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Left ventricular dyssynergy and dispersion as determinant factors of
Left ventricular dyssynergy and dispersion as determinant factors of

... Heart failure (HF) patients with severely reduced left ventricular (LV) ejection fraction (EF) are at high risk of fatal ventricular arrhythmias, and their condition is associated with worsening of long-term outcome. Such patients can die suddenly and unpredictably from malignant arrhythmias despite ...
Automated external defibrillators: What`s established? What`s new?
Automated external defibrillators: What`s established? What`s new?

... Approximately 1.000 people in the United States suffer from cardiac arrest each day, ...
Blood Pressure and Heart Rate Variability
Blood Pressure and Heart Rate Variability

... al. 1990). Regardless of the underlying mechanism(s), an increase in HRV in the HF spectrum indicates improved neural control of heart rate while on NPPV. In order to determine the exact role of different potential mechanisms involved in the observed increases in parasympathetic regulation of heart ...
The Cardiac Cycle
The Cardiac Cycle

... Page 1. Introduction • The cardiac cycle includes all the events related to the flow of blood through the heart during one complete heartbeat. Page 2. Goals • To list the phases of the cardiac cycle in consecutive order. • To recognize that the pressure changes determine valve action and direction o ...
File
File

... fraction of the wall thickness involved. Half of the deaths associated with acute MI occur within 1 hour of onset, most commonly due to a fatal arrhythmia. anterior transmural infarcts are at greatest risk for free-wall rupture, expansion, mural thrombi, and aneurysm. In contrast, posterior transmur ...
Progressive improvement in hemodynamic response to muscle
Progressive improvement in hemodynamic response to muscle

... muscle alterations that aggravate cardiac dysfunction by activation of nervous reflexes arising from muscle (6, 7, 29). According to the muscle hypothesis, one possible explanation for CHF symptoms is an exaggerated activity of muscle metaboreflex that takes place in response to underperfusion of co ...
AtriAl FibrillAtion - Life Line Screening
AtriAl FibrillAtion - Life Line Screening

... What are the Risks of Atrial Fibrillation? The main risk associated with AF is stroke. This occurs because the atria are fibrillating and not beating in a coordinated way. This may increase the risk of blood clots because when the heart beats irregularly, the blood does not flow properly through the ...
Diapositivo 1
Diapositivo 1

... • Identifying AMI signals (retrosternal discomfort or dyspnea, for example) with subsequent activation of the emergency number is the first step towards a speedy and effective action leading to a reduction of injuries and consequent harm to the patient. ...
evaluation and family history in the pre
evaluation and family history in the pre

... the USA may be 2–4 times greater than initial estimates and is supported by studies having a mandatory reporting system for SCA. Eckart and colleagues reported on 126 non-traumatic sudden deaths in US military recruits (median age 19, range 18– 35 years) and found the incidence of exercise-related S ...
Pericardium
Pericardium

... Cardiac Chambers Structure of the Heart Conduction System ...
Full Article - Medical Ultrasonography Journal
Full Article - Medical Ultrasonography Journal

... trajectory to the posterior, thus the two vessels cross each other in an angle which is almost right. The ramification of the pulmonary artery occurs immediately after having left the RV, serving for its differentiation from the aorta. If this crossing does not exist and the two arteries are paralle ...
Investigation and management of congestive heart failure
Investigation and management of congestive heart failure

... Fluid retention may be present in patients who have dyspnoea, an increase in weight from baseline of more than 2 kg in under three days, raised jugular venous pressure, crepitations on chest auscultation, hepatomegaly, or signs of peripheral oedema. Exercise tolerance The degree of exertion needed t ...
ecG in non cardiac Disorders - The Association of Physicians of India
ecG in non cardiac Disorders - The Association of Physicians of India

... The electrocardiogram (ECG) is still the basic cardiologic test and is widely applied in patients with suspected or known heart disease as a basic reference. However, ECG abnormalities can be present in a wide variety of noncardiac conditions like electrolyte abnormalities, pulmonary embolism, CNS d ...
Acute coronary syndromes and atrial fibrillation
Acute coronary syndromes and atrial fibrillation

... atrial fibrillation was associated with increased risk of inhospital and long-term mortality, irrespective of the time of occurrence, i.e., whether it was new onset or chronic.3 However, in a different meta-analysis, new onset atrial fibrillation in patients with acute myocardial infarction was asso ...
Congenitally Corrected Transposition of the Great Arteries (CCTGA)
Congenitally Corrected Transposition of the Great Arteries (CCTGA)

... of new heart symptoms that lead to a diagnosis of CCTGA. Sometimes it is found accidentally when routine heart tests are done. Echocardiography can be used to diagnose CCTGA in adulthood. But the heart’s unusual shape makes imaging CCTGA difficult. Many doctors now prefer cardiac MRI (magnetic reson ...
Brain natriuretic peptide: is it a predictor of
Brain natriuretic peptide: is it a predictor of

... cardiomyopathy may be aggravated by sodium retention in cirrhosis, with increases in total and central blood volumes. Therefore early detection and intervention may prove beneficial for these patients. A clinical diagnosis of cirrhotic cardiomyopathy is often not made, since the signs of cardiac dys ...
Rhythm management devices
Rhythm management devices

... III. Dual-chamber pacing is helpful in maintaining physiologic timing between atrial and ventricular systole. I. When ventricular pacing alone is used, this physiologic timing is lost. In some patients the loss of timed atrial contractions causes a marked reduction in cardiac output. II. Dual-chambe ...
Left Ventricular Filling Pressure Assessment Using Left Atrial Transit
Left Ventricular Filling Pressure Assessment Using Left Atrial Transit

... Background—Left atrial (LA) size and function reflect left ventricular (LV) hemodynamics. In the present study, we developed a novel method to determine LA circulation transit time (LATT) by MRI and demonstrated its close association with LV filling pressure. Methods and Results—All subjects were pr ...
Diastolic heart dysfunction, increased pulmonary capillary wedge
Diastolic heart dysfunction, increased pulmonary capillary wedge

... from myocardial fibrosis. However, the role of myocardial ischaemia is also important. The diastolic function of the myocardium is very sensitive to ischaemia [22]. Even small regions of low-perfused myocardium may aggravate diastolic dysfunction resulting from fibrosis. An important finding was tha ...
ECG Interpretation
ECG Interpretation

Characteristics and outcome among patients having out of
Characteristics and outcome among patients having out of

... home—was still a strong independent predictor of an adverse outcome. This is in agreement with previous observations16 and suggests that there are other factors which we did not incorporate in the multivariate model that explain at least part of the adverse outcome among these patients. Such factors ...
Understanding the Heart Defect PFO
Understanding the Heart Defect PFO

... problems in most patients, undergoing surgery to possibly prevent migraines and/or stroke usually isn’t worth the risk. In a few cases, where patients have already suffered a confirmed cryptogenic stroke without any other possible cause, closing a PFO may be a viable option to prevent future strokes ...
Jemds.com
Jemds.com

... levels were associated with Massive Adverse Cardiac Events (MACE) like Cardiac Arrhythmias, Cardiac Blocks, Cardiogenic Shock, Cardiac Failure, etc. The correlation between the higher levels of Serum Neopterin more than 25 nmol/litre and the occurrence of MACE in the patients was statistically signi ...
Hawthorn (Crataegus laevigata, C. oxyacantha, C. monogyna, C
Hawthorn (Crataegus laevigata, C. oxyacantha, C. monogyna, C

... cardiovascular disease, dating back to the 1st Century. Modern day animal and in vitro studies suggest that flavonoids and other pharmacologically active compounds found in hawthorn may synergistically improve performance of the damaged myocardium, and further, may prevent or reduce symptoms of coro ...
Takayasus arteritis presenting with dilated cardiomyopathy – a rare
Takayasus arteritis presenting with dilated cardiomyopathy – a rare

... weakened and enlarged and cannot pump blood efficiently. The decreased heart function can affect the lungs, liver, and other body systems.[1] In DCM, a portion of the myocardium is dilated, often without any obvious cause. Left ventricular (LV) or right ventricular systolic pump function of the hear ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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