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Mitral valve repair for heart failure
Mitral valve repair for heart failure

... •Refractory right heart failure, severe PHT • Cardiac cachexia ...
The preoperative assessment of patients with valvular heart disease
The preoperative assessment of patients with valvular heart disease

... As the mitral orifice narrows the pressure gradient between the left atrium and the left ventricle must increase to maintain adequate flow across the stenotic MV causing left atrium dilatation, while the left ventricle is small, poorly filled with the normal function. Increasing the pressure in the ...
function in uraemia: echocardiographic evidence ofa specific
function in uraemia: echocardiographic evidence ofa specific

... was done twice, and the average of the results obtained over three consecutive cardiac cycles Patients and methods Sixty four patients receiving haemodialysis was used. Blood pressure was measured before and long term for chronic renal failure underwent echocardiographic and doppler assessment as af ...
Titin:a stiff proposal
Titin:a stiff proposal

... subsequently reduced diastolic filling capacities of the heart ventricles. Because titin greatly contributes to cardiac wall stiffness, and because phosphorylation can reduce this, we are looking into therapeutic approaches which target titin, or enzymes that phosphorylate this protein. Reducing thi ...
relatively inactive adults - British Journal of Sports Medicine
relatively inactive adults - British Journal of Sports Medicine

PTCA and Thrombolytic Therapy in Myocardial Infarction
PTCA and Thrombolytic Therapy in Myocardial Infarction

... out to the body and lungs. • Low ejection fractions if known can help guide therapy ...
Eisenmenger syndrome in an adult patient with a large patent
Eisenmenger syndrome in an adult patient with a large patent

... patients has now been confirmed in large registries [31]. There is also evidence of a beneficial effect of advanced therapies on survival from a single centre retrospective study [32]. Data are still lacking on the optimal mode of following Eisenmenger patients in terms of assessing the need for sta ...
COPD, CHF, Capnography, VADs
COPD, CHF, Capnography, VADs

... • Chronic condition; develops over time; causes difficulty for the heart to function as a forward pump – Less blood is pumped = less oxygen distributed – Blood may back-up – Oxygen supply decreases in muscle and lung tissues ...
Pathogenic Gut Flora in Patients With
Pathogenic Gut Flora in Patients With

... that the CHF intestine may be colonized by more ...
Imaging Pediatric Cardiomyopathies and Myocarditis
Imaging Pediatric Cardiomyopathies and Myocarditis

... conditions (valvular regurgitation) or ischemic heart disease • Unclear etiology – genetic, viral, metabolic or toxic • Progressive interstitial fibrosis with wall thinning – progressive heart failure • MRI considered the best, most accurate imaging technique to follow ventricular size, function and ...
Detection and management of preclinical heart failure
Detection and management of preclinical heart failure

... Study of Survival and Ventricular Enlargement Trial ...
ECG Analysis - Antrim ED Meducation
ECG Analysis - Antrim ED Meducation

... II, with some variation in lead III. Lead II will have the most positive deflection because it is situated in a similar direction to the normal electrical activity of the heart Applying knowledge of these lead positions can help determine what area of the heart is being affected in an abnormal ECG F ...
Outcome of surgical repair of atrial septal defect in adult age group
Outcome of surgical repair of atrial septal defect in adult age group

... Introduction: Surgical closure of an atrial septal defect (ASD) before the age of 30 years has been demonstrated to reduce complications during adulthood. However, the outcome of patients operated after the age of 30 is still debated. Methods: In a prospective study we examined the outcome of surgic ...
Surgical Management of Traumatic Aorta
Surgical Management of Traumatic Aorta

... admission. Chest X-ray showed slightly increased pulmonary blood flow and cardiomegaly. ECG showed left ventricular hypertrophy with normal sinus rhythm. Echocardiography revealed enlarged left ventricule and shunt flow from the right sinus of valsalva to the RVOT with moderate aortic regurgitation ...
Preoperative Evaluation of the Patient With Hypertension
Preoperative Evaluation of the Patient With Hypertension

... secutive adult patients undergoing noncardiac surgery were not able to identify hypertension as a predictor of cardiovascular complications.8,9 There are several issues in interpreting these results. These studies acknowledge the absence of patients with diastolic BPs of more than 110 mm Hg, limitin ...
SURESCAN MRI CHECKLIST
SURESCAN MRI CHECKLIST

Accuracy of natriuretic peptides levels in the diagnosis of left
Accuracy of natriuretic peptides levels in the diagnosis of left

... Nowadays, heart failure, such as left ventricular dysfunction (LVD), is a major health problem, especially in developed countries, where it is associated with coronary artery disease, obesity and hypertension [2]. HF is the most common cause of hospitalization due to cardiovascular disease in patien ...
Radiofrequency catheter ablation of ventricular tachycardia in
Radiofrequency catheter ablation of ventricular tachycardia in

... This study shows that catheter ablation of VT in patients with structural heart disease is associated with high acute procedural success and good intermediateterm outcomes. In their study on patient with ARVD/C, Ellison et al. [4] did not observe any recurrence of VT during a mean follow-up of 17 mo ...
Disclaimer
Disclaimer

... parasympathetic function in the control group. This is consistent with others studies that have found similar results. Evrengul et al. (9) showed reduced high frequency power in 38 patients with CAD compared to controls and a reduction in PNN50 (a marker of parasympathetic activity). Interestingly, ...
Haemodynamic Alterations Induced By Cardiac Pacing: Is Clinical
Haemodynamic Alterations Induced By Cardiac Pacing: Is Clinical

... In a small group of 43 patients who were chronically paced due to complete AV block exercise myocardial scintigraphy was performed to assess myocardial perfusion in combination with radionuclide ventriculography to assess left ventricular function.4 This study revealed a relevant incidence of myocar ...
Solid Tumour Section Heart: Cardiac Myxoma Atlas of Genetics and Cytogenetics
Solid Tumour Section Heart: Cardiac Myxoma Atlas of Genetics and Cytogenetics

... with a left atrial tumour. Consequently, the differential diagnosis in cases of peripheral embolism must include cardiac myxoma. Emboli are typically derived from tumour fragments, detachment of the tumour as a whole, overlying thrombi or foci of infection, and have been reported in every organ syst ...
Cardiovascular Conditions: The Therapeutic Use of Beta
Cardiovascular Conditions: The Therapeutic Use of Beta

... CARDIOVASCULAR CONDITIONS: THE THERAPEUTIC USE OF BETA-BLOCKERS IN ATHLETES ...
Diagnostic value of cardiac computed tomography angiography in
Diagnostic value of cardiac computed tomography angiography in

... patients with LBBB is common (either reversible or fixed), but is not necessarily due to CAD. Normal CCTA is known to have excellent negative predictive value and acts as a filter for further cardiac testing or imaging. Vasodilator SPECT is more accurate than exercise in excluding left anterior desc ...
Coronary Artery Bypass Surgery in Left Main Disease
Coronary Artery Bypass Surgery in Left Main Disease

... Pulmonary hypertension and its most consequence, RV dysfunction, are important mortality risk factors in cardiac surgery. In the case we report which therapy with prostaglandin (alprostadil) has been effective in allowing weaning post-operative conditions of right ventricular failure with pulmonary ...
Patients - St. Jude Medical
Patients - St. Jude Medical

... including potential clinical successes, anticipated regulatory approvals and future product launches, and projected revenues, margins, earnings, market sizes and market shares. The statements made by the Company are based upon management’s current expectations and are subject to certain risks and un ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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