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临床医学英语Unit 12
临床医学英语Unit 12

... unnecessary and unwanted invasive treatment at the end of life. ...
Prevalence and clinical characteristics of left ventricular dysfunction
Prevalence and clinical characteristics of left ventricular dysfunction

... is increasing, and this rise is predicted to continue.1–4 Improving the diagnosis and care of patients with heart failure is therefore likely to have a major impact on morbidity, mortality, and healthcare costs, which in the United Kingdom are estimated to be £360 million a year.5 Systolic left vent ...
Cardiac auscultation - Veterinary Ireland Journal
Cardiac auscultation - Veterinary Ireland Journal

... diagnosis of moderate sub-aortic valve stenosis. Dogs with a stenosis of the severity seen here will often tolerate the lesion and have a normal lifespan, without showing referable clinical signs or requiring treatment. However, dogs with this condition should not be used for breeding as their offsp ...
Sudden Cardiac Death in Chagas Disease
Sudden Cardiac Death in Chagas Disease

... Echocardiography is one of the most useful diagnostic tests for initial evaluation and follow-up of patients with chronic Chagas disease. Different prognostic echocardiographic parameters have been described, most of them related to left ventricular function. Some studies have found than left ventri ...
Summer/Fall 2005 - Heart and Vascular Services UCLA
Summer/Fall 2005 - Heart and Vascular Services UCLA

... are being performed using minimally invasive transcatheter methods, valve replacements are now also possible without any surgery. Both pediatric and adult interventional cardiologists have begun trials utilizing transcatheter heart valves for either the pulmonary or aortic position. Phillip Bonhoeff ...
click here - British Cardiovascular Society
click here - British Cardiovascular Society

... fraction, CTCA– computed tomography of the coronary arteries. ...
Cardiomyopathies and Myocarditides
Cardiomyopathies and Myocarditides

... • May present with syncope, palpitation with AV block or ventricular arrhythmia • May cause sudden death – myocarditis found at autopsy in 20% of Air Force recruits with sudden death* ...
importance of right ventricular end-systolic regional wall stress in
importance of right ventricular end-systolic regional wall stress in

... changes of the RV to clinical parameters of right heart failure in IPAH. Hemodynamic markers of adverse long-term outcome such as elevated right atrial mean pressure, reduced cardiac output, and reduced RV ejection fraction are all measures of the severity of RV failure; however the ability of any o ...
Read more - Heart Rhythm Alliance
Read more - Heart Rhythm Alliance

... 12-lead ECGs of immediate relatives did not reveal long-QT syndrome. Sixteen patients (43%) experienced aborted sudden death, and all but 3 (92%) had syncope. Table 1 summarizes the clinical characteristics. There were 32 female and 5 male patients. All patients except 1 were symptomatic with long-Q ...
Lecture 3 LRC
Lecture 3 LRC

... Signs and Symptoms of Right Heart Failure Usually develops after left heart failure. Causing the effect of increased fluid pressure ultimately damages the right side of the heart. RV failure results in the inability of the heart to pump oxygen-poor blood from the systemic venous circulation to the ...
Delivery for Pulmonary Arterial Hypertension (PAH)
Delivery for Pulmonary Arterial Hypertension (PAH)

... Pulmonary arterial hypertension (PAH) is a rare and devastating disease characterized by high blood pressure in the arteries leading to the lung that ultimately results in right heart failure and premature death. Current external systems for parenteral administration of prostanoids (vasodilators) ex ...
Microsoft Word - 12 Analyzing Heart EKG.doc
Microsoft Word - 12 Analyzing Heart EKG.doc

... node) which initiates an electrical sequence. This impulse then passes down natural conduction pathways between the atria to the atrioventricular node and from there to both ventricles. The natural conduction pathways facilitate orderly spread of the impulse and coordinated contraction of first the ...
Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With
Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With

... Context Implantable cardioverter defibrillator (ICD) therapy with backup ventricular pacing increases survival in patients with life-threatening ventricular arrhythmias. Most currently implanted ICD devices provide dual-chamber pacing therapy. The most common comorbid cause for mortality in this pop ...
Electro Cardio Gram “MCQ”
Electro Cardio Gram “MCQ”

... 9- The configuration of QRS complex in normal ECG: a- Depends only on the direction of depolarizing current. b- Is mainly positive in right ventricular surface pattern. c- Exhibits growing R in chest leads. d- Is positive in aVR. ...
Pacing Non-Capture in a Child with Compound Heterozygous
Pacing Non-Capture in a Child with Compound Heterozygous

... syndrome [15], whereas the T1645M mutation is a gain-offunction mutation, previously described in long QT3 syndrome patient [16]. The interaction between two pathogenic mutations in a single patient has not been previously reported. Our patient had symptomatic sinus node dysfunction, first degree AV ...
Cardiovascular Manifestations of Hypothyroidism
Cardiovascular Manifestations of Hypothyroidism

... ‫‪poor exercise tolerance due to‬‬ ‫‪weakness in the skeletal muscles; but‬‬ ‫‪in patients with heart disease, the‬‬ ‫‪symptoms may be due to worsening‬‬ ‫‪heart failure [10, 14].‬‬ ‫‪ Slow heart rate, as heart rate is‬‬ ‫‪modulated by thyroid hormone, so that‬‬ ‫‪in hypothyroidism the heart rate i ...
Abbott Announces CE Mark for TactiCath™ Contact Force Ablation
Abbott Announces CE Mark for TactiCath™ Contact Force Ablation

... chambers of the heart beat too fast. When integrated with Abbott's EnSite Precision™ cardiac mapping system, physicians are able to utilize dual impedance and magnetic technologies to help more precisely model the heart. This integrated system also helps physicians determine where to apply optimal c ...
Ischemic Heart Disease MI
Ischemic Heart Disease MI

... Ischemic Heart Disease Myocardial infarction • The severity or duration of ischemia is enough to cause cardiac muscle death • Typically results from acute thromboses that ...
Giant left atrial myxoma mimicking severe mitral valve stenosis and
Giant left atrial myxoma mimicking severe mitral valve stenosis and

... attached to the interatrial septum and confined to the left atrium in systole (Figure 1). In diastole (Figure 2) the tumor was seen prolapsing across the mitral valve into the left ventricle and partially obstructing it and causing severe functional mitral stenosis with a mean gradient of 21,3 mmHg. ...
Premature Ventricular Contractions
Premature Ventricular Contractions

... dangerous heart rhythm, or even death. In severe cases, an ICD (implantable cardioverter defibrillator) may be implanted. This can help normalize the heart rhythm. © 2000-2012 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a subs ...
NVCC Bio 212 - gserianne.com
NVCC Bio 212 - gserianne.com

... • atria relaxed; low pressure allows blood return from veins • blood flows into atria • ventricular pressure increases and opens both semilunar valves • blood flows into pulmonary trunk and aorta ...
diseases of the cardiovascular system
diseases of the cardiovascular system

... almost always fatal Most dogs die within 6 months -2 years Death may occur suddenly due to arrhythmias ...
Public Summary Document (Word 95 KB)
Public Summary Document (Word 95 KB)

... of 19 studies (84%). The papers by Pleger et al (2013), Rudolph et al (2013) and Surder et al (2013) reported procedure success of 86%, 88% and 85% respectively. However, the number of clips placed, procedure time, time for recovery and post-procedure hospitalisation were not reported. In the identi ...
The Heart
The Heart

... Phenomenon occurs during running with little or no change in speed; increased HR, decreased MAP & SV with no parallel increased in effort (workload), breathing rate, or calories burned. Decreased SV is due to dehydration that accompany rise in internal temperature. Drift is affected by factors : - A ...
Understanding Atrial Fibrillation
Understanding Atrial Fibrillation

... to the brain and result in a stroke. In non-valvular AF, the left atrial appendage (LAA) is believed to be the source of a majority of stroke-causing blood clots.* In addition, untreated AF may lead to a condition known as heart failure. Heart failure is a progressive condition in which the heart mu ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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