Hereditary Pick’s disease with the G272V tau mutation shows predominant three-repeat
... specific antibodies) should supplement standard (immuno)histochemistry results and western blotting. Hereditary Pick disease as a clinicopathological phenotype of FTDP-17 has been associated with the G272V mutation in the tau gene (Sanders, 1939; Schenk, 1959; Groen and Endtz, 1982; Heutink et al., ...
... specific antibodies) should supplement standard (immuno)histochemistry results and western blotting. Hereditary Pick disease as a clinicopathological phenotype of FTDP-17 has been associated with the G272V mutation in the tau gene (Sanders, 1939; Schenk, 1959; Groen and Endtz, 1982; Heutink et al., ...
Attractor concretion as a mechanism for the formation of context
... number of trials, the CS-reinforcement contingencies were reversed and monkeys had to learn the new contingencies. In the experiments, the CS–US associations were reversed only once. However, in principle, the two contexts defined by the sets of CS–US associations could be alternated multiple times. ...
... number of trials, the CS-reinforcement contingencies were reversed and monkeys had to learn the new contingencies. In the experiments, the CS–US associations were reversed only once. However, in principle, the two contexts defined by the sets of CS–US associations could be alternated multiple times. ...
Functional anatomy of neural circuits regulating fear and extinction
... into postsynaptic sites. This was further confirmed by double- and triple-immunofluorescence (IF) staining for Venus (with use of anti-GFP antibody), Bassoon (presynaptic marker; Fig. 1D), and drebrin (postsynaptic marker; Fig. 1E). Three-dimensional reconstruction of confocal images of individual spi ...
... into postsynaptic sites. This was further confirmed by double- and triple-immunofluorescence (IF) staining for Venus (with use of anti-GFP antibody), Bassoon (presynaptic marker; Fig. 1D), and drebrin (postsynaptic marker; Fig. 1E). Three-dimensional reconstruction of confocal images of individual spi ...
The neuropharmacology of impulsive behaviour
... findings have implicated the orbitofrontal cortex in impulsive action [20], whereas, to date, damage to this brain area was mainly found to produce or alter delay aversion [21– 24] and not impulsive action [25]. In addition, a role for limbic regions such as the habenula and hippocampus in impulsive ...
... findings have implicated the orbitofrontal cortex in impulsive action [20], whereas, to date, damage to this brain area was mainly found to produce or alter delay aversion [21– 24] and not impulsive action [25]. In addition, a role for limbic regions such as the habenula and hippocampus in impulsive ...
Neurodynamical modeling of arbitrary visuomotor tasks
... In the introductory section, we give first a review of the literature of conditional visuomotor learning. We focus on the specific experiments used to study this paradigm. This view has not been extensively considered in the literature so far, but it is central to the manuscript presented in Chapter ...
... In the introductory section, we give first a review of the literature of conditional visuomotor learning. We focus on the specific experiments used to study this paradigm. This view has not been extensively considered in the literature so far, but it is central to the manuscript presented in Chapter ...
Free recall and recognition in a network model of the... simulating effects of scopolamine on human memory function
... Excitatory feedback in CA3 mediates auto-associative storage and recall of these representations. (4) Schaffer collaterals mediate heteroassociative storage and recall of associations between activity in CA3 and the self-organized representations formed by entorhinal input to region CA1. (5) Perfora ...
... Excitatory feedback in CA3 mediates auto-associative storage and recall of these representations. (4) Schaffer collaterals mediate heteroassociative storage and recall of associations between activity in CA3 and the self-organized representations formed by entorhinal input to region CA1. (5) Perfora ...
Functional Organization in the Motor Cortex
... BOLD signal is in fact sensitive to movement direction. In addition, a model was constructed to estimate cluster size. This model estimated that cluster diameter is several hundreds of microns, which is comparable to the cluster size estimated in other studies in monkey M1. Given these results, the ...
... BOLD signal is in fact sensitive to movement direction. In addition, a model was constructed to estimate cluster size. This model estimated that cluster diameter is several hundreds of microns, which is comparable to the cluster size estimated in other studies in monkey M1. Given these results, the ...
- D-Scholarship@Pitt
... evidence that the postsynaptic target favors and selects inputs that are more efficient in driving the postsynaptic targets. Although these studies have provided evidence that synaptic refinement occurs through activity-dependent competition, all were performed by blocking or reducing electrical act ...
... evidence that the postsynaptic target favors and selects inputs that are more efficient in driving the postsynaptic targets. Although these studies have provided evidence that synaptic refinement occurs through activity-dependent competition, all were performed by blocking or reducing electrical act ...
Different Stimuli, Different Spatial Codes: A Visual Map and an
... In contrast, for auditory stimuli, responses typically showed an open-ended pattern. As target eccentricity increased, responses either continued to increase, reached a plateau, or showed only a modest dip in activity. The auditory motor responses of the neuron in Figure 3A (bottom right panel) reac ...
... In contrast, for auditory stimuli, responses typically showed an open-ended pattern. As target eccentricity increased, responses either continued to increase, reached a plateau, or showed only a modest dip in activity. The auditory motor responses of the neuron in Figure 3A (bottom right panel) reac ...
Representation of Behavioral Tactics and Tactics
... pmPFC and the SMA. Right, Spatial distribution of task-related neurons in Monkey H whose brain was sectioned for histological verification of recording sites. Histology was not available from the other animal. However, physiological properties of the analyzed areas were in accordance with the previo ...
... pmPFC and the SMA. Right, Spatial distribution of task-related neurons in Monkey H whose brain was sectioned for histological verification of recording sites. Histology was not available from the other animal. However, physiological properties of the analyzed areas were in accordance with the previo ...
stimulus conditions area MT of the macaque monkey under matched
... 1991b; Ohzawa et al. 1985; Priebe et al. 2002). However, these have focused on changes in responsivity (or contrast sensitivity) to a single stimulus and have not probed whether tuning is altered in a similar way at successive stages of processing. Changes in tuning are critical because they indicat ...
... 1991b; Ohzawa et al. 1985; Priebe et al. 2002). However, these have focused on changes in responsivity (or contrast sensitivity) to a single stimulus and have not probed whether tuning is altered in a similar way at successive stages of processing. Changes in tuning are critical because they indicat ...
Mesodermal and neuronal retinoids regulate the induction and
... expression of LIM homeodomain protein family members (Tsuchida et al., 1994). These transcription factors functionally contribute to the settling patterns of motor neuron cell bodies and their axonal projection profiles (Pfaff et al., 1996; Sharma et al., 1998, 2000; Kania et al., 2000). Biochemical ...
... expression of LIM homeodomain protein family members (Tsuchida et al., 1994). These transcription factors functionally contribute to the settling patterns of motor neuron cell bodies and their axonal projection profiles (Pfaff et al., 1996; Sharma et al., 1998, 2000; Kania et al., 2000). Biochemical ...
Lights, Camembert, Action! - Human Reward and Decision Making lab
... in behavioral strategy. Thus, the degree to which these different processes are engaged in a given task, and the extent to which these different processes are disambiguated from each other in the experimental design and analysis, could contribute to discrepancies in reported results between studies. ...
... in behavioral strategy. Thus, the degree to which these different processes are engaged in a given task, and the extent to which these different processes are disambiguated from each other in the experimental design and analysis, could contribute to discrepancies in reported results between studies. ...
Activity in the Lateral Prefrontal Cortex Reflects Multiple Steps of
... ning of multistep behaviors? More specifically, does the activity of PFC neurons during the process of planning reflect the multiple movements required during future actions or the individual future events that occur as a result of the actions? To answer this question, we examined neuronal activity ...
... ning of multistep behaviors? More specifically, does the activity of PFC neurons during the process of planning reflect the multiple movements required during future actions or the individual future events that occur as a result of the actions? To answer this question, we examined neuronal activity ...
Regulation of thalamocortical axon branching by BDNF and synaptic vesicle cycling
... During development, axons form elaborate arbors to make synaptic contacts with their target cells. Neurotrophins, such as brainderived neurotrophic factor (BDNF), have been shown to regulate axon branching in the developing brain (Cohen et al., 1954; Vicario-Abejón et al., 1998; Cohen-Cory, 1999; Ma ...
... During development, axons form elaborate arbors to make synaptic contacts with their target cells. Neurotrophins, such as brainderived neurotrophic factor (BDNF), have been shown to regulate axon branching in the developing brain (Cohen et al., 1954; Vicario-Abejón et al., 1998; Cohen-Cory, 1999; Ma ...
A Quantitative Map of the Circuit of Cat Primary Visual Cortex
... Let Sju be the number of synapses in cortical layer u (of cat area 17) formed by the presynaptic neurons of type j and Nu the number of neurons in layer u. In its simplest form, Peters’s rule states that the Sju synapses distribute evenly over the Nu potential target neurons (i.e., each neuron in la ...
... Let Sju be the number of synapses in cortical layer u (of cat area 17) formed by the presynaptic neurons of type j and Nu the number of neurons in layer u. In its simplest form, Peters’s rule states that the Sju synapses distribute evenly over the Nu potential target neurons (i.e., each neuron in la ...
Learned Movements Elicited by Direct Stimulation of Cerebellar
... An example is seen in Figure 4C (lower right). When the stimulation electrode was withdrawn about 100 mm, these responses disappeared, while the long latency responses remained. Apart from this, there was no trace of any short latency EMG activity elicited by the MCP stimulation. The observations th ...
... An example is seen in Figure 4C (lower right). When the stimulation electrode was withdrawn about 100 mm, these responses disappeared, while the long latency responses remained. Apart from this, there was no trace of any short latency EMG activity elicited by the MCP stimulation. The observations th ...
Gap Junctions in the Ventral Hippocampal-Medial
... Departments of 1Psychology and 2Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544 ...
... Departments of 1Psychology and 2Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544 ...
Impaired insulin and insulin-like growth factor expression
... Abstract. The neurodegeneration that occurs in sporadic Alzheimer’s disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities, including cell loss, abundant neurofibrillary tangles and dystrophic neurites, amyloid-β deposits, ...
... Abstract. The neurodegeneration that occurs in sporadic Alzheimer’s disease (AD) is consistently associated with a number of characteristic histopathological, molecular, and biochemical abnormalities, including cell loss, abundant neurofibrillary tangles and dystrophic neurites, amyloid-β deposits, ...
Emotional and Behavioral Correlates of Mediodorsal Thalamic
... two screws to serve as a ground. Two bipolar electrodes for intracranial stimulation were implanted in the medial forebrain bundle (anterior, 25.2 from bregma; lateral, 60.8; ventral, 8.2), according to the atlas of Paxinos and Watson (1986). After the cut end of the temporal muscle was covered with ...
... two screws to serve as a ground. Two bipolar electrodes for intracranial stimulation were implanted in the medial forebrain bundle (anterior, 25.2 from bregma; lateral, 60.8; ventral, 8.2), according to the atlas of Paxinos and Watson (1986). After the cut end of the temporal muscle was covered with ...
Dynamics of Propofol-Induced Loss of Consciousness Across
... from wakefulness to unconsciousness is not a continuous process, but rather a series of discrete neural changes. Key words: general anesthesia; local field potential; loss of consciousness; primate; sensory premotor network; single-neuron activity ...
... from wakefulness to unconsciousness is not a continuous process, but rather a series of discrete neural changes. Key words: general anesthesia; local field potential; loss of consciousness; primate; sensory premotor network; single-neuron activity ...
Kandel ch. 43 + Two review papers
... highly organized connections with virtually the entire cerebral cortex, as well as the hippocampus and amygdala. Finally, a wide range of motor and nonmotor behaviors have been correlated with activity in individual basal ganglia neurons in experimental animals and with metabolic activity in the bas ...
... highly organized connections with virtually the entire cerebral cortex, as well as the hippocampus and amygdala. Finally, a wide range of motor and nonmotor behaviors have been correlated with activity in individual basal ganglia neurons in experimental animals and with metabolic activity in the bas ...
Circadian and histaminergic regulation of the sleep
... comparable to its level during wakefulness, whereas when the sleep deprivation ceased, the release of histamine immediately dropped to the baseline level. Constant administration of histamine into the basal forebrain region caused a significant increase in the high θ- and γrange power throughout inf ...
... comparable to its level during wakefulness, whereas when the sleep deprivation ceased, the release of histamine immediately dropped to the baseline level. Constant administration of histamine into the basal forebrain region caused a significant increase in the high θ- and γrange power throughout inf ...
What is the function of the claustrum? - Christof Koch
... percepts, but of a single, unifying experience. When holding a rose, you smell its fragrance and see its red petals while feeling its textured stem with your fingers. The philosopher Searle (2004) refers to the ‘conscious field’ in this context.1 There is an approximate consensus among scholars who ...
... percepts, but of a single, unifying experience. When holding a rose, you smell its fragrance and see its red petals while feeling its textured stem with your fingers. The philosopher Searle (2004) refers to the ‘conscious field’ in this context.1 There is an approximate consensus among scholars who ...
Role of the Basal Ganglia in the Control of Purposive - lsr
... globus pallidus, substantia nigra, and subthalamic nucleus (STN).1 The globus pallidus is further divided into the external segment (GPe) and the internal segment (GPi); the substantia nigra is divided into the pars reticulata (SNr) and pars compacta (SNc). The CD and PUT are the two input stations, ...
... globus pallidus, substantia nigra, and subthalamic nucleus (STN).1 The globus pallidus is further divided into the external segment (GPe) and the internal segment (GPi); the substantia nigra is divided into the pars reticulata (SNr) and pars compacta (SNc). The CD and PUT are the two input stations, ...