Feb 1
... 4) Subdivide each AC into lambda contigs 5) Subdivide each lambda into plasmids 6) sequence the plasmids 7) Nowadays sometimes “shotgun sequence”: Sequence libraries directly, then assemble genome by computer ...
... 4) Subdivide each AC into lambda contigs 5) Subdivide each lambda into plasmids 6) sequence the plasmids 7) Nowadays sometimes “shotgun sequence”: Sequence libraries directly, then assemble genome by computer ...
Genomics Post-ENCODE
... Other projects of relevance: eQTL • Gtex – Genotype Tissue Expression project • Hunting for genetic variants that influence gene expression Linking genetic variants to changes in gene expression – regulatory variants or “expression quantitative trait loci” (eQTL) These will be different between ...
... Other projects of relevance: eQTL • Gtex – Genotype Tissue Expression project • Hunting for genetic variants that influence gene expression Linking genetic variants to changes in gene expression – regulatory variants or “expression quantitative trait loci” (eQTL) These will be different between ...
Notes on Chromosomal Mutations
... REMEMBER THIS FROM CH. 12? What is a mutation? __________________________________________ There are two types of mutations that can occur in gamete cells: ...
... REMEMBER THIS FROM CH. 12? What is a mutation? __________________________________________ There are two types of mutations that can occur in gamete cells: ...
Birth of a new gene on the Y chromosome of Drosophila melanogaster
... the X. This pattern is consistent with the mammalian sex chromosomes having originated from an ordinary pair of chromosomes, followed by massive gene loss from the Y (1–4). In contrast, the closest homologs of all Drosophila melanogaster Y-linked protein-encoding genes are autosomal, strongly sugges ...
... the X. This pattern is consistent with the mammalian sex chromosomes having originated from an ordinary pair of chromosomes, followed by massive gene loss from the Y (1–4). In contrast, the closest homologs of all Drosophila melanogaster Y-linked protein-encoding genes are autosomal, strongly sugges ...
GENETICS – BIO 300
... several different IS sequences inserted in different places all encode transposase enzyme multiple copies, can recombine ...
... several different IS sequences inserted in different places all encode transposase enzyme multiple copies, can recombine ...
Classroom Activity - Faculty of Sciences
... Agriculturalists have long been using breeding, and therefore genetics, to develop cattle that better suit their needs. While some genetic traits are complex, others are quite simple to identify and map through generations. In this activity, we will assume a number of cattle traits follow Mendelian ...
... Agriculturalists have long been using breeding, and therefore genetics, to develop cattle that better suit their needs. While some genetic traits are complex, others are quite simple to identify and map through generations. In this activity, we will assume a number of cattle traits follow Mendelian ...
Conference title
... something, as each species appears to be a bit different, so comparing different methods is the ...
... something, as each species appears to be a bit different, so comparing different methods is the ...
Gene duplication and rearrangement
... Co-expression clusters • MPSS data provides evidence for clusters of co-expression among nonrelated genes in Arabidopsis • Co-expression is greater in regions of low recombination • Thus, co-expression clusters may be maladapative, at least on average ...
... Co-expression clusters • MPSS data provides evidence for clusters of co-expression among nonrelated genes in Arabidopsis • Co-expression is greater in regions of low recombination • Thus, co-expression clusters may be maladapative, at least on average ...
genome_map.pdf
... 13.) Atrial septal defect may be caused by other genes in different families. To see if there are any known genes that are associated with atrial septal defect, use the search option at the top of the page in map viewer. Return to the map viewer for the human genome http://www.ncbi.nlm.nih.gov/mapvi ...
... 13.) Atrial septal defect may be caused by other genes in different families. To see if there are any known genes that are associated with atrial septal defect, use the search option at the top of the page in map viewer. Return to the map viewer for the human genome http://www.ncbi.nlm.nih.gov/mapvi ...
Genomics
... • Humans share most of the same protein families with worms, flies, and plants, but the number of gene family members has expanded in humans, especially in proteins involved in development and immunity. • The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11 ...
... • Humans share most of the same protein families with worms, flies, and plants, but the number of gene family members has expanded in humans, especially in proteins involved in development and immunity. • The human genome has a much greater portion (50%) of repeat sequences than the mustard weed (11 ...
Clinical Next Generation Sequencing (From Bench to Clinitions)
... Such targeted analysis can include the exome (the protein-coding portion of the genome), specific genes of interest (custom content), targets within genes, or mitochondrial DNA. ...
... Such targeted analysis can include the exome (the protein-coding portion of the genome), specific genes of interest (custom content), targets within genes, or mitochondrial DNA. ...
What Can You Do With qPCR?
... Single-nucleotide polymorphisms (SNPs) account for more than 90% of all genome sequence differences between individuals. ...
... Single-nucleotide polymorphisms (SNPs) account for more than 90% of all genome sequence differences between individuals. ...
BIN-2002
... identification of complete genes and their annotation. Assembly provides also information on the genome architecture (linear or circular chromosomes, their number etc.). Contigs may be up to millions of nucleotides in size. An average read coverage >10 is required for decent assemblies. Long reads o ...
... identification of complete genes and their annotation. Assembly provides also information on the genome architecture (linear or circular chromosomes, their number etc.). Contigs may be up to millions of nucleotides in size. An average read coverage >10 is required for decent assemblies. Long reads o ...
Gene Mapping and Disease Gene Identification
... Reich et al. Nature Genetics May 2001 rather large blocks of LD interspersed with recombination hot spots ...
... Reich et al. Nature Genetics May 2001 rather large blocks of LD interspersed with recombination hot spots ...
2004-06-GO_labday_aireland
... eg. signal transduction, behavior, glycolysis, regulation of cell size GO terms are made up of a term name, a unique ID, and (for 90% of terms) a definition. GO terms may also have synonyms, which can be either identical or related concepts; the relationship between the term and synonym is stored in ...
... eg. signal transduction, behavior, glycolysis, regulation of cell size GO terms are made up of a term name, a unique ID, and (for 90% of terms) a definition. GO terms may also have synonyms, which can be either identical or related concepts; the relationship between the term and synonym is stored in ...
Gene models - Wheat Training
... they are based on. Transcriptome data and gene models from related species are often used to help define correct gene models in a species. As with genome assemblies it is vital for researchers using gene models to understand how they were created in order to be aware of shortcomings and potential pi ...
... they are based on. Transcriptome data and gene models from related species are often used to help define correct gene models in a species. As with genome assemblies it is vital for researchers using gene models to understand how they were created in order to be aware of shortcomings and potential pi ...
Chromosomal Inheritance pdf
... Sections of DNA where specific triplet of nucleotides is repeated many times Occur normally in many places in human genome Progressive addition of triplet repeats can lead to genetic disorders such as Fragile X ...
... Sections of DNA where specific triplet of nucleotides is repeated many times Occur normally in many places in human genome Progressive addition of triplet repeats can lead to genetic disorders such as Fragile X ...
More detail on linkage and Morgan
... • In humans, the anatomical signs of sex first appear when the embryo is about two months old. • In individuals with the SRY gene (sex-determining region of the Y chromosome), the generic embryonic gonads are modified into testes. – Activity of the SRY gene triggers a cascade of biochemical, physiol ...
... • In humans, the anatomical signs of sex first appear when the embryo is about two months old. • In individuals with the SRY gene (sex-determining region of the Y chromosome), the generic embryonic gonads are modified into testes. – Activity of the SRY gene triggers a cascade of biochemical, physiol ...
HMIVT
... 1. Homologous duplicated chromosomes pair up. Intimate contact encourages crossovers at various intervals along length of non-sister chromatids. Non-sister chromatids exchange segments at cross over site. Crossing over breaks up old combinations of alleles and puts new ones together in homologous ch ...
... 1. Homologous duplicated chromosomes pair up. Intimate contact encourages crossovers at various intervals along length of non-sister chromatids. Non-sister chromatids exchange segments at cross over site. Crossing over breaks up old combinations of alleles and puts new ones together in homologous ch ...
IntroToBioinformatics
... Experimental proof is still the “Gold Standard”. Bioinformatics is used to help “focus” the experiments of the benchtop scientist ...
... Experimental proof is still the “Gold Standard”. Bioinformatics is used to help “focus” the experiments of the benchtop scientist ...
ppt - Sol Genomics Network
... - all available full-length tomato genes in GENBANK - TIGR full-length cDNA sequences (redundantly sequenced) - SGN unigene contigs with 5 or more ESTs - redundnacy correction 456 of 8,097 genes found in available genome sequence (5.6%) Correcting for 85% expectation yields 6.6% of target gene space ...
... - all available full-length tomato genes in GENBANK - TIGR full-length cDNA sequences (redundantly sequenced) - SGN unigene contigs with 5 or more ESTs - redundnacy correction 456 of 8,097 genes found in available genome sequence (5.6%) Correcting for 85% expectation yields 6.6% of target gene space ...
SNP Discovery by sequencing 1000 genomes
... different alleles. there are several methods and this is an area of intense investigation and ...
... different alleles. there are several methods and this is an area of intense investigation and ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.