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Chapter 11 Slides
Chapter 11 Slides

... cannot be based on heart or pulse rate but should be prescribed based on work rate and perceived exertion. ...
The Heart
The Heart

... Phenomenon occurs during running with little or no change in speed; increased HR, decreased MAP & SV with no parallel increased in effort (workload), breathing rate, or calories burned. Decreased SV is due to dehydration that accompany rise in internal temperature. Drift is affected by factors : - A ...
Randomized Controlled Trials on Hypertension
Randomized Controlled Trials on Hypertension

... (SHEP, Syst-Eur, Syst-China). (2) As for the types of antihypertensives, efficacy of diuretics has been established (EWPHE, STOP-Hypertension, MRC II, SHEP). Efficacy of Ca-antagonists, particularly of long acting dihydropyridine, has been demonstrated (Syst-Eur, SystChina, STONE, NICS-EH). (3) In t ...
Chapter 9 - University of Amsterdam
Chapter 9 - University of Amsterdam

... Overall the QRS score was 6.90 (SD 3.94) in the primary prevention group, compared to 6.17 (SD 4.50) in the secondary prevention group, which is not significantly different (p=0.26) (table 2, figure 1). The QRS scores in the primary and secondary prevention group were comparable for both infarcts ≤ ...
ECG Assignment
ECG Assignment

... 8-10) Watch for these cardiac conditions in the laboratory this week, they are much more common than you might think and need not always indicate a serious medical condition. Although sometimes they are important indicators of disease. It is always advised that you always see your physician for full ...
Surgical left ventricular reshaping in postinfarctual cardiomyopathy
Surgical left ventricular reshaping in postinfarctual cardiomyopathy

... Ø  Preoperative WMSI is a surrogate measure of residual remote myocardial function Ø  Echocardiographic WMSI will help to improve results after SVR procedures for advanced ischemic heart failure (in predicting mortality or poor functional result: cutoff value: 2,19) ...
Understanding Atrial Fibrillation
Understanding Atrial Fibrillation

... to the brain and result in a stroke. In non-valvular AF, the left atrial appendage (LAA) is believed to be the source of a majority of stroke-causing blood clots.* In addition, untreated AF may lead to a condition known as heart failure. Heart failure is a progressive condition in which the heart mu ...
PHYSICAL EXAMINATION OF THE HEART
PHYSICAL EXAMINATION OF THE HEART

... S4: Atrial contraction fills ventricle rapidly just before mitral valve closes, i.e. just before S1 ; low pitched (hear with bell) Heard if left ventricle is stiff: from high blood pressure, heart attack, etc. Murmurs: How to describe them 1. Timing: Systolic: Between S1 and S2 If unsure: check caro ...
Lab - Zoology, UBC
Lab - Zoology, UBC

... Record a series of l2 control heartbeats on a chart moving at moderate speed (2.5 mm/sec), then bathe the heart with epinephrine solution using an eyedropper. Start with five drops. Indicate on the chart recording the time of epinephrine addition and the number of drops added. Continue recording unt ...
Evaluation and Management of Patients with Heart Failure and
Evaluation and Management of Patients with Heart Failure and

... A substantial number of patients with heart failure (HF) have preserved left ventricular ejection fraction (LVEF), variably defined as an LVEF O40%, O45%, or O50%.1,2 When these patients have invasive or non-invasive evidence of abnormal diastolic function (either abnormal relaxation, filling or sti ...
Use of Primary Prevention Implantable Cardioverter
Use of Primary Prevention Implantable Cardioverter

... Parkash et al   Underuse of Primary Prevention Implantable Cardioverter Defibrillators   707 Scotia (CVHNS) registry. ICONS was a 5-year study (October 1997– April 2002; population, 932 402 [1997]; 935 015 [2001])15 that aimed to determine whether management of patients with an acute coronary syndr ...
Relationship Between Tricuspid Annular Excursion and Velocity in
Relationship Between Tricuspid Annular Excursion and Velocity in

... critically ill population shows that when TAPSE is indicative of depressed RV function, it does not necessarily mean depressed output performance. Other conformational changes may be responsible for the ejection volume. In an animal study, Leather et al found that RV longitudinal function correlated ...
A-Fib - MultiCultural IPA
A-Fib - MultiCultural IPA

... – Atrial Fibrillation (427.31) is the most common form of cardiac dysrhythmia, characterized by rapid, randomized contractions of the atrial myocardium causing a totally irregular, often rapid ventricular rate (400-600 per min) and may occur in patients with and without other heart disease. Medicati ...
Effects of Early Mobilization Program on the Heart Rate and Blood
Effects of Early Mobilization Program on the Heart Rate and Blood

... initial days after admission due to myocardial infarction are the main goals of treatment that decrease the pressure on the myocardium. Objectives: This study was performed to determine the effects of patients early mobilization program on heart rate and blood pressure of patients with MI hospitalize ...
Congestive Heart Failure
Congestive Heart Failure

... – Describes the relationship between preload and cardiac output – The greater the heart muscle fibers are stretched (b/c of increases in volume), the greater their subsequent force of contraction – but only up to a point. Beyond that point, fibers get over-stretched and the force of contraction is r ...
Slides - gserianne.com
Slides - gserianne.com

... • atria relaxed; low pressure allows blood return from veins • blood flows into atria • ventricular pressure increases and opens both semilunar valves • blood flows into pulmonary trunk and aorta ...
Biventricular Pacemakers in Patients With Heart Failure
Biventricular Pacemakers in Patients With Heart Failure

... Left bundle branch block is a common cause of QRS duration greater than 120 ms. In left bundle branch block, the left ventricle is activated through the septum, but activation through the left ventricle is delayed, resulting in delayed contraction of the posterolateral left ventricular wall and dela ...
Heart Foundation (Victoria) - Hazelwood Mine Fire Inquiry
Heart Foundation (Victoria) - Hazelwood Mine Fire Inquiry

... warning signs of heart attack. Messages should be tailored to the local community. 2. Encourage people suffering heart attack symptoms – or worried someone close by is suffering a heart attack – to call Triple Zero (000) and ask for an ambulance. As well as broadcast media, education messages can be ...
Atrial fibrillation - patient information
Atrial fibrillation - patient information

... pounding, fluttering or beating irregularly, often for a few seconds or possibly a few minutes. As well as an irregular heartbeat, your heart may also beat very fast (often considerably higher than 100 beats per minute). Other symptoms you may experience if you have atrial fibrillation include: • t ...
ANATOMY AND PHYSIOLOGY TEST: THE HEART
ANATOMY AND PHYSIOLOGY TEST: THE HEART

... What is considered a normal blood pressure? ...
2012_02_23_Tamara_Koopmann - Erasmus Observatory on Health …
2012_02_23_Tamara_Koopmann - Erasmus Observatory on Health …

... Identifying genetic cause for a disease Many human diseases/phenotypes are affected by single genes. Examples include: Brown eyes (dominant to blue eyes); Ability to curl or roll up tongue (dominant to inability) PEDIGREES of large families can help identify whether a genetic disease is caused by a ...
Ten-year experience of pediatric heart transplants
Ten-year experience of pediatric heart transplants

... emerged as a new and successful therapy in terminal cardiac patients and has evolved to date with the emergence of new immunosuppressive agents. The first pediatric heart transplant took place in 1982.19 From then until 2010 there have been 532 transplants worldwide. According to reports, 52% of tra ...
Conductive System Of Heart - Rawal College Of Dentistry
Conductive System Of Heart - Rawal College Of Dentistry

... Purkinje fibers is believed to be caused by a very high level of permeability of gap junctions at the intercalated discs between the successive cells of Purkinje fibers. • The rapid conduction through the purkinje fibers ensures that different parts of ventricles are excited almost simultaneously; t ...
Implantable Cardioverter Defibrillator
Implantable Cardioverter Defibrillator

... events, quality of life, and treatment-related morbidity and mortality. In these studies, the annual rate of appropriate ICD discharge ranged from 3.6% to 5.3%. Given the long-term high risk of patients with HCM for SCD risk, with the assumption that appropriate shocks are life-saving, these rates a ...
Commentary - University of Texas School of Public Health
Commentary - University of Texas School of Public Health

... the first data on a new measure of left ventricular regional wall motion. Similarly, the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (POSEIDON)29 examined end points in 3 domains: quality of life, functional capacity, and left ventricular structure and function, pr ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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