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Cytochrome P450 Genotyping
Cytochrome P450 Genotyping

... be performed by an individual with experience and expertise in genetic medicine and genetic testing methods. Background Drug efficacy and toxicity vary substantially across individuals. Because drugs and doses are typically adjusted, if needed, by trial and error, clinical consequences may include a ...
Comparative genomics and Target discovery
Comparative genomics and Target discovery

Structure-Based Drug Design
Structure-Based Drug Design

... reoccurrence. For example, cancer patients, who had a very low rate of survival in 1970’s, can now be treated more efficiently by chemotherapy. At present, the cancer death rate has declined by 20% in comparison to 1990 [1]. However, along with rapid progress in the efficacy of these pharmaceutical ...
Human Genetic Disorders PPT
Human Genetic Disorders PPT

... both normal and sickle shaped cells. These people will not usually have symptoms of the disease ...
AP Biology Study Guide Chapter 8: Monohybrid cross Law
AP Biology Study Guide Chapter 8: Monohybrid cross Law

... § The  law  of  segregation  states  that  the  two  copies  of  a  gene  separate  when   an  individual  makes  gametes     § Each  gamete  receives  only  one  copy     Ø A  gene  is  a  short  sequence  of  a  larger  DNA ...
Rediscovering Compounding Pharmacies
Rediscovering Compounding Pharmacies

... all causes. Research shows that when phenytoin is added to a conventional antibiotic ointment, healing times were speeded up by over 60 percent. Furthermore, there was no detectable phenytoin in the blood serum when it was applied as a topical treatment, and no study reported any adverse effects. Hy ...
EDITORIAL Dissecting Complex Genetic Diseases: Promises and
EDITORIAL Dissecting Complex Genetic Diseases: Promises and

... complementary analytical methods, linkage analysis and association (linkage disequilibrium) mapping have been used to detect the specific genetic regions involved in the disease process. However, in complex diseases, due to the large number of loci that may be involved, it has often been difficult b ...
DRUG PRESCRIBING PATTERN IN DERMATOLOGY IN A
DRUG PRESCRIBING PATTERN IN DERMATOLOGY IN A

... Irrational prescription of drugs is of common occurrence in clinical practice. 1 The patterns of drug use in a hospital setting need to be monitored intermittently in order to analyze their rationality and to offer feedback and/or suggestions to drug prescribers so as to enable and effect suitable m ...
Genetic Nomenclature
Genetic Nomenclature

... Allele designation is sometimes historical. The name of a gene is often based on mutations for the trait. Cy is the gene for curly wings in Drosophila. Wild-type phenotype is straight wings. w is the gene for white eyes in Drosophila. Wild-type phenotype is brick-red eyes. ...
Clinical Toxicology
Clinical Toxicology

... are usually given to individuals in order to give relief for symptoms or to treat and prevent diseases. ...
Document
Document

... • Canalization - Cases in which genes restrict development to a small number of outcomes • Example – Babbling in infants • Canalization and critical periods Implications of canalization • Multiple pathways of development • Some circumstances, genes may limit the extent to which environments can infl ...
to see the full press release
to see the full press release

... exchange under the symbol THR. More information is available at www.thrombogenics.com ...
Assessment of Alzheimer`s disease risk genes with CSF
Assessment of Alzheimer`s disease risk genes with CSF

... University and DZNE Magdeburg, Magdeburg, Germany; 12Technische Universitaet Muenchen, M€unchen, Germany; 13Technische Universit€at M€unchen, Munich, Germany; 14Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts, United States; 15University Medicine Rostock and DZNE Ro ...
Drug disposition in pregnancy MEDSCI 722 Anna Ponnampalam
Drug disposition in pregnancy MEDSCI 722 Anna Ponnampalam

... situation or for a serious disease for which safer drugs cannot be used or are ineffective). ...
Genetic Nomenclature
Genetic Nomenclature

... Allele designation is sometimes historical. The name of a gene is often based on mutations for the trait. Cy is the gene for curly wings in Drosophila. Wild-type phenotype is straight wings. w is the gene for white eyes in Drosophila. Wild-type phenotype is brick-red eyes. ...
Presentation Slides
Presentation Slides

... Addiction is a complex but treatable disease that affects brain function and behavior. No single treatment is right for everyone. People need to have quick access to treatment. Effective treatment addresses all of the patient’s needs, not just his or her drug use. Staying in treatment long enough is ...
File
File

... N-acetyltransferase (NAT2 isoform) is in liver, gut ...
Narcan Overview - Telco House Bed & Breakfast
Narcan Overview - Telco House Bed & Breakfast

... Onset, Duration—Less than 2 minutes 30 to 60 minutes (IV) Elimination—Liver; half-life of 60 to 90 minutes (IV) ...
Amoeboisis Clinical Case 10
Amoeboisis Clinical Case 10

... epithelial cells by means of a lectin on the parasite ...
Adverse Effects
Adverse Effects

... Patients taking somatropin should have which lab values monitored on a routine basis due to adverse effects of the drug therapy? A. TSH B. CBC C. Glucose level D. All of the above Answer: Both A and C. Somatropin can cause hypothyroidism and glucose intolerance; therefore, these lab values should be ...
Lesson Outline continued
Lesson Outline continued

... b. When two alleles of a gene are the same, its genotype is homozygous. c. If two alleles of a gene are different, its genotype is heterozygous. B. Modeling Inheritance 1. In a situation based on chance, such as flipping a coin, the chance of getting a certain outcome can be represented by a(n) rati ...
Slide 1
Slide 1

... – allele that will affect phenotype only if it matches allele of partner gene (inherits same recessive allele from each parent). E.g. Baldness only if the gene pair is homozygous for the recessive trait. ...
human-genome-project
human-genome-project

... proteins involved in development and immunity. Scientists have identified about 3 million locations where single-base DNA differences (SNPs) occur in humans. This information promises to revolutionize the processes of finding chromosomal locations for disease-associated sequences and tracing human h ...
Phenytoin
Phenytoin

... • Ciprofloxacin and ofloxacin possess good absorption characteristics, so they are usually given enterally rather than intravenously. However, in patients receiving enteral feeding, studies suggest that significantly lower plasma concentrations than expected are attained. This is due to the formatio ...
PrescriptionDrugs
PrescriptionDrugs

... suspicion drug screen. If a prescription drug is detected and it was legally prescribed- policy becomes paramount. The MRO will NOT be able to determine impairment using urine drug levels. If the employee failed to disclose a detected prescription drug- you will have a policy violation. If a tra ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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