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Thermal Regulation: Adrenal, Thyroid & Pituitary Systems Question Where are the adrenal glands located? A. Brain B. Pancreas C. Liver D. Kidneys Question Where are the adrenal glands located? A. Brain B. Pancreas C. Liver D. Kidneys Answer: D. They sit on top of the kidneys Physiology: Adrenal Glands The hormones of the endocrine system are important chemical messengers in the body. Two adrenal glands are located one at the top of each kidney. Each gland is composed of two distinct parts—the medulla and the cortex. The adrenal glands are crucial to metabolism (glucocorticoids) and fluid and electrolyte balances (mineralcorticoids). Cushing Syndrome A disorder resulting from increased adrenocortical secretion of cortisol, resulting in chronic elevation in glucocorticoid and adrenal androgen (male) hormones. Cushing syndrome also occurs in persons with long-term use of cortisones (Prednisone, Deltasone). Melissa’s Story: Cushing’s Disease https://www.youtube.com/watch?v=IOXQ--XzwaA Glucocorticoids The primary endogenous glucocorticoids produced by the adrenal gland are cortisol and cortisone. All natural and synthetic glucocorticoids act by binding to a specific cytoplasmic glucocorticoid receptor. Abrupt discontinuation of a glucocorticoid following prolonged administration may result in acute adrenal insufficiency. Chronic, long-term use results in a chemically induced Cushing syndrome. Prototype drug: prednisone (Deltasone) Prednisone: Core Drug Knowledge Pharmacotherapeutics Anti-inflammatory and immunosuppressive effects Pharmacokinetics Absorbed from GI tract. Metabolized: liver. Excreted: urine. Pharmacodynamics Primarily glucocorticoid activity, although some mineralocorticoid activity is present and more apparent when the drug is administered in high doses. Prednisone: Core Drug Knowledge (cont.) Contraindications and precautions Hypersensitivity and systemic fungal infections Side effects & Adverse effects Anxiety, mood swings, insomnia, headache, GI complaints, menstrual irregularities, hyperglycemia Prednisone: Nursing Problems Excess Fluid Volume related to sodium and water retention. Risk for Infection related to immunosuppressive effects Weight gain due to increased appetite Altered Body Image related to physical Cushingoid characteristics Risk for injury with long-term use due to fragile skins and organs (higher risk of peptic ulcers) Drugs Affecting Pituitary, Thyroid, Parathyroid, and Hypothalamic Function The Pituitary Gland https://www.youtube.com/watch?v=qJj_-3dZ4ZQ Hypothalamus Physiology: Pituitary gland function Anterior lobe of the pituitary gland: Controls the function of glucocorticoid hormone levels (ACTH) Body growth and metabolism (Growth Hormone) Function of the thyroid gland (Thyroid Stimulating Hormone) Gonadal function (Folicular Stimulating Hormone and Luteinizing Hormone) and Milk production and breast growth (prolactin). Physiology: Pituitary gland function Posterior lobe of the pituitary gland: Stores and secretes two effector hormones (hormones that produce an effect when stimulated): Oxytocin, which stimulates labor Vasopressin (also known as antidiuretic hormone or ADH). Physiology Thyroid gland function The thyroid gland controls cellular metabolism and promotes normal growth and development. Thyroid Tests: https://www.youtube.com/watch?v=yz15eiEuWQQ Physiology Parathyroid gland function PTH affects three target organs: bone, kidneys, and GI tract. The major controlling factor for PTH secretion is serum calcium. Hyperparathyroidism https://www.youtube.com/watch?v=sD9st1ZPFrQ Recap: Pathophysiology of Pituitary Gland Anterior pituitary gland dysfunction: Includes growth hormone deficiency and excess. Posterior pituitary gland dysfunction: Major disorders are diabetes insipidus (DI) and syndrome of inappropriate antidiuretic hormone (SIADH). Thyroid gland dysfunction: Hyper-functioning or hypo-functioning gland, malfunctions that may be caused by either a congenital defect or by a problem that occurs later in life. Parathyroid gland dysfunction: Parathyroid Hormone is a major regulator of serum calcium and phosphate. Human Growth Hormones GH deficiency, leading to short stature Initially treated with GH injections extracted from the pituitary glands of cadavers. Presently, synthetic human GH (rhGH), produced from recombinant DNA, is available. Prototype drug: somatropin Disorders of Human Growth Hormone Acromegaly Dwarfism Somatropin: Core Drug Knowledge Pharmacotherapeutics Used as long-term replacement of inadequate endogenous GH secretion Pharmacokinetics Administered: SC and IM. Excreted: liver and kidneys. Pharmacodynamics It stimulates cell growth and cellular mitosis, facilitates cellular uptake of amino acids for protein synthesis, and promotes use of fatty acids for energy. Somatropin: Core Drug Knowledge (cont.) Contraindications and precautions Growth promotion in children with closed epiphyses Adverse effects Headache, hypertension, joint and back pain, peripheral edema, muscle aches, and rhinitis Drug interactions Anabolic steroids, androgens, estrogens, or thyroid hormones may accelerate epiphyseal maturation. Somatropin: Planning and Interventions Maximizing therapeutic effects Hypothyroidism may develop during somatropin therapy. Patients who require chronic cycling peritoneal dialysis should receive their doses of somatropin in the morning, after the dialysis is completed. Minimizing adverse effects GH therapy may induce insulin resistance. Be alert for the development of a limp or complaints of hip or knee pain, and tell parents to do the same. Question Patients taking somatropin should have which lab values monitored on a routine basis due to adverse effects of the drug therapy? A. TSH B. CBC C. Glucose level D. All of the above Question Patients taking somatropin should have which lab values monitored on a routine basis due to adverse effects of the drug therapy? A. TSH B. CBC C. Glucose level D. All of the above Answer: Both A and C. Somatropin can cause hypothyroidism and glucose intolerance; therefore, these lab values should be monitored during therapy. Posterior Pituitary Hormone Regulators The posterior pituitary stores two hormones that are produced in the hypothalamus: vasopressin and oxytocin. Desmopressin and vasopressin are synthetic analogues of the naturally occurring posterior pituitary hormone. Desmopressin is commonly used to treat nocturnal enuresis. Prototype drug: desmopressin (DDAVP) Desmopressin: Core Drug Knowledge Pharmacotherapeutics Manages central diabetes insipidus and nocturnal enuresis and maintains homeostasis in hemophilia A Pharmacokinetics Administered: intranasally, orally, or parenterally (IV or SC route). Metabolism: liver. Excreted: kidneys. Pharmacodynamics It works at the level of the renal collecting duct by binding to vasopressin (V2) receptors to cause increasing water reabsorption from the urine. Desmopressin: Core Drug Knowledge Contraindications and precautions Hypersensitivity Side effects Transient headache, nasal congestion, nausea, rhinitis, and facial flushing Adverse effects Risk for Fluid Volume Excess related to administration of desmopressin, secondary to diabetes insipidus Watch for signs of water intoxication Low K+, Low Na+ Confusion, ataxia (staggering gait) Drug interactions Carbamazepine, chlorpromazine, and nonsteroidal antiinflammatory drugs Thyroid Drugs Thyroid hormones influence essentially every organ system in the body. Thyroid disorders involve: An alteration in the quantity of thyroid hormone secretion Enlargement of the thyroid gland (goiter) Thyroid disorders are classified as either hyperthyroidism or hypothyroidism. Thyroid Goiter Thyroid Drugs Hypothyroidism may be mistaken for the normal aging process. Fatigue, cold intolerance, sluggishness, hypersomnia, weight gain Hypothyroidism may be mistaken for depression. The only treatment for hypothyroidism is lifelong replacement of thyroid hormones adequate to meet the individual’s metabolic needs. These drugs are considered safe for use in pregnancy. Prototype drug: levothyroxine (Levothroid, Synthroid) Levothyroxine: Core Drug Knowledge Pharmacotherapeutics Used as replacement therapy in hypothyroidism Pharmacokinetics Administered: oral. Metabolism: liver. Excreted: bile. Onset: 6 to 8 hours. Protein bound Pharmacodynamics Acts as replacement for natural thyroid hormone Levothyroxine: Core Drug Knowledge (cont.) Contraindications and precautions Hypersensitivity, thyrotoxicosis, and acute MI complicated by hypothyroidism Side and Adverse effects Hypertension, tachycardia, arrhythmias, anxiety, headache, nervousness, GI irritation, sweating, and heat intolerance Drug interactions Many drugs Maximizing therapeutic effects Replacement therapy is a lifelong occurrence. During drug therapy, monitor cardiovascular response and serum thyroid function. Ongoing assessment and evaluation In patients taking levothyroxine, monitor serum thyroid hormone levels periodically. Anti-thyroid Compounds Hyperthyroidism is treated with thyroid-hormone antagonist drugs, surgery, or radioactive iodine. The purpose of treatment is to reduce the amount of functional thyroid tissue. Prototype drug: Propylthiouracil (PTU) Propylthiouracil: Core Drug Knowledge Pharmacotherapeutics Palliative treatment of hyperthyroidism Pharmacokinetics Administered: oral. Metabolism: liver. Excreted: kidneys. Pharmacodynamics Inhibits the synthesis of thyroid hormones Side effects Hives, itching, rash, fever, arthralgia, joint swelling, vertigo, drowsiness, nausea and vomiting, and altered taste sensation Adverse effects Blood dyscrasias (e.g., agranulocytosis) Propylthiouracil : Planning and Interventions Life span and gender Pregnancy Category D drug (not safe to use) Drug interactions Beta-blocking agents, theophylline, and warfarin Maximizing therapeutic effects Ensure that the drug is being administered appropriately. Minimizing adverse effects During drug therapy, arrange for periodic blood tests to monitor for hematologic and thyroid functions. Monitor the patient’s bone marrow function. Radioactive Iodine Radioactive Iodine is absorbed by the thyroid and destroys thyroid-hormone producing cells Pharmacotherapeutics RI is used in the treatment of thyroid cancer and severe hyperthyroidism Adverse Effects Radiation sickness (vomiting blood, nosebleed, nausea & vomiting) Bone marrow depression Drug-induced Hypothyroidism Radioactive Iodine Radioactive Iodine is a Pregnancy Category X – DO NOT USE Minimizing Risk Limit contact with patients to 30 minutes/day Treat bodily wastes as contaminated (including cough expectorants) Use gloves to handle the medication Pregnant nurses should not handle the product Encourage clients to void frequently to avoid irradiating the gonads No breastfeeding Anti-hypercalcemic, Calcium-Regulator Drugs Anti-hypercalcemic drugs do not directly affect the parathyroid gland (or PTH) but rather inhibit bone reabsorption of calcium. These agents are frequently used in the treatment of Paget’s disease. Antihypercalcemic, Calcium-Regulator Drugs Paget’s Disease Individuals with Paget’s disease experience bone pain and deformity, fractures, spinal cord compression, or cranial and spinal cord entrapment. Prototype drug: calcitonin Anti-hypo-calcemic Drugs Vitamin D works together with PTH and calcitonin to regulate calcium homeostasis. Metabolites of Vitamin D metabolites control intestinal absorption of dietary calcium, tubular reabsorption of calcium by the kidney, and mobilization of calcium from the skeleton, in conjunction with PTH. Vitamin D is also involved in magnesium metabolism. Prototype drug: calcitriol (Vitamin D3) Case Study: Grave’s Disease Jane Winslow, age 43, has sought help at the urgent care clinic, complaining of weakness, insomnia, awakening during the night with “a rapid heart beat,” and “feeling anxious.” Ms. Winslow denies chest pain or shortness of breath associated with her rapid heartbeat. She also complains of muscle tremors when doing small motor activities and is “ready for summer to end” because she cannot tolerate the heat. Past medical history includes hypertension diagnosed 5 years ago. Family history includes one sister with “thyroid problems.” She drinks minimally and quit smoking 5-years ago. A system review reveals a thin woman with complaints of increasing fatigue and weakness for the past 3 to 4 months, increased frequency of bowel movements—now “watery”—hyperactive bowel sounds, 9-pound weight loss over the past 6 weeks with a noticeable increase in appetite—“I’ve lost weight without even trying”—and slight hand tremor. Ms. Winslow complains “my eyes look like they are bulging.” Data from her nursing assessment are as follows: • She is diaphoretic. • Vital signs: B/P 130/86, HR 132, RR, 16, Temp. 36.4°C • Neck is supple with a nontender, palpable and enlarged thyroid. • Eyes are protruding, non-painful and equally reactive to light and accommodation. • Laboratory tests: Free T3: 720 pg/dL uU/mL Free T4: 5.8 ng/dL TSH: 0.2 A diagnosis of hyperthyroidism, specifically Graves disease is made and prophylthiouracil (PTU) 50 mg TID is prescribed. Approximately 2 months later, Ms. Winslow returns to the clinic for a follow-up visit. Her nursing assessment indicates the following: Vital signs: B/P 110/80, HR 88, RR 14, Temp. 35°C Weight gain of 5 pounds. During the interview, Ms. Winslow states, “My heart is not beating as fast” and “I am not sweating as much,” although she does have occasional periods of vertigo and dizziness. Labs: Free T3: 500 pg/dL Free T4: 2.9 ng/dL TSH: 0.5 uU/mL Questions 1. What is the mechanism of action of prophylthiouracil (PTU)? 2. Describe the concept of thyroid crisis. 3. What are the potential minor side effects and major adverse effects ofprophylthiouracil (PTU)?