Inadequate Treatment of Congestive Heart Failure in
... Data on ACE inhibitors and beta-blockers in the general population: Since very limited evidence from properly executed RCTs is available for the treatment of CHF in ESRD patients, physicians have to rely on the evidence obtained in the general population. In “non-renal” patients, compelling data are ...
... Data on ACE inhibitors and beta-blockers in the general population: Since very limited evidence from properly executed RCTs is available for the treatment of CHF in ESRD patients, physicians have to rely on the evidence obtained in the general population. In “non-renal” patients, compelling data are ...
Normal cardiac function in mice with supraphysiological - AJP
... effect in murine models of global cardiac ischemia and hypertension-induced heart failure (1, 14). Cardiomyocytes are not capable of Cr synthesis and depend on transport from the extracellular environment by the creatine transporter (CrT) to maintain an adequate intracellular Cr pool. CrT function i ...
... effect in murine models of global cardiac ischemia and hypertension-induced heart failure (1, 14). Cardiomyocytes are not capable of Cr synthesis and depend on transport from the extracellular environment by the creatine transporter (CrT) to maintain an adequate intracellular Cr pool. CrT function i ...
Pregnancy and Heart Disease
... There may be an abrupt decrease in afterload as the baby is delivered, and hypovolemia from blood loss can cause hypoxia, syncope, and sudden death. Vagal responses to pain may also be lifethreatening. Death may also occur from pulmonary embolism or in situ pulmonary infarction ...
... There may be an abrupt decrease in afterload as the baby is delivered, and hypovolemia from blood loss can cause hypoxia, syncope, and sudden death. Vagal responses to pain may also be lifethreatening. Death may also occur from pulmonary embolism or in situ pulmonary infarction ...
Dynamic Left Ventricular Outflow Tract Obstruction with Cardiogenic
... multivessel epicardial or microvascular spasm and dynamic LVOT obstruction were also documented.10 From these studies, we did note that the ABS always recovered completely in two to four weeks. However, there were complications observed in some studies, such as cardiogenic shock, congestive heart fa ...
... multivessel epicardial or microvascular spasm and dynamic LVOT obstruction were also documented.10 From these studies, we did note that the ABS always recovered completely in two to four weeks. However, there were complications observed in some studies, such as cardiogenic shock, congestive heart fa ...
Elevated sympathetic nervous system activity in patients with
... in reaction to standardized tasks. However, ANS activity in the natural environment may better reflect the common state than responses to laboratory stressors. Moreover, except for one study (18), autonomic nervous activity was studied in patients with longstanding RA. In such patients ANS function ...
... in reaction to standardized tasks. However, ANS activity in the natural environment may better reflect the common state than responses to laboratory stressors. Moreover, except for one study (18), autonomic nervous activity was studied in patients with longstanding RA. In such patients ANS function ...
slides
... cross-sectional diameter measured at 21 mm • Baffle pressure normal at 8 mmHg throughout ...
... cross-sectional diameter measured at 21 mm • Baffle pressure normal at 8 mmHg throughout ...
Risk Stratification and Outcome of Patients With
... (n=133, 31%), including a substantial proportion from noncardiac disease (n=54). Sixteen patients (3.7%) had HCMrelated mortality events (0.64%/y), including embolic stroke (n=6), progressive heart failure or transplantation (n=3), postoperative complications (n=2), and arrhythmic sudden death event ...
... (n=133, 31%), including a substantial proportion from noncardiac disease (n=54). Sixteen patients (3.7%) had HCMrelated mortality events (0.64%/y), including embolic stroke (n=6), progressive heart failure or transplantation (n=3), postoperative complications (n=2), and arrhythmic sudden death event ...
Radiation-induced valvular heart disease
... the severity of valve dysfunction increased over time in 56% of their cohort with valvular heart disease. Left ventricular myocardial systolic impairment is relatively common in patients exposed to mediastinal radiotherapy. Heidenreich et al14 found 36% of patients had evidence of left ventricular s ...
... the severity of valve dysfunction increased over time in 56% of their cohort with valvular heart disease. Left ventricular myocardial systolic impairment is relatively common in patients exposed to mediastinal radiotherapy. Heidenreich et al14 found 36% of patients had evidence of left ventricular s ...
NON-VALVULAR ATRIAL FIBRILLATION AND STROKE
... associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it. Five trials have established the safety of warfarin in reducing the risk by 70% in well selected Thromboembolism, cardiac failure, patients, with ...
... associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it. Five trials have established the safety of warfarin in reducing the risk by 70% in well selected Thromboembolism, cardiac failure, patients, with ...
082301 prognostic Importance of Elevated Jugular Venous
... trial has been described in detail previously.8,9 A total of 2569 patients with symptomatic congestive heart failure or a history of it and a left ventricular ejection fraction of 0.35 or less were randomly assigned to receive enalapril or placebo. Patients were enrolled from June 1986 to March 1989 ...
... trial has been described in detail previously.8,9 A total of 2569 patients with symptomatic congestive heart failure or a history of it and a left ventricular ejection fraction of 0.35 or less were randomly assigned to receive enalapril or placebo. Patients were enrolled from June 1986 to March 1989 ...
Impact of impaired myocardial deformations on exercise tolerance
... 16.3% for longitudinal, circumferential, and radial components, respectively. For longitudinal strain, a significant difference was observed between apical and basal strains (223.9 + 4.9 vs. 212.4 + 2.9%, P , 0.001) (Figure 1). Compared with controls, longitudinal strain was significantly lower in A ...
... 16.3% for longitudinal, circumferential, and radial components, respectively. For longitudinal strain, a significant difference was observed between apical and basal strains (223.9 + 4.9 vs. 212.4 + 2.9%, P , 0.001) (Figure 1). Compared with controls, longitudinal strain was significantly lower in A ...
Echocardiographic evaluation of cardiac function response to
... strain rate), respectively. In AS patients, the longitudinal velocity, strain and strain rate (SR) are significantly decreased even in mild AS and deteriorate further as it becomes severe, similar to the previously reported M-mode and Pulsed TDI findings. The reduction in long-axis function is relat ...
... strain rate), respectively. In AS patients, the longitudinal velocity, strain and strain rate (SR) are significantly decreased even in mild AS and deteriorate further as it becomes severe, similar to the previously reported M-mode and Pulsed TDI findings. The reduction in long-axis function is relat ...
2 Cardiogenic Shock Simon G.Williams, ,
... The primary objectives of hemodynamic evaluation in cardiogenic shock are to guide the treatment of this precarious condition (29) and to provide prognostic information (26,27). One of the earliest attempts to use hemodynamic evaluation to determine prognosis and to guide therapy was by Ratshin and ...
... The primary objectives of hemodynamic evaluation in cardiogenic shock are to guide the treatment of this precarious condition (29) and to provide prognostic information (26,27). One of the earliest attempts to use hemodynamic evaluation to determine prognosis and to guide therapy was by Ratshin and ...
Systolic and Diastolic Myocardial Mechanics in Patients with
... myocardial mechanics in patients with cardiac disease and preserved LV ejection fraction (LVEF) ($50%). Methods: Patients referred for cardiac catheterization underwent comprehensive echocardiography within 20 minutes of catheterization. Strain and strain rate in longitudinal, radial, and circumfere ...
... myocardial mechanics in patients with cardiac disease and preserved LV ejection fraction (LVEF) ($50%). Methods: Patients referred for cardiac catheterization underwent comprehensive echocardiography within 20 minutes of catheterization. Strain and strain rate in longitudinal, radial, and circumfere ...
Genome-wide association study of
... 1547-5271/$ -see front matter © 2009 Heart Rhythm Society. All rights reserved. ...
... 1547-5271/$ -see front matter © 2009 Heart Rhythm Society. All rights reserved. ...
Chronic heart failure patients with restrictive LV filling pattern have
... Patients were eligible if they had chronic heart failure due to either ischaemic or idiopathic dilated cardiomyopathy and had symptoms consistent with NYHA functional class III–IV dyspnoea. Patients who were classified as bunstable class IIQ patients (who often described class III symptoms) were als ...
... Patients were eligible if they had chronic heart failure due to either ischaemic or idiopathic dilated cardiomyopathy and had symptoms consistent with NYHA functional class III–IV dyspnoea. Patients who were classified as bunstable class IIQ patients (who often described class III symptoms) were als ...
ECG-gated multidetector-row computed tomography in the
... performed only in patients with a stable heart rate below 65 beats per min. Furthermore, to evaluate functional parameters, a double trigger needs to be set at end-diastolic and end-systolic phases, which are usually centered at 0 and 30–50% of the cardiac cycle, respectively. To date, this double a ...
... performed only in patients with a stable heart rate below 65 beats per min. Furthermore, to evaluate functional parameters, a double trigger needs to be set at end-diastolic and end-systolic phases, which are usually centered at 0 and 30–50% of the cardiac cycle, respectively. To date, this double a ...
giant left atrial myxoma presenting with heart failure
... There was an associated history of paroxysmal nocturnal dyspnea, orthopnea, easy fullness, nocturia and bilateral leg swelling. There was no abdominal pain and he was not a previously diagnosed hypertensive or diabetic patient, and had no previous history of previous body swelling. There was no feve ...
... There was an associated history of paroxysmal nocturnal dyspnea, orthopnea, easy fullness, nocturia and bilateral leg swelling. There was no abdominal pain and he was not a previously diagnosed hypertensive or diabetic patient, and had no previous history of previous body swelling. There was no feve ...
Myocardial determinants in regulation of the heart rate | SpringerLink
... subject is controversial, and up to now there are good arguments which favor both a linear and a chaotic organization of such a biological oscillator. The discussion has a broader interest and also concerns other biological rhythms including respiration, nonconscious motricity, vasomotricity, and el ...
... subject is controversial, and up to now there are good arguments which favor both a linear and a chaotic organization of such a biological oscillator. The discussion has a broader interest and also concerns other biological rhythms including respiration, nonconscious motricity, vasomotricity, and el ...
Diagnosis and Management of Diastolic Dysfunction and Heart Failure
... irreversible structural alterations and systolic dysfunction. However, no single drug has pure lusitropic properties (i.e., selective enhancement of myocardial relaxation without inhibiting left ventricular contractility or function). Therefore, medical therapies for diastolic dysfunction and diasto ...
... irreversible structural alterations and systolic dysfunction. However, no single drug has pure lusitropic properties (i.e., selective enhancement of myocardial relaxation without inhibiting left ventricular contractility or function). Therefore, medical therapies for diastolic dysfunction and diasto ...
Non-invasive methods for assessing pulmonary exercise
... When a normal person exercises, there is an increase in cardiac output which rises from approximately 5 ltrs/min at rest to up to 30 ltrs/min on exercise. This is not usually accompanied by any rise in pulmonary artery pressures or, if there is a rise in pulmonary artery pressures, these are matched ...
... When a normal person exercises, there is an increase in cardiac output which rises from approximately 5 ltrs/min at rest to up to 30 ltrs/min on exercise. This is not usually accompanied by any rise in pulmonary artery pressures or, if there is a rise in pulmonary artery pressures, these are matched ...
Idiopathic ventricular tachycardia arising from the right ventricular apex
... that started while he was working at his desktop. Twelvelead ECG showed wide QRS complex tachycardia, left bundle with left superior axis morphology, late transition at a cycle length of 230 ms (Figure 1B). The tachycardia was haemodynamically well tolerated. Following failure to convert the patient ...
... that started while he was working at his desktop. Twelvelead ECG showed wide QRS complex tachycardia, left bundle with left superior axis morphology, late transition at a cycle length of 230 ms (Figure 1B). The tachycardia was haemodynamically well tolerated. Following failure to convert the patient ...
Decreased left ventricular longitudinal contraction
... in the distance of motion. The range of distance of motion displayed by the seven colour bands can be altered. The maximal distance of motion during systole was adjusted depending on the LV function to stretch the seven colour bands between the apex and the mitral annular level. When analysing the l ...
... in the distance of motion. The range of distance of motion displayed by the seven colour bands can be altered. The maximal distance of motion during systole was adjusted depending on the LV function to stretch the seven colour bands between the apex and the mitral annular level. When analysing the l ...
PRACE ORYGINALNE ORIGINAL PAPERS
... Xt, Yt+τ – compared time series shifted by τ one to another µX, µY – average values of time series σX, σY – a standard deviation of time series Analyzed values of cross correlations are for zero time shift. Justification for such selection of time shift is short time series obtained in the study and ...
... Xt, Yt+τ – compared time series shifted by τ one to another µX, µY – average values of time series σX, σY – a standard deviation of time series Analyzed values of cross correlations are for zero time shift. Justification for such selection of time shift is short time series obtained in the study and ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.