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Pulmonary Heart Disease
Pulmonary Heart Disease

... block was present in the tracings of 5 patients. Two of these showed no other evidence of heart disease, but in both electrocardiographic changes were also consistent w'ith right ventricular hypertrophy. Three other cases showed evidence of heart disease, and in 2 (40 per cent) cardiac failure was p ...
Change in Diastolic Left Ventricular Filling After One Year of
Change in Diastolic Left Ventricular Filling After One Year of

... relaxation time and E/A ratio became more normal, and LV inflow deceleration time prolonged (all P⬍0.001). Directionally opposite changes in isovolumic relaxation time (IVRT) and deceleration time indicate improvement in active LV relaxation and passive chamber stiffness during early diastole. Preva ...
6. Development of circulatory system II. Cardiac looping. Septation
6. Development of circulatory system II. Cardiac looping. Septation

... − the ventral and the dorsal walls are interconnected by an endocardial cushion named septum intermedium; the atria communicate with the ventricles via the right and the left atrioventricular canals on both sides if the septum intermedium − at the end of the week 4, the roof of the common atrium pro ...
Klasifikasi, Kodifikasi Penyakit 2 Pertemuan 12
Klasifikasi, Kodifikasi Penyakit 2 Pertemuan 12

... Birth injury to the heart usually occur in car accidents through impact with the steering wheel. .The heart is compressed between the sternum and the spine and the may suffer injury ranging from mild bruising to complete rupture. In immediately fatal car accidents, up to two thirds of the victims ha ...
ECG recording: basic principles
ECG recording: basic principles

... return again to their resting charge, known as repolarisation. These waves of depolarisation and repolarisation represent an electrical current and can be detected by placing electrodes on the surface of the body.2 After the current has spread from the heart through the body, the changes are picked ...
Magnesium in the acute management of atrial fibrillation: noise or
Magnesium in the acute management of atrial fibrillation: noise or

... about four to nine minutes quicker than control medications. Even though this is statistically significant it is not of much practical significance in the acute management of AF. The side effect profile and adverse event rates for magnesium are comparable to placebo and control medications used in t ...
Gated MIBI myocardial SPECT showing balanced ischemia and
Gated MIBI myocardial SPECT showing balanced ischemia and

... ischemic electrocardiographic changes during test is more likely due to ischemia.8 This patient showed >2 mm ST segment depression at peak exercise. Other evidences on electrocardiographic exercise test include reduced exercise capacity (<5 metabolic equivalents), abnormally low peak systolic blood ...
Prolonged QT interval is linked to all‐cause and cardiac mortality in
Prolonged QT interval is linked to all‐cause and cardiac mortality in

... malnutrition. The lower physical activity and malnutrition may be responsible for the This article is protected by copyright. All rights reserved. ...
Anticoagulation in pulmonary arterial hypertension: a qualitative systematic review S.R. Johnson*, S. Mehta
Anticoagulation in pulmonary arterial hypertension: a qualitative systematic review S.R. Johnson*, S. Mehta

... study evaluated the effect of the anticoagulant fraxiparin in patients with IPAH; however, it was excluded as it did not evaluate the end-points of interest [8]. Another study was excluded as it reported duplicate data (fig. 1) [9]. One study reported outcomes in both IPAH and PAH associated with ot ...
Prospective Evaluation of Relatives for Familial Arrhythmogenic
Prospective Evaluation of Relatives for Familial Arrhythmogenic

... the 67 families, representing familial involvement in 28%. Of these affected relatives, 72% were asymptomatic, 17% had ventricular tachycardia (sustained VT 10%, nonsustained VT 7%) and 21% had left ventricular involvement. A further 32 relatives (11%; 37.7 ⫾ 12.4 years) exhibited nondiagnostic ECG, ...
APPROACH TO HEART MURMURS IN PEDIATRIC PATIENTS
APPROACH TO HEART MURMURS IN PEDIATRIC PATIENTS

... Heart murmurs in children are a source of concern for doctors and parents alike until cardiac diseases are ruled out. While most heart murmurs are innocent, they can also be the first sign of previously asymptomatic structural heart disease, and for this reason they must not be overlooked (1, 2). Ac ...
Training - faculty at Chemeketa
Training - faculty at Chemeketa

... Fast Na+ Channels Open Cell now positive +25mV Fast Na+ Channels Close K+ still being lost ...
the influence of renal alograft function on cardiovscular status and
the influence of renal alograft function on cardiovscular status and

... posttransplant diabetes mellitus and left ventricular hypertrophy. More non-traditional cardiovascular risk factors, such as CRP, homocysteine, advanced glycation end products may also be important. Recently, it has been shown that renal function in the first posttransplant year was good predictor n ...
The most common cause of sudden cardiac death
The most common cause of sudden cardiac death

... leads to pseudo hypertrophy of myocardial wall, while he is thinned and weakened in the areas of fibrosis (18, 19). ARVC is clinically manifested tachyarrhythmia in chambers and hemodynamic disorders due to dysfunction of ventricular. The first symptoms usually manifest between 15 and 35 years and c ...
Beginning 12 Lead ECG Workshop - California Association for
Beginning 12 Lead ECG Workshop - California Association for

... Taking a good picture • II & aVF should look similar • aVR is upside down (negative deflection) • Precordial R wave progression – V1 is mostly negative – As you look through the V leads from 1 – 6, the R wave will continually become more positive ...
Fluid Management Strategies in Heart Failure Cover Article
Fluid Management Strategies in Heart Failure Cover Article

... In patients with chronic heart failure, fluid retention (or hypervolemia) is often the stimulus for acute decompensated heart failure that requires hospitalization. The pathophysiology of fluid retention is complex and involves both hemodynamic and clinical congestion. Signs and symptoms of both hem ...
Epidemiology, Pathophysiology, Prognosis, and Treatment of
Epidemiology, Pathophysiology, Prognosis, and Treatment of

... dysfunction, or LV diastolic dysfunction with normal LV systolic function (diastolic HF) may be present in HF. Remodeling stimuli such as increased mechanical LV wall stress, neurohormonal activation, cytokines, and oxidative stress lead to hypertrophy of cardiac myocytes, alterations in the interst ...
Cardiac Arrhythmias (Part 2)
Cardiac Arrhythmias (Part 2)

... liters/min/m2. Stein et al.9 reported similar results. On the other hand Samet et al.10 reported data on the effect of right atrial pacing in 33 normal subjects and 136 patients with cardiac or pulmonary disease. These latter data demonstrated that cardiac output increases in a statistically (but no ...
Excessive vasoconstriction in rheumatic mitral stenosis with
Excessive vasoconstriction in rheumatic mitral stenosis with

... tend to cause an underestimation of contractility in the former and would not obscure the presence of a myocardial facto,P.Conversely, present indexes of contractility are not completely independent of load, and the present methods might not detect some degree of contractile dysfunction. 2. Although ...


... intact or restrictive atrial septum should prompt term high-risk delivery in an institution where an urgent postdelivery atrial septectomy can be performed safely and rapidly. The use of prenatal screening improves the prenatal condition of the child but may not translate into an improved outcome (a ...
Review - p - the Health Science Program
Review - p - the Health Science Program

... (Pulmonary and Aortic valves) close. Murmurs are caused by diseases of the valves or other structural abnormalities. Heart Rate is the number of heart contractions per minute. The normal heart rate is 60 to 100 bpm (beat per minute). HR is controlled by Chemo-receptors (chemical sensors) and Baro-r ...
Exercise–based cardiac rehabilitation for heart failure
Exercise–based cardiac rehabilitation for heart failure

... A review to determine the efficacy of exercise training and its effects on outcomes in patients with heart failure. A total of 81 studies were identified: 30 randomized controlled trials, five nonrandomized controlled trials, nine randomized crossover trials, and 37 longitudinal cohort studies. Exer ...
Effects of captopril on ventricular arrhythmias in the early and late
Effects of captopril on ventricular arrhythmias in the early and late

... from the onset of symptoms of suspected acute myocardial infarction. ST segment elevation of the initial ECG was present in 73% of the patients (33% in anterior leads, 38% in inferior leads alone and 2% in both or other leads). Slightly more of the patients allocated captopril had evidence of inferi ...
Predicative value of preoperative C
Predicative value of preoperative C

... cohort formulated that the RCRI was an effective parameter for the estimate of cardiac events as it incorporated many clinical factors including medical history of stoke, coronary disease, renal dysfunction, surgery risk and medications, etc [15]. RCRI was validated as an effective evaluation tool f ...
Electrophysiology
Electrophysiology

... due to the opening of the fast Na+ channels causing a rapid increase in the membrane conductance to Na+ (GNa) and thus a rapid influx of Na+ ions (INa) into the cell; a Na+ current. • The ability of the cell to open the fast Na+ channels during phase 0 is related to the membrane potential at the mom ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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