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Chromosomes and Genetics
Chromosomes and Genetics

... Chromosomes can be broken by X-rays and by certain chemicals. The broken ends spontaneously rejoin, but if there are multiple breaks, the ends join at random. This leads to alterations in chromosome structure. Problems with structural changes: breaking the chromosome often means breaking a gene. Sin ...
bb2013_03 - Territory Stories
bb2013_03 - Territory Stories

... affecting polledness, but there are 2 other genes that can also affect polledness in some cattle. These are the Scur gene (which can occur in all breeds) and the African horn gene (which only occurs in tropical breeds). The frequency of the African horn gene (Af) in different breeds is not known but ...
DUAL TRAFFICKING PATHWAYS OF CONNEXINS TO GAP …
DUAL TRAFFICKING PATHWAYS OF CONNEXINS TO GAP …

Characterization of cDNAs Induced in Meiotic Prophase in Lily
Characterization of cDNAs Induced in Meiotic Prophase in Lily

... Key words: meiosis; zygotene; stage-specific genes; cDNA; Lilium longiflorum during meiotic prophase of microsporogenesis in Lilium, longiflorum, by means of a cDNA subtraction screening Meiosis is a complex process involving a highly reg- method.21 Using these cDNAs as probes, the correspondulated ...
No Slide Title
No Slide Title

... Telomerases are nucleoproteins whose function is to add DNAsequence repeats to the 3' end of the DNA strands in the telomeres at the ends of linear eukaryotic chromosomes. The de novo addition of TTAGGG repeats by the enzyme telomerase partially or wholly compensates for telomere shortening. Telomer ...
2006
2006

... Spider silk proteins and their genes are very attractive to researchers in a wide range of disciplines because they permit linking many levels of organization. However, hypotheses of silk gene evolution have been built primarily upon single sequences of each gene each species, and little is known ab ...
SNPs - Biology, Genetics and Bioinformatics Unit
SNPs - Biology, Genetics and Bioinformatics Unit

Slide
Slide

...  If read r overlaps to the right reads r1, r2, and r1 overlaps r2, then (r, r2) can be inferred by (r, r1) and (r1, r2) ...
Understanding the Adaptation of Halobacterium Species NRC
Understanding the Adaptation of Halobacterium Species NRC

... computational methods and reveal characteristics relevant to life in an extreme environment distinguished by hypersalinity and high solar radiation: (1) The proteome is highly acidic, with a median pI of 4.9 and mostly lacking basic proteins. This characteristic correlates with high surface negative ...
Word - NIEHS SNPs Program - University of Washington
Word - NIEHS SNPs Program - University of Washington

... 6. Notice the SNP sites across the top of the image are listed by RS_ID. What is the RS_ID for the first nonsynonymous SNP from the left? 7. Close the VG2 image and Select Display Type windows and return to the Genome Variation Server Page. Now, change the allele frequency cutoff to 5. How many SNPs ...
Take home quiz (due Monday April 4th)
Take home quiz (due Monday April 4th)

Sex Chromosomes
Sex Chromosomes

... ___________________ is relatively common among ______________ and much less common among __________________ ...
Document
Document

Exercises Biological databases PART
Exercises Biological databases PART

... Bioinformatics (updated 2015 january) ...
Text S1. Supporting Information Supporting Information Figure
Text S1. Supporting Information Supporting Information Figure

... bars. The coverage of the genome from previous sequencing studies is depicted with blue bars, with each blue bar representing a sequence study and the width of the bar being proportional to the length of the sequenced region. Although some regions have been sequenced in multiple studies (for example ...
Power Point - Microbial Genome Program
Power Point - Microbial Genome Program

... local similarity between sequences ...
Emerson_AnnMissBot_1945
Emerson_AnnMissBot_1945

... still inadequateon this point as there is no one case in which antibodiesto a particular antigen have been shown to inauce mutations in the gene responsiblefor the production of that antigen. If such evidence is forthcoming, it would indicate that the surface of the antigen is duplicatedin either th ...
Gene finding: putting the parts together
Gene finding: putting the parts together

... finding by several groups. The only fundamental difference from the dynamic programming schemes discussed in the previous section is that these models are fully probabilistic, which have certain advantages. One of the advantages is that the weighting problem is easier. VEIL (Henderson, Salzberg, & F ...
Supplementary Information (doc 104K)
Supplementary Information (doc 104K)

... from the precomputed null GWAS. The FDR here is defined as the number of times the observed gene had a P-value equal or smaller than the 20 null GWAS, divided by the rank of the observed gene in the observed data. ...
Revised Tetrahymena Nomenclature Rules
Revised Tetrahymena Nomenclature Rules

... 7. Multiple features of a single allele are separated by commas inside the brackets as follows: btu1-19[K350M,438-440,HAC] means that there is a K350M replacement, amino acid codons for residues 438 to 440 are deleted and a C-terminal HA tag sequence is present in the BTU1 locus. 8. Alleles to whic ...
The hidden impact of inter-individual genomic variations on cellular
The hidden impact of inter-individual genomic variations on cellular

... also affect the behavior and function of gene products2. All together, DNA sequence variations can lead to changes in binding affinity, gain or loss of molecular interaction partners, changes in half-life, and changes in spatial localization of the affected gene products. Regulatory regions are thou ...
Chapter 19: Human Genetics
Chapter 19: Human Genetics

... 17. Color blindness is considered a sex-linked recessive disorder. Explain what this means. Ans: The gene that causes color blindness occurs on the X chromosome. Females require two copies of this recessive gene in order to be affected. Males require only one copy of the recessive gene. 18. Explain ...
Chapter 19: Human Genetics
Chapter 19: Human Genetics

... 17. Color blindness is considered a sex-linked recessive disorder. Explain what this means. Ans: The gene that causes color blindness occurs on the X chromosome. Females require two copies of this recessive gene in order to be affected. Males require only one copy of the recessive gene. 18. Explain ...
Down Syndrome: Antonarakis et al. (2004)
Down Syndrome: Antonarakis et al. (2004)

... published in May 2000 (REF. 18). There are three cloning gaps on 21q, each of which is only 20–30 Kb long. There are, therefore, 4 contigs for 21q (from centromere to telomere): 28,602; 229; 1,378; 3,432 Kb for a total length of 33,642,989 nucleotides (NCBI Build 34). Only a region of 281 Kb has bee ...
Gene List Enrichment Analysis
Gene List Enrichment Analysis

< 1 ... 52 53 54 55 56 57 58 59 60 ... 142 >

Copy-number variation



Copy-number variations (CNVs)—a form of structural variation—are alterations of the DNA of a genome that results in the cell having an abnormal or, for certain genes, a normal variation in the number of copies of one or more sections of the DNA. CNVs correspond to relatively large regions of the genome that have been deleted (fewer than the normal number) or duplicated (more than the normal number) on certain chromosomes. For example, the chromosome that normally has sections in order as A-B-C-D might instead have sections A-B-C-C-D (a duplication of ""C"") or A-B-D (a deletion of ""C"").This variation accounts for roughly 13% of human genomic DNA and each variation may range from about one kilobase (1,000 nucleotide bases) to several megabases in size. CNVs contrast with single-nucleotide polymorphisms (SNPs), which affect only one single nucleotide base.
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