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Regional Wall Motion Abnormalities During Early Diastole in
Regional Wall Motion Abnormalities During Early Diastole in

... tricular hypertrophy, and shows normal systolic function and abnormal diastolic filling properties. Although the regional relaxation abnormality is an important determinant of global left ventricular diastolic dysfunction in coronary artery disease18–20 and hypertrophic cardiomyopathy7,21–22, the ro ...
Arrhythmogenic right ventricular dysplasia masquerading as right
Arrhythmogenic right ventricular dysplasia masquerading as right

... RV and RVOT although small anatomical changes have been demonstrated during MRI examination [3, 4]. The difference between ARVD and RVOT is important when discussing prognosis and management options. An RVOT is considered to be curative with radiofrequency catheter ablation. This is the first line t ...
Outcome of Watchful Waiting in Asymptomatic Severe Mitral
Outcome of Watchful Waiting in Asymptomatic Severe Mitral

... were changes compared with previous measurements, or if measurements were close to the predefined cutoff values (see below). Patients were referred to surgery at the onset of symptoms even if they were mild or if asymptomatic patients developed 1 or more of the following: LV end-systolic diameter ⱖ4 ...
Mitral Valve Repair Results in Better Right Ventricular Remodelling
Mitral Valve Repair Results in Better Right Ventricular Remodelling

... deformation).4,5 When the LV becomes volume loaded, as in severe mitral regurgitation (MR), pulmonary venous hypertension will develop, which leads to RV dilatation, hypertrophy and eventually RV failure.5,6 The RV plays an important role, not only for survival, but also for the postoperative course ...
PDF - Circulation: Arrhythmia and Electrophysiology
PDF - Circulation: Arrhythmia and Electrophysiology

historical summary of the relevant facts in
historical summary of the relevant facts in

... Waller from the St. Mary's Medical School of London, makes the first human ECG, using the mercury capillary electrometer, recorded in a patient called Thomas Goswell, a technician working at the lab1. It was Waller who introduced the term ECG into science. This author proposed the creation of ten le ...
Intensive Care Unit Management of Transcatheter Aortic Valve
Intensive Care Unit Management of Transcatheter Aortic Valve

... TF-TAVR patients.41 Preoperatively, patients with severe AS were found to have significantly elevated cTnT levels, which increased 7-fold post-procedure, peaking on day 3. The degree of increase was predicted by baseline renal function, duration of intra-procedure rapid ventricular pacing, and preop ...
ECG-derived Markers to Identify Patients Prone to Atrial Fibrillation
ECG-derived Markers to Identify Patients Prone to Atrial Fibrillation

A PAtient`s Guide - St. Peter`s Health Partners
A PAtient`s Guide - St. Peter`s Health Partners

... to the major blood vessels. The procedure takes several hours. To prevent the body from rejecting the donor heart, your medical team will give you powerful drugs (immunosuppressants) immediately after surgery, and you must continue to take them. ...
A Patient`s Guide to the Ventricular Assist Device
A Patient`s Guide to the Ventricular Assist Device

... to the major blood vessels. The procedure takes several hours. To prevent the body from rejecting the donor heart, your medical team will give you powerful drugs (immunosuppressants) immediately after surgery, and you must continue to take them. ...
Book 1 - 33rd Annual Meeting of the European Section of the ISHR
Book 1 - 33rd Annual Meeting of the European Section of the ISHR

... of major national centres (CNRS, INSERM, INRA, INRIA, IFREMER, etc.). Ranked among the top universities in France, the University of Bordeaux is renowned for the quality of its academic courses and research. Cardiology, whether it concerns clinical care or research, is a field for which Bordeaux has ...
MENNONITE COLLEGE OF NURSING AT ILLINOIS STATE
MENNONITE COLLEGE OF NURSING AT ILLINOIS STATE

... The cardiac cycle occurs because of electrically active tissue which forms the conduction system of the heart. Every cell of the conduction system (and muscles) has a sodium-potassium pump which pumps sodium and potassium ions in and out. When the resting electrical gradient is disturbed, a cell con ...
Depression and Cardiovascular Disease
Depression and Cardiovascular Disease

... 502 pts with >10PVC/hr or >5 NSVT episodes evaluated Results indicated that higher levels of depression and lower pulse rate reactivity were significant risk factors for death or cardiac arrest, after adjusting statistically for a ...
092001 Cardiac Rehabilitation and Secondary Prevention
092001 Cardiac Rehabilitation and Secondary Prevention

... neurohumoral abnormalities,50 autonomic tone,50 and mitochondrial oxidative-enzyme activity in skeletal muscle.51 In a randomized, controlled trial, moderately intense aerobic exercise for one year improved patient-reported measures of the quality of life and reduced overall mortality and hospital-r ...
Form versus disease: optimizing geometry during ventricular
Form versus disease: optimizing geometry during ventricular

... more spherical. This may be the unifying geometric concept of heart failure, with similar alteration of spatial configuration in non-ischemic diffuse myocyte disease, ischemic cardiomyopathy with and without scar, and in valvular heart disease. Methods: This change in architecture alters fiber direc ...
Curtis_BLOCK HF AHA Presentation Final
Curtis_BLOCK HF AHA Presentation Final

... (LVEF < 50%), BiV pacing compared to RV pacing leads to a significant 26% reduction in the combined endpoint of mortality, heart-failure related urgent care, and increase in ...
AED Automatic External Defibrillator
AED Automatic External Defibrillator

... Terminology V-Tach Ventricular tachycardia is where the heart is producing a very fast electrical contraction that does not allow the chambers of the heart to fill with blood. Blood will not circulate and the victim will be in cardiac arrest ...
Infant Heart Dissection in a Forensic Context
Infant Heart Dissection in a Forensic Context

... Requirements for Graduate Medical Education in Forensic Pathology (11). As a result, some forensic pathology fellows will transition into their staff forensic pathologist roles without having achieved competency with pediatric heart dissections. For those pathologists who find themselves in such a p ...
- Keele Research Repository
- Keele Research Repository

... Where possible, we chose to pool adjusted risk estimates from primary studies and when this data was not available raw data was used to calculate unadjusted risk estimates. The primary outcome was all-cause mortality and analysis was performed considering adjusted and unadjusted group separately. Su ...
Name of presentation
Name of presentation

... Late ventricular depolarization “J point” should be within 0.2 mV of baseline in dogs Should be on baseline in cats • Between QRS and T waves • Elevation or depression means regional myocardial hypoxia • Myocardial infarction not as common in dogs and cats as in people – Can see in cats with HCM ...
Clinical Benefit of Preserving Residual Renal Function in Dialysis
Clinical Benefit of Preserving Residual Renal Function in Dialysis

... • Loss of RRF is correlated with an increased inflammatory response as denoted by elevated solute vascular cell adhesion molecules (vascular cell adhesion molecule 1) and Creactive protein levels in patients on PD. • It has also been shown that loss of RRF may be correlated with increased production ...
A noninvasive estimation of mixed venous oxygen saturation using
A noninvasive estimation of mixed venous oxygen saturation using

... signal component reflecting arterial circulation, whereas cerebral oximetry monitors the nonpulsatile signal component reflecting tissue circulation (arterioles, capillaries, and venules). Because the cerebral microcirculation contains arterial, venous, and capillary components, cerebral saturation ...
Removal of superfluous ICD leads
Removal of superfluous ICD leads

... The decision to extract an ICD lead is ultimately based upon those success-failure/life-and-death realities associated with the procedure, and not biocompatibility. Separating lead extraction into success-failure and life-death focuses on the two key components of a lead extraction. Three true state ...
Increased alveolar/capillary membrane resistance
Increased alveolar/capillary membrane resistance

... relatively constant at about 50%.'4 A reduction in lung volumes is well documented in patients with heart failure.23 If this were to be the main mechanism responsible for the increase in alveolar/capillary membrane diffusive resistance, then a significant correlation between vital capacity and TLcO/ ...
Sudden death due to arrhythmogenic right ventricular
Sudden death due to arrhythmogenic right ventricular

... there is identifiable a transmural adiposus infiltration, with pseudo-hypertrophy of the right ventricle, affecting mostly the anterolateral and infundibular regions of the right ventricle. The postero-inferior part of the right ventricle and the left ventricle are usually normal. Histologically the ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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