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The Cardiac Cycle - Dr. Salah A. Martin
The Cardiac Cycle - Dr. Salah A. Martin

... Page 1. Introduction • The cardiac cycle includes all the events related to the flow of blood through the heart during one complete heartbeat. Page 2. Goals • To list the phases of the cardiac cycle in consecutive order. • To recognize that the pressure changes determine valve action and direction o ...
Reptile Cardiology - University of Illinois College of Veterinary
Reptile Cardiology - University of Illinois College of Veterinary

... study with red-eared sliders (Trachemys scripta elegans), this repolarization phase was very prolonged, with QT intervals of 1.41 seconds and a mean R-R interval of 2.38 seconds.15 A shortened TP interval was also reported, and represented one-quarter of the cardiac cycle. The ST interval, which was ...
1 Cardiac Electrical Activity
1 Cardiac Electrical Activity

... along the left septal endocardial surface and toward the two papillary muscles of the mitral valve. The right bundle branch remains compact until it reaches the right distal septal surface, where it branches into the interventricular septum and toward the free wall of the right ventricle. These intr ...
Media Packet - Simon`s Fund
Media Packet - Simon`s Fund

... • Innovation. There are so many questions and a void of research and resources around the study of SCA in youth. What is “normal” for a child’s heart? How many children have undetected heart conditions? ...
Lecture 14 - CV Pump physiology
Lecture 14 - CV Pump physiology

... – The Pressure in the Ventricle is the same as in the great veins – The Ventricle contracts – The AV valves close – Since the Aortic and Pulmonic valves were already closed, the heart is a closed ball – As the heart contracts, the pressure in the ball rises at a fixed volume. ...
Putting Out the Fire Shadwan Alsafwah, MD Staff Support: Dr. Richard Davis
Putting Out the Fire Shadwan Alsafwah, MD Staff Support: Dr. Richard Davis

... • There was no difference in the primary end point between placebo (17.9%) and either the pooled adenosine dose groups (16.3%) or, separately, the 50-μg/kg/min dose and 70μg/kg/min groups (16.5% vs. 16.1%, respectively, p = 0.43) • likely explanation for failure of the trial to demonstrate a clinica ...
PowerPoint Presentation - Aucun titre de diapositive
PowerPoint Presentation - Aucun titre de diapositive

... b) Diagnostic Holter • Negative test does not rule out atrial fibrillation • Holter is often insufficient to diagnose paroxysmal atrial fibrillation • Cardiac loop monitor over 7 days or 2 weeks is better; documents arrhythmia, assesses rate control, assesses episodes of bradycardia ...
Some Haemodynamic Effects of Compound AH
Some Haemodynamic Effects of Compound AH

... The hypotensive effect of compound AH 5158 ( n = 12) developed over 15 min and was usually maximal within 30 min. The average systolic pressure fell from its initial value of 176 (SD 31) mmHg to 146 (SD 23) mmHg, with the diastolic pressure falling from 1 13 (SD 19) mmHg to 92 (sD 18) mmHg. The mean ...
An Experimental Study of 3-dimensional Cardiac Electrical Imaging
An Experimental Study of 3-dimensional Cardiac Electrical Imaging

... averaged localization error of the initiation site at RVA was 7.9±0.7 mm, and 6.9±1.9 mm at LVAn. Figure 1 shows an example of the imaging results when the pig was paced from the LV anterior. The activation sequence (AS) on the endocardium of LV is shown in panel (a) from three viewing angles: RAO, ...
A Clinical Randomized Trial to Evaluate the Safety
A Clinical Randomized Trial to Evaluate the Safety

... small observational, noncontrolled studies and expert opinion (4,5). The usefulness of the strategy of prophylactic revascularization was not confirmed by the recently completed CARP (Coronary Artery Revascularization Prophylaxis) randomized trial (6). In this trial, the incidence of perioperative m ...
Free PDF - European Review for Medical and
Free PDF - European Review for Medical and

... causative factor71. Patients with TICM do not present with symptoms from AF and only present clinically with systolic HF due to declining ejection fractions from uncontrolled rapid rates that often occur for weeks or months45, and many patients mistakenly attribute their symptoms to pneumonia or an ...
Electrocardiogram Events Detection
Electrocardiogram Events Detection

... skin to an instrument (electrocardiograph) that detects the electrical changes in the heart. When the sinoatrial node sends an impulse the atrial fibers generate an electrical change that is called the P wave, as depicted in Fig. 1. This wave provides information that the auricle are about to contra ...
ACHD-Pacemakers-and
ACHD-Pacemakers-and

... together to perform two main functions: pacing and sensing. ¾ Pacing is when a pacemaker sends tiny electrical signals to the heart through a pacing lead. ¾ Each tiny electrical signal is called a pacing pulse (pacing impulse, pace) and it is this pacing pulse that starts a heartbeat. ¾ The pacemake ...
Mechanical Dyssynchrony Precedes QRS Widening in ATPSensitive
Mechanical Dyssynchrony Precedes QRS Widening in ATPSensitive

... and time-to-peak strain (VevoStrain, VisualSonics).16 The endocardium was traced with 48 sampling points within a 3.4- to 20-mm length (70- to 400-lm intervals), dividing the left ventricle into 6 segments. Strain was defined as change in length during myocardial contraction and relaxation. Peak stra ...
Peer-reviewed Article PDF - e
Peer-reviewed Article PDF - e

... Institute catheterization lab registry with IRB approval. Patients with STEMI that were either directly admitted to the hospital or transferred from the satellite campus for primary PCI were included. NSTEMI patients who experienced acute anginal type chest pain within 48 hours of admission, had pos ...
Can heart rate variation rule out sleep-
Can heart rate variation rule out sleep-

... extensively developed and described in a previous study by ROCHE et al. [13]. For analysis of HRV it was necessary to exclude patients who had atrial fibrillation (n518). In addition ECG traces in which there were extensive periods of ventricular pacing (n52), frequent atrial/ventricular ectopics .1 ...
Mechanical Dyssynchrony Precedes QRS Widening in ATPSensitive
Mechanical Dyssynchrony Precedes QRS Widening in ATPSensitive

Congenital Heart Disease - Cleveland Clinic Center for Continuing
Congenital Heart Disease - Cleveland Clinic Center for Continuing

... surgical repair of native discrete coarctation should be determined by consultation with a team of ACHD cardiologists, interventionalists, and surgeons at an ...
A client has been admitted to the hospital for UTI and dehydration
A client has been admitted to the hospital for UTI and dehydration

... Chamber of the heart receiving blood from systemic circulation: Right atrium __________ is the pressure generated at the end of the diastole: Pre-load Pressure in Left ventricle must exceed pressure in __________ before the Left ventricle can eject blood: Aorta Multiplying heart rate by stroke volum ...
Syncope in Small-Breed Dogs
Syncope in Small-Breed Dogs

... How to Proceed 1. The history is important in patients that present with collapse. Distinguishing syncope from seizure can be difficult. Features that often distinguish these two conditions are the precipitants of the episode, prodromal behavioral changes, clinical signs that occur during the episod ...
Cardiopulmonary Resuscitation: Current Status
Cardiopulmonary Resuscitation: Current Status

... be re-established from the sinus node. The current delivered to the heart is determined by both the energy level chosen (J) and the transthoracic impedance present. For example, the use of bare paddles without a couplant (eg, gel, cream) results in very high transthoracic impedance; impedance can be ...
Factors Affecting the Cardiac Cycle
Factors Affecting the Cardiac Cycle

... it beats, and note the sequence of chamber movements during a cardiac cycle. 2. Tie a piece of thread about 45 cm long to a small metal hook, and insert the hook into the tip (apex) of the ventricle without penetrating the chamber (fig. S-3.2). The laboratory instructor will demonstrate how to co ...
Atrioventricular Nodal Reentrant Tachycardia in a Patient with
Atrioventricular Nodal Reentrant Tachycardia in a Patient with

... stimulation showed no inducible AVNRT despite persistence of slow pathway conduction. Measurement of the intracardiac intervals at the end of the study showed an AH of 108 ms and HV of 58 ms. At this point the procedure was terminated and the patient made an uneventful recovery. Exercise testing 2 m ...
EKG Update
EKG Update

... node, has narrow complex. Associated with inferior MI. Look for group beating due to shortening of RR interval. Non-conducted P wave is < 2 RR. 2nd strip: Mobitz 2. PR unchanged with dropped QRS. Block is in His and may have wide complex. Associated with anterior MI. atropine 3rd strip: 2:1. Could b ...
Incidental finding of a large pulmonary valve fibroelastoma: A case
Incidental finding of a large pulmonary valve fibroelastoma: A case

... obstruction resulting in cerebral vascular accidents, pulmonary embolism and myocardial infarction.5 It is now suggested that all PFE, regardless of size and location, should be resected to avoid embolic or occlusive-related complications.1,6,7 To ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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