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057 Meta AT2
057 Meta AT2

... cardiovascular system producing progressive impairment of left ventricular structure and function as well as vascular damage.[5,7 – 11] ACEi are clearly beneficial for prognosis, even though doubts remain on optimal dosage and interactions with other drugs.[12 13] However, ACEi alone, even if at ful ...
PDF - Circulation: Arrhythmia and Electrophysiology
PDF - Circulation: Arrhythmia and Electrophysiology

... fascicular block, or single or double foci in the distal His purkinje system and also reentry.10,12,13 Recently, Ping-Pong mechanism or reciprocating bigeminy in the distal his purkinje system because of delayed after depolarization has been proposed as the mechanism for BVT. It was shown that when ...
ECG Filtering
ECG Filtering

... The electrocardiogram (ECG) is a time-varying signal reflecting the ionic current flow which causes the cardiac fibers to contract and subsequently relax. The surface ECG is obtained by recording the potential difference between two electrodes placed on the surface of the skin. A single normal cycle ...
Cardiac Physiology
Cardiac Physiology

... income, or foreclosure of a home may lead to a condition commonly referred to as broken heart syndrome. This condition may also be called Takotsubo cardiomyopathy, transient apical ballooning syndrome, apical ballooning cardiomyopathy, stress-induced cardiomyopathy, Gebrochenes-Herz syndrome, and st ...
Management of Transient Ischemic Attack (TIA)
Management of Transient Ischemic Attack (TIA)

... Scale to assess patient for signs/ symptoms of stroke. Rapidly assess from initial time of symptom onset (last know well time (LKW)) per patient and/or family. ...
Prognostic Significance of Post- Exercise Blood Pressure Response
Prognostic Significance of Post- Exercise Blood Pressure Response

... to be useful for predicting the outcome of patients with chronic heart failure secondary to dilated cardiomyopathy. Several mechanisms may be considered to explain this result. First, delayed decrease of cardiac output after exercise, due to the impairment of left ventricular function during exercis ...
Clinical Practice Guideline for Anticoagulation
Clinical Practice Guideline for Anticoagulation

... This guideline is to inform practitioners of the Standard of Care for evaluation and treatment of patients with atrial fibrillation, and is not intended to replace a practitioner’s judgment. Atrial fibrillation is the most common form of arrhythmia. Atrial fibrillation increases the risk of stroke b ...
cardiac outpatient rehabilitation (exercise training)
cardiac outpatient rehabilitation (exercise training)

... with protocols that vary in duration, intensity, and modalities across a variety of cardiac disorders. One study that addressed long-term outcomes after cardiac rehabilitation showed additional benefit to ongoing patient monitoring and counseling over a 4-year period for those with ischemic heart di ...
Print - Circulation
Print - Circulation

... We next studied transesophageal countershock in five unanesthetized patients (table 2). Fifty or 75 mg. of Demerol were given 1 hour before the procedure. The esophageal and precordial electrodes were located as in the first group. Each patient was given one shock. the intensity was 40 watt-seconds ...
Arrhythmic Sudden Cardiac Death: Substrate, Mechanisms and
Arrhythmic Sudden Cardiac Death: Substrate, Mechanisms and

... the infarcted myocardial zones. Such areas favour the development of re-entrant circuits and the initiation of monomorphic ventricular tachycardia. Lowamplitude, high-frequency currents located in the late segment of the QRS complex (late potentials) can be revealed and quantified with the SAECG sig ...
A Novel Noninvasive Device to Assess Sympathetic Nervous
A Novel Noninvasive Device to Assess Sympathetic Nervous

... (McFetridge-Durdle, Routledge, Parry, Dean, & Tucker, 2008). However, it has not been used clinically to assess sympathetic nervous system dysfunction in persons with heart failure with reduced ejection fraction (HFrEF), who are at high risk for cognitive and emotional decline, increased disability, ...
Brochure_Enterprise AED Solutions_3309482_C
Brochure_Enterprise AED Solutions_3309482_C

... What SCA is. What it can mean. During sudden cardiac arrest, the normally organized electrical impulses that initiate cardiac contraction (our heartbeats) discharge chaotically, and the heart muscle twitches spasmodically. There’s rarely any warning, and a victim of SCA usually collapses and stops ...
Abdelhamid Fathi Ali Radwan_New Microsoft Word Document
Abdelhamid Fathi Ali Radwan_New Microsoft Word Document

... significance was defined as a probability value equal to or less than 0.05. All analyses were performed with statistical package of MINITAB, release 12.1 for WINDOWS. Study design: The study is a prospective observational ...
8. and 9. Stroke Volume, Regulation of Stroke Volume, Cardiac output
8. and 9. Stroke Volume, Regulation of Stroke Volume, Cardiac output

... Discuss the role of the heart as the central pump of the cardiovascular system. Define cardiac output, cardiac reserve and venous return and relate venous return to cardiac output. State and describe the determinants of cardiac performance and explain how cardiac output is altered according to tissu ...
The Construction of a Volumetric Cardiac Model for Real-time ECG Simulation
The Construction of a Volumetric Cardiac Model for Real-time ECG Simulation

... six major parts, Figure 1. The voxels that define the SA and AV nodes are determined from the volumization process, and are typically represented by a single or small group of cells. However, the complicated network that follows the AV node could not be derived during volumization since a reasonable ...
The Function of an ECG in Diagnosing Heart Conditions
The Function of an ECG in Diagnosing Heart Conditions

... distinguishable waves of a normal ECG present. The peaks and valleys are seen again, however they are slightly larger. This is due to there being more ventricular cells than atrial cells. Thus in ventricular fibrillation, all of the autorhythmic cells of the ventricles are beating on their own witho ...
Rate or rhythm control for the patient twith atrial fibrillation?
Rate or rhythm control for the patient twith atrial fibrillation?

... conditions. Considerable effort is expended by the heart to maintain sinus rhythm. Cardiac electrophysiologists…are frustrated by the conundrum that atrial fibrillation is associated with increased morbidity and mortality, yet attempts to prove that a strategy to maintain nature’s rhythm has a favor ...
T The broken heart syndrome
T The broken heart syndrome

... Electrocardiographic features Patients with broken heart syndrome can present with a variety of electrocardiographic (ECG) findings. At the time of admission, the ECG can look normal, can have nonspecific ST- and T-wave changes, or can demonstrate Q waves and ST-segment elevation. In the original de ...
Pericardial Disease: Review Questions
Pericardial Disease: Review Questions

... is pathognomonic for pericarditis; however, its absence does not exclude the diagnosis. The sound typically has 3 components related to (1) atrial systole, (2) ventricular systole, and (3) ventricular diastole. The sound should be differentiated from a pleural rub, which although similar in quality ...
Arrhythmic risk stratification of post–myocardial infarction patients
Arrhythmic risk stratification of post–myocardial infarction patients

... Post–myocardial infarction risk stratification, especially arrhythmic risk stratification, is an issue that has still not been wholly addressed in modern clinical cardiology. In the past 10 years, arrhythmic risk stratification has been approached mainly by evaluating frequency and complexity of pre ...
209 Pathology C 601 Cardiac Disease Reading: Robbins: Chapter
209 Pathology C 601 Cardiac Disease Reading: Robbins: Chapter

Presentation Slides - AAFP Learning Link
Presentation Slides - AAFP Learning Link

... None noted in the prescribing information ...
Cardiac Arrest in the Athlete
Cardiac Arrest in the Athlete

... “The unexpected death of an athlete during exercise is tragic irony. ... much remains unknown regarding optimal screening strategies, pathophysiologic mechanisms,and prevention” Mark Link, MD Tufts University ...
Heart Center 2011 Annual report covers
Heart Center 2011 Annual report covers

... the cutting-edge belief that patients can go from ambulance to the catheterization lab in minutes if ST-elevation exists, saving myocardium and leading to survival rates not thought imaginable 10 years ago. A strong heart failure team has enrolled more than 1,000 patients. Our goal is to combine the ...
How to diagnose heart failure with preserved ejection fraction
How to diagnose heart failure with preserved ejection fraction

... BNP: B-type natriuretic peptide; DD: diastolic dysfunction; HFpEF: heart failure with preserved ejection fraction; LV: left ventricular acute episode of heart failure, and most have normal LV filling pressure at rest. They tend to be old, and have comorbidities that may also explain their symptoms, ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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