Repeat Prescribing
Example of Irish GP Repeat Prescribing

... For reasons of safety when requesting a repeat prescription please note: 1. Verbal requests/phone requests will no longer be routinely accepted for safety reasons. In exceptional circumstances your doctor will accept such requests, eg, (housebound patients). 2. This list of your current medication i ...
Topics / Performance Enhancing Drugs / Performance Enhancing
Topics / Performance Enhancing Drugs / Performance Enhancing

... investigation of Johnson's case. Her testimony was shocking. Between 1979 and 1988 she had regularly taken massive doses of 10 different anabolic steroids, three forms of human growth hormones (HGH), and numerous other substances, including anti-inflammatory drugs, diuretics, and mega-doses of B-12 ...
outline21590
outline21590

... c. HGP began 1990 d. Joint effort by DOE and NIH e. Estimated completion 15 years f. Working draft announced June 2000 2. HGP - Working Draft a. 16 Sequencing centers b. 22.1 billion bases of raw data c. 30% high quality finished sequence d. Map of 90% of genes on every chromosome e. 3164.7 million ...
Antihistamines
Antihistamines

... organ transplantation, is also a treatment for several autoimmune disorders with good results. Because IC may have an autoimmune component, this medicine is being studied as a possible IC treatment. So far the results of testing in humans have been encouraging, but the drug does have many potential ...
Referral patterns in de-addiction services
Referral patterns in de-addiction services

... current drug abuse pattern and notes change in pattern of drug abuse over years2. It contains service provider’s identification, basic socio-demographic data of the patient, a checklist of drugs of abuse ever used and drugs currently being used in the last one month, questions on injection drug use ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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