Milestone1
... 3) When trying to determine whether two genes are orthologous, one must consider the possibility that two different genes are similar because, over time, their sequences converged towards one another instead of sharing similarity because they diverged from a common ancestral gene. If two genes have ...
... 3) When trying to determine whether two genes are orthologous, one must consider the possibility that two different genes are similar because, over time, their sequences converged towards one another instead of sharing similarity because they diverged from a common ancestral gene. If two genes have ...
Very harmful dominant gene
... Gene Flow in Lions Introduction • One of the greatest dangers to small populations is related to gene flow • Deleterious alleles can crop up and spread throughout a small population, pushing the population towards extinction • It may be possible, as conservationists, to use gene flow in small popula ...
... Gene Flow in Lions Introduction • One of the greatest dangers to small populations is related to gene flow • Deleterious alleles can crop up and spread throughout a small population, pushing the population towards extinction • It may be possible, as conservationists, to use gene flow in small popula ...
Paroxysmal movement disorders
... though rarely can last as long as 20 minutes) + age of onset <20 (unless family hx, as some cases can start as late as age 33) + no LOC/pain during attack + normal exam in between attacks + control of attacks with carbamazepine or phenytoin. -One possible causative gene is PRRT2, but many patients h ...
... though rarely can last as long as 20 minutes) + age of onset <20 (unless family hx, as some cases can start as late as age 33) + no LOC/pain during attack + normal exam in between attacks + control of attacks with carbamazepine or phenytoin. -One possible causative gene is PRRT2, but many patients h ...
Many of the slides that I`ll use have been borrowed from Dr. Paul
... Can we infer phylogenies from character data using deductive ...
... Can we infer phylogenies from character data using deductive ...
Cis-regulatory modules in Drosophila
... A significant character of cis-regulatory sites: the multiple binding sites for different transcriptional factors tend to cluster together in one region around the gene, forming the Cis-Regulatory Modules (CRM). The searching of cis-regulatory sites gives out too many candidate positions, which make ...
... A significant character of cis-regulatory sites: the multiple binding sites for different transcriptional factors tend to cluster together in one region around the gene, forming the Cis-Regulatory Modules (CRM). The searching of cis-regulatory sites gives out too many candidate positions, which make ...
The mouse that roared
... now then thyself, presume not God to scan; The proper study of mankind is man,” wrote Alexander Pope in 1733. What better reason could there have been to sequence the human genome? But the planners of the Human Genome Project realized that the data could not be fully understood, or used to advance b ...
... now then thyself, presume not God to scan; The proper study of mankind is man,” wrote Alexander Pope in 1733. What better reason could there have been to sequence the human genome? But the planners of the Human Genome Project realized that the data could not be fully understood, or used to advance b ...
Chromosomal mutation
... • adjacent-1: segregation of each structurally normal chromosome with one of the translocated ones (T1 + N2 and T2 + N1) • alternate segregation: segregation of the two normal and two translocated chromosomes (N1 + N2 and T1 + T2) - Crossing-over results in gene imbalance, semisterility • equal numb ...
... • adjacent-1: segregation of each structurally normal chromosome with one of the translocated ones (T1 + N2 and T2 + N1) • alternate segregation: segregation of the two normal and two translocated chromosomes (N1 + N2 and T1 + T2) - Crossing-over results in gene imbalance, semisterility • equal numb ...
Document
... • Genome size has varied over evolutionary time; • Increases or decreases in size do not correlate with number of genes; • Polyploidy in plants does not by itself explain differences in genome size; • A greater amount of DNA is explained by the presence of introns and nonprotein-coding sequences tha ...
... • Genome size has varied over evolutionary time; • Increases or decreases in size do not correlate with number of genes; • Polyploidy in plants does not by itself explain differences in genome size; • A greater amount of DNA is explained by the presence of introns and nonprotein-coding sequences tha ...
Human Genome Project
... (SNPs) occur in humans. This information promises to revolutionize the processes of finding chromosomal locations for disease-associated sequences and tracing human ...
... (SNPs) occur in humans. This information promises to revolutionize the processes of finding chromosomal locations for disease-associated sequences and tracing human ...
Document
... (SNPs) occur in humans. This information promises to revolutionize the processes of finding chromosomal locations for disease-associated sequences and tracing human ...
... (SNPs) occur in humans. This information promises to revolutionize the processes of finding chromosomal locations for disease-associated sequences and tracing human ...
1. Changes to the number of chromosomes
... chromosomes in excess (extra) of the normal diploid number. In crop plants this often confers increased vigour. (Bigger crop yields due to increased seed or fruit size). If a polyploid plant has an uneven number of chromosome sets, it will be sterile (because homologous chromosomes cannot pair up at ...
... chromosomes in excess (extra) of the normal diploid number. In crop plants this often confers increased vigour. (Bigger crop yields due to increased seed or fruit size). If a polyploid plant has an uneven number of chromosome sets, it will be sterile (because homologous chromosomes cannot pair up at ...
Input: window.results files (output of Stage 4).
... A gene network is compiled using the input files for (1) the input gene list and (2) each of the N requested random gene networks. The input gene network contains all genes in the input gene list that have a 3’-UTR listed in the target prediction files, a weighted set of scores for each target site ...
... A gene network is compiled using the input files for (1) the input gene list and (2) each of the N requested random gene networks. The input gene network contains all genes in the input gene list that have a 3’-UTR listed in the target prediction files, a weighted set of scores for each target site ...
BIOL/PBIO 3333 Genetics Quiz 2 9/27/13 For the answers to the quiz
... 1. Which of the following dihybrid x dihybrid ratios show independent assortment? a) 9:3:3:1; b) 9:7; c) 9:3:4; d) all of the above; e) none of the above. 2. Tribbles are animals that have a sex determination mechanism similar to humans. The trait marine (m), with short, stiff hair, is recessive to ...
... 1. Which of the following dihybrid x dihybrid ratios show independent assortment? a) 9:3:3:1; b) 9:7; c) 9:3:4; d) all of the above; e) none of the above. 2. Tribbles are animals that have a sex determination mechanism similar to humans. The trait marine (m), with short, stiff hair, is recessive to ...
Array comparative genomic hybridization (array
... Different array platforms use different levels of analysis; some examine DNA spaced at large intervals along the genome and are described as low resolution (e.g. BAC arrays), whilst others examine more DNA spaced close together and hence are described as high resolution (e.g. oligo or SNP arrays). I ...
... Different array platforms use different levels of analysis; some examine DNA spaced at large intervals along the genome and are described as low resolution (e.g. BAC arrays), whilst others examine more DNA spaced close together and hence are described as high resolution (e.g. oligo or SNP arrays). I ...
Separating derived from ancestral features of mouse and human
... Duplicated genes form a far from random selection of all genes. Aside from the bias in gene sizes mentioned above, several functional categories are overrepresented among genes specific to either primate or rodent lineages. These include (i) chemosensation genes which are more numerous in rodents, a ...
... Duplicated genes form a far from random selection of all genes. Aside from the bias in gene sizes mentioned above, several functional categories are overrepresented among genes specific to either primate or rodent lineages. These include (i) chemosensation genes which are more numerous in rodents, a ...
The identification of human quantitative trait loci
... Use Bayesian model selection to choose best models and average parameters over models. Eliminates problem of multiple testing. Yields unbiased estimates of effect size. Allows prioritization of polymorphisms for further lab evaluation. Calculation of Posterior Probability of Effect. ...
... Use Bayesian model selection to choose best models and average parameters over models. Eliminates problem of multiple testing. Yields unbiased estimates of effect size. Allows prioritization of polymorphisms for further lab evaluation. Calculation of Posterior Probability of Effect. ...
Assembling the Sequence of the Genome
... SQ4. Does looking for ORFs overestimate or underestimate the number of real genes? The next level of ab initio analysis includes additional information available about the genome itself. Several of the most popular programs are listed below. In the simplest terms, these programs ask “what do known g ...
... SQ4. Does looking for ORFs overestimate or underestimate the number of real genes? The next level of ab initio analysis includes additional information available about the genome itself. Several of the most popular programs are listed below. In the simplest terms, these programs ask “what do known g ...
Document
... hypothesis of genetic heterogeneity, majority of the 16 genes has no or very weak linkage support in 94 families, while some genes provide good support – but, unfortunately those genes have few known direct physical interactions and are either disconnected or poorly connected in molecular-interactio ...
... hypothesis of genetic heterogeneity, majority of the 16 genes has no or very weak linkage support in 94 families, while some genes provide good support – but, unfortunately those genes have few known direct physical interactions and are either disconnected or poorly connected in molecular-interactio ...
NeuroAnatomic and Genetic Approaches to Memory Formation
... Gene replacement and transgenic animals • Some genes are identified through mutant analysis Forward Genetics (mutant phenotype---> genotype) • To determine the function of these genes, it is possible to replace an organism’s wild type gene with an inactive gene to create a “gene knockout” Reverse G ...
... Gene replacement and transgenic animals • Some genes are identified through mutant analysis Forward Genetics (mutant phenotype---> genotype) • To determine the function of these genes, it is possible to replace an organism’s wild type gene with an inactive gene to create a “gene knockout” Reverse G ...
Gene set tes-ng
... • Too difficult to go through one by one • Want to understand pathways involved in the biological system being studied ...
... • Too difficult to go through one by one • Want to understand pathways involved in the biological system being studied ...
Karyotype SingleGeneInheritance
... (arranged in the same order), but often exhibit slight differences in the DNA sequence of the genes. Crossover is a unique meiotic event that occurs between homologous chromosomes aligned at the metaphase plate in meiosis I2. Here, the diploid set of parental chromosomes may transpose homologous (re ...
... (arranged in the same order), but often exhibit slight differences in the DNA sequence of the genes. Crossover is a unique meiotic event that occurs between homologous chromosomes aligned at the metaphase plate in meiosis I2. Here, the diploid set of parental chromosomes may transpose homologous (re ...
bio ch 15.3 ppt - Mrs. Graves Science
... • The data can be searched for any specific gene or sequence. • Robotic devices are now used to sequence genomes rapidly. ...
... • The data can be searched for any specific gene or sequence. • Robotic devices are now used to sequence genomes rapidly. ...
PCR Lecture - Woods Hole Oceanographic Institution
... make the information related to these SNPs available to the public without intellectual property restrictions. The project started in April 1999 and is anticipated to continue until the end of 2001.” ...
... make the information related to these SNPs available to the public without intellectual property restrictions. The project started in April 1999 and is anticipated to continue until the end of 2001.” ...
Pi kur, 2004
... speciation in yeasts. Nature 422: 68–72. Frazer, K.A., et al. (2003) Cross-species sequence comparisons: a review of methods and available resources.Genome Res 13: ...
... speciation in yeasts. Nature 422: 68–72. Frazer, K.A., et al. (2003) Cross-species sequence comparisons: a review of methods and available resources.Genome Res 13: ...
Copy-number variation
Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.