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Learning, remembering and forgetting in the mammalian brain
Learning, remembering and forgetting in the mammalian brain

... innocuous stimulus (the conditioned stimulus), such as a tone or light, is contingently paired with a noxious one (typically an electric shock, the unconditioned stimulus) so that the conditioned stimulus now predicts the onset of an aversive stimulus. After a number of conditional stimulus–uncondit ...
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Proc. Natl. Acad. Sci. USA
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... The use of internal models of the body and the environment can improve the performance of motor control [57,58•]. Such internal models could be acquired by supervised learning with the motor command as the input and the sensory outcome as the teacher signal. Furthermore, for supervised or reinforcem ...
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Thalamic Activity that Drives Visual Cortical Plasticity
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... Readings for the week focus on sprouting, changing receptive fields and cortical remapping What patterns of neuronal activity follow a lesion? How do these changing patterns of activity play a role in plasticity? Specifically, what are the effects of depriving visual input from one eye on the LGN a ...
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Eyeblink conditioning

Eyeblink conditioning (EBC) is a form of classical conditioning that has been used extensively to study neural structures and mechanisms that underlie learning and memory. The procedure is relatively simple and usually consists of pairing an auditory or visual stimulus (the conditioned stimulus (CS)) with an eyeblink-eliciting unconditioned stimulus (US) (e.g. a mild puff of air to the cornea or a mild shock). Naïve organisms initially produce a reflexive, unconditioned response (UR) (e.g. blink or extension of nictitating membrane) that follows US onset. After many CS-US pairings, an association is formed such that a learned blink, or conditioned response (CR), occurs and precedes US onset. The magnitude of learning is generally gauged by the percentage of all paired CS-US trials that result in a CR. Under optimal conditions, well-trained animals produce a high percentage of CRs (> 90%). The conditions necessary for, and the physiological mechanisms that govern, eyeblink CR learning have been studied across many mammalian species, including mice, rats, guinea pigs, rabbits, ferrets, cats, and humans. Historically, rabbits have been the most popular research subjects.
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