• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Drug interaction of plasma protein binding
Drug interaction of plasma protein binding

... Drugs-induced glomerular pathology ...
Informed Consent for Treatment - Medical Associates of North Georgia
Informed Consent for Treatment - Medical Associates of North Georgia

... Addiction—Addiction is a primary, chronic, neurobiologic disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations. It is characterized by behaviors that include the following: impaired control over drug use, craving, compulsive use, and continued ...
BuSpar (buspirone)
BuSpar (buspirone)

... observe caution while driving or performing other tasks requiring alertness. Some individuals may be especially sensitive to the CNS adverse effects (e.g., dizziness) of the medication. Prolonged use of BuSpar is not known to lead to dependence. The medication may be abruptly withdrawn without induc ...
Advisory Committee Mtgs. Sample PPT
Advisory Committee Mtgs. Sample PPT

... • Meeting minutes which do not show RDRC members recusing themselves from voting on studies which they are associated with. • Failure to convert RDRC study into IND. • Special Summary Reports not filed, or not filed in timely ...
Draft Genetic and Metabolic Medicine knowledge guide
Draft Genetic and Metabolic Medicine knowledge guide

... Genetic testing techniques, such as polymerase chain reaction (PCR), gene sequencing, chromosomal microarray, and exome and genome ...
SR6e Chapter 3 - Flip Flop Ranch
SR6e Chapter 3 - Flip Flop Ranch

...  Meiosis: process producing sperm, ova  Mitosis: cell-division process creating all other cells ...
Prescription Compliance or Illicit Designer Drug
Prescription Compliance or Illicit Designer Drug

... (A), The KIMS assay is calibrated such that a signal of 0 corresponds to 1000 ng/mL d-amphetamine. Samples with signals ⱖ0 are reported as positive. Two QC samples run in parallel demonstrated that the assay and instrument were running properly (positive control, 1250 ng/mL d-amphetamine; negative c ...
Pharmacology Test #1 Outline Lec. 1: Intro to Principles of
Pharmacology Test #1 Outline Lec. 1: Intro to Principles of

... o If Clcr is 30-60 minor dose adjustment o If Clcr is 15-30 moderate dose adjustment o If Clcr is <15 major dose adjustment  (Drug not being cleared well by kidneys)  Hepatic Disease  No test to estimate liver drug metabolism  Indicators of poor metabolism in liver: serum bilirubin, serum albu ...
SOP 006 Reporting Procedures - University of Kansas Medical Center
SOP 006 Reporting Procedures - University of Kansas Medical Center

... methods and material to be used in obtaining and documenting informed consent of the trial subjects. KUMC has several IRB’s. Radioactive Drug Research Committee (RDRC): the duly constituted governing body at KUMC authorized and approved by the U.S. Food and Drug Administration to review and approve ...
Prescription drugs
Prescription drugs

... usage—final tweaking ...
Antiparasitic Agents
Antiparasitic Agents

... 2. cross links the two strands so that they cannot unwind 3. the amidine group donates reacts with the extra electrons on the nitrogen ii. available IV or aerosol 1. good since PCP is a lung condition iii. 50% of patients on IV have toxic reactions 1. correlates to the rate of injection 2. breathles ...
presentation - Critical Path to TB Drug Regimens
presentation - Critical Path to TB Drug Regimens

... coordination and sharing of data between key partners; • Introduction of new TB drugs should be adaptable to countries settings according to country's own health infrastructure and preparedness; • Need for rapid approval of new TB drugs by regulatory authorities in high-TB burden countries so as to ...
Innovative Ideen 2009
Innovative Ideen 2009

... Ezetimibe “During the trial, investigators reported an increased number of cancers and cancer-related deaths in patients using Vytorin compared to placebo. Cancer was reported in 105 patients (11.1%) in the Vytorin group and in 70 patients (7.5%) in the placebo group. The number of deaths from canc ...
Ch. 9: Presentation Slides
Ch. 9: Presentation Slides

... For example in the case of pathogen resistance, a good marker avoids elaborate infection tests for the selection of resistant plants. • DNA-markers allow the breeder to introduce into their cultivated plant only the gene(s) of interest from a related species. While conventional breeding methods rely ...
Lecture # 6 Date
Lecture # 6 Date

Drugs Used in Coagulation Disorders
Drugs Used in Coagulation Disorders

... – readily absorbed after oral administration ...
Drugs of Abuse - Teach Genetics (Utah)
Drugs of Abuse - Teach Genetics (Utah)

... online activity of the same title located in The New Science of Addiction: Genetics and the Brain module on our website (url above). Students learn about the short and long-term effect of a number of drugs of abuse. ...
Proprietary Databases
Proprietary Databases

... The Personalis Disease Variant Database is the most comprehensive, detailed, high-quality manually-curated variant to common disease, Mendelian disease, and phenotype database of its kind containing over 600,000 variant-to-disease relationships. This database enables highly reliable biomedical inter ...
A aa - Albinizms
A aa - Albinizms

... If A represents the normal healthy allele and a represents the recessive albino allele, then we can assume that: ...
CLINICALLY IMPORTANT DRUG INTERACTIONS
CLINICALLY IMPORTANT DRUG INTERACTIONS

... Antianabolic effect of tetracycline increases urea production which is retained by the ...
How should we consider pharmacogenomics application in
How should we consider pharmacogenomics application in

... genotyping PK-related genes •Useful for understanding PK variability •Necessary to rationalize the dosage regimen ...
| Bedaquiline: 10 years later, the drug susceptibility testing protocol is still pending
| Bedaquiline: 10 years later, the drug susceptibility testing protocol is still pending

... clavulanate Meropenem plus clavulanate High-dose isoniazid Clarithromycin Thioacetazone ...
policy statement
policy statement

... Use in lactation - oxycodone is excreted into human milk in low concentrations. Because of the possibility of adverse effects in breastfed infants (sedation, respiratory depression, withdrawal symptoms upon cessation of maternal administration), oxycodone is not recommended for breastfeeding mothers ...
Press release
Press release

... therapy, today announced updated clinical data from its ongoing Phase I/II trial of AMT-060, its proprietary, investigational gene therapy, in patients with severe hemophilia B. The updated data show that all patients in the low-dose cohort have sustained improvements in their disease phenotype and ...
Medication Issues and Behavioral Treatment
Medication Issues and Behavioral Treatment

... These drinks also can aggravate irritable bladder. Caffeine: Although there are many magazine articles on sleep that permit caffeinated beverages before noon for people with insomnia, patients with pain and sleep disorders are so hypersensitive that even a morning caffeine drink can disturb their sl ...
< 1 ... 1071 1072 1073 1074 1075 1076 1077 1078 1079 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report