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NT-proBNP levels, as predictor of left ventricular systolic and
NT-proBNP levels, as predictor of left ventricular systolic and

... left ventricular dysfunction. Some authors suggest that echocardiographic findings may be important in determining the individual target level [23]. The findings of the present study showed the mitral annular velocities from TDI in all patients were lower than in previously published studies of norm ...
Homogeneity out of heterogeneity.
Homogeneity out of heterogeneity.

... known. The fatal consequences of disordered ventricular depolarization were noted more than 75 years ago by Sir Thomas Lewis, who wrote, "When the ventricles fibrillate, the co-ordinate beat of these chambers is lost; the muscle is divided up into small areas, which show independent activities; as a ...
Novel pathophysiological insight and treatment strategies for heart
Novel pathophysiological insight and treatment strategies for heart

... results in either cardiac hypertrophy, conduction block, or HF.21 Furthermore, there is now a consensus view that mutations in mtDNA and abnormalities in mitochondrial function are associated with common forms of cardiac diseases such as ischemic heart disease22 and dilated cardiomyopathy.23 In thes ...
Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using
Evaluation of Subclinical Left Ventricular Systolic Dysfunction Using

... receptor signalling, cardiomyocyte plasma membrane function, intracellular calcium kinetics, and humoral factors such as endogenous cannabinoids, nitric oxide and carbon monoxide. The inflammatory changes in the myocardial structure and the fibrosis that occur in patients with cir- ...
of Heart Failure - Besancon.cardio.com
of Heart Failure - Besancon.cardio.com

... An important investigation in a patient with suspected heart failure is the echocardiogram. This ultrasonic examination visualises the cardiac chambers and valves. Systolic and diastolic ventricular contractile function can be measured, as can chamber size and wall thickness. Similarly, Doppler ultr ...
ACLS Drug Therapy
ACLS Drug Therapy

... can counteract with IV Ca ♦ Do not use with wide complex ...
Periodic Report Summary
Periodic Report Summary

... For LAL, a knot is tied at left atria of chicken embryos at embryonic day (ED) 4. At that stage, heart has not fully septated into left and right sections. Previous studies have shown that LAL at ED4, result in severely underdeveloped left ventricle and AV valves at ED10, when heart septation into l ...
Title goes here (Arial Narrow 28 pt) second line
Title goes here (Arial Narrow 28 pt) second line

... ‘An understanding of the basis of electrical activity of cardiac muscle and its relationship to basic mechanical events’ ● Bundle Branches ● Anatomy varies ● Right bundle extends down right side of interventricular septum to base of anterior papillary muscle where it divides ● Left bundle usually d ...
ACVIM Consensus Statement Guidelines for the
ACVIM Consensus Statement Guidelines for the

... functional classification systems. The new system describes 4 basic stages of heart disease and failure:  Stage A identifies patients at high risk for developing heart disease but that currently have no identifiable structural disorder of the heart (eg, every Cavalier King Charles Spaniel without a he ...
Implantable Ventricular Assist Devices and Total
Implantable Ventricular Assist Devices and Total

... Thoratec, Columbia University, and the National Institutes of Health. The randomized trial found that patients with end-stage heart failure who are not candidates for cardiac transplantation have significantly better survival on a VAD compared with treatment by optimal medical therapy. Median surviv ...
CVS_Part2
CVS_Part2

... pain that occurs with progressively increasing frequency, is precipitated with progressively less effort, often occurs at rest, and tends to be of more prolonged duration. It is induced by disruption of an atherosclerotic plaque with superimposed partia) thrombosis and possibly embolization or vasos ...
- ~
- ~

... The generic medication Nifedipine may elicit different side effects than most other types of calcium channel blockers. Nifedipine will increase resting and exercise heart rates, while other types of calcium channel blockers will decrease resting and exercise heart rates. Some general effects of all ...
PDF Article
PDF Article

... heart failure have traditionally been attributed to the bemodynamic improvements produced by this agent: that is, iniL..+:-creasesin cardiac output and left ventricular ejc&ir UUIUII together with decreases in cardiac filling pressures and volumes (2,3,5). However, it is not clear that the clinical ...
Clinical History and Imaging Procedures
Clinical History and Imaging Procedures

... Henrique Rodrigues; Pedro Belo Oliveira; Paulo Donato; Cristina Marques Patient male, 55 year(s) ...
Congenitally Corrected TGA (cc-TGA) and the - sha
Congenitally Corrected TGA (cc-TGA) and the - sha

... Fontan Operation . . . .? ? ? ...
Cardiac tumors
Cardiac tumors

... the body. Usually arise in the ventricular muscle and may become quite large. Do not regress spontaneously. Arise approximately 5 times more frequently in the LV than RV ...
Electrocardiogram and Heart Sounds
Electrocardiogram and Heart Sounds

... chambers of the heart at a low pressure and leaves the ventricles at a higher pressure; it is this high arterial pressure that provides the energy to force blood through the circulatory system. Figure 1 shows the organization of the human heart and the circulatory system, in schematic form. Blood re ...
Document
Document

... 1. Most impairment of (the stronger) left heart function is only manifest under load (e.g. exercise) and not at rest until very late. Therefore, any "decompensation" only occurs intermittently, with time in between for circulatory readjustment to the status quo - any tendency for "forward" failure ...
Improved Long-Term Prognosis of Dilated - J
Improved Long-Term Prognosis of Dilated - J

... was defined as death due to cardiovascular origins. Non-cardiovascular death was defined as death due to non-cardiovascular causes. For all patients, only the main mode of death was used. Hospitalization for worsening HF was defined as documentation of worsening HF requiring hospitalization. A patie ...
Myocardial Infarction: Management of the Subacute Period
Myocardial Infarction: Management of the Subacute Period

... process, implementing therapies early to prevent recurrent myocardial infarction, and avoiding hospital readmission. Evidence-based guidelines for the care of patients with acute coronary syndrome are not followed up to 25% of the time. Antiplatelet therapy, renin-angiotensin-aldosterone system inhi ...
cardiomyopathies - howMed Lectures
cardiomyopathies - howMed Lectures

... DILATED CARDIOMYOPATHIES (DCM) • Progressive cardiac dilation and contractile dysfunction • Enlarged, flabby, weight 2-3 times of normal • Mural thrombi emboli • Functional regurgitation of mitral/tricuspid valve • Myocytes: hypertrophied, Nuclei enlarged, irregular, stretched • Interstial and endo ...
Print This Information
Print This Information

... Right-sided heart failure means that the right side of the heart is not pumping blood to the lungs as well as normal. It is also called cor pulmonale or pulmonary heart disease. ...
4
4

... Pulmonary arterial hypertension (PH) eventually leads to right heart failure. The use of β-blockers is strongly discouraged in PH, because of their acute negative inotropic and chronotropic effects. However, use of β-blockers in chronic (left) heart failure is safe and significantly reduces mortalit ...
Malignant Arrhythmia as the First Manifestation of Wolff
Malignant Arrhythmia as the First Manifestation of Wolff

... Unfortunately, the rate of arrhythmia in the minimal preexcitation group has not been reported. In case of clinical suspicion of WPW, atrioventricular blocking agents such as adenosine which facilitates the antegrade conduction through AP during sinus rhythm can be used to expose delta waves on ECG. ...
Long-term mortality in older patients discharged after acute
Long-term mortality in older patients discharged after acute

... United States, and Israel [5, 7, 10, 11, 14], in keeping with the 41.7% rate in our ELISA cohort. Other studies obtained variable results. In a Scottish study, 1-year mortality rates were 49% and 56% in the groups aged 75–84 years and >84 years, respectively [4]. In contrast, several studies from Sp ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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