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arrhythmias
arrhythmias

... Tachyarrhythmias • Class I – Impede Na transport across cell membrane – Ia increase AP duration eg quinidine, ...
CASE STUDY 1 Acute coronary syndrome Patrick Gallagher
CASE STUDY 1 Acute coronary syndrome Patrick Gallagher

... usually lasts longer than 20 minutes. The pain may radiate to the back, arms (particularly the left), neck, lower face and even upper abdomen (Naik et al. 2007). Furthermore, Naik et al. suggest the pain may be described as ‘discomfort’, ‘tightness’, ‘heaviness’ or ‘gripping’. Patients with suspecte ...
On Measuring the Absolute Ventricular Volumes for the Estimation of
On Measuring the Absolute Ventricular Volumes for the Estimation of

... one in the diastolic (V1, P1) and the other the systolic phase (V2, P2) of the same cardiac cycle (Figure 2). The algorithm computes an initial estimate of V0 using these states of equal elastance: ...
Congenital Cardiac Disease
Congenital Cardiac Disease

... *Ventricular septal defect (VSD) is a hole in the wall that separates the lower chambers (ventricles) of the heart. * Overriding aorta is a defect in the position of the large artery (aorta) that takes red (oxygen-rich blood) to the body. In a normal heart the aorta attaches to the left ventricle. ...
Relation of left ventricular free wall rupture and/or
Relation of left ventricular free wall rupture and/or

... myocardial infarcts. Aronow and colleagues (8) studied by echocardiogram 1797 older patients (mean age 82 years) and found AS in 301 (17%)—severe in 40, moderate in 96, and mild in 165. Among their 301 patients with AS, 158 (52%) had had an earlier AMI that healed, and 217 (72%) had a new AMI or die ...
Left Ventricular Apical Ballooning Due to Severe
Left Ventricular Apical Ballooning Due to Severe

... The possibility of regional differences in either sympathetic innervation or catecholamine receptor density should be further investigated2 with the evaluation of levels of circulating factors such as natriuretic peptide, lipopolysaccharides, prostanoids, and cytokines in order to better define this ...
Congestive Heart Failure
Congestive Heart Failure

... – Describes the relationship between preload and cardiac output – The greater the heart muscle fibers are stretched (b/c of increases in volume), the greater their subsequent force of contraction – but only up to a point. Beyond that point, fibers get over-stretched and the force of contraction is r ...
Cardiovascular system Cardiac muscle
Cardiovascular system Cardiac muscle

... Depolarization – Na+ influx via voltagegated Na+ channels Plateau – balance of Ca++ influx and K+ efflux through voltage-gated ion channels Repolarization – more K+ efflux through voltage-gated ion channel ...
Ventricular hypertrophy icd 10
Ventricular hypertrophy icd 10

... ectopic impulses originating from an area distal to the His Purkinje system. VPCs are the most common. The ECG criteria to diagnose left ventricular hypertrophy, or LVH, on a 12lead ECG is discussed including Cornell criteria, Sokolow-Lyon criteria and the Romhilt. Aneurysm of heart; Heart left vent ...
revised manuscript_clean_Oct 2015
revised manuscript_clean_Oct 2015

... exemplified by N-terminal B-type natriuretic peptide (NTproBNP) which offers both diagnostic and incremental prognostic utility over conventional variables (4-7) Other pathways may be informative and may further help to understand the complex pathophysiology of acute HF. This clinical syndrome is do ...
fainting_(syncope)
fainting_(syncope)

...  Treat as outpatient, unless important heart disease is evident ...
atrial flutter with complete heart block - Heart
atrial flutter with complete heart block - Heart

... In 1957 he was admitted to hospital with severe vertigo, vomiting, and paraesthesiae down the left half of the body due to thrombosis of the right posterior inferior cerebellar artery. He also described central chest pain on effort, rapidly relieved by rest, and present for the previous five years. ...
Ventricular Ectopy - 167theclinic.co.nz
Ventricular Ectopy - 167theclinic.co.nz

... What are the symptoms of ectopic beats? A single ventricular ectopic beat has very little effect on the pumping ability of the heart and usually does not cause any symptoms. If a symptom is felt, it is the feeling of a strong or skipped beat, often described as a thump, kick, or flip-flop. Sometimes ...
CoffinLowry syndrome and left ventricular noncompaction
CoffinLowry syndrome and left ventricular noncompaction

... cardiologists and medical geneticists. Left ventricular noncompaction (LVNC) is a genetically and clinically heterogeneous disorder characterized by prominent left ventricular (LV) myocardial trabeculations and intertrabecular recesses that communicate with the LV cavity [Sasse-Klaassen et al., 2004 ...
View PDF - CiteSeerX
View PDF - CiteSeerX

... benefits of ACE inhibitors have been mostly attributed to blockade of angiotensin II production and/or to a decrease in the breakdown of bradykinin.10,11 Bradykinin has been shown to have beneficial effects associated with the release of nitric oxide and prostacyclin, which may contribute to the hae ...
acute coronary syndrome with left bundle branch block síndrome
acute coronary syndrome with left bundle branch block síndrome

... Dear Andres: The clinical story of chest pain, diaphoresis, nausea/vomiting and dyspnea suggests an acute coronary syndrome. In the setting of complete LBBB, acute myocardial infarction is indicated in this case by the concordant ST segment elevation (≥1mm) in leads V4-5. This is the best of the th ...
11 Heart - bloodhounds Incorporated
11 Heart - bloodhounds Incorporated

... After Diastole occurs the ventricles begin to contract from the apex towards the base of the heart The deoxygenated blood on the right side of the heart is pushed through the pulmonary trunk after opening the semi-lunar valve to the pulmonary arteries into the lungs to become oxygenated. The oxygena ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)

... Recent upsurge in referral of patients with high perioperative risk or compromised left ventricular failure for cardiac surgery has lead to an increase of pharmacologic support in the form of vasodilator and inotropic therapy to achieve improvement of tissue perfusion in the perioperative period or ...
Alternatives to Nifedipine in the Oral Treatment of Hypertensive
Alternatives to Nifedipine in the Oral Treatment of Hypertensive

... It is important to distinguish HU from true hypertensive emergencies which usually require IV therapy (with nitroprusside, nitroglycerin, labetalol, etc.) and hospitalization. The presence of acute or ongoing end organ damage constitutes a hypertensive emergency rather than a HU. Asymptomatic patien ...
Cardiovascular Disorders in Children
Cardiovascular Disorders in Children

... • in infancy, muscle fibers are less developed and organized • results in less functional capacity or less compliance • less compliance means the infant is unable or less able to distend or expand the ventricles to achieve an increase stroke volume in order to compensate for increased demands. ...
Cardiac Rehabilitation Jan-09-07
Cardiac Rehabilitation Jan-09-07

... ACC/AHA Coronary Artery Bypass Graft Surgery (CABG): Guideline Update for Date: 2004 ...
Heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction

... impaired diastolic performance and elevated filling pressures • Exercise right heart catheterisation – the gold standard measurement of haemodynamics, but not available in all centres • Stress echocardiography – noninvasive, but relies on good image quality and the presence of tricuspid regurgitat ...
What is atrial fibrillation? Why has my cat got atrial fibrillation? How
What is atrial fibrillation? Why has my cat got atrial fibrillation? How

... Heart rhythm disturbance (atrial fibrillation) There are many different heart problems that can affect cats. Some of these affect the rhythm of the heart beat and one such condition is atrial fibrillation. This is most commonly seen in association with severe heart disease. Atrial fibrillation does ...
ORIGINAL ARTICLE Does diastolic dysfunction precede systolic
ORIGINAL ARTICLE Does diastolic dysfunction precede systolic

... function have been proposed to detect early cardiotoxicity.15 However, conclusive evidence on the use of the most optimal and meaningful combination of cardiac function parameters is still lacking. The present study retrospectively investigated whether impairment of systolic function is preceded by ...
Teaching Handout – Cardiology 1
Teaching Handout – Cardiology 1

... 1.Therapy Minimise the effect on the patient’s life with the aid of physiotherapy, occupational therapy 2. Support Arrange support from community heart failure nurses and relevant support groups 3. Medical – symptom control: diuretic therapy - long term survival benefit – ace inhibitors (reducing ca ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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