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2005 American Heart Association Guidelines for CPR and ECC
2005 American Heart Association Guidelines for CPR and ECC

... Effectiveness has been found to deteriorate after two minutes of chest compressions. As a consequence, it is recommended that rescuers delivering chest compressions be relieved every two minutes. Significant changes have been made in recommendations for treatment of ventricular fibrillation (VF). In ...
100708 Basic Dysrhythmias  2902KB Jan 14 2015 08:21:37 AM
100708 Basic Dysrhythmias 2902KB Jan 14 2015 08:21:37 AM

... Fast Na+ Channels Open Cell now positive +25mV Fast Na+ Channels Close K+ still being lost ...
giant left atrial myxoma presenting with heart failure
giant left atrial myxoma presenting with heart failure

... There was an associated history of paroxysmal nocturnal dyspnea, orthopnea, easy fullness, nocturia and bilateral leg swelling. There was no abdominal pain and he was not a previously diagnosed hypertensive or diabetic patient, and had no previous history of previous body swelling. There was no feve ...
Idiopathic ventricular tachycardia arising from the right ventricular apex
Idiopathic ventricular tachycardia arising from the right ventricular apex

... that started while he was working at his desktop. Twelvelead ECG showed wide QRS complex tachycardia, left bundle with left superior axis morphology, late transition at a cycle length of 230 ms (Figure 1B). The tachycardia was haemodynamically well tolerated. Following failure to convert the patient ...
PRACE ORYGINALNE ORIGINAL PAPERS
PRACE ORYGINALNE ORIGINAL PAPERS

... Xt, Yt+τ – compared time series shifted by τ one to another µX, µY – average values of time series σX, σY – a standard deviation of time series Analyzed values of cross correlations are for zero time shift. Justification for such selection of time shift is short time series obtained in the study and ...
Original Article Ventricular septal rupture complicating acute
Original Article Ventricular septal rupture complicating acute

... (AMI). While the incidence has decreased, the mortality rate from VSR has remained extremely high. The use of mechanical circulatory support with intra-aortic balloon pump (IABP) and extracorporal membrane oxygenation (ECMO) may be useful in providing hemodynamic stability and time for myocardial sc ...
PDF - Cardio
PDF - Cardio

... the dynamic pacing protocol yielded significant differences in restitution kinetics between patients with and patients without structural heart disease, but no significant difference was observed using the S2 pacing protocol. The authors speculated that the dynamic protocol may improve the predictiv ...
Figure 1 - Cardiac Mechanics Research Group
Figure 1 - Cardiac Mechanics Research Group

... ventricular arrhythmias recorded by ECG and optical mapping. These hearts showed disturbed activation wavefront propagation, quantified by a greater negative wavefront curvature. Volume loading of the wild-type ventricle to 30 mmHg resulted in decreased conduction velocity by approximately 10%. The ...
What is Atrial Fibrillation?
What is Atrial Fibrillation?

... This is an atrial fibrillation that has started suddenly, or has made symptoms get worse. This could be a recent-onset atrial fibrillation (AF) - it has happened for the first time - or the patient may have had AF before. Acute-onset AF can occur in patients with either persistent or paroxysmal AF, ...
PPT - Arne Christensen | Anna Maria College
PPT - Arne Christensen | Anna Maria College

... eggs were placed in Petri dishes containing different concentrations of ethanol. Results indicated that the ethanol exposure in chicks reduced the heart rates significantly, while in zebrafish, physical deformities of the heart and body structure were observed. In both cases, ethanol had adverse eff ...
Gated SPECT myocardial perfusion imaging in
Gated SPECT myocardial perfusion imaging in

... pre-transplant screening, helping to identify individuals that may require a more aggressive evaluation and treatment. Moreover, it helps to detect existing cardiac conditions amenable to risk modification, and to exclude individuals with such short life expectancy that transplantation would not yie ...
Heart rate variability during breathing at 0.1 Hz frequency in the
Heart rate variability during breathing at 0.1 Hz frequency in the

... breathing frequency falls within the HF range and hence the HRV due to RSA also occurs in the HF range and is thought to be due to respiration modulating the cardiac vagal activity [3]. The longer response time of the sympathetic nervous system prevents its modulation at higher frequencies [4]. HRV ...
TAVR - SCACVPR
TAVR - SCACVPR

... valve as compensatory mechanisms do not have time to develop • Causes rapid onset of CHF, tachycardia, and decreased cardiac output • Acute aortic regurgitation usually occurs from infective endocarditis • Endocarditis is treated with antibiotics for a minimum of 48 hours prior to replacement of the ...
Left Atrial Functional Reserve in Patients With Nonischemic Dilated
Left Atrial Functional Reserve in Patients With Nonischemic Dilated

... Association functional class III. Diagnosis of DCM was based on the echocardiographic findings of a dilated left ventricle (left ventricular end-diastolic diameter [LVEDD] ⬎ 60 mm) with severely affected systolic function, left ventricular fractional shortening [LVFS] ⬍ 20%, and left ventricular eje ...
Atrial systole: its role in normal and diseased hearts
Atrial systole: its role in normal and diseased hearts

... decreases atrial volume available for subsequent ventricular filling. The second explanation, therefore, for Gesell’s original findings was that atrial systole does indeed augment cardiac output by its effect on ventricular filling. Repeated experiments in isolated mammalian heart preparations confi ...
Vasorelaxation in Space
Vasorelaxation in Space

... detected by cardiopulmonary and arterial baroreflexes, which initiate constriction of the vasculature to prevent blood pressure from falling. Therefore, gravity is a chronic systemic vasoconstrictor in upright humans during normal everyday life. Previous cardiovascular measurements in astronauts in ...
Sympathetic Nervous System Modulation of
Sympathetic Nervous System Modulation of

... hypertrophy through ␣- and ␤-adrenergic receptors, respectively.2 However, concomitant with elevated SNS activity, induction of an inflammatory infiltrate into the heart also occurs, which appears to mediate the development of hypertension-induced cardiac fibrosis but not hypertrophy. This inflammat ...
Pathophysiology and current therapy of congestive heart failure
Pathophysiology and current therapy of congestive heart failure

... thetic nervous system (22) and arginine vasopressin (antidiuretie hormone) (30). The marked increased in catecholamines is probably a reflection of the overall severity of the heart failure state (31), because it is presumed that this increase in sympathetic tone is intended to be compensatory. For ...
Vital Capacity and Congestive Heart Failure
Vital Capacity and Congestive Heart Failure

... of function can be present in the absence of any or all of these morbid phenomena.2 It would seem reasonable to attempt to detect impaired left ventricular function while some myocardial reserve still exists and there are compensatory mechanisms on which the heart can call. Assistance by judiciously ...
Heart failure with preserved ejection fraction: is this diastolic heart
Heart failure with preserved ejection fraction: is this diastolic heart

... methods and detailed analysis, these methods are difficult to use in patient screening or to perform in large clinical trials. Noninvasive measurements of diastolic function have a low sensitivity, specificity, and predictive accuracy (2). This is caused, at least in part, because all indices of dia ...
The Role of Epicardial Adipose Tissue in Heart Disease
The Role of Epicardial Adipose Tissue in Heart Disease

... unchanged in patients without diabetes or obesity (Sharma et al. 2004). Contrary to that, myocardial fatty acid oxidation was activated in diabetics and obese patients with fatty heart. These studies further speculate that triglyceride accumulation could be regarded as a maladaptive defense response ...
Is it time for home treatment of pulmonary embolism? REVIEW
Is it time for home treatment of pulmonary embolism? REVIEW

... and home treatment appear theoretically easy to define, as: 1) Absence of overt right heart failure (persistent arterial hypotension or cardiogenic shock); 2) absence of RV dysfunction; 3) absence of serious comorbidity, including (but not confined to) pre-existing heart failure, chronic pulmonary d ...
Ventricular Septal Defect
Ventricular Septal Defect

... Ventricular septal defects may be isolated or occur in association with other cardiac abnormalities. In infants, they are the most commonly diagnosed congenital cardiac defect. Bicuspid, non-stenotic aortic valves are more common, but frequently go unrecognized because of the subtle nature of the ...
Who survives from out-of-hospital pulseless electrical activity
Who survives from out-of-hospital pulseless electrical activity

... were excluded. Cardiac cause and defibrillation (in case of conversion of PEA into a shockable rhythm) were associated with decreased short-term survival rate and use of adrenaline was associated with decreased long-term survival rate. All factors that were associated with survival with p < 0.5 were ...
Coronary artery bypass surgery in patients with impaired left
Coronary artery bypass surgery in patients with impaired left

... Postoperative echocardiography was done before discharge and six months later to evaluate recovery of left ventricular function. Five patients (6.7%) died in total : three deaths were cardiac related (4%) and two patients (2.7%) died due to other causes. The left ventricular ejection fraction improv ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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