Genome structure, analysis and evolufion Lecture 1
... Further poten?al for confusion comes from new uses of the term ‘genome’ recently spawned by genome sequencers. These concern the counter-‐intui?ve meaning of a ‘wholly’, ‘completely’ or ‘en?rely’ sequenced geno ...
... Further poten?al for confusion comes from new uses of the term ‘genome’ recently spawned by genome sequencers. These concern the counter-‐intui?ve meaning of a ‘wholly’, ‘completely’ or ‘en?rely’ sequenced geno ...
Sex Chromosomes and Male Functions
... obvious: genes with male germline function would be enriched in autosomes after sufficient evolutionary time. This prediction is well corroborated by Drosophila expression analysis using DNA microarray technology26,28 and for many individual genes.17,25-28 Male germline genes also show a strong pref ...
... obvious: genes with male germline function would be enriched in autosomes after sufficient evolutionary time. This prediction is well corroborated by Drosophila expression analysis using DNA microarray technology26,28 and for many individual genes.17,25-28 Male germline genes also show a strong pref ...
Lecture 14 - The Chromosomal Basis of Inheritance
... inherited together – They are located very close to each other on a chromosome – They are unlikely to be separated during homologous recombination and independent assortment Homologous recombination during meiosis “can cause alleles previously on the same chromosome to be separated and end up in dif ...
... inherited together – They are located very close to each other on a chromosome – They are unlikely to be separated during homologous recombination and independent assortment Homologous recombination during meiosis “can cause alleles previously on the same chromosome to be separated and end up in dif ...
Human Genome and Human Genome Project
... And a broader programme was recommended in a report by NRC, USA in 1998: • Sequencing the human genome: creation of genetic, physical and sequence maps of the human genome. • Parallel efforts in key model organisms. • The development of technology in support of these objectives • Research in the eth ...
... And a broader programme was recommended in a report by NRC, USA in 1998: • Sequencing the human genome: creation of genetic, physical and sequence maps of the human genome. • Parallel efforts in key model organisms. • The development of technology in support of these objectives • Research in the eth ...
slides
... Linkage disequilibrium (LD) describes the nonrandom association of nucleotides on the same chromosome in a population One nucleotide at one position (locus) predicts the occurrence of another nucleotide at another locus No LD ...
... Linkage disequilibrium (LD) describes the nonrandom association of nucleotides on the same chromosome in a population One nucleotide at one position (locus) predicts the occurrence of another nucleotide at another locus No LD ...
G.tigrina Hox
... • More information concerning its expression and function in G.tigrina can be found in “Planarian Hox genes: novel patterns of expression during regeneration”, (Bayascas et al.) ...
... • More information concerning its expression and function in G.tigrina can be found in “Planarian Hox genes: novel patterns of expression during regeneration”, (Bayascas et al.) ...
Supplementary Information (doc 46K)
... produced a better hit that was not annotated. The tblastx hits have no Bombyx ...
... produced a better hit that was not annotated. The tblastx hits have no Bombyx ...
Fact Sheet 9 | X-LINKED RECESSIVE INHERITANCE This fact sheet
... An X-linked recessive gene is a gene located on the X chromosome and effects males and females differently. ...
... An X-linked recessive gene is a gene located on the X chromosome and effects males and females differently. ...
GENE EXPRESSION ANALYSIS
... Gene expression analysis is often an integral component of feed and vaccine trials. Xelect is a spin-out company from a University research group with substantial expertise in fish genomics and gene expression analysis including experimental design and normalisation strategies. Xelect offers a compl ...
... Gene expression analysis is often an integral component of feed and vaccine trials. Xelect is a spin-out company from a University research group with substantial expertise in fish genomics and gene expression analysis including experimental design and normalisation strategies. Xelect offers a compl ...
Populus - University of Washington
... The Populus genome sequence will overcome many of the limitations inherent in forest tree genetics • Long generation interval • Outcrossing mating system • Lack of inbred lines • Lack of efficient mutagenesis ...
... The Populus genome sequence will overcome many of the limitations inherent in forest tree genetics • Long generation interval • Outcrossing mating system • Lack of inbred lines • Lack of efficient mutagenesis ...
Document
... • Cross-shaped configuration at meiosis I • Crossing-over results in gene imbalance, semisterility ...
... • Cross-shaped configuration at meiosis I • Crossing-over results in gene imbalance, semisterility ...
CSE280A Class Projects
... The goal of this project is to understand selection signatures in multi-allelic (soft-sweep) and polygenic selection. Start by building a forward simulator that can simulate these kinds of selections. 1. Build a standard forward-simulator for haploid population as follows: assume a Wright-Fisher mod ...
... The goal of this project is to understand selection signatures in multi-allelic (soft-sweep) and polygenic selection. Start by building a forward simulator that can simulate these kinds of selections. 1. Build a standard forward-simulator for haploid population as follows: assume a Wright-Fisher mod ...
$doc.title
... (without considering orthogonal biological systems and xenobiology: Wright, Stan, Ellis 2013, Moe-‐Behrens, Davis, Haynes 2013). ...
... (without considering orthogonal biological systems and xenobiology: Wright, Stan, Ellis 2013, Moe-‐Behrens, Davis, Haynes 2013). ...
Linkage analysis - Scheid Signalling Lab @ York University
... sibs that have both alleles in common are identical by decent • IBS: if parental alleles are not know, then we can only say sibs are identical by state ...
... sibs that have both alleles in common are identical by decent • IBS: if parental alleles are not know, then we can only say sibs are identical by state ...
Intro Data Clustering - Genomics & Bioinformatics at Purdue
... • Different methods often provide different clusters. • No overall “best” clustering method. • Clustering applied to unrelated data will still provide clusters. • Use biological insight in method selection and interpretation. ...
... • Different methods often provide different clusters. • No overall “best” clustering method. • Clustering applied to unrelated data will still provide clusters. • Use biological insight in method selection and interpretation. ...
Leishmania major Friedlin chromosome 1 has an unusual
... clustered on the same DNA strand may be more efficient than if they were dispersed. Experiments to investigate transcription along chr1 are underway. The region where the coding-strand changes (between XPP and PAXP) is of particular interest, because it is an obvious candidate for a transcription in ...
... clustered on the same DNA strand may be more efficient than if they were dispersed. Experiments to investigate transcription along chr1 are underway. The region where the coding-strand changes (between XPP and PAXP) is of particular interest, because it is an obvious candidate for a transcription in ...
Expression Analysis of the Sphingolipid Metabolism
... GenMAPP v2.1, a Windows operating program, provides a technique for conducting a genomic analysis through the visualization of gene expression data within a metabolic pathway. Expression data derived from microarray and other similar genomic experiments can be imported and recognized by GenMAPP usin ...
... GenMAPP v2.1, a Windows operating program, provides a technique for conducting a genomic analysis through the visualization of gene expression data within a metabolic pathway. Expression data derived from microarray and other similar genomic experiments can be imported and recognized by GenMAPP usin ...
(GWAS) and Personalized Medicine
... – Associated with elevated liver enzyme (e.g., ALT) – Derived from preclinical studies for Exanta – Found to be genetically associated with adverse effects ...
... – Associated with elevated liver enzyme (e.g., ALT) – Derived from preclinical studies for Exanta – Found to be genetically associated with adverse effects ...
An Investigation into the Genomic Evolution of the Histone Gene
... conversion - have been documented to occur, and are understood in molecular detail, but their role in concerted evolution is primarily based on theoretical and/or mathematical models with limited data from actual genome sequence to support them. It is the hypothesis of this research that if unequal ...
... conversion - have been documented to occur, and are understood in molecular detail, but their role in concerted evolution is primarily based on theoretical and/or mathematical models with limited data from actual genome sequence to support them. It is the hypothesis of this research that if unequal ...
Mild dystrophic epidermolysis bullosa
... have fragile skin and blisters. A person with one defective copy of the gene is healthy and is said to be a carrier of the disorder. However, if two such people who carry a defective copy have children, there is a 1 in 4 risk that the child will inherit both defective copies of the skin and will hav ...
... have fragile skin and blisters. A person with one defective copy of the gene is healthy and is said to be a carrier of the disorder. However, if two such people who carry a defective copy have children, there is a 1 in 4 risk that the child will inherit both defective copies of the skin and will hav ...
Lecture6-Chap4 Sept19 - Department Of Biological Sciences
... • Embryonic stem (ES) cells that are injected into a mouse blastocyst generate descendant cells that become part of a chimeric adult mouse. – When the ES cells contribute to the germline, the next generation of mice may be derived from the ES cell. – Genes can be added to the mouse germline by trans ...
... • Embryonic stem (ES) cells that are injected into a mouse blastocyst generate descendant cells that become part of a chimeric adult mouse. – When the ES cells contribute to the germline, the next generation of mice may be derived from the ES cell. – Genes can be added to the mouse germline by trans ...
Document
... to the hypothesis that their adaptation to different aphid species is an ongoing process. ...
... to the hypothesis that their adaptation to different aphid species is an ongoing process. ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.