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Occurring During Cardiac Catheterization
Occurring During Cardiac Catheterization

... measurement of the QRS-to-retrograde P interval; the onset of activation may be recorded better in some leads than in others.9 Some of the records were obtained with an Electronics for Medicine DR-8 photographic recorder. Others ...
Document
Document

... DFT testing was a critical part of the implant procedure when ICD technology was less mature in its application and is still considered to prove the clinical effectiveness of an implanted system. There is debate about the need for an assessment of defibrillation efficacy at the time of device imp ...
Key messages - acute coronary syndrome
Key messages - acute coronary syndrome

... The cell responsible for the overgrowth of connective tissue associated with atheroma is the arterial smooth muscle cell which normally resides in the media. These cells exist in one of two phenotypes, dependent on the local chemical environment (cytokine mediated). These are referred to as 'contrac ...
Atrial_Fibrillation
Atrial_Fibrillation

... The irregular ventricular contractions cause the systolic arterial pressure to vary from beat to beat as ventricular filling time changes. The pulse pressure also may vary from beat to beat because the diastolic runoff time varies from beat to beat. Atrial fibrillation often involves microreentry. A ...
Cardiac Muscle Contraction
Cardiac Muscle Contraction

... The contraction of the heart is called systole and the relaxation, diastole; the final e is a separate syllable in both terms. The left and right sides of the heart beat in unison. Atrial systole occurs just before ventricular systole and the atria are in diastole when ventricular systole is occurri ...
Market Analysis of Cardiac Electrical Mapping
Market Analysis of Cardiac Electrical Mapping

... systemic circuit carries blood to and from the rest of the body. The heart is the driving force for both these circuits. The heart is composed of four chambers – the right atrium, the right ventricle, the left atrium and the left ventricle. The pulmonary circuit transport blood using the right side ...
Multiple Cerebral Aneurysms and Brain Metastasis from Primary
Multiple Cerebral Aneurysms and Brain Metastasis from Primary

... positive staining for smooth muscle actin and HHF35, and focally for desmin. Stainings for myoglobulin, myogenin, myo D1, S100, CD31, CD34, and calretinin were negative. The diagnosis was consistent with myxosarcoma (Fig. 1). Postoperatively, the patient received radiotherapy (4500 cGy/25 fractions) ...
Normal Sinus Rhythm
Normal Sinus Rhythm

... • May be seen in individuals with high vagal tone especial during sleep. • Where it occurs in complication of inferior MI, it does not usually require a pacemaker and often may be reversed with myocardial reperfusion. © Hayley Coxon 2014 ...
Artificial Pacemakers - McMaster University > ECE
Artificial Pacemakers - McMaster University > ECE

... Autorhythmic fibers are specialized cardiac muscle cells that cause an inherent and rhythmical electrical activity in the heart Autorhythmic fibers are self excitable- they simulate contraction without a requisite electrical impulse from the central nervous ...
Peds 819 TF - Heart Volunteer
Peds 819 TF - Heart Volunteer

... For the critical outcome of survival to hospital discharge, we have identified no clinical evidence that a specific anesthetic in patients with dilated cardiomyopathy shows benefit. The incidence of cardiac arrest in patient with DCM undergoing procedural anesthesia is relatively low (1.7%). (Lynch, ...
Right Ventricular Failure in Patients With Preserved Ejection
Right Ventricular Failure in Patients With Preserved Ejection

... venous vasoconstrictor, binds to the of pulmonary hypertension. It was right ventricle. This leads to a reducendothelin receptor on smooth muscle shown that pulmonary hypertension tion in wall stress for any given intracells, which leads to vasoconstriction in patients with LV dysfunction is not cav ...
The New England Journal of Medicine
The New England Journal of Medicine

... Randomized Aldactone Evaluation Study (RALES) to test the hypothesis that daily treatment with 25 mg of spironolactone would significantly reduce the risk of death from all causes among patients who had severe heart failure as a result of systolic left ventricular dysfunction and who were receiving ...
Slides from Galen - Scientific Computing and Imaging Institute
Slides from Galen - Scientific Computing and Imaging Institute

... Wagner et al – Durham NC ...
5 HOW TO READ AN EKG
5 HOW TO READ AN EKG

... seconds. The PR interval is measured from the start of the P wave to the start of Q wave. It represents the duration of atria depolarization. Normal duration is from 0.12 to 0.20 seconds. If the PR interval is greater than 200 milliseconds, then an AV block might be present. QRS Duration: Ventricula ...
presentation source
presentation source

... because it inhibits the enzyme phosphodiesterase, which caused a build up of cyclic AMP. This build up excited the sympathetic nerves in the heart and increased the heart rate. ...
Systemic Scleroderma with Complete Heart Block
Systemic Scleroderma with Complete Heart Block

... extrasystoles (Fig. 2). The heart rate varied between 40-70 beats per minute during this period. Over the following week she experienced numerous StokesAdams attacks. Response to ephedrine was unsatisfactory. Syncopal attacks became less ...
Large Right Ventricular Thrombus
Large Right Ventricular Thrombus

Unfavourable Effects of Continuous, Atrial
Unfavourable Effects of Continuous, Atrial

... heart failure did not differ between the patient groups. Other studies failed to demonstrate significant haemodynamic or functional changes induced by VP that would imply that VP predisposes to heart failure development in patients with normal LV systolic function.8-10 In particular, the issue of th ...
Mixed venous oxygen saturation predicts short-
Mixed venous oxygen saturation predicts short-

... subgroups with or without treatment for intraoperative heart failure. Methods: 2755 consecutive CABG patients and subgroups consisting of 344 patients with and 2411 patients without history of intraoperative heart failure respectively were investigated. SvO2 was routinely measured on admission to th ...
Guideline for the Management of Heart Failure Caused
Guideline for the Management of Heart Failure Caused

... †—The guidelines agree on the administration of beta blockers to all patients with symptoms, except those who are having symptoms at rest. In addition, the guidelines agree that beta blockers should not be given to patients having symptoms at rest, pending the completion of ongoing trials. The Unive ...
ChaP te r 1 General introduction 1 2
ChaP te r 1 General introduction 1 2

... (TNO/BMI). All these three pulse contour methods utilize an invasively measured arterial blood pressure and need to be calibrated to increase the accuracy of flow prediction. Recalibrating every 4 hours (or at least before any important data acquisition) may augment the accuracy of pulse contour est ...
Secondary Prevention of Coronary Artery Disease
Secondary Prevention of Coronary Artery Disease

... stratification by exercise stress testing with left ventricular functional assessment or radionuclide myocardial perfusion imaging to identify who would benefit from surgical intervention.23 The role of PCI in the secondary prevention of CAD is limited. Clinical trials involving patients with stable ...
Factors Influencing Repolarization
Factors Influencing Repolarization

... is certainly one of the most common reasons for QT prolongation. It has been shown that food intake will seriously influence QT/QTc duration either. This relates to the influence by a shift in electrolytes, water, serum glucosis/insulin and fatty acids, which in turn impact on the regulation of the ...
What is Heart Failure? - National Forum for Heart Disease and
What is Heart Failure? - National Forum for Heart Disease and

... Heart failure symptoms usually develop over weeks and months as your heart becomes weaker and less able to pump the blood that your body needs. Heart failure usually results in an enlarged heart (left ventricle). ...
Percutaneous left ventricular assist devices in acute
Percutaneous left ventricular assist devices in acute

... after standard transseptal puncture and pre-dilatation of the fossa ovalis, a venous inflow cannula is inserted into the left atrium (Figure 5). Afterwards an arterial cannula (usually 17 French) needs to be inserted into the femoral artery. Once all air has been removed from the system, the cannulae ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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